-
1
-
-
84876289106
-
Durable efficacy and safety of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naive HIV-1-infected patients: final 5-year results from STARTMRK
-
Rockstroh JK, DeJesus E, Lennox JL et al. Durable efficacy and safety of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naive HIV-1-infected patients: final 5-year results from STARTMRK. J Acquir Immune Defic Syndr 2013; 63: 77-85.
-
(2013)
J Acquir Immune Defic Syndr
, vol.63
, pp. 77-85
-
-
Rockstroh, J.K.1
DeJesus, E.2
Lennox, J.L.3
-
2
-
-
84879799713
-
Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: final results of two randomised, placebo-controlled trials
-
Eron JJ, Cooper DA, Steigbigel RT et al. Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: final results of two randomised, placebo-controlled trials. Lancet Infect Dis 2013; 13: 587-96.
-
(2013)
Lancet Infect Dis
, vol.13
, pp. 587-596
-
-
Eron, J.J.1
Cooper, D.A.2
Steigbigel, R.T.3
-
3
-
-
84872239331
-
Clinical use of HIV integrase inhibitors: a systematic review and meta-analysis
-
Messiaen P, Wensing AM, Fun A et al. Clinical use of HIV integrase inhibitors: a systematic review and meta-analysis. PLoS One 2013; 8: e52562.
-
(2013)
PLoS One
, vol.8
, pp. e52562
-
-
Messiaen, P.1
Wensing, A.M.2
Fun, A.3
-
4
-
-
79960219397
-
HIV-2 integrase variation in integrase inhibitor-naive adults in Senegal, West Africa
-
Gottlieb GS, Smith RA, Dia Badiane NM et al. HIV-2 integrase variation in integrase inhibitor-naive adults in Senegal, West Africa. PLoS One 2011; 6: e22204.
-
(2011)
PLoS One
, vol.6
, pp. e22204
-
-
Gottlieb, G.S.1
Smith, R.A.2
Dia Badiane, N.M.3
-
5
-
-
84885948765
-
Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, noninferiority trial
-
Raffi F, Jaeger H, Quiros-Roldan E et al. Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, noninferiority trial. Lancet Infect Dis 2013; 13: 927-35.
-
(2013)
Lancet Infect Dis
, vol.13
, pp. 927-935
-
-
Raffi, F.1
Jaeger, H.2
Quiros-Roldan, E.3
-
6
-
-
84894424714
-
A randomized, double-blind comparison of single-tablet regimen elvitegravir/cobicistat/emtricitabine/tenofovir DF vs ritonavir-boosted atazanavir plus emtricitabine/tenofovir DF for initial treatment of HIV-1 infection: analysis of week 144 results
-
Clumeck N, Molina JM, Henry K et al. A randomized, double-blind comparison of single-tablet regimen elvitegravir/cobicistat/emtricitabine/tenofovir DF vs ritonavir-boosted atazanavir plus emtricitabine/tenofovir DF for initial treatment of HIV-1 infection: analysis of week 144 results. J Acquir Immune Defic Syndr 2014; 65: e121-4.
-
(2014)
J Acquir Immune Defic Syndr
, vol.65
, pp. e121-e124
-
-
Clumeck, N.1
Molina, J.M.2
Henry, K.3
-
7
-
-
84862843404
-
Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavirboosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial
-
DeJesus E, Rockstroh JK, Henry K et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavirboosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet 2012; 379: 2429-38.
-
(2012)
Lancet
, vol.379
, pp. 2429-2438
-
-
DeJesus, E.1
Rockstroh, J.K.2
Henry, K.3
-
8
-
-
84862876886
-
Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks
-
Sax PE, DeJesus E, Mills A et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Lancet 2012; 379: 2439-48.
-
(2012)
Lancet
, vol.379
, pp. 2439-2448
-
-
Sax, P.E.1
DeJesus, E.2
Mills, A.3
-
9
-
-
84898987717
-
Dolutegravir in antiretroviralexperienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study
-
Castagna A, Maggiolo F, Penco G et al. Dolutegravir in antiretroviralexperienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study. J Infect Dis 2014; 210: 354-62.
