Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation

Biochemical and Biophysical Research Communications

Volumn 459, Issue 4, 2015, Pages 673-678

  Li, Zheng Jun ^a   Shin, Jung Min ^a   Choi, Dae Kyoung ^a   Lim, Seul Ki ^a   Yoon, Tae Jin ^b   Lee, Young Ho ^a   Sohn, Kyung Cheol ^a   Im, Myung ^a   Lee, Young ^a   Seo, Young Joon ^a   Lee, Jeung Hoon ^a,c  

^a Chungnam National University   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

^c Skin Med Co   (South Korea)

Author keywords

Cucurbitacin B; Imiquimod; Keratinocytes; NF B; STAT3

Indexed keywords

AMINOQUINOLINE DERIVATIVE; CUCURBITACIN B; IMIQUIMOD; PRIMER DNA; TRITERPENE;

DERMATITIS; HUMAN; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION;

AMINOQUINOLINES; BASE SEQUENCE; DERMATITIS; DNA PRIMERS; HUMANS; IN VITRO TECHNIQUES; REAL-TIME POLYMERASE CHAIN REACTION; TRITERPENES;

EID: 84930702940     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.03.001     Document Type: Article

References (28)

1. M.A. Lowes, A.M. Bowcock, and J.G. Krueger Pathogenesis and therapy of psoriasis Nature 445 2007 866 873
2. Y. Li, and A.B. Begovich Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis Semin. Immunol. 21 2009 318 327
3. R. Medzhitov Toll-like receptors and innate immunity Nat. Rev. Immunol. 1 2001 135 145
4. J.E. McInturff, R.L. Modlin, and J. Kim The role of toll-like receptors in the pathogenesis and treatment of dermatological disease J. Invest. Dermatol 125 2005 1 8
5. G. Trinchieri, and A. Sher Cooperation of toll-like receptor signals in innate immune defence Nat. Rev. Immunol. 7 2007 179 190
6. H. Hemmi, T. Kaisho, O. Takeuchi, S. Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, and S. Akira Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway Nat. Immunol. 3 2002 196 200
7. T. Kono, S. Kondo, S. Pastore, G.M. Shivji, M.A. Tomai, R.C. McKenzie, and D.N. Sauder Effects of a novel topical immunomodulator, imiquimod, on keratinocyte cytokine gene expression Lymphokine Cytokine Res. 13 1994 71 76
8. M.P. Schön, M. Schön, and K.N. Klotz The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion J. Invest. Dermatol 126 2006 1338 1347
9. M. Gilliet, C. Conrad, M. Geiges, A. Cozzio, W. Thürlimann, G. Burg, F.O. Nestle, and R. Dummer Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors Arch. Dermatol 140 2004 1490 1495
10. B. Flutter, and F.O. Nestle TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis Eur. J. Immunol. 43 2013 3138 3146
11. A. Walter, M. Schäfer, V. Cecconi, C. Matter, M. Urosevic-Maiwald, B. Belloni, N. Schönewolf, R. Dummer, W. Bloch, S. Werner, H.D. Beer, A. Knuth, and M. van den Broek Aldara activates TLR7-independent immune defence Nat. Commun. 4 2013 1560
12. B. Jayaprakasam, N.P. Seeram, and M.G. Nair Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana Cancer Lett. 189 2003 11 16
13. J.S. Lee, D.H. Kim, D.K. Choi, C.D. Kim, G.B. Ahn, T.Y. Yoon, J.H. Lee, and J.Y. Lee Comparison of gene expression profiles between keratinocytes, melanocytes and fibroblasts Ann. Dermatol 25 2013 36 45
14. H.I. Choi, K.C. Sohn, D.K. Hong, Y. Lee, C.D. Kim, T.J. Yoon, J.W. Park, S. Jung, J.H. Lee, and Y.H. Lee Melanosome uptake is associated with the proliferation and differentiation of keratinocytes Arch. Dermatol. Res. 306 2014 59 66
15. R.M. Andrés, M.C. Montesinos, P. Navalón, M. Payá, and M.C. Terencio NF-κB and STAT3 inhibition as a therapeutic strategy in psoriasis: in vitro and in vivo effects of BTH J. Invest. Dermatol 133 2013 2362 2371
16. A.O. Huen, and A.H. Rook Toll receptor agonist therapy of skin cancer and cutaneous T-cell lymphoma Curr. Opin. Oncol. 26 2014 237 244
17. Z.J. Li, K.C. Sohn, D.K. Choi, G. Shi, D. Hong, H.E. Lee, K.U. Whang, Y.H. Lee, M. Im, Y. Lee, Y.J. Seo, C.D. Kim, and J.H. Lee Roles of TLR7 in activation of NF-κB signaling of keratinocytes by imiquimod PLoS One 8 2013 e77159
18. S. Sano, K.S. Chan, S. Carbajal, J. Clifford, M. Peavey, K. Kiguchi, S. Itami, B.J. Nickoloff, and J. DiGiovanni Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model Nat. Med. 11 2005 43 49
19. L. van der Fits, S. Mourits, J.S. Voerman, M. Kant, L. Boon, J.D. Laman, F. Cornelissen, A.M. Mus, E. Florencia, E.P. Prens, and E. Lubberts Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis J. Immunol. 182 2009 5836 5845
20. A.E. Kalinin, A.V. Kajava, and P.M. Steinert Epithelial barrier function: assembly and structural features of the cornified cell envelope Bioessays 24 2002 789 800
21. C.M. Sweeney, A.M. Tobin, and B. Kirby Innate immunity in the pathogenesis of psoriasis Arch. Dermatol. Res. 303 2011 691 705
22. A.M. Arel-Dubeau, F. Longpré, J. Bournival, C. Tremblay, J. Demers-Lamarche, P. Haskova, E. Attard, M. Germain, and M.G. Martinoli Cucurbitacin e has neuroprotective properties and autophagic modulating activities on dopaminergic neurons Oxid. Med. Cell. Longev. 2014 2014 425496
23. C. Jacquot, B. Rousseau, D. Carbonnelle, I. Chinou, M. Malleter, C. Tomasoni, and C. Roussakis Cucurbitacin-D-induced CDK1 mRNA up-regulation causes proliferation arrest of a non-small cell lung carcinoma cell line (NSCLC-N6) Anticancer Res. 34 2014 4797 4806
24. Y. Kong, J. Chen, Z. Zhou, H. Xia, M.H. Qiu, and C. Chen Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer PLoS One 9 2014 e103760
25. M. Promkan, S. Dakeng, S. Chakrabarty, O. Bögler, and P. Patmasiriwat The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells PLoS One 8 2013 e55732
26. M. Zhang, H. Zhang, C. Sun, X. Shan, X. Yang, J. Li-Ling, and Y. Deng Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B Cancer Chemother. Pharmacol. 63 2009 635 642
27. M.C. Recio, M. Prieto, M. Bonucelli, C. Orsi, S. Máñez, R.M. Giner, M. Cerdá-Nicolás, and J.L. Ríos Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots Planta Med. 70 2004 414 420
28. S. Yubero, L. Ramudo, M.A. Manso, and I. De Dios Mechanisms of dexamethasone-mediated chemokine down-regulation in mild and severe acute pancreatitis Biochim. Biophys. Acta 1792 2009 1205 1211