Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

Journal of Psychopharmacology

Volumn 29, Issue 5, 2015, Pages 642-651

  Cox, Katherine H M ^a   Pipingas, Andrew ^a   Scholey, Andrew B ^a  

^a SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

attention; cholesterol; cognition; Curcumin; elderly; fatigue; mood; older; working memory

Indexed keywords

CURCUMIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO;

ADULT; AGED; ALERTNESS; ARTICLE; BECK DEPRESSION INVENTORY; CHALDER FATIGUE SCALE; CHOLESTEROL BLOOD LEVEL; COGNITION; CONTENTEDNESS; CONTROLLED STUDY; DEPRESSION ANXIETY STRESS SCALE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MOOD; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SINGLE DRUG DOSE; STATE TRAIT ANXIETY INVENTORY; TREATMENT DURATION; WORKING MEMORY; AFFECT; ATTENTION; DRUG EFFECTS; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PSYCHOMOTOR PERFORMANCE; SHORT TERM MEMORY; VERY ELDERLY;

AFFECT; AGED; AGED, 80 AND OVER; ATTENTION; COGNITION; CURCUMIN; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MEMORY, SHORT-TERM; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE;

EID: 84930653295     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881114552744     Document Type: Article

References (92)

1. Aalto S, Brück A, Laine M, et al. Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: A positron emission tomography study using the high-affinity dopamine d2 receptor ligand [11C]FLB 457. J Neurosci. 2005 ; 25: 2471-2477
2. Agarwal KA, Tripathi CD, Agarwal BB, et al. Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: A double-blind, randomized placebo-controlled study. Surg Endosc. 2011 ; 25: 3805-3810
3. Agrawal R, Mishra B, Tyagi E, et al. Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat. Pharmacol Res. 2010 ; 61: 247-252
4. Anand P, Kunnumakkara AB, Newman RA, et al. Bioavailability of curcumin: Problems and promises. Mol Pharmaceut. 2007 ; 4: 807-818
5. Avlund K. Fatigue in older adults: An early indicator of the aging process?. Aging Clin Exp Res. 2010 ; 22: 100-115
6. Avlund K, Damsgaard MT, Schroll M. Tiredness as determinant of subsequent use of health and social services among nondisabled elderly people. J Aging Health. 2001 ; 13: 267-286
7. Baum L, Lam CWK, Cheung SKK, et al. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J Clin Psychopharmacol. 2008 ; 28: 110-113
8. Beck AT, Steer RA, Brown GK BDI-II Manual. San Antonio, TX: Psychological Corporation ; 1996 :
9. Begum AN, Jones MR, Lim GP, et al. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Therapeut. 2008 ; 326: 196-208
10. Bhutani MK, Bishnoi M, Kulkarni SK. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol Biochem Behav. 2009 ; 92: 39-43
11. Bond A, Lader M. The use of analogue scales in rating subjective feelings. Br J Med Psychol. 1974 ; 47: 211-218
12. Byers AL, Covinsky KE, Barnes DE, et al. Dysthymia and depression increase risk of dementia and mortality among older veterans. Am J Geriatr Psychiatry. 2012 ; 20: 664-672
13. Calderon J, Perry R, Erzinclioglu S, et al. Perception, attention, and working memory are disproportionately impaired in dementia with lewy bodies compared with Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001 ; 70: 157-164
14. Carriere I, Ryan J, Norton J, et al. Anxiety and mortality risk in community-dwelling elderly people. Br J Psychiatry. 2013 ; 203: 303-309
15. Chalder T, Berelowitz G, Pawlikowska T, et al. Development of a fatigue scale. J Psychosom Res. 1993 ; 37: 147-153
16. Chandra V, Pandav R, Dodge HH, et al. Incidence of Alzheimer's disease in a rural community in India: The Indo-US study. Neurology. 2001 ; 57: 985-989
17. Chimakurthy J, Talasila M. Effects of curcumin on pentylenetetrazole-induced anxiety-like behaviors and associated changes in cognition and monoamine levels. Psychol Neurosci. 2010 ; 3: 238-244
