Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs

Journal of Pharmacological Sciences

Volumn 127, Issue 1, 2015, Pages 2-5

  Hayashi, Teruo ^a  

^a Seiwakai Nishikawa Hospital   (Japan)

Author keywords

Chaperone; ER stress; MAM; Sigma receptor; Sigma 1 receptor

Indexed keywords

CHAPERONE; SIGMA 1 OPIATE RECEPTOR; PSYCHOTROPIC AGENT; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR;

BIOENERGY; CELL COMMUNICATION; CELL ORGANELLE; CELL SURVIVAL; CELLULAR DISTRIBUTION; ENDOPLASMIC RETICULUM MEMBRANE; ENDOPLASMIC RETICULUM STRESS; HUMAN; MOLECULAR CLONING; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN LOCALIZATION; REVIEW; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; ENDOPLASMIC RETICULUM; METABOLISM; MITOCHONDRION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ENDOPLASMIC RETICULUM; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; PSYCHOTROPIC DRUGS; RECEPTORS, SIGMA; SIGNAL TRANSDUCTION;

EID: 84924050942     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2014.07.001     Document Type: Review

References (28)

1. T.P. Su, and T. Hayashi Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 receptors are intracellular amplifiers for signal transduction Cur Med Chem 10 20 2003 2073 2080
2. T. Hayashi, S.Y. Tsai, T. Mori, M. Fujimoto, and T.P. Su Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders Expert Opin Ther Targets 15 5 2011 557 577
3. M. Hanner, F.F. Moebius, A. Flandorfer, H.G. Knaus, J. Striessnig, and E. Kempner Purification, molecular cloning, and expression of the mammalian sigma1-binding site Proc Natl Acad Sci U S A 93 15 1996 8072 8077
4. W.D. Bowen, S.B. Hellewell, and K.A. McGarry Evidence for a multi-site model of the rat brain sigma receptor Eur J Pharmacol 163 2-3 1989 309 318
5. K. Hashimoto Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship Cent Ner Syst Agents Med Chem 9 3 2009 197 204
6. R.R. Matsumoto Targeting sigma receptors: novel medication development for drug abuse and addiction Expert Rev Clin Pharmacol 2 4 2009 351 358
7. T. Maurice, and B.P. Lockhart Neuroprotective and anti-amnesic potentials of sigma (sigma) receptor ligands Prog Neuropsychopharmacol Biol Psychiatry 21 1 1997 69 102
8. C.C. Chien, and G.W. Pasternak Sigma antagonists potentiate opioid analgesia in rats Neurosci Lett 190 2 1995 137 139
9. R. Quirion, R.P. Hammer Jr., M. Herkenham, and C.B. Pert Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film Proc Natl Acad Sci U S A 78 9 1981 5881 5885
10. T. Hayashi, and T.P. Su Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival Cell 131 3 2007 596 610
11. T. Hayashi, and T.P. Su Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export J Pharmacol Exp Ther 306 2 2003 718 725
12. T.A. Mavlyutov, M.L. Epstein, K.A. Andersen, L. Ziskind-Conhaim, and A.E. Ruoho The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study Neuroscience 167 2 2010 247 255
13. G. Alonso, V. Phan, I. Guillemain, M. Saunier, A. Legrand, and M. Anoal Immunocytochemical localization of the sigma(1) receptor in the adult rat central nervous system Neuroscience 97 1 2000 155 170
14. Y. Chen, A.R. Hajipour, M.K. Sievert, M. Arbabian, and A.E. Ruoho Characterization of the cocaine binding site on the sigma-1 receptor Biochemistry 46 11 2007 3532 3542
15. T.P. Su, E.D. London, and J.H. Jaffe Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems Science 240 4849 1988 219 221
16. D. Fontanilla, M. Johannessen, A.R. Hajipour, N.V. Cozzi, M.B. Jackson, and A.E. Ruoho The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator Science 323 5916 2009 934 937
17. A.E. Ruoho, U.B. Chu, S. Ramachandran, D. Fontanilla, T. Mavlyutov, and A.R. Hajipour The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines Curr Pharm Des 18 7 2012 920 929
18. T. Hayashi, and M. Fujimoto Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction Mol Pharmacol 77 4 2010 517 528
19. T. Hayashi, E. Hayashi, M. Fujimoto, H. Sprong, and T.P. Su The lifetime of UDP-galactose: ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones J Biol Chem 287 51 2012 43156 43169
20. T. Hayashi, R. Rizzuto, G. Hajnoczky, and T.P. Su MAM: more than just a housekeeper Trends Cell Biol 19 2 2009 81 88
21. T.P. Su, T. Hayashi, T. Maurice, S. Buch, and A.E. Ruoho The sigma-1 receptor chaperone as an inter-organelle signaling modulator Trends Pharmacol Sci 31 12 2010 557 566
22. M. Fujimoto, T. Hayashi, and T.P. Su The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria Biochem Biophys Res Commun 417 1 2012 635 639
23. M. Fujimoto, and T. Hayashi New insights into the role of mitochondria-associated endoplasmic reticulum membrane Int Rev Cell Mol Biol 292 2011 73 117
24. T. Mori, T. Hayashi, E. Hayashi, and T.P. Su Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival PloS One 8 10 2013 e76941
25. J. Meunier, and T. Hayashi Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB J Pharmacol Exp Ther 332 2 2010 388 397
26. S. Kourrich, T. Hayashi, J.Y. Chuang, S.Y. Tsai, T.P. Su, and A. Bonci Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine Cell 152 1-2 2013 236 247
27. M. Fujimoto, T. Hayashi, R. Urfer, S. Mita, and T.P. Su Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor Synapse 66 7 2012 630 639
28. J.L. Ortega-Roldan, F. Ossa, and J.R. Schnell Characterization of the human sigma-1 receptor chaperone domain structure and binding immunoglobulin protein (BiP) interactions J Biol Chem 288 29 2013 21448 21457