ERβ induces the differentiation of cultured osteoblasts by both Wnt/β-catenin signaling pathway and estrogen signaling pathways

Experimental Cell Research

Volumn 335, Issue 1, 2015, Pages 107-114

  Yin, Xinhua ^a   Wang, Xiaoyuan ^b   Hu, Xiongke ^a   Chen, Yong ^a   Zeng, Kefeng ^a   Zhang, Hongqi ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b XI'AN HONGHUI HOSPITAL   (China)

Author keywords

17 estradial (E2); ER ; GSK3 ; Osteoblast; Wnt catenin signaling; catenin

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; CYCLIN D1; ESTRADIOL; ESTROGEN RECEPTOR BETA; GLYCOGEN SYNTHASE KINASE 3BETA; OSTEOCALCIN; OSTEOPONTIN; SERINE; SMALL INTERFERING RNA; WNT PROTEIN; ATRNL1 PROTEIN, MOUSE; CARCINOEMBRYONIC ANTIGEN; CCND1 PROTEIN, MOUSE; CEACAM1 PROTEIN, MOUSE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MEMBRANE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ANIMAL; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE; WNT SIGNALING PATHWAY;

3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BETA CATENIN; CARCINOEMBRYONIC ANTIGEN; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CYCLIN D1; ESTRADIOL; ESTROGEN RECEPTOR BETA; GLYCOGEN SYNTHASE KINASE 3; MEMBRANE PROTEINS; MICE; OSTEOBLASTS; OSTEOGENESIS; PHOSPHORYLATION; RNA INTERFERENCE; RNA, SMALL INTERFERING; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84930759316     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2015.04.020     Document Type: Article

References (32)