18. Chopra MP, Zubritsky C, Knott K, et al. Importance of subsyndromal symptoms of depression in elderly patients. Am J Geriatr Psychiatry. 2005 ; 13: 597-606
19. Choudhary KM, Mishra A, Poroikov VV, et al. Ameliorative effect of curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice. Eur J Pharmacol. 2013 ; 704: 33-40
20. Davis JM, Murphy EA, Carmichael MD, et al. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol. 2007 ; 292: R2168 - R2173
21. De Jager CA, Budge MM, Clarke R. Utility of Tics-M for the assessment of cognitive function in older adults. Int J Geriatr Psychiatry. 2003 ; 18: 318-324
22. De Rooij SR, Schene AH, Phillips DI, et al. Depression and anxiety: Associations with biological and perceived stress reactivity to a psychological stress protocol in a middle-aged population. Psychoneuroendocrinology. 2010 ; 35: 866-877
23. DiMatteo M, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: Meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 ; 160: 2101-2107
24. DiSilvestro RA, Joseph E, Zhao S, et al. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 ; 11: 79
25. Dong SZ, Zeng QW, Mitchell ES, et al. Curcumin enhances neurogenesis and cognition in aged rats: Implications for transcriptional interactions related to growth and synaptic plasticity. Plos One. 2012 ; 7: e31211
26. Eckert GP, Schiborr C, Hagl S, et al. Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8. Neurochem Int. 2013 ; 62: 595-602
27. Ellis KA, Nathan PJ. The pharmacology of human working memory. Int J Neuropsychopharmacol. 2001 ; 4: 299-313
28. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 ; 12: 189-198
29. Gallacher J, Bayer A, Fish M, et al. Does anxiety affect risk of dementia? Findings from the caerphilly prospective study. Psychosom Med. 2009 ; 71: 659-666
30. Gao M, Zhou H, Li X. Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: Possible involvement of the ERK1/2 pathway. Basic Clin Pharmacol Toxicol. 2009 ; 104: 236-240
31. Garcia-Alloza M, Borrelli LA, Rozkalne A, et al. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem. 2007 ; 102: 1095-1104
32. Gota VS, Maru GB, Soni TG, et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 ; 58: 2095-2099
33. Gupta A, Vij G, Sharma S, et al. Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model. Immunobiology. 2009 ; 214: 33-39
34. Han L, McCusker J, Cole M, et al. 12-month cognitive outcomes of major and minor depression in older medical patients. Am J Geriatr Psychiatry. 2008 ; 16: 742-751
35. Hurley LL, Akinfiresoye L, Nwulia E, et al. Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF. Behav Brain Res. 2013 ; 239: 27-30
36. Ishrat T, Hoda MN, Khan MB, et al. Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT). Eur Neuropsychopharmacol. 2009 ; 19: 636-647
37. Jiang H, Wang Z, Wang Y, et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 ; 47: 33-39
38. Kang C, Kim E. Synergistic effect of curcumin and insulin on muscle cell glucose metabolism. Food Chem Toxicol. 2010 ; 48: 2366-2373
39. Kang H-J, Stewart R, Jeong B-O, et al. Suicidal ideation in elderly Korean population: A two-year longitudinal study. Int Psychogeriatr. 2014 ; 26: 59-67
40. Kazama M, Kondo N, Suzuki K, et al. Early impact of depression symptoms on the decline in activities of daily living among older Japanese: Y-HALE cohort study. Environ Health Prev Med. 2011 ; 16: 196-201
41. Kennedy D, Veasey R, Watson A, et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology. 2010 ; 211: 55-68
42. Kennedy G, Spence VA, McLaren M, et al. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Rad Biol Med. 2005 ; 39: 584-589
43. Kensinger EA, Shearer DK, Locascio JJ, et al. Working memory in mild Alzheimer's disease and early Parkinson's disease. Neuropsychology. 2003 ; 17: 230-239
