An assessment of cardiopulmonary bypass-induced changes in platelet function using whole blood and classical light transmission aggregometry: The results of a pilot study

Anesthesia and Analgesia

Volumn 108, Issue 6, 2009, Pages 1747-1754

  Velik Salchner, Corinna ^a   Maier, Stephan ^a   Innerhofer, Petra ^a   Kolbitsch, Christian ^a   Streif, Werner ^a   Mittermayr, Markus ^a   Praxmarer, Michael ^b   Fries, Dietmar ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b Assign Data Management and Biostatistics   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; CLOPIDOGREL; COLLAGEN; HEPARIN; PROTAMINE; ANTITHROMBOCYTIC AGENT; DRUG DERIVATIVE; TICLOPIDINE;

ARTERIAL BLOOD; ARTICLE; CARDIOPULMONARY BYPASS; CORONARY ARTERY BYPASS GRAFT; DEVICE; DRUG WITHDRAWAL; ELECTRIC RESISTANCE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; AGED; ANESTHESIA; BLEEDING; BLOOD CLOTTING PARAMETERS; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY; ROC CURVE; THROMBOCYTE;

AGED; ANESTHESIA; ASPIRIN; BLOOD LOSS, SURGICAL; BLOOD PLATELETS; CARDIOPULMONARY BYPASS; FEMALE; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; ROC CURVE; TICLOPIDINE;

EID: 66349088505     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e3181a198ac     Document Type: Article

References (19)

1. Karkouti K, Wijeysundera DN, Yau TM, Beattie WS, Abdelnaem E, McCluskey SA, Ghannam M, Yeo E, Djaiani G, Karski J. The independent association of massive blood loss with mortality in cardiac surgery. Transfusion 2004;44:1453-62
2. Moulton MJ, Creswell LL, Mackey ME, Cox JL, Rosenbloom M. Reexploration for bleeding is a risk factor for adverse outcomes after cardiac operations. J Thorac Cardiovasc Surg 1996;111: 1037-46
3. Hegi TR, Bombeli T, Seifert B, Baumann PC, Haller U, Zalunardo MP, Pasch T, Spahn DR. Effect of rofecoxib on platelet aggregation and blood loss in gynaecological and breast surgery compared with diclofenac. Br J Anaesth 2004;92:523-31
4. Fox KA, Mehta SR, Peters R, Zhao F, Lakkis N, Gersh BJ, Yusuf S. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial. Circulation 2004;110:1202-8
5. Hongo RH, Ley J, Dick SE, Yee RR. The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting. J Am Coll Cardiol 2002;40:231-7
6. Yende S, Wunderink RG. Effect of clopidogrel on bleeding after coronary artery bypass surgery. Crit Care Med 2001;29:2271-5
7. Cardinal DC, Flower RJ. The electronic aggregometer: a novel device for assessing platelet behavior in blood. J Pharmacol Methods 1980;3:135-58
8. Toth O, Calatzis A, Penz S, Losonczy H, Siess W. Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thromb Haemost 2006;96:781-8
9. Mercuriali F, Inghilleri G. Proposal of an algorithm to help the choice of the best transfusion strategy. Curr Med Res Opin 1996;13:465-78
10. Lasne D, Fiemeyer A, Chatellier G, Chammas C, Baron JF, Aiach M. A study of platelet functions with a new analyzer using high shear stress (PFA 100) in patients undergoing coronary artery bypass graft. Thromb Haemost 2000;84:794-9
11. Velik-Salchner C, Maier S, Innerhofer P, Streif W, Klingler A, Kolbitsch C, Fries D. Point-of-care whole blood impedance aggregometry versus classical light transmission aggregometry for detecting aspirin and clopidogrel: the results of a pilot study. Anesth Analg 2008;107:1798-806
12. Menys VC, Belcher PR, Noble MI, Evans RD, Drossos GE, Pillai R, Westaby S. Macroaggregation of platelets in plasma, as distinct from microaggregation in whole blood (and plasma), as determined using optical aggregometry and platelet counting respectively, is specifically impaired following cardiopulmo-nary bypass in man. Thromb Haemost 1994;72:511-18
13. Wenger RK, Lukasiewicz H, Mikuta BS, Niewiarowski S, Edmunds LH Jr. Loss of platelet fibrinogen receptors during clinical cardiopulmonary bypass. J Thorac Cardiovasc Surg 1989;97:235-9
14. Cammerer U, Dietrich W, Rampf T, Braun SL, Richter JA. The predictive value of modified computerized thromboelastogra-phy and platelet function analysis for postoperative blood loss in routine cardiac surgery. Anesth Analg 2003;96:51-7, table of contents
15. Mengistu AM, Wolf MW, Boldt J, Rohm KD, Lang J, Piper SN. Evaluation of a new platelet function analyzer in cardiac surgery: a comparison of modified thromboelastography and whole-blood aggregometry. J Cardiothorac Vasc Anesth 2008;22:40-6
16. van der Linden J, Lindvall G, Sartipy U. Aprotinin decreases postoperative bleeding and number of transfusions in patients on clopidogrel undergoing coronary artery bypass graft surgery: a double-blind, placebo-controlled, randomized clinical trial. Circulation 2005;112:I276-I280
17. Mengistu AM, Rohm KD, Boldt J, Mayer J, Suttner SW, Piper SN. The influence of aprotinin and tranexamic acid on platelet function and postoperative blood loss in cardiac surgery. Anesth Analg 2008;107:391-7
18. Ogus TN, Basaran M, Selimoglu O, Yildirim T, Ogus H, Ozcan H, Us MH. Long-term results of the left anterior descending coronary artery reconstruction with left internal thoracic artery. Ann Thorac Surg 2007;83:496-501
19. Sibbing D, Braun S, Jawansky S, Vogt W, Mehilli J, Schomig A, Kastrati A, von Beckerath N. Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopi-dogrel treatment. Thromb Haemost 2008;99:121-6