A novel substrate for testosterone: Biodegradable and biocompatible oil gel

Polymer Journal

Volumn 47, Issue 6, 2015, Pages 460-463

  Takemura, Kazuya ^a   Ajiro, Hiroharu ^a   Fujiwara, Tomoko ^b   Akashi, Mitsuru ^a  

^a OSAKA UNIVERSITY   (Japan)

^b University of Memphis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; CARBONATION; CONTROLLED DRUG DELIVERY; PROTEINS; TARGETED DRUG DELIVERY;

BONE FRACTURE; BONE MORPHOGENETIC PROTEINS; DIMETHYL CARBONATE; DISPERSION MEDIA; LIPOPHILIC DRUGS; LOW TOXICITY; POLY (L-LACTIDE); POLY (TRIMETHYLENE CARBONATE);

DIMETHYL SULFOXIDE;

EID: 84930587233     PISSN: 00323896     EISSN: 13490540     Source Type: Journal    
DOI: 10.1038/pj.2015.17     Document Type: Article

References (29)

1. Floerkemeier, T., Witte, F., Nellese, J., Thorey, F., Windhagen, H. & Wellmann, M. Repetitive recombinant human bone morphogenetic protein 2 injections improve the callus microarchitecture and mechanical stiffness in a sheep model of distraction osteogenesis. Orthop. Rev. 4, e13 (2012).
2. Miller, M. A., Ivkovic, A., Porter, R., Harris, M. B., Estok, D. M. 2nd, Smith, R. M., Evans, C. H. & Vrahas, M. S. Autologous bone grafting on steroids: preliminary clinical results. A novel treatment for nonunions and segmental bone defects. Int. Orthop. 35, 599-605 (2011).
3. Ridha, H., Bernard, J., Gateley, D. & Vesely, M. J. Reconstruction of large traumatic segmental defects of the femur using segmental allograft with vascularized fibula inlay. J. Reconstr. Microsurg. 27, 383-390 (2011).
4. Diab, T., Pritchard, E. M., Uhrig, B. A., Boerckel, J. D., Kaplan, D. L. & Guldberg, R. E. A silk hydrogel-based delivery system of bone morphogenic protein for the treatment of large bone defects. J. Mech. Behav. Biomed. Mater. 11, 123-131 (2012).
5. Chu, T.-M. G., Warden, S. J., Turner, C. H. & Stewart, R. L. Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2. Biomaterials 28, 459-467 (2007).
6. Cheng, B.-H., Chu, T.-M. G., Chang, C. & Huang, K.-E. Bone morphologic protein-2 in promoting the repair of critical-size segmental defect of femoral bone in mice. PLoS ONE8, e70234 (2013).
7. Lutolf, M. P., Weber, F. E., Schmoekel, H. G., Schense, J. C., Kohler, T., Muller, R. & Hubbell, J. A. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat. Biotech 21, 513-518 (2003).
8. Gong, J., Kawakami, I. & Osada, Y. Electroconductive organogel. 4. Electrodriven chemomechanical behaviors of charge-transfer complex gel in organic solvent. Macro-molecules 24, 6582-6587 (1991).
9. Basak, S., Nanda, J. & Banerjee, A. A new aromatic amino acid based organogel for oil spill recovery. J. Mater. Chem. 22, 11658-11664 (2012).
10. Zhang, C., Zhang, X., Yang, D. & Wang, P. Biodegradation of in situ-forming gel of poly (DLLA-co-CL) in vivo. J. Appl. Polym. Sci. 130, 3800-3808 (2013).
11. Vintiloiu, A. & Leroux, J.-C. Organogels and their use in drug delivery - Areview. J. Control. Release 125, 179-192 (2008).
12. Tsuge, T., Hamada, Y., Watanabe, Y., Tomizawa, S., Yamamoto, T. & Abe, H. Characterization of biosynthsized P(3HB-co-3HA)s swellable in organic solvents. Polym. Degrad. Stab. 95, 1345-1348 (2010).
13. Zhu, Y., Akagi, T. & Akashi, M. Preparation and characterization of nanoparticles formed through stereocomplexation between enantiomeric poly(y-glutamic acid)-graft-poly(lactide) copolymers. Polymer J. 45, 560-566 (2013).