-
(2014)
J Infect Dis
, vol.210
, pp. 354-362
-
-
Castagna, A.1
Maggiolo, F.2
Penco, G.3
-
10
-
-
84882912698
-
Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study
-
Cahn P, Pozniak AL, Mingrone H et al. Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study. Lancet 2013; 382: 700-8.
-
(2013)
Lancet
, vol.382
, pp. 700-708
-
-
Cahn, P.1
Pozniak, A.L.2
Mingrone, H.3
-
11
-
-
84930513073
-
HIV/AIDS Update - Approval of Vitekta
-
US Food and Drug Administration. HIV/AIDS Update - Approval of Vitekta. http://content.govdelivery.com/accounts/USFDA/bulletins/d162bb.
-
-
-
-
12
-
-
84880204551
-
A randomized phase 3 study comparing once-daily elvitegravir with twice-daily raltegravir in treatment-experienced subjects with HIV-1 infection: 96-week results
-
Elion R, Molina JM, Ramon Arribas Lopez J et al. A randomized phase 3 study comparing once-daily elvitegravir with twice-daily raltegravir in treatment-experienced subjects with HIV-1 infection: 96-week results. J Acquir Immune Defic Syndr 2013; 63: 494-7.
-
(2013)
J Acquir Immune Defic Syndr
, vol.63
, pp. 494-497
-
-
Elion, R.1
Molina, J.M.2
Ramon Arribas Lopez, J.3
-
13
-
-
84904266222
-
Switching to coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus continuation of nonnucleoside reverse transcriptase inhibitor with emtricitabine and tenofovir in virologically suppressed adults with HIV (STRATEGY-NNRTI): 48 week results of a randomised, open-label, phase 3b non-inferiority trial
-
Pozniak A, Markowitz M, Mills A et al. Switching to coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus continuation of nonnucleoside reverse transcriptase inhibitor with emtricitabine and tenofovir in virologically suppressed adults with HIV (STRATEGY-NNRTI): 48 week results of a randomised, open-label, phase 3b non-inferiority trial. Lancet Infect Dis 2014; 14: 590-9.
-
(2014)
Lancet Infect Dis
, vol.14
, pp. 590-599
-
-
Pozniak, A.1
Markowitz, M.2
Mills, A.3
-
14
-
-
84904698918
-
Simplification to coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus continuation of ritonavir-boosted protease inhibitor with emtricitabine and tenofovir in adults with virologically suppressed HIV (STRATEGY-PI): 48 week results of a randomised, open-label, phase 3b, non-inferiority trial
-
Arribas JR, Pialoux G, Gathe J et al. Simplification to coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus continuation of ritonavir-boosted protease inhibitor with emtricitabine and tenofovir in adults with virologically suppressed HIV (STRATEGY-PI): 48 week results of a randomised, open-label, phase 3b, non-inferiority trial. Lancet Infect Dis 2014; 14: 581-9.
-
(2014)
Lancet Infect Dis
, vol.14
, pp. 581-589
-
-
Arribas, J.R.1
Pialoux, G.2
Gathe, J.3
-
17
-
-
79954626457
-
HIV-1 integrase inhibitor resistance and its clinical implications
-
Blanco JL, Varghese V, Rhee SY et al. HIV-1 integrase inhibitor resistance and its clinical implications. J Infect Dis 2011; 203: 1204-14.
-
(2011)
J Infect Dis
, vol.203
, pp. 1204-1214
-
-
Blanco, J.L.1
Varghese, V.2
Rhee, S.Y.3
-
18
-
-
84866595664
-
Risk factors for raltegravir resistance development in clinical practice
-
Malet I, Fourati S, Morand-Joubert L et al. Risk factors for raltegravir resistance development in clinical practice. J Antimicrob Chemother 2012; 67: 2494-500.
