Thermoresponsive nanostructured polycarbonate block copolymers as biodegradable therapeutic delivery carriers

Biomaterials

Volumn 32, Issue 23, 2011, Pages 5505-5514

  Kim, Sung Ho ^a,b   Tan, Jeremy P K ^c   Fukushima, Kazuki ^a   Nederberg, Fredrik ^a   Yang, Yi Yan ^c   Waymouth, Robert M ^b   Hedrick, James L ^a  

^a IBM ALMADEN RESEARCH CENTER   (United States)

^b STANFORD UNIVERSITY   (United States)

^c INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

Author keywords

Biodegradable; Drug delivery; Polycarbonate; Ring opening polymerization; Thermally responsive micelles

Indexed keywords

2 ,2-BIS(METHYLOL)PROPIONIC ACID; ANTICANCER DRUG; AQUEOUS POLYMER SOLUTIONS; BIODEGRADABLE; BODY TEMPERATURE; CARCINOMA CELLS; CELLULAR UPTAKE; CMC VALUES; CYCLIC CARBONATES; CYTOTOXIC; DRUG DELIVERY SYSTEM; FUNCTIONAL MONOMER; FUNCTIONALIZED; HUMAN LIVER; HYDROPHILIC AND HYDROPHOBIC; HYDROPHOBIC CORE; HYDROPHOBIC MONOMERS; LOWER CRITICAL SOLUTION TEMPERATURE; MOLAR RATIO; NANO-SIZED PARTICLES; NANO-STRUCTURED; NANOCARRIERS; NARROW MOLECULAR WEIGHT DISTRIBUTIONS; NARROW SIZE DISTRIBUTIONS; PACLITAXEL; THERAPEUTIC DELIVERY; THERMALLY RESPONSIVE; THERMO-RESPONSIVE; THERMORESPONSIVE POLYMER; TRANSMITTANCE MEASUREMENTS; TUMOR TISSUES;

BIODEGRADABLE POLYMERS; BLOCK COPOLYMERS; COPOLYMERIZATION; DISEASES; DRUG DELIVERY; ETHYLENE; ETHYLENE GLYCOL; FATTY ACIDS; FUNCTIONAL POLYMERS; HYDROGELS; HYDROPHILICITY; HYDROPHOBICITY; MICELLES; MOLECULAR WEIGHT DISTRIBUTION; MONOMERS; PHYSIOLOGY; PLASTIC PRODUCTS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; TISSUE;

RING OPENING POLYMERIZATION;

COPOLYMER; MACROGOL; MONOMER; NANOMATERIAL; PACLITAXEL; POLYCARBONATE;

ARTICLE; BIODEGRADABILITY; CANCER CELL; CELL STRAIN HEK293; DRUG DELIVERY SYSTEM; DRUG RELEASE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; LIVER CARCINOMA; MICELLE; MOLECULAR WEIGHT; NANOTECHNOLOGY; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RING OPENING; TEMPERATURE;

BIOLOGICAL AVAILABILITY; CARBONATES; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; ETHANOL; FLUORESCEIN-5-ISOTHIOCYANATE; HEK293 CELLS; HEP G2 CELLS; HOT TEMPERATURE; HUMANS; HYDROCARBONS, BROMINATED; LIGHT; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; NANOSTRUCTURES; PACLITAXEL; PARTICLE SIZE; POLYCARBOXYLATE CEMENT; POLYETHYLENE GLYCOLS; POLYMERS; PYRENES; SCATTERING, RADIATION; SPECTROMETRY, FLUORESCENCE; TRANSITION TEMPERATURE;

EID: 79956315543     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.04.017     Document Type: Article

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