Mechanisms of dexamethasone-mediated chemokine down-regulation in mild and severe acute pancreatitis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1792, Issue 12, 2009, Pages 1205-1211

  Yubero, S ^a   Ramudo, L ^a   Manso, M A ^a   De Dios, I ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Acute pancreatitis; Chemokines; Dexamethasone; MAPK; NF B; STAT3

Indexed keywords

AMYLASE; CHEMOKINE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; DEXAMETHASONE SODIUM PHOSPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT PROTEIN; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ACINAR CELL; ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; HEMATOCRIT; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELL NUCLEUS; CHEMOKINE CCL2; CHEMOKINE CXCL1; DEXAMETHASONE; DOWN-REGULATION; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PANCREATITIS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR;

RATTUS;

EID: 71849098246     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2009.10.001     Document Type: Article

References (46)

1. Adams D.H., and Lloyd A.R. Chemokines: leukocyte recruitment and activation cytokines. Lancet 349 (1997) 490-495
2. Murphy PM. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12 (1994) 593-633
3. Regnér S., Appelros S., Hjalmarsson C., Manjer J., Sadic J., and Borgstrom A. Monocyte chemoattractant protein 1, active carboxypeptidase B and CAPAP at hospital admission are predictive markers for severe acute pancreatitis. Pancreatology 8 (2008) 42-49
4. Naskalski J.W., Kusnierz-Cabala B., Panek J., and Kedra B. Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and sTNFR55/sTNFR75 in plasma of patients with acute pancreatitis. J. Physiol. Pharmacol. 54 (2003) 439-448
5. Samuel I., Yorek M.A., Zaheer A., and Fisher R.A. Bile-pancreatic juice exclusion promotes Akt/NF-kappaB activation and chemokine production in ligation-induced acute pancreatitis. J Gastrointest. Surg. 10 (2006) 950-959
6. Yubero S., Ramudo L., Manso M.A., and De Dios I. The role of redox status on chemokine expression in acute pancreatitis. Biochim. Biophys. Acta 1792 (2009) 148-154
7. Bhatia M., and Hegde A. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul. Pept. 138 (2007) 40-48
8. Brady M., Bhatia M., Christmas S., Boyd M.T., Neoptolemos J.P., and Slavin J. Expression of the chemokines MCP-1/JE and cytokine-induced neutrophil chemoattractant in early acute pancreatitis. Pancreas 25 (2002) 260-269
9. Sun J., and Bhatia M. Blockade of neurokinin-1 receptor attenuates CC and CXC chemokine production in experimental acute pancreatitis and associated lung injury. Am. J. Physiol. Gastrointest. Liver Physiol. 292 (2007) G143-153
10. Bhatia M., Brady M., Kang Y.K., Costello E., Newton D.J., Christmas S.E., Neoptolemos J.P., and Slavin J. MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation. Am. J. Physiol. Gastrointest. Liver Physiol. 282 (2002) G77-85
11. Ramnath R.D., Sun J., Adhikari S., and Bhatia M. Effect of mitogen-activated protein kinases on chemokine synthesis induced by substance P in mouse pancreatic acinar cells. J. Cell. Mol. Med. 11 (2007) 1326-1341
12. Yubero S., Ramudo L., Manso M.A., and De Dios I. Targeting peripheral immune response reduces the severity of necrotizing acute pancreatitis. Crit. Care Med. 37 (2009) 240-245
13. Auphan N., DiDonato J.A., Rosette C., Helmberg A., and Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270 (1995) 286-290
14. Scheinman R.I., Gualberto A., Jewell C.M., Cidlowski J.A., and Baldwin Jr. A.S. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol. Cell. Biol. 15 (1995) 943-953
15. Yang-Yen H.F., Chambard J.C., Sun Y.L., Smeal T., Schmidt T.J., Drouin J., and Karin M. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62 (1990) 1205-1215
16. Ramudo L., Yubero S., Manso M.A., Vicente S., and De Dios I. Signal transduction of MCP-1 expression induced by pancreatitis-associated ascitic fluid in pancreatic acinar cells. J. Cell. Mol. Med. 7 (2009) 1314-1320
17. Unterberger C., Staples K.J., Smallie T., Williams L., Foxwell B., Schaefer A., Kempkes B., Hofer T.P., Koeppel M., Lohrum M., Stunnenberg H., Frankenberger M., and Ziegler-Heitbrock L. Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene. Mol. Immunol. 45 (2008) 3230-3237
18. Bladh L., Johansson-Haque K., Rafter I., Nilsson S., and Okret S. Inhibition of extracellular signal-regulated kinase (ERK) signaling participates in repression of nuclear factor (NF)-κB activity by glucocorticoids. Biochim. Biophys. Acta 1793 (2009) 439-446
19. Swantek J.L., Cobb M.H., and Geppert T.D. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-α) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK. Mol. Cell. Biol. 17 (1997) 6274-6282
20. Qi A.Q., Qui J., Xiao L., and Chen Y.Z. Rapid activation of JNK and p38 by glucocorticoids in primary cultured hippocampal cells. J. Neurosci. Res. 80 (2005) 510-517
21. Osman M.O., Jacobsen N.O., Kristensen J.U., Larsen C.G., and Jensen S.L. Beneficial effects of hydrocortisone in a model of experimental acute pancreatitis. Dig. Surg. 16 (1999) 214-221