14. Chu, H., Ajiro, H., Takahashi, Y., Chen, M. & Akashi, M. Nanoparticle fabrication with biodegradable block copolymer composed of hydrophilic poly(trimethylene carbonate) derivative and hydrophobic polylactide. Chem. Lett. 42, 74-76 (2013).
15. Kondo, K., Kida, T., Ogawa, Y., Arikawa, Y. & Akashi, M. Nanotube formation through the continuous one-dimensional fusion of hollow nanocapsules composed of layer-by-layer poly(lactic acid)s stereocomplex films. J. Am. Chem. Soc. 132, 8236-8237 (2010).
16. Pang, X., Zhuang, X., Tang, Z. & Chen, X. Polylactic acid (PLA): Research, development and industrialization. Biotechnol. J. 5, 1125-1136 (2010).
17. Okamura, Y., Kabata, K., Kinoshita, M., Miyazaki, H., Saito, A., Fujie, T., Ohtsubo, S., Saitoh, D. & Takeoka, S. Fragmentation of poly(lactic acid) nanosheets and patchwork treatment for burn wounds. Adv. Mater. 25, 545-551 (2013).
18. Akagi, T., Fujiwara, T. & Akashi, M. Rapid Fabrication of polylactide stereocomplex using layer-by-layer deposition by inkjet printing. Angew. Chem. Int. Ed. 51, 5493-5496 (2012).
19. Akagi, T., Fujiwara, T. & Akashi, M. Inkjet printing of layer-by-layer assembled poly(lactide) stereocomplex with encapsulated proteins. Langmuir. 30, 1669-1676 (2014).
20. Takemura, K., Ajiro, H., Fujiwara, T. & Akashi, M. Oil gels with a chemically cross-linked copolymer of a trimethylene carbonate derivative and L-lactide: preparation and stereocomplex formation within gels. RSC Adv. 4, 33462-33465 (2014).
21. Kim, S. H., Tan, J. P. K., Fukushima, K., Nederberg, F., Yang, Y. Y., Waymouth, R. M. & Hedrick, J. L. Thermoresponsive nanostructured polycarbonate block copolymers as biodegradable therapeutic delivery carriers. Biomaterials 32, 5505-5514 (2011).
22. Dargaville, B. L., Vaquette, C., Peng, H., Rasoul, F., Chau, Y. Q., Copper-White, J. J., Campbell, J. H. & Whittaker, A. K. Cross-Linked Poly(trimethylene carbonate-co-L-lactide) as a biodegradable, elastomeric scaffold for vascular engineering applications. Biomacromolecules 12, 3856-3869 (2011).
23. Ajiro, H., Takahashi, Y. & Akashi, M. Thermosensitive biodegradable homopolymer of trimethylene carbonate derivative at bodytemperature. Macromolecules 45, 2668-2674 (2012).
24. Fitzpatrick, S. D., Fitzpatrick, L. E., Thakur, A., Mazumder, M. A. J. & Sheardown, H. Temperature-sensitive polymers for drug delivery. Expert Rev. Med. Devices 9, 339-351 (2012).
25. am Ende, M. T. & Peppas, N. A. Transport of ionizable drugs and proteins in crosslinked poly(acrylic acid) and poly(acrylic acid-co-2-hydroxyethyl methacrylate) hydrogels. II. Diffusion and release studies. J. Control. Release 48, 47-56 (1997).
26. Ninawe, P. R. & Parulekar, S. J. Drug loading into and drug release from pH- and temperature-responsive cylindrical hydrogels. Biotechnol. Prog. 27, 1442-1454 (2011).
27. Kim, Y.-H., Kim, H.-K., Kim, T.-G., Lee, J.-H., Lim, Y.-K., Kim, Y.-J. & Choi, S.-Y. Sustained drug release system using porous structured poly(L-lactic acid) fabricated by solvent dispersion method. J. Porous Mater. 20, 303-308 (2013).
28. Tokuyama, H. & Kato, Y. Preparation of thermosensitive polymeric organogels and their drug. Eur. Polym. J. 46, 277-282 (2010).
29. Costa, D., Valente, A. J., Miguel, M. G. & Queiroz, J. Gel network photodisruption: a new strategy for the codelivery of plasmid DNA and drugs. Langmuir 27, 13780-13789 (2011).