-
(2012)
J Antimicrob Chemother
, vol.67
, pp. 2494-2500
-
-
Malet, I.1
Fourati, S.2
Morand-Joubert, L.3
-
19
-
-
84892766007
-
Resistance to HIV integrase strand transfer inhibitors among clinical specimens in the United States, 2009-2012
-
Hurt CB, Sebastian J, Hicks CB et al. Resistance to HIV integrase strand transfer inhibitors among clinical specimens in the United States, 2009-2012. Clin Infect Dis 2014; 58: 423-31.
-
(2014)
Clin Infect Dis
, vol.58
, pp. 423-431
-
-
Hurt, C.B.1
Sebastian, J.2
Hicks, C.B.3
-
20
-
-
80053065898
-
European recommendations for the clinical use of HIV drug resistance testing: 2011 update
-
Vandamme AM, Camacho RJ, Ceccherini-Silberstein F et al. European recommendations for the clinical use of HIV drug resistance testing: 2011 update. AIDS Rev 2011; 13: 77-108.
-
(2011)
AIDS Rev
, vol.13
, pp. 77-108
-
-
Vandamme, A.M.1
Camacho, R.J.2
Ceccherini-Silberstein, F.3
-
21
-
-
84864131448
-
Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel
-
Thompson MA, Aberg JA, Hoy JF et al. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA 2012; 308: 387-402.
-
(2012)
JAMA
, vol.308
, pp. 387-402
-
-
Thompson, M.A.1
Aberg, J.A.2
Hoy, J.F.3
-
23
-
-
2442670063
-
Detection of HIV-1 antiretroviral resistance from patients with persistently low but detectable viraemia
-
Mackie N, Dustan S, McClure MO et al. Detection of HIV-1 antiretroviral resistance from patients with persistently low but detectable viraemia. J Virol Methods 2004; 119: 73-8.
-
(2004)
J Virol Methods
, vol.119
, pp. 73-78
-
-
Mackie, N.1
Dustan, S.2
McClure, M.O.3
-
24
-
-
33745081536
-
Successful use of genotypic resistance testing in HIV-1-infected individuals with detectable viraemia between 50 and 1000 copies/mL
-
Waters L, Mandalia S, Asboe D. Successful use of genotypic resistance testing in HIV-1-infected individuals with detectable viraemia between 50 and 1000 copies/mL. AIDS 2006; 20: 778-9.
-
(2006)
AIDS
, vol.20
, pp. 778-779
-
-
Waters, L.1
Mandalia, S.2
Asboe, D.3
-
25
-
-
84897450288
-
Performance of HIV-1 drug resistance testing at low-level viremia and its ability to predict future virologic outcomes and viral evolution in treatment-naive individuals
-
Gonzalez-Serna A, Min JE, Woods C et al. Performance of HIV-1 drug resistance testing at low-level viremia and its ability to predict future virologic outcomes and viral evolution in treatment-naive individuals. Clin Infect Dis 2014; 58: 1165-73.
-
(2014)
Clin Infect Dis
, vol.58
, pp. 1165-1173
-
-
Gonzalez-Serna, A.1
Min, J.E.2
Woods, C.3
-
26
-
-
84897431077
-
Reliability and clinical relevance of the HIV-1 drug resistance test in patients with low viremia levels
-
Santoro MM, Fabeni L, Armenia D et al. Reliability and clinical relevance of the HIV-1 drug resistance test in patients with low viremia levels. Clin Infect Dis 2014; 58: 1156-64.
-
(2014)
Clin Infect Dis
, vol.58
, pp. 1156-1164
-
-
Santoro, M.M.1
Fabeni, L.2
Armenia, D.3
-
27
-
-
84881541888
-
Performance comparison of an in-house integrase genotyping assay versus the ViroSeq Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong
-
To SW, Chen JH, Wong KH et al. Performance comparison of an in-house integrase genotyping assay versus the ViroSeq Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong. J Clin Virol 2013; 58: 299-302.