22. Paszt A., Takács T., Rakonczay Z., Kaszaki J., Wolfard A., Tiszlavicz L., Lázár G., Duda E., Szentpáli K., Czakó L., Boros M., Balogh A., and Jr G. Lázár. The role of the glucocorticoid-dependent mechanism in the progression of sodium taurocholate-induced acute pancreatitis in the rat. Pancreas 29 (2004) 75-82
23. Gloor B., Uhl W., Tcholakov O., Roggo A., Muller C.A., Worni M., and Büchler M.W. Hydrocortisone treatment of early SIRS in acute experimental pancreatitis. Dig. Dis. Sci. 46 (2001) 2154-2161
24. Lázár Jr. G., Varga J., Lázár G., Duda E., Takács T., Balogh A., and Lonovics J. The effects of glucocorticoids and a glucocorticoid antagonist (RU 38486) on experimental acute pancreatitis in rat. Acta Chir. Hung. 36 (1997) 190-191
25. Wang Z.F., Liu C., Lu Y., Dong R., Xu J., Yu L., Yao Y.M., Liu Q.G., and Pan C.E. Dexamethasone and dextran 40 treatment of 32 patients with severe acute pancreatitis. World J. Gastroenterol. 10 (2004) 1333-1336
26. Rakonczay Jr. Z., Duda E., Kaszaki J., Iványi B., Boros I., Lonovics J., and Takács T. The anti-inflammatory effect of methylprednisolone occurs down-stream of nuclear factor-kappaB DNA binding in acute pancreatitis. Eur. J. Pharmacol. 464 (2003) 217-227
27. Zhang X.P., Zhang L., Wang Y., Cheng Q.H., Wang J.M., Cai W., Shen H.P., and Cai J. Study of the protective effects of dexamethasone on multiple organ injury in rats with severe acute pancreatitis. J. Pancreas 8 (2007) 400-412
28. Zhang X.P., Zhang L., Xu H.M., Xu Y.P., Cheng Q.H., Wang J.M., and Shen H.P. Application of tissue microarrays to study the influence of dexamethasone on NF-kappaB expression of pancreas in rat with severe acute pancreatitis. Dig. Dis. Sci. 53 (2008) 571-580
29. Kimura T., Zuidema G.D., and Cameron J.L. Acute pancreatitis. Experimental evaluation of steroid, albumin and trasylol therapy. Am. J. Surg. 140 (1980) 403-408
30. Cosen-Binker L.I., Binker M.G., Negri G., and Tiscornia O. Experimental model of acute pancreatitis in Wistar rat. Glucocorticoid treatment profile. Dig. Dis. Sci. 48 (2003) 1453-1464
31. Sevillano S., De la Mano A.M., De Dios I., Ramudo L., and Manso M.A. Major pathological mechanisms of acute pancreatitis are prevented by N-acetylcysteine. Digestion 68 (2003) 34-40
32. Aho H.J., and Nevalainen T.J. Experimental pancreatitis in the rat. Ultrastructure of sodium taurocholate-induced pancreatic lesions. Scand. J. Gastroenterol. 15 (1980) 417-424
33. Ramudo L., Manso M.A., Sevillano S., and de Dios I. Kinetic study of TNF-alpha production and its regulatory mechanisms in acinar cells during acute pancreatitis induced by bile-pancreatic duct obstruction. J. Pathol. 206 (2005) 9-16
34. Hickson J.C. The secretion of pancreatic juice in response to stimulation of the vagus nerves in the pig. J. Physiol. 206 (1970) 275-297
35. Leach S.D., Modlin I.M., Scheele G.A., and Gorelick F.S. Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin. J. Clin. Invest. 87 (1991) 362-366
36. Wilckens T., and De Rijk R. Glucocorticoids and immune function: unknown dimensions and new frontiers. Immunol. Today 18 (1997) 418-424
37. Ramnath R.D., and Bhatia M. Substance P treatment stimulates chemokine synthesis in pancreatic acinar cells via the activation of NF-kappaB. Am. J. Physiol. Gastrointest. Liver Physiol. 291 (2006) G1113-1119
38. Bogoyevitch M.A., Gillespie-Brown J., Ketterman A.J., Fuller S.J., Ben-Levry R., Ashworth A., Marshall C.J., and Sugden P.H. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. P38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion. Circ. Res. 79 (1996) 162-173
39. Kyriakis J.M. Signalling by the germinal center kinase family of protein kinases. J. Biol. Chem. 274 (1999) 5259-5262
40. Turkson J., Bowman T., Adnane J., Zhang Y., Djeu J.Y., Sekharam M., Frank D.A., Holzman L.B., Wu J., Sebti S., and Jove R. Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein. Mol. Cell. Biol. 19 (1999) 7519-7528
41. Mordelet E., Davies H.A., Hillyer P., and Romero I.A. D. Male. Chemokine transport across human vascular endothelial cells. Endothelium 14 (2007) 7-15
42. Masamune A., Suzuki N., Kikuta K., Satoh M., Satoh K., and Shimosegawa T. Curcumin blocks activation of pancreatic stellate cells. J. Cell. Biochem. 97 (2006) 1080-1093
43. Hohmann H.P., Remy R., Pöschl B., and van Loon A.P. Tumor necrosis factors-alpha and -beta bind to the same two types of tumor necrosis factor receptors and maximally activate the transcription factor NF-kappa B at low receptor occupancy and within minutes after receptor binding. J. Biol. Chem. 265 (1990) 15183-15188
44. Takeda K., and Akira S. STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev. 11 (2000) 199-207
45. Poch B., Gansauge F., Rau B., Wittel U., Gansauge S., Nüssler A.K., Schoenberg M., and Beger H.G. The role of polymorphonuclear leukocytes and oxygen-derived free radicals in experimental acute pancreatitis: mediators of local destruction and activators of inflammation. FEBS Lett. 461 (1999) 268-272
46. Castellino F., Heuser J., Marchetti S., Bruno B., and Luini A. Glucocorticoid stabilization of actin filaments: a possible mechanism for inhibition of corticotropin release. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 3775-3779