Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations

Molecular Pharmaceutics

Volumn 12, Issue 6, 2015, Pages 1980-1991

  Sahbaz, Yasemin ^a   Williams, Hywel D ^a,b   Nguyen, Tri Hung ^a   Saunders, Jessica ^a   Ford, Leigh ^a   Charman, Susan A ^a   Scammells, Peter J ^a   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b CAPSUGEL   (France)

Author keywords

cinnarizine; drug absorption; ionic liquid; itraconazole; lipid based formulation; poorly water soluble drug

Indexed keywords

ALCOHOL; CHLORIDE; CINNARIZINE; COUNTERION; DOCUSATE SODIUM; HALOFANTRINE; IONIC LIQUID; ITRACONAZOLE; MEDIUM CHAIN ACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; COLLOID; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG EXPOSURE; DRUG SOLUBILITY; IN VIVO STUDY; LIPID ABSORPTION; LIPID SOLUBILITY; LIPOPHILICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MELTING POINT; NONHUMAN; PRIORITY JOURNAL; RAT; SUSPENSION; ANIMAL; CHEMISTRY; MEDICINAL CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CINNARIZINE; DRUG DELIVERY SYSTEMS; IONIC LIQUIDS; ITRACONAZOLE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84930676120     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500790t     Document Type: Article

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