-
(2013)
J Clin Virol
, vol.58
, pp. 299-302
-
-
To, S.W.1
Chen, J.H.2
Wong, K.H.3
-
28
-
-
84927912939
-
HIV drug resistance detected during low-level viraemia is associated with subsequent virologic failure
-
Swenson LC, Min JE,Woods CK et al. HIV drug resistance detected during low-level viraemia is associated with subsequent virologic failure. AIDS 2014; 28: 1125-34.
-
(2014)
AIDS
, vol.28
, pp. 1125-1134
-
-
Swenson, L.C.1
Min, J.E.2
Woods, C.K.3
-
29
-
-
84861008847
-
Impact of low-level-viremia on HIV-1 drug-resistance evolution among antiretroviral treated-patients
-
Delaugerre C, Gallien S, Flandre P et al. Impact of low-level-viremia on HIV-1 drug-resistance evolution among antiretroviral treated-patients. PLoS One 2012; 7: e36673.
-
(2012)
PLoS One
, vol.7
, pp. e36673
-
-
Delaugerre, C.1
Gallien, S.2
Flandre, P.3
-
30
-
-
79952443361
-
Emerging integrase inhibitor resistance mutations in raltegravir-treated HIV-1-infected patients with low-level viremia
-
Gallien S, Delaugerre C, Charreau I et al. Emerging integrase inhibitor resistance mutations in raltegravir-treated HIV-1-infected patients with low-level viremia. AIDS 2011; 25: 665-9.
-
(2011)
AIDS
, vol.25
, pp. 665-669
-
-
Gallien, S.1
Delaugerre, C.2
Charreau, I.3
-
31
-
-
84891517193
-
Impact of pre-therapy viral load on virological response tomodern first-line HAART
-
Santoro MM, Armenia D, Alteri C et al. Impact of pre-therapy viral load on virological response tomodern first-line HAART. Antivir Ther 2013; 18: 867-76.
-
(2013)
Antivir Ther
, vol.18
, pp. 867-876
-
-
Santoro, M.M.1
Armenia, D.2
Alteri, C.3
-
32
-
-
0027968068
-
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
-
Thompson JD, Higgins DG, Gibson TJ. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994; 22: 4673-80.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4673-4680
-
-
Thompson, J.D.1
Higgins, D.G.2
Gibson, T.J.3
-
33
-
-
0019296687
-
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences
-
Kimura M. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 1980; 16: 111-20.
-
(1980)
J Mol Evol
, vol.16
, pp. 111-120
-
-
Kimura, M.1
-
34
-
-
84905735621
-
2014 update of the drug resistance mutations in HIV-1
-
Wensing AM, Calvez V, Gunthard HF et al. 2014 update of the drug resistance mutations in HIV-1. Top Antivir Med 2014; 22: 642-50.
-
(2014)
Top Antivir Med
, vol.22
, pp. 642-650
-
-
Wensing, A.M.1
Calvez, V.2
Gunthard, H.F.3
-
36
-
-
84863393356
-
Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir
-
Quashie PK, Mesplede T, Han YS et al. Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir. J Virol 2012; 86: 2696-705.
-
(2012)
J Virol
, vol.86
, pp. 2696-2705
-
-
Quashie, P.K.1
Mesplede, T.2
Han, Y.S.3
-
37
-
-
84887463456
-
Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase
-
Quashie PK, Mesplede T, Han YS et al. Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase. Antimicrob Agents Chemother 2013; 57: 6223-35.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 6223-6235
-
-
Quashie, P.K.1
Mesplede, T.2
Han, Y.S.3
-
38
-
-
81855199761
-
The HIV-1 integrase G118R mutation confers raltegravir resistance to the CRF02_AG HIV-1 subtype
-
Malet I, Fourati S, Charpentier C et al. The HIV-1 integrase G118R mutation confers raltegravir resistance to the CRF02_AG HIV-1 subtype. J Antimicrob Chemother 2011; 66: 2827-30.
