Characterization of pulmonary sigma receptors by radioligand binding

European Journal of Pharmacology

Volumn 762, Issue , 2015, Pages 118-126

  Lever, John R ^a,b   Litton, Tyler P ^a,b   Fergason Cantrell, Emily A ^a,b  

^a University of Missouri   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Mouse; Pulmonary pharmacology; Radioligand binding; Sigma receptor

Indexed keywords

1,3 BIS(2 METHYLPHENYL)GUANIDINE; DEXTROMETHORPHAN; HALOPERIDOL; IFENPRODIL; N ALLYLNORMETAZOCINE; PENTAZOCINE; PHENYTOIN; RADIOLIGAND; RECEPTOR BLOCKING AGENT; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG; [1 [2 (3,4 DICHLORO PHENYL)ETHYL] 4 METHYLPIPERAZINE]DIHYDROCHLORIDE;

ADULT; ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG RECEPTOR BINDING; ENANTIOMER; HEART; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; STEADY STATE; ANIMAL; CELL MEMBRANE; CYTOLOGY; METABOLISM; RADIOASSAY;

ANIMALS; CELL MEMBRANE; LUNG; MALE; MICE; RADIOLIGAND ASSAY; RECEPTORS, SIGMA;

EID: 84930656400     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.05.026     Document Type: Article

References (49)