44. Kim JH, Park JM, Kim E-K, et al. Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in l6 myotube cells. J Cell Physiol. 2010 ; 223: 771-778
45. Kulkarni S, Bhutani M, Bishnoi M. Antidepressant activity of curcumin: Involvement of serotonin and dopamine system. Psychopharmacology. 2008 ; 201: 435-442
46. Kumar TP, Antony S, Gireesh G, et al. Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. J Biomed Sci. 2010 ; 17: 43
47. Lim GP, Chu T, Yang F. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 ; 21: 8370-8377
48. Lovibond SH, Lovibond PF Manual for the Depression Anxiety Stress Scales. Sydney: Psychology Foundation ; 1995 :
49. Meng B, Li J, Cao H. Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications. Curr Pharmaceut Des. 2013 ; 19: 2101-2113
50. Moreh E, Jacobs JM, Stessman J. Fatigue, function, and mortality in older adults. J Gerontol A Biol Sci Med Sci. 2010 ; 65A: 887-895
51. Myin-Germeys I, Peeters F, Havermans R, et al. Emotional reactivity to daily life stress in psychosis and affective disorder: An experience sampling study. Acta Psychiatr Scand. 2003 ; 107: 124-131
52. Nelson HE National Adult Reading Test (NART): Test manual. Windsor: NFER-Nelson ; 1991 :
53. Ng T-P, Chiam P-C, Lee T, et al. Curry consumption and cognitive function in the elderly. Am J Epidemiol. 2006 ; 164: 898-906
54. Norton J, Ancelin ML, Stewart R, et al. Anxiety symptoms and disorder predict activity limitations in the elderly. J Affect Disord. 2012 ; 141: 276-285
55. Ohayon MM, Vecchierini MF. Daytime sleepiness and cognitive impairment in the elderly population. Arch Intern Med. 2002 ; 162: 201-208
56. Ono K, Hasegawa K, Naiki H, et al. Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. J Neurosci Res. 2004 ; 75: 742-750
57. Park DC, Smith AD, Lautenschlager G, et al. Mediators of long-term memory performance across the life span. Psychol Aging. 1996 ; 11: 621-637
58. Pistone G, Marino A, Leotta C, et al. Levocarnitine administration in elderly subjects with rapid muscle fatigue: Effect on body composition, lipid profile and fatigue. Drugs Aging. 2003 ; 20: 761-767
59. Pyrzanowska J, Piechal A, Blecharz-Klin K, et al. The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats. Pharmacol Biochem Behav. 2010 ; 95: 351-358
60. Ringman JM, Frautschy SA, Teng E, et al. Oral curcumin for Alzheimer's disease: Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther. 2012 ; 4: 43
61. Rinwa P, Kumar A. Piperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice. Brain Res. 2012 ; 1488: 38-50
62. Rinwa P, Kumar A, Garg S. Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression. Plos One. 2013 ; 8: e61052
63. Sanmukhani J, Satodia V, Trivedi J, et al. Efficacy and safety of curcumin in major depressive disorder: A randomized controlled trial. Phytother Res. 2014 ; 28: 579-585
64. Scapagnini G, Colombrita C, Amadio M, et al. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid Redox Signal. 2006 ; 8: 395-403
65. Scholey AB, French SJ, Morris PJ, et al. Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. J Psychopharmacol. 2010 ; 24: 1505-1514
66. Scholey AB, Kennedy DO. Acute, dose-dependent cognitive effects of Ginkgo biloba, Panax ginseng and their combination in healthy young volunteers: Differential interactions with cognitive demand. Hum Psychopharmacol. 2002 ; 17: 35-44
67. Schultz-Larsen K, Avlund K. Tiredness in daily activities: A subjective measure for the identification of frailty among non-disabled community-living older adults. Arch Gerontol Geriatr. 2007 ; 44: 83-93
68. Sharma S, Zhuang Y, Ying Z, et al. Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. Neuroscience. 2009 ; 161: 1037-1044
