How many molecules does it take to tell a story? Case studies, language, and an epistemic view of medicinal chemistry

ChemMedChem

Volumn 10, Issue 6, 2015, Pages 949-956

  Stahl, Martin ^a   Baier, Sabine ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Swiss Federal Institute of Technology Collegium Helveticum   (Switzerland)

Author keywords

case studies; drug discovery; evolutionary epistemology; medicinal chemistry; tacit knowledge

Indexed keywords

RALTEGRAVIR;

ARTICLE; CHEMICAL STRUCTURE; CREATIVITY; DRUG DEVELOPMENT; KNOWLEDGE; MEDICINAL CHEMISTRY; MOLECULE; NATURAL SCIENCE; PRIORITY JOURNAL;

CHEMISTRY, PHARMACEUTICAL;

EID: 84930675270     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201500091     Document Type: Article

References (50)

1. R. Hoffmann, Angew. Chem. Int. Ed. 2001, 40, 3337-3340
2. Angew. Chem. 2001, 113, 3439-3443.
3. R. W. Hoffmann, Synthese 2007, 155, 321-336.
4. M. Polanyi, The Tacit Dimension, University of Chicago Press, Chicago, 1966.
5. A. L. Hopkins, A. Polinsky, in Annual Reports in Medicinal Chemistry, Vol. 41 (Ed.:, A. Wood,), Elsevier, Amsterdam, 2006, pp. 425-435.
6. A. Mayweg, U. Hofer, P. Schnider, F. Agnetti, G. Galley, P. Mattei, M. Lucas, H.-J. Boehm, Drug Discovery Today 2011, 16, 691-696.
7. P. D. Leeson, B. Springthorpe, Nat. Rev. Drug Discovery 2007, 6, 881-890
8. G. M. Keserü, G. M. Makara, Nat. Rev. Drug Discovery 2009, 8, 203-212.
9. P. A. Charifson, W. P. Walters, J. Med. Chem. 2014, 57, 9701-9717.
10. Expert Opinion on Therapeutic Patents, informahealthcare.com/loi/etp; accessed March 20, 2015.
11. W. M. Welch, in Advances in Medicinal Chemistry, Vol. 41 (Ed.:, A. Wood,), JAI Press, Greenwich, 1995, pp. 113-148.
12. C. Barber, D. Pryde, in Accounts in Drug Discovery: Case Studies in Medicinal Chemistry, Vol. 4 (Eds.:, J. C. Barrish, P. H. Carter, P. T. W. Cheng, R. Zahler,), RSC, Cambridge, 2011, pp. 183-214.
13. W. Sneader, Drug Prototypes and Their Exploitation, Wiley, Chichester, 1996.
14. The Handbook of Medicinal Chemistry (Eds.:, A. Davis, S. E. Ward,), RSC Press, Cambridge, 2014
15. J. Fischer, C. R. Ganellin, D. P. Rotella, Analogue-based Drug Discovery III, Wiley-VCH, Weinheim, 2012.
16. Progress in Medicinal Chemistry, Vol. 42 (Eds.:, F. D. King, G. Lawton, A. W. Oxford,), Elsevier, Amsterdam, 2004.
17. Latest volume: Annual Reports in Medicinal Chemistry, Vol. 49 (Ed.:, M. C. Desai,), Elsevier, Amsterdam, 2014.
18. D. Middlemiss, S. P. Watson, Tetrahedron 1994, 50, 13049-13080.
19. M. S. Egbertson, N. J. Anthony, in HIV-1 Integrase: Mechanism and Inhibitor Design (Ed.:, N. Neamati,), John Wiley & Sons, New York, 2011, pp. 197-228.
20. C. A. Lipinski, N. K. Litterman, C. Southan, A. J. Williams, A. M. Clark, S. Ekins, J. Med. Chem. 2015, 58, 2068-2076.
21. S. J. Lusher, R. McGuire, R. C. van Schaik, C. D. Nicholson, J. de Vlieg, Drug Discovery Today 2014, 19, 859-868.
