-
1
-
-
84859105504
-
Size estimation of chemical space: How big is it?
-
K.L.M. Drew Size estimation of chemical space: how big is it? J. Pharm. Pharmacol. 64 2012 490 495
-
(2012)
J. Pharm. Pharmacol.
, vol.64
, pp. 490-495
-
-
Drew, K.L.M.1
-
2
-
-
0035204617
-
Realism in drug discovery-could Cassandra be right?
-
D.F. Horrobin Realism in drug discovery-could Cassandra be right? Nat. Biotechnol. 19 2001 1099 1100
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 1099-1100
-
-
Horrobin, D.F.1
-
3
-
-
79952131874
-
Impact of high-throughput screening in biomedical research
-
R. Macarron Impact of high-throughput screening in biomedical research Nat. Rev. Drug Discov. 10 2011 188 195
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 188-195
-
-
MacArron, R.1
-
4
-
-
4344668661
-
Drug repositioning: Identifying and developing new uses for existing drugs
-
T.T. Ashburn, and K.B. Thor Drug repositioning: identifying and developing new uses for existing drugs Nat. Rev. Drug Discov. 3 2004 673 683
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
5
-
-
77649234756
-
How to improve R&D productivity: The pharmaceutical industry's grand challenge
-
S.M. Paul How to improve R&D productivity: the pharmaceutical industry's grand challenge Nat. Rev. Drug Discov. 9 2010 203 214
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
-
6
-
-
84863393476
-
Hypothesis driven drug design: Improving quality and effectiveness of the design-make-test-analyse cycle
-
A.T. Plowright Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle Drug Discov. Today 17 2012 56 62
-
(2012)
Drug Discov. Today
, vol.17
, pp. 56-62
-
-
Plowright, A.T.1
-
7
-
-
67349164247
-
Making medicinal chemistry more effective-application of Lean Sigma to improve processes, speed and quality
-
S. Andersson Making medicinal chemistry more effective-application of Lean Sigma to improve processes, speed and quality Drug Discov. Today 14 2009 598 604
-
(2009)
Drug Discov. Today
, vol.14
, pp. 598-604
-
-
Andersson, S.1
-
8
-
-
78651365936
-
Creativity, innovation and lean sigma: A controversial combination?
-
C. Johnstone Creativity, innovation and lean sigma: a controversial combination? Drug Discov. Today 16 2011 50 57
-
(2011)
Drug Discov. Today
, vol.16
, pp. 50-57
-
-
Johnstone, C.1
-
9
-
-
79952442525
-
Outsourcing chemical synthesis in the drug discovery process
-
G. Festel Outsourcing chemical synthesis in the drug discovery process Drug Discov. Today 16 2011 237 243
-
(2011)
Drug Discov. Today
, vol.16
, pp. 237-243
-
-
Festel, G.1
-
10
-
-
84866734946
-
Outsourcing drug discovery to India and China: From surviving to thriving
-
Subramaniam, S. and Dugar, S. (2012) Outsourcing drug discovery to India and China: from surviving to thriving. Drug Discov. Today, http://dx.doi.org/10. 1016/j.drudis.2012.04.005 (http://www.drugdiscoverytoday.com).
-
(2012)
Drug Discov. Today
-
-
Subramaniam, S.1
Dugar, S.2
-
11
-
-
73349100019
-
Project-focused activity and knowledge tracker: A unified data analysis, collaboration, and workflow tool for medicinal chemistry Project Teams
-
M.D. Brodney Project-focused activity and knowledge tracker: a unified data analysis, collaboration, and workflow tool for medicinal chemistry Project Teams J. Chem. Inf. Model. 49 2009 2639 2649
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 2639-2649
-
-
Brodney, M.D.1
-
12
-
-
84863115789
-
DEGAS: Sharing and tracking target compound ideas with external collaborators
-
M. Lee DEGAS: sharing and tracking target compound ideas with external collaborators J. Chem. Inf. Model. 52 2012 278 284
-
(2012)