1. M.W. Anderson, T.C. Orton, R.D. Pickett, and T.E. Eling Accumulation of amines in the isolated perfused rabbit lung J. Pharmacol. Exp. Ther. 189 1974 456 466
2. S.H. Audi, C.A. Dawson, J.H. Linehan, G.S. Krenz, S.B. Ahlf, and D.L. Roerig Pulmonary disposition of lipophilic amine compounds in the isolated perfused rabbit lung J. Appl. Physiol. 84 1998 516 530
3. 3H]DTG binding sites in guinea pig cerebellum: evidence for the presence of non-specific binding Eur. J. Pharmacol. 252 1994 139 146
4. F. Boer Drug handling by the lungs Br. J. Anaesth. 91 2003 50 60
5. 3H](+)- Pentazocine: a potent and highly selective benzomorphan-based probe for sigma-1 recepto Mol. Neuropharmacol. 3 1993 117 126
6. C. Brown, M. Fezoui, W.M. Selig, C.E. Schwartz, and J.L. Ellis Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br. J. Pharmacol. 141 2004 233 240
7. 50) of an enzymatic reaction Biochem. Pharmacol. 22 1973 3099 3108
8. U.B. Chu, S. Ramachandran, A.R. Hajipour, and A.E. Ruoho Photoaffinity labeling of the sigma-1 receptor with N-[3-(4-nitrophenyl)propyl]-N-dodecylamine: evidence of receptor dimers Biochemistry 52 2013 859 868
9. 1 receptors of guinea pig brain Synapse 55 2005 192 195
10. T.L. Collier, R.N. Waterhouse, and M. Kassiou Imaging sigma receptors: applications in drug development Curr. Pharm. Des. 13 2007 51 72
11. 3H](+)-pentazocine to sigma recognition sites in guinea pig brain Eur. J. Pharmacol. 227 1992 371 378
12. 3H](+)pentazocine-defined sigma recognition sites by phenytoin Life Sci. 53 1993 41 48
13. D.L. DeHaven-Hudkins, L.F. Lanyon, F.Y. Ford-Rice, and M.A. Ator σ recognition sites in brain and peripheral tissues. Characterization and effects of cytochrome P450 inhibito Biochem. Pharmacol. 47 1994 1231 1239
14. 2 receptor on Jurkat cell membranes, but σ compounds fail to influence immunomodulatory events in human peripheral blood lymphocytes Immunopharmacology 35 1996 27 39
15. D. Fontanilla, M. Johannessen, A.R. Hajipour, N.V. Cozzi, M.B. Jackson, and A.E. Ruoho The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator Science 323 2009 934 937
16. H. Foth Role of the lung in accumulation and metabolism of xenobiotic compounds implications for chemically induced toxicity Crit. Rev. Toxicology 25 1995 165 205
17. E. Frecska, A. Szabo, M.J. Winkelman, L.E. Luna, and D.J. McKenna A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity J. Neural. Transm. 120 2013 1295 1303
18. 3H] ifenprodil binding to σ receptors in rat brain Eur. J. Pharmacol. 236 1993 159 163
19. 2+ signaling and cell survival Cell 131 2007 596 610
20. T. Hayashi Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs J. Pharmacol. Sci. 127 2015 2 5
21. 2 receptors: characterization by ligand binding and photoaffinity labeling Eur. J. Pharmacol. 268 1994 9 18
22. H. Kashiwagi, J.E. McDunn, P.O. Simon Jr., P.S. Goedegebuure, J. Xu, L. Jones, K. Chang, F. Johnston, K. Trinkaus, R.S. Hotchkiss, R.H. Mach, and W.G. Hawkins Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy Mol. Cancer 6 2007 48
23. 3H]pentazocine binding sites in post-mortem human frontal cortex J. Neural Transm. 103 1996 45 53
24. K.J. Kovács, and A.A. Larson Discrepancies in characterization of sigma sites in the mouse central nervous system Eur. J. Pharmacol. 285 1995 127 134
25. F. Langa, X. Codony, V. Tovar, A. Lavado, E. Giménez, P. Cozar, M. Cantero, A. Dordal, E. Hernández, R. Pérez, X. Monroy, D. Zamanillo, X. Guitart, and L. Montoliu Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice Eur. J. Neurosci. 18 2003 2188 2196
26. 2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503 Synapse 59 2006 350 358
27. S.Z. Lever, R. Xu, K.-H. Fan, E.A. Fergason-Cantrell, T.L. Carmack, L.D. Watkinson, and J.R. Lever Synthesis, radioiododination and in vitro and in vivo sigma receptor studies of N-1-allyl-N'-4-phenethylpiperazine analogs Nucl. Med. Biol. 39 2012 401 414
28. J.R. Lever, D.K. Miller, C.L. Green, E.A. Fergason-Cantrell, L.D. Watkinson, T.L. Carmack, K.-H. Fan, and S.Z. Lever A selective sigma-2 receptor ligand antagonizes cocaine-induced hyperlocomotion in mice Synapse 68 2014 73 84
29. J.R. Lever, D.K. Miller, E.A. Fergason-Cantrell, C.L. Green, L.D. Watkinson, T.L. Carmack, and S.Z. Lever Relationships between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418 J. Pharmacol. Exp. Ther. 351 2014 153 163
30. 2 receptors Life Sci. 57 1995 PL57 PL62
31. 35S]GTPγS stimulated by (+)-pentazocine sigma receptor agonist, is abundant in the guinea pig spleen Life Sci. 67 2000 599 603
32. 2 receptor: a novel protein for the imaging and treatment of cancer J. Med. Chem. 56 2013 7137 7160
33. R.R. Matsumoto, K.L. Hewett, B. Pouw, W.D. Bowen, S.M. Husbands, J.J. Cao, and A.H. Newman Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters Neuropharmacology 41 2001 878 886
34. R.R. Matsumoto, K.A. McCracken, B. Pouw, Y. Zhang, and W.D. Bowen Involvement of sigma receptors in the behavioral effects of cocaine: Evidence from novel ligands and antisense oligodeoxynucleotides Neuropharmacology 42 2002 1043 1055
35. R.R. Matsumoto, W.D. Bowen, and T.P. Su Sigma Receptors: Chemistry 2007 Cell Biology and Clinical Implications. Springer New York
36. T. Maurice, R. Martin-Fardon, P. Romieu, and R.R. Matsumoto Sigma1 (σ1) receptor antagonists represent a new strategy against cocaine addiction and toxicity Neurosci. Biobehav. Rev. 26 2002 499 527
37. S.U.R. Mir, I.S.A. Ahmed, S. Arnold, and R.J. Craven Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients Int. J. Cancer 131 2012, E1-9
38. L. Monassier, and P. Bousquet Sigma receptors: from discovery to highlights of their implications in the cardiovascular system Fundam. Clin. Pharmacol. 16 2002 1 8
39. A. Pal, D. Fontanilla, A. Gopalakrishnan, Y.K. Chae, J.L. Markley, and A.E. Ruoho The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements Eur. J. Pharmacol. 682 2012 12 20
40. P. Seth, F. Leibach, and V. Ganapathy Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor Biochem. Biophys. Res. Commun. 241 1997 535 540
41. 2-site in rat and human brain Neuropharmacology 43 2002 95 100
42. T.P. Su, T. Hayashi, T. Maurice, S. Buch, and A.E. Ruoho The sigma-1 receptor chaperone as an inter-organelle signaling modulator Trends Pharmacol. Sci. 31 2010 557 566
43. C. Vogel, and E.M. Marcotte Insights into the regulation of protein abundance from proteomic and transcriptomic analyses Nat. Rev. Genet. 13 2012 227 232
44. N.D. Volkow, J.S. Fowler, A.P. Wolf, G.J. Wang, J. Logan, R. MacGregor, S.L. Dewey, D. Schlyer, and R. Hitzemann Distribution and kinetics of carbon-11-cocaine in the human body measured with PET J. Nucl. Med. 33 1992 521 525
45. J.M. Walker, W.D. Bowen, F.O. Walker, R.R. Matsumoto, B. De Costa, and K.C. Rice Sigma receptors: biology and function Pharmacol. Rev 42 1990 355 402
46. L.L. Werling, A. Keller, J.G. Frank, and S.J. Nuwayhid A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder Exp. Neurol. 207 2007 248 257
47. L.L. Werling, E.C. Lauterbach, and U. Calef Dextromethorphan as a potential neuroprotective agent with unique mechanisms of action Neurologist 13 2007 272 293
48. J. Xu, C. Zeng, W. Chu, F. Pan, J.M. Rothfuss, F. Zhang, Z. Tu, D. Zhou, D. Zeng, S. Vangveravong, F. Johnston, D. Spitzer, K.C. Chang, R.S. Hotchkiss, W.G. Hawkins, K.T. Wheeler, and R.H. Mach Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site Nat. Commun. 22 2011 380
49. A. van Waarde, A.A. Rybczynska, N.K. Ramakrishnan, K. Ishiwata, P.H. Elsinga, and R.A. Dierckx Potential applications for sigma receptor ligands in cancer diagnosis and therapy Biochim. Biophys. Acta S0005-2736 14 2014 00304 00306 10.1016/j.bbamem.2014.08.022 Aug 27. pii