1. Rizzoli R., Bonjour J.P. Hormones and bones. Lancet 1997, 349(Suppl 1):sI20-23.
2. Sturm E. Liver, hormones, and bones. J. Pediatr. Gastroenterol. Nutr. 2012, 54:308-309.
3. Riggs B.L., Khosla S., Melton L.J. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. 1998, 13:763-773.
4. Seeman E. Estrogen therapy and variable-resistance weight training. J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. 1992, 7:709-711.
5. Zallone A. Direct and indirect estrogen actions on osteoblasts and osteoclasts. Ann. N. Y. Acad. Sci. 2006, 1068:173-179.
6. Kim H., Tabata A., Tomoyasu T., Ueno T., Uchiyama S., Yuasa K., Tsuji A., Nagamune H. Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells. J. Bone Miner. Metab. 2014.
7. Matsumoto Y., Otsuka F., Takano M., Mukai T., Yamanaka R., Takeda M., Miyoshi T., Inagaki K., Sada K.E., Makino H. Estrogen and glucocorticoid regulate osteoblast differentiation through the interaction of bone morphogenetic protein-2 and tumor necrosis factor-alpha in C2C12 cells. Mol. Cell Endocrinol. 2010, 325:118-127.
8. Tomkinson A., Reeve J., Shaw R.W., Noble B.S. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J. Clin. Endocrinol. Metab. 1997, 82:3128-3135.
9. Yang Y.H., Chen K., Li B., Chen J.W., Zheng X.F., Wang Y.R., Jiang S.D., Jiang L.S. Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER-ERK-mTOR pathway. Apoptosis Int. J. Program. Cell Death 2013, 18:1363-1375.
10. Manolagas S.C., Kousteni S., Jilka R.L. Sex steroids and bone. Recent Prog. Horm. Res. 2002, 57:385-409.
11. Ernst M., Heath J.K., Rodan G.A. Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones. Endocrinology 1989, 125:825-833.
12. Mamalis A., Markopoulou C., Lagou A., Vrotsos I. Oestrogen regulates proliferation, osteoblastic differentiation, collagen synthesis and periostin gene expression in human periodontal ligament cells through oestrogen receptor beta. Arch. Oral Biol. 2011, 56:446-455.
13. Mao J., Wang J., Liu B., Pan W., Farr G.H., Flynn C., Yuan H., Takada S., Kimelman D., Li L., Wu D. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 2001, 7:801-809.
14. Bennett C.N., Longo K.A., Wright W.S., Suva L.J., Lane T.F., Hankenson K.D., MacDougald O.A. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc. Natl. Acad. Sci. USA 2005, 102:3324-3329.
15. Gaur T., Lengner C.J., Hovhannisyan H., Bhat R.A., Bodine P.V., Komm B.S., Javed A., van Wijnen A.J., Stein J.L., Stein G.S., Lian J.B. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J. Biol. Chem. 2005, 280:33132-33140.
16. Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., Wang H., Cundy T., Glorieux F.H., Lev D., Zacharin M., Oexle K., Marcelino J., Suwairi W., Heeger S., Sabatakos G., Apte S., Adkins W.N., Allgrove J., Arslan-Kirchner M., Batch J.A., Beighton P., Black G.C., Boles R.G., Boon L.M., Borrone C., Brunner H.G., Carle G.F., Dallapiccola B., De Paepe A., Floege B., Halfhide M.L., Hall B., Hennekam R.C., Hirose T., Jans A., Juppner H., Kim C.A., Keppler-Noreuil K., Kohlschuetter A., LaCombe D., Lambert M., Lemyre E., Letteboer T., Peltonen L., Ramesar R.S., Romanengo M., Somer H., Steichen-Gersdorf E., Steinmann B., Sullivan B., Superti-Furga A., Swoboda W., van den Boogaard M.J., Van Hul W., Vikkula M., Votruba M., Zabel B., Garcia T., Baron R., Olsen B.R., Warman M.L., Osteoporosis-Pseudoglioma G. Syndrome collaborative, LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001, 107:513-523.
17. Krishnan V., Bryant H.U., Macdougald O.A. Regulation of bone mass by Wnt signaling. J. Clin. Invest. 2006, 116:1202-1209.
18. Varea O., Arevalo M.A., Garrido J.J., Garcia-Segura L.M., Wandosell F., Mendez P. Interaction of estrogen receptors with insulin-like growth factor-I and Wnt signaling in the nervous system. Steroids 2010, 75:565-569.
19. Armstrong V.J., Muzylak M., Sunters A., Zaman G., Saxon L.K., Price J.S., Lanyon L.E. Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J. Biol. Chem. 2007, 282:20715-20727.
20. Westendorf J.J., Kahler R.A., Schroeder T.M. Wnt signaling in osteoblasts and bone diseases. Gene 2004, 341:19-39.
21. Liu B., Che W., Xue J., Zheng C., Tang K., Zhang J., Wen J., Xu Y. SIRT4 prevents hypoxia-induced apoptosis in H9c2 cardiomyoblast cells. Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol. 2013, 32:655-662.
22. Varea O., Garrido J.J., Dopazo A., Mendez P., Garcia-Segura L.M., Wandosell F. Estradiol activates beta-catenin dependent transcription in neurons. PloS One 2009, 4:e5153.
23. Kuiper G.G., Lemmen J.G., Carlsson B., Corton J.C., Safe S.H., van der Saag P.T., van der Burg B., Gustafsson J.A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998, 139:4252-4263.
24. Plant A., Samuels A., Perry M.J., Colley S., Gibson R., Tobias J.H. Estrogen-induced osteogenesis in mice is associated with the appearance of Cbfa1-expressing bone marrow cells. J. Cell. Biochem. 2002, 84:285-294.
25. Gordon M.D., Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J. Biol. Chem. 2006, 281:22429-22433.
26. Wu D., Pan W. GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem. Sci. 2010, 35:161-168.
27. Bhukhai K., Suksen K., Bhummaphan N., Janjorn K., Thongon N., Tantikanlayaporn D., Piyachaturawat P., Suksamrarn A., Chairoungdua A. A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3beta protein-dependent activation of the Wnt/beta-catenin signaling pathway. J. Biol. Chem. 2012, 287:36168-36178.
28. Hall J.M., Couse J.F., Korach K.S. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J. Biol. Chem. 2001, 276:36869-36872.
29. Zhou W., Liu Z., Yao J., Chi F., Dong K., Yue X., Teng T., Rausch X. The Effects of Exenatide Microsphere on Serum BGP and ALP Levels in ZDF Rats after Implantation. Clin. Implant. Dent. Relat. Res. 2013.
30. Akman A.C., Seda Tigli R., Gumusderelioglu M., Nohutcu R.M. Bone morphogenetic protein-6-loaded chitosan scaffolds enhance the osteoblastic characteristics of MC3T3-E1 cells. Artif. Org. 2010, 34:65-74.
31. Korulu S., Yildiz-Unal A., Yuksel M., Karabay A. Protein kinase C activation causes neurite retraction via cyclinD1 and p60-katanin increase in rat hippocampal neurons. Eur. J. Neurosci. 2013, 37:1610-1619.
32. Lee J.Y., Lee N.K. Up-regulation of cyclinD1 and Bcl2A1 by insulin is involved in osteoclast proliferation. Life Sci. 2014, 114:57-61.