Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer

Gut

Volumn 65, Issue 4, 2016, Pages 635-646

  Xu, Lixia ^a,b   Li, Xiaoxing ^a,c   Cai, Muyan ^c   Chen, Jinna ^d   Li, Xiangchun ^a   Wu, William K K ^a   Kang, Wei ^a   Tong, Joanna ^a   To, Ka Fai ^a   Guan, Xin Yuan ^d   Sung, Joseph J Y ^a   Chan, Francis K L ^a,e   Yu, Jun ^a,e  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHLORIDE COTRANSPORTER 2; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; TUMOR MARKER;

ADULT; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; OVERALL SURVIVAL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SLC12A5 GENE; TUMOR INVASION; COLORECTAL TUMOR; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MORTALITY; PATHOLOGY; PROGNOSIS; SURVIVAL RATE; TISSUE MICROARRAY;

APOPTOSIS; BIOMARKERS, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROGNOSIS; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; SURVIVAL RATE; TISSUE ARRAY ANALYSIS;

EID: 84930535818     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-308257     Document Type: Article

References (48)

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
2. Sung JJ, Lau JY, Young GP, etal. Asia Pacific consensus recommendations for colorectal cancer screening. Gut 2008;57:1166-76.
3. Lubbe WJ, Zuzga DS, Zhou Z, etal. Guanylyl cyclase C prevents colon cancer metastasis by regulating tumor epithelial cell matrix metalloproteinase-9. Cancer Res 2009;69:3529-36.
4. Rokavec M, Oner MG, Li H, etal. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest 2014;124:1853-67.
5. Fearon ER. Molecular genetics of colorectal cancer. Annu Rev Pathol 2011;6:479-507.
6. Beroukhim R, Mermel CH, Porter D, etal. The landscape of somatic copy-number alteration across human cancers. Nature 2010;463:899-905.
7. Brosens RP, Haan JC, Carvalho B, etal. Candidate driver genes in focal chromosomal aberrations of stage II colon cancer. J Pathol 2010;221: 411-24.
8. Ji H, Kumm J, Zhang M, etal. Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. Cancer Res 2006;66:7910-19.
9. Nakao K, Mehta KR, Fridlyand J, etal. High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization. Carcinogenesis 2004;25:1345-57.
10. Ried T, Knutzen R, Steinbeck R, etal. Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosomes Cancer 1996;15:234-45.
11. Nakao M, Kawauchi S, Furuya T, etal. Identification of DNA copy number aberrations associated with metastases of colorectal cancer using array CGH profiles. Cancer Genet Cytogenet 2009;188:70-6.
12. Postma C, Koopman M, Buffart TE, etal. DNA copy number profiles of primary tumors as predictors of response to chemotherapy in advanced colorectal cancer. Ann Oncol 2009;20:1048-56.
13. Poulogiannis G, Ichimura K, Hamoudi RA, etal. Prognostic relevance of DNA copy number changes in colorectal cancer. J Pathol 2010;220:338-47.
14. Sheffer M, Bacolod MD, Zuk O, etal. Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci USA 2009;106:7131-6.
15. Venkatachalam R, Ligtenberg MJ, Hoogerbrugge N, etal. Predisposition to colorectal cancer: exploiting copy number variation to identify novel predisposing genes and mechanisms. Cytogenet Genome Res 2008;123:188-94.
16. Jia D, Jing Y, Zhang Z, etal. Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Res 2014;24:204-17.
17. Hobaus J, Hummel DM, Thiem U, etal. Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer. Int J Cancer 2013;133:1380-8.
18. Jiang MC, Yeh CM, Tai CJ, etal. CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression. Am J Surg 2013;206:418-27.
19. Rooney PH, Murray GI, Stevenson DA, etal. Comparative genomic hybridization and chromosomal instability in solid tumours. Br J Cancer 1999;80:862-73.
20. Weiss MM, Snijders AM, Kuipers EJ, etal. Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization. J Pathol 2003;200:320-6.
21. Xie T, Ario G, Lamb JR, etal. A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations. PLoS ONE 2012;7:e42001.
22. Yu C, Yu J, Yao X, etal. Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing. Cell Res 2014;24:701-12.
23. Yu J, Wu WK, Li X, etal. Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. Gut 2015;64:636-45.
24. Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl-cotransport: the SLC12 family. Pflugers Arch 2004;447:580-93.
25. Payne JA, Stevenson TJ, Donaldson LF. Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. J Biol Chem 1996;271:16245-52.
26. Song L, Mercado A, Vazquez N, etal. Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter. Brain Res Mol Brain Res 2002;103:91-105.
27. Xie D, Sham JS, Zeng WF, etal. Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray. Int J Cancer 2003;107:896-902.
28. Zhu W, Cai MY, Tong ZT, etal. Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition. Gut 2012;61:562-75.
29. Guan XY, Sham JS, Tang TC, etal. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer. Cancer Res 2001;61:3806-9.
30. Galluzzi L, Joza N, Tasdemir E, etal. No death without life: vital functions of apoptotic effectors. Cell Death Differ 2008;15:1113-23.
31. Arnoult D, Gaume B, Karbowski M, etal. Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J 2003;22:4385-99.
32. Liu T, Brouha B, Grossman D. Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene 2004;23:39-48.
33. Pavlyukov MS, Antipova NV, Balashova MV, etal. Survivin monomer plays an essential role in apoptosis regulation. J Biol Chem 2011;286:23296-307.
34. Starczynowski DT, Lockwood WW, Delehouzee S, etal. TRAF6 is an amplified oncogene bridging the RAS and NF-kappaB pathways in human lung cancer. J Clin Invest 2011;121:4095-105.
35. Tsafrir D, Bacolod M, Selvanayagam Z, etal. Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res 2006;66:2129-37.
36. Wei WC, Akerman CJ, Newey SE, etal. The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism. J Physiol 2011;589:5349-59.
37. Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002;108:153-64.
38. Broker LE, Kruyt FA, Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res 2005;11:3155-62.
39. Ren SX, Cheng AS, To KF, etal. Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res 2012;72:6512-23.
40. Ishitsuka K, Hideshima T, Hamasaki M,etal. Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway. Oncogene 2005;24:5888-96.
41. Gopalani NK, Meena RN, Prasad DN, etal. Cooperativity between inhibition of cytosolic K+ efflux and AMPK activation during suppression of hypoxia-induced cellular apoptosis. Int J Biochem Cell Biol 2012;44:211-23.
42. Dong C, Li Q, Lyu SC, etal. A novel apoptosis pathway activated by the carboxyl terminus of p21. Blood 2005;105:1187-94.
43. Parr C, Jiang WG. Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer. Eur J Cancer 2009;45:1673-83.
44. Soikkeli J, Podlasz P, Yin M, etal. Metastatic outgrowth encompasses COL-I, FN1, and POSTN up-regulation and assembly to fibrillar networks regulating cell adhesion, migration, and growth. Am J Pathol 2010;177:387-403.
45. Waalkes S, Atschekzei F, Kramer MW, etal. Fibronectin 1 mRNA expression correlates with advanced disease in renal cancer. BMC Cancer 2010;10:503.
46. Mendes O, Kim HT, Lungu G, etal. MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. Clin Exp Metastasis 2007;24:341-51.
47. Yamada T, Oshima T, Yoshihara K, etal. Overexpression of MMP-13 gene in colorectal cancer with liver metastasis. Anticancer Res 2010;30:2693-9.
48. Otte JM, Schmitz F, Kiehne K, etal. Functional expression of HGF and its receptor in human colorectal cancer. Digestion 2000;61:237-46.