69. Shichiri M, Harada N, Ishida N, et al. Oxidative stress is involved in fatigue induced by overnight deskwork as assessed by increase in plasma tocopherylhydroqinone and hydroxycholesterol. Biol Psychol. 2013 ; 94: 527-533
70. Sinoff G, Werner P. Anxiety disorder and accompanying subjective memory loss in the elderly as a predictor of future cognitive decline. Int J Geriatr Psychiatry. 2003 ; 18: 951-959
71. Sood PK, Nahar U, Nehru B. Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain. Neurotox Res. 2011 ; 20: 351-361
72. Spielberger CD, Gorsuch RL, Lushene RE STAI: Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press ; 1969 :
73. Staub B, Doignon-Camus N, Després O, et al. Sustained attention in the elderly: What do we know and what does it tell us about cognitive aging?. Ageing Res Rev. 2013 ; 12: 459-468
74. Sun CY, Qi SS, Zhou P, et al. Neurobiological and pharmacological validity of curcumin in ameliorating memory performance of senescence-accelerated mice. Pharmacol Biochem Behav. 2013 ; 105: 76-82
75. Tiwari V, Chopra K. Attenuation of oxidative stress, neuroinflammation, and apoptosis by curcumin prevents cognitive deficits in rats postnatally exposed to ethanol. Psychopharmacology. 2012 ; 224: 519-535
76. Tsai Y-M, Chien C-F, Lin L-C, et al. Curcumin and its nano-formulation: The kinetics of tissue distribution and blood-brain barrier penetration. Int J Pharmaceut. 2011 ; 416: 331-338
77. Vas CJ, Pinto C, Panikker D, et al. Prevalence of dementia in an urban Indian population. Int Psychogeriatr. 2001 ; 13: 439-450
78. Vasiliadis H-M, Dionne P-A, Préville M, et al. The excess healthcare costs associated with depression and anxiety in elderly living in the community. Am J Geriatr Psychiatry. 2013 ; 21: 536-548
79. Waern M, Runeson BS, Allebeck P, et al. Mental disorder in elderly suicides: A case-control study. Am J Psychiatry. 2002 ; 159: 450-455
80. Wang R, Xu Y, Wu H-L, et al. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors. Eur J Pharmacol. 2008 ; 578: 43-50
81. Witkin JM, Leucke S, Thompson LK, et al. Further evaluation of the neuropharmacological determinants of the antidepressant-like effects of curcumin. CNS Neurol Disord Drug Targets. 2013 ; 12: 498-505
82. Witkin JM, Li X. Curcumin, an active constituent of the ancient medicinal herb Curcuma Longa L.: Some uses and the establishment and biological basis of medical efficacy. CNS Neurol Disord Drug Targets. 2013 ; 12: 487-497
83. Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol. 2006 ; 197: 309-317
84. Xu Y, Ku B-S, Yao H-Y, et al. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem Behav. 2005 ; 82: 200-206
85. Xu Y, Ku B, Cui L, et al. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1a MRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res. 2007 ; 1162: 9-18
86. Xu Y, Lin D, Li S, et al. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Neuropharmacology. 2009 ; 57: 463-471
87. Yadav RS, Chandravanshi LP, Shukla RK, et al. Neuroprotective efficacy of curcumin in arsenic induced cholinergic dysfunctions in rats. NeuroToxicology. 2011 ; 32: 760-768
88. Yanagisawa D, Amatsubo T, Morikawa S, et al. In vivo detection of amyloid β deposition using 19f magnetic resonance imaging with a 19f-containing curcumin derivative in a mouse model of Alzheimer's disease. Neuroscience. 2011 ; 184: 120-127
89. Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 ; 280: 5892-5901
90. Yu SY, Zhang M, Luo J, et al. Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice. Prog Neuropsychopharmacol Biol Psychiatry. 2013 ; 45: 47-53
91. Zhang L, Xu T, Wang S, et al. Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice. Behav Brain Res. 2012 ; 235: 67-72
92. Zhang L, Xu T, Wang S, et al. NMDA GLUN2B receptors involved in the antidepressant effects of curcumin in the forced swim test. Prog Neuropsychopharmacol Biol Psychiatry. 2013 ; 40: 12-17