Autologous bone grafting on steroids: Preliminary clinical results. A novel treatment for nonunions and segmental bone defects

International Orthopaedics

Volumn 35, Issue 4, 2011, Pages 599-605

  Miller, Micah A ^a   Ivkovic, Alan ^b   Porter, Ryan ^c   Harris, Mitchel B ^d   Estok II, Daniel M ^d   Smith, R Malcolm ^a   Evans, Christopher H ^c   Vrahas, Mark S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b KBC Zagreb   (Croatia)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE; INFUSE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE DEFECT; BONE GRAFT; BONE GROWTH; BONE RADIOGRAPHY; CELL DIFFERENTIATION; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; FEMALE; FOLLOW UP; FRACTURE NONUNION; GROWTH STIMULATION; HUMAN; MALE; ORTHOPEDIC EQUIPMENT; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; REAMER IRRIGATOR ASPIRATOR DEVICE; SCORING SYSTEM; TISSUE ENGINEERING;

ADULT; AGED; AGED, 80 AND OVER; BONE TRANSPLANTATION; DEXAMETHASONE; FEMALE; FRACTURE HEALING; FRACTURES, UNUNITED; GLUCOCORTICOIDS; HUMANS; MALE; MIDDLE AGED; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME;

EID: 79955611380     PISSN: 03412695     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00264-010-1013-9     Document Type: Article

References (23)

1. Biasibetti A, Aloj D, Di Gregorio G, Massè A, Salomone C (2005) Mechanical and biological treatment of long bone non-unions. Injury 36(Suppl 4):S45-S50 (Pubitemid 41608590)
2. Siddappa R, Fernandes H, Liu J, van Blitterswijk C, de Boer J (2007) The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering. Curr Stem Cell Res Ther 2:209-220 (Pubitemid 47496605)
3. Caplan AI (2009) Why are MSCs therapeutic? New data: new insight. J Pathol 217:318-324
4. Deng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J, Bennett E, Reid R, Manning D et al (2008) Regulation of osteogenic differentiation during skeletal development. Front Biosci 13:2001-2021 (Pubitemid 351589231)
5. White AP, Vaccaro AR, Hall JA, Whang PG, Friel BC, McKee MD (2007) Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion. Int Orthop 31:735-741 (Pubitemid 350160312)
6. Jones AL, Bucholz RW, Bosse MJ, Mirza SK, Lyon TR, Webb LX, Pollak AN, Golden JD, Valentin-Opran A et al (2006) Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. J Bone Joint Surg Am 88:1431-1441
7. Diefenderfer DL, Osyczka AM, Garino JP, Leboy PS (2003) Regulation of BMP-induced transcription in cultured human bone marrow stromal cells. J Bone Joint Surg Am 85-A(Suppl 3):19-28 (Pubitemid 36957900)
8. Ivkovic A, Porter RM, Glatt V, Liu F, Vrahas MS, Harris MB, Estok DM 2nd, Evans CH (2008) Short term exposure to dexamethasone significantly enhances osteoblastic differentiation of human mesenchymal progenitors. Poster presentation, 2008 meeting of the Orthopedic Research Society (ORS)
9. Hammer TO, Wieling R, Green JM et al (2007) Effect of reimplanted particles from intramedullary reaming on mechanical properties and callus formation. A laboratory study. J Bone Joint Surg Br 89:1534-1538 (Pubitemid 350273255)
10. Scharfenberger A, Weber T (2005) RIA for bone graft harvest: applications for grafting large segmental defects in the tibia and femur. Poster presented at the Orthopaedic Trauma Association 21st Annual Meeting, Ottawa, Ontario, Canada
11. Rudd J, Norris BL, Stafford PR et al (2007) Reamer irrigator aspirator (RIA) bone graft harvesting in non-union and segmental defect repair. Poster presented at the American Academy of Orthopaedic Surgeons Annual Meeting, San Diego, CA
12. Stafford PR, Norris B (2007) Reamer-irrigator-aspirator as a bone graft harvester. Tech Foot Ankle Surg 6:100-107 (Pubitemid 46889690)
13. Porter RM, Liu F, Pilapil C, Betz OB, Vrahas MS, Harris MB, Evans CH (2009) Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty. J Orthop Res 27:42-49
14. Lane JM, Sandhu HS (1987) Current approaches to experimental bone grafting. Orthop Clin North Am 18:213-225 (Pubitemid 17061148)
15. Karaoglu S, Baktir A, Kabak S, Arasi H (2002) Experimental repair of segmental bone defects in rabbits by demineralized allograft covered by free autogenous periosteum. Injury 33:679-683
16. Christie J, Robinson CM, Pell AC et al (1995) Transcardiac echocardiography during invasive intramedullary procedures. J Bone Joint Surg Br 77:450-455
17. Wenda K, Runkel M, Degreif J et al (1993) Pathogenesis and clinical relevance of bone marrow embolism in medullary nailing - demonstrated by intraoperative echocardiography. Injury 24 (Suppl 3):S73-S81 (Pubitemid 24093880)
18. Pape HC, Auf'm'Kolk M, Paffrath T et al (1993) Primary intramedullary femur fixation in multiple trauma patients with associated lung contusion - a cause of posttraumatic ARDS? J Trauma 34:540-547, discussion 547-548
19. Kim DH, Rhim R, Li L, Martha J, Swaim B, Banco RJ, Jenis LG, Tromanhauser SG (2009) Prospective study of iliac crest bone graft harvest site pain and morbidity. Spine J 9:886-892
20. Schwartz CE, Martha JF, Kowalski P, Wang DA, Bode R, Li L, Kim DH (2009) Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome. Health Qual Life Outcomes 7:49
21. Cockin J (1971) Autologous bone grafting - complications at the donor site. In: Proceedings of the British Orthopaedic Association. J Bone Joint Surg Br 53:153
22. Bovill DF, Skinner HB (1989) Unicameral bone cysts. A comparison of treatment options. Orthop Rev 18(4):420-427
23. Gautschi OP, Cadosch D, Frey SP, Skirving AP, Filgueira L, Zellweger R (2009) Serum-mediated osteogenic effect in traumatic brain-injured patients. ANZ J Surg 79(6):449-455