22. WikiPathways, www.wikipathways.org; accessed March 20, 2015.
23. D. M. Andrews, M. E. Swarbrick, A. T. Merritt, Drug Discovery Today 2014, 19, 496-501.
24. K. Knorr-Cetina, Die Fabrikation von Erkenntnis. Zur Anthropologie der Naturwissenschaft, Suhrkamp, Frankfurt, 2012.
25. E. Martin, P. Mukherjee, J. Chem. Inf. Model. 2012, 52, 156-170.
26. O. P. J. van Linden, A. J. Kooistra, R. Leurs, I. J. P. de Esch, C. de Graaf, J. Med. Chem. 2014, 57, 249-277
27. N. Furtmann, Y. Hu, J. Bajorath, J. Med. Chem. 2015, 58, 252-264.
28. S. Toulmin, Human Understanding. The Collective Use and Evolution of Concepts, Princeton University Press, Princeton, 1972.
29. D. Oehlrich, H. Prokopcova, H. J. M. Gijsen, Bioorg. Med. Chem. Lett. 2014, 24, 2033-2045.
30. A. T. Chadwick, M. D. Segall, Drug Discovery Today 2010, 15, 561-569.
31. G. A. Patani, E. J. LaVoie, Chem. Rev. 1996, 96, 3147-3176
32. R. P. Sheridan, J. Med. Chem. 2002, 42, 103-108
33. N. A. Meanwell, J. Med. Chem. 2011, 54, 2529-2591.
34. H.-J. Böhm, A. Flohr, M. Stahl, Drug Discovery Today Technol. 2004, 1, 217-224.
35. A. G. Dossetter, E. J. Griffen, A. G. Leach, Drug Discovery Today 2013, 18, 724-731.
36. H.-J. Rheinberger, Experimentalsysteme und Epistemische Dinge, Wallstein Verlag, Göttingen, 2002.
37. D. G. Brown, M. M. Gagnon, J. Boström, J. Med. Chem. 2015, 58, 2390-2405.
38. A. L. Hopkins, C. R. Groom, A. Alex, Drug Discovery Today 2004, 9, 430-431
39. M. D. Shultz, Bioorg. Med. Chem. Lett. 2013, 23, 5980-5991.
40. D. R. Cheshire, Drug Discovery Today 2011, 16, 817-821.
41. G. R. Robb, D. McKerrecher, N. J. Newcombe, M. J. Waring, Drug Discovery Today 2013, 18, 141-147.
42. J. G. March, Organ. Sci. 1991, 2, 71-87.
43. D. Cook, D. Brown, R. Alexander, R. March, P. J. Morgan, G. Satterthwaite, M. N. Pangalos, Nat. Rev. Drug Discovery 2014, 13, 419-431.
44. R. P. Feynman, Cargo Cult Science, calteches.library.caltech.edu/51/2/CargoCult.pdf, accessed March 20, 2015.
45. G. Wilson, Am. Sci. 2009, 97, 360.
46. P. C. Wong, J. Thomas, IEEE Comp. Graph. 2004, 24, 20-21
47. J. J. Thomas, K. A. Cook, Illuminating the Path: The Research and Development Agenda for Visual Analytics, IEEE Press, Piscatway, NJ, 2005.
48. H. Hilpert, H. Mauser, R. Humm, L. Anselm, H. Kuehne, G. Hartmann, S. Gruener, D. W. Banner, J. Benz, B. Gsell, A. Kuglstatter, M. Stihle, R. Thoma, R. Alvarez Sanchez, H. Iding, B. Wirz, W. Haap, J. Med. Chem. 2013, 56, 9789-9801.
49. P. Filippakopoulos, J. Qi, S. Picaud, Y. Shen, W. B. Smith, O. Fedorov, E. M. Morse, T. Keates, T. T. Hickman, I. Felletar, M. Philpott, S. Munro, M. R. McKeown, Y. Wang, A. L. Christie, N. West, M. J. Cameron, B. Schwartz, T. D. Heightman, N. La Thangue, C. A. French, O. Wiest, A. L. Kung, S. Knapp, J. E. Bradner, Nature 2010, 468, 1067-1073.
50. W. Sneader, Drug Prototypes and Their Exploitation, Wiley, Chichester, 1996, pp. 276-277.