Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer

European Journal of Cancer

Volumn 45, Issue 9, 2009, Pages 1673-1683

  Parr, Christian ^a   Jiang, Wen G ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Breast cancer; Invasion; Metastasis suppressor; MIM; Motility; MTSS1; Prognosis; Survival status

Indexed keywords

MESSENGER RNA; PROTEIN METASTASIS SUPPRESSOR 1; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; METASTASIS; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS;

BREAST NEOPLASMS; CELL ADHESION; CELL MOVEMENT; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICROFILAMENT PROTEINS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NEOPLASM STAGING; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SURVIVAL ANALYSIS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 65849498431     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2009.02.019     Document Type: Article

References (27)

1. Stafford L.J., Vaidya K.S., and Welch D.R. Metastasis suppressors genes in cancer. Int J Biochem Cell Biol 40 (2008) 874-891
2. Lee Y.G., Macoska J.A., Korenchuk S., and Pienta K.J. MIM, a potential metastasis suppressor gene in bladder cancer. Neoplasia 4 (2002) 291-294
3. Woodings J.A., Sharp S.J., and Machesky L.M. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. Biochem J 371 (2003) 463-471
4. Pollard T.D., and Borisy G.G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112 (2003) 453-465
5. Zhong C., Kinch M.S., and Burridge K. Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells. Mol Biol Cell 8 (1997) 2329-2344
6. Qiu R.G., Chen J., McCormick K., and Symons M. An essential role for Rac in Ras transformation. Nature 374 (1995) 457-459
7. Loberg R.D., Neeley C.K., Adam-Day L.L., et al. Differential expression analysis of MIM (MTSS1) splice variants and a functional role of MIM in prostate cancer cell biology. Int J Oncol 26 (2005) 1699-1705
8. Utikal J., Gratchev A., Muller-Molinet I., et al. The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation. Int J Cancer 119 (2006) 2287-2293
9. Nixdorf S., Grimm M.O., Loberg R., et al. Expression and regulation of MIM (missing in metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. Cancer Lett 215 (2004) 209-220
10. Bompard G., Sharp S.J., Freiss G., and Machesky L.M. Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. J Cell Sci 118 (2005) 5393-5403
11. Ma S., Guan X.Y., Lee T.K., and Chan K.W. Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma. Hum Pathol 38 (2007) 1201-1206
12. Callahan C.A., Ofstad T., and Horng L. MIM/BEG4, a sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev 18 (2004) 2724-2729
13. Gonzalez-Quevedo R., Shoffer M., Horng L., and Oro A.E. Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. J. Cell Biol 168 (2005) 453-463
14. Jiang W.G., Douglas-Jones A., and Mansel R.E. Level of expression of PPAR-gamma and its co-activator (PPAR-GCA) in human breast cancer. Int J Cancer 106 (2003) 752-757
15. Parr C., Watkins G., Mansel R.E., and Jiang W.G. The hepatocyte growth factor regulatory factors in human breast cancer. Clin Cancer Res 10 (2004) 202-211
16. Parr C., and Jiang W.G. Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells. Int J Cancer 119 (2006) 1176-1183
17. Jiang W.G., Grimshaw D., Lane J., et al. A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells. Clin Cancer Res 7 (2001) 2555-2562
18. Jiang W.G., Hiscox S., Hallett M.B., et al. Inhibition of invasion and motility of human colon cancer cells by gamma linolenic acid. Br J Cancer 71 (1995) 744-752
19. Jiang W.G., Hiscox S., Parr C., et al. Antagonistic effects of NK4, a novel HGF variant, on the in vitro angiogenesis of human vascular endothelial cells. Clin Cancer Res 5 (1999) 3695-3703
20. Parr C., and Jiang W.G. Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells. Int J Oncol 19 (2001) 857-863
21. Mattila P.K., Salminen M., Yamashiro T., and Lappalainen P. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. J Biol Chem 278 (2003) 8452-8459
22. Wang Y., Liu J., Smith E., et al. Downregulation of missing in metastasis gene (MIM) is associated with the progression of bladder transitional carcinomas. Cancer Invest 25 (2007) 79-86
23. Lin J., Liu J., Wang Y., et al. Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein. Oncogene 24 (2005) 2059-2066
24. Lee S.H., Kerff F., Chereau D., et al. Structural basis for the actin-binding function of missing-in-metastasis. Structure 15 (2007) 145-155
25. Pawlak G., and Helfman D.M. Cytoskeletal changes in cell transformation and tumourigenesis. Curr Opin Genet Dev 11 (2001) 41-47
26. Mattila P.K., Pykäläinen A., Saarikangas J., et al. Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism. J Cell Biol 176 (2007) 953-964
27. Pan H., Gao F., Papageorgis P., et al. Aberrant activation of gamma-catenin promotes genomic instability and oncogenic effects during tumour progression. Cancer Biol Ther 6 (2007) 1638-1643