J. Chem. Inf. Model.
, vol.52
, pp. 278-284
-
-
Lee, M.1
-
13
-
-
65249170905
-
OSIRIS, an entirely in-house developed drug discovery informatics system
-
T. Sander OSIRIS, an entirely in-house developed drug discovery informatics system J. Chem. Inf. Model. 49 2009 232 246
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 232-246
-
-
Sander, T.1
-
14
-
-
61849137243
-
Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery
-
M. Hohman Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery Drug Discov. Today 14 2009 261 270
-
(2009)
Drug Discov. Today
, vol.14
, pp. 261-270
-
-
Hohman, M.1
-
15
-
-
44649178588
-
Internet-based tools for communication and collaboration in chemistry
-
A.J. Williams Internet-based tools for communication and collaboration in chemistry Drug Discov. Today 13 2008 502 506
-
(2008)
Drug Discov. Today
, vol.13
, pp. 502-506
-
-
Williams, A.J.1
-
16
-
-
80051673274
-
ROCK: The Roche medicinal chemistry knowledge application-design, use and impact
-
A. Mayweg ROCK: the Roche medicinal chemistry knowledge application-design, use and impact Drug Discov. Today 16 2011 691 696
-
(2011)
Drug Discov. Today
, vol.16
, pp. 691-696
-
-
Mayweg, A.1
-
17
-
-
80052830823
-
How well do medicinal chemists learn from experience?
-
D.R. Cheshire How well do medicinal chemists learn from experience? Drug Discov. Today 16 2011 817 821
-
(2011)
Drug Discov. Today
, vol.16
, pp. 817-821
-
-
Cheshire, D.R.1
-
18
-
-
51849123990
-
What is Web2.0: Design patterns and business models for the next generation of software
-
T. O'Reilly What is Web2.0: design patterns and business models for the next generation of software Commun. Strat. 65 2007 17 37
-
(2007)
Commun. Strat.
, vol.65
, pp. 17-37
-
-
O'Reilly, T.1
-
20
-
-
79958773884
-
Predictivity of simulated ADME AutoQSAR models over time
-
S.L. Rodgers Predictivity of simulated ADME AutoQSAR models over time Mol. Informatics 30 2011 256 266
-
(2011)
Mol. Informatics
, vol.30
, pp. 256-266
-
-
Rodgers, S.L.1
-
21
-
-
72449198009
-
Improving compound quality through in vitro and in silico physicochemical profiling
-
H. van de Waterbeemd Improving compound quality through in vitro and in silico physicochemical profiling Chem. Biodivers. 6 2009 1760 1766
-
(2009)
Chem. Biodivers.
, vol.6
, pp. 1760-1766
-
-
Van De Waterbeemd, H.1
-
22
-
-
37249039935
-
QSAR modeling using automatically updating correction libraries: Application to a human plasma protein binding model
-
S.L. Rodgers QSAR modeling using automatically updating correction libraries: application to a human plasma protein binding model J. Chem. Inf. Model. 47 2007 2401 2407
-
(2007)
J. Chem. Inf. Model.
, vol.47
, pp. 2401-2407
-
-
Rodgers, S.L.1
-
23
-
-
49849094738
-
Physiochemical drug properties associated with in vivo toxicological outcomes
-
J.D. Hughes Physiochemical drug properties associated with in vivo toxicological outcomes Bioorg. Med. Chem. Lett. 18 2008 4872 4875
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 4872-4875
-
-
Hughes, J.D.1
-
24
-
-
35748934487
-
The influence of drug-like concepts on decision-making in medicinal chemistry
-
P.D. Leeson, and B. Springthorpe The influence of drug-like concepts on decision-making in medicinal chemistry Nat. Rev. Drug Discov. 6 2007 881 890
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
25
-
-
79961133381
-
Matrix-based multiparameter optimisation of glucokinase activators: The discovery of AZD1092
-
M.J. Waring Matrix-based multiparameter optimisation of glucokinase activators: the discovery of AZD1092 MedChemComm 2 2011 775 779
-
(2011)
MedChemComm
, vol.2
, pp. 775-779
-
-
Waring, M.J.1
|