-
(2011)
J Antimicrob Chemother
, vol.66
, pp. 2827-2830
-
-
Malet, I.1
Fourati, S.2
Charpentier, C.3
-
39
-
-
84879218945
-
A cohort study of treatment-experienced HIV-1-infected patients treated with raltegravir: factors associated with virological response and mutations selected at failure
-
Marcelin AG, Delaugerre C, Beaudoux C et al. A cohort study of treatment-experienced HIV-1-infected patients treated with raltegravir: factors associated with virological response and mutations selected at failure. Int J Antimicrob Agents 2013; 42: 42-7.
-
(2013)
Int J Antimicrob Agents
, vol.42
, pp. 42-47
-
-
Marcelin, A.G.1
Delaugerre, C.2
Beaudoux, C.3
-
40
-
-
84884730779
-
Factors associated with virological success with raltegravir-containing regimens and prevalence of raltegravir-resistance-associated mutations at failure in the ARCA database
-
Rusconi S, Vitiello P, Adorni F et al. Factors associated with virological success with raltegravir-containing regimens and prevalence of raltegravir-resistance-associated mutations at failure in the ARCA database. Clin Microbiol Infect 2013; 19: 936-42.
-
(2013)
Clin Microbiol Infect
, vol.19
, pp. 936-942
-
-
Rusconi, S.1
Vitiello, P.2
Adorni, F.3
-
41
-
-
84893691010
-
Four years data of raltegravirbased salvage therapy in HIV-1-infected, treatment-experienced patients: the SALIR-E Study
-
Capetti A, Meraviglia P, Landonio S et al. Four years data of raltegravirbased salvage therapy in HIV-1-infected, treatment-experienced patients: the SALIR-E Study. Int J Antimicrob Agents 2014; 43: 189-94.
-
(2014)
Int J Antimicrob Agents
, vol.43
, pp. 189-194
-
-
Capetti, A.1
Meraviglia, P.2
Landonio, S.3
-
42
-
-
84896490811
-
HIV-1-infected patients with advanced disease failing a raltegravir-containing salvage regimen in Sao Paulo, Brazil
-
de Souza Cavalcanti J, de Paula Ferreira JL, Vidal JE et al. HIV-1-infected patients with advanced disease failing a raltegravir-containing salvage regimen in Sao Paulo, Brazil. Int J Antimicrob Agents 2014; 43: 287-91.
-
(2014)
Int J Antimicrob Agents
, vol.43
, pp. 287-291
-
-
de Souza Cavalcanti, J.1
de Paula Ferreira, J.L.2
Vidal, J.E.3
-
43
-
-
85027921809
-
The activity of the integrase inhibitor dolutegravir against HIV-1 variants isolated from raltegravirtreated adults
-
Underwood MR, Johns BA, Sato A et al. The activity of the integrase inhibitor dolutegravir against HIV-1 variants isolated from raltegravirtreated adults. J Acquir Immune Defic Syndr 2012; 61: 297-301.
-
(2012)
J Acquir Immune Defic Syndr
, vol.61
, pp. 297-301
-
-
Underwood, M.R.1
Johns, B.A.2
Sato, A.3
-
44
-
-
84856247092
-
Study of genotypic and phenotypic HIV-1 dynamics of integrase mutations during raltegravir treatment: a refined analysis by ultra-deep 454 pyrosequencing
-
Armenia D, Vandenbroucke I, Fabeni L et al. Study of genotypic and phenotypic HIV-1 dynamics of integrase mutations during raltegravir treatment: a refined analysis by ultra-deep 454 pyrosequencing. J Infect Dis 2012; 205: 557-67.
-
(2012)
J Infect Dis
, vol.205
, pp. 557-567
-
-
Armenia, D.1
Vandenbroucke, I.2
Fabeni, L.3
-
45
-
-
81155162631
-
Switching between raltegravir resistance pathways analyzed by deep sequencing
-
Mukherjee R, Jensen ST, Male F et al. Switching between raltegravir resistance pathways analyzed by deep sequencing. AIDS 2011; 25: 1951-9.
-
(2011)
AIDS
, vol.25
, pp. 1951-1959
-
-
Mukherjee, R.1
Jensen, S.T.2
Male, F.3
-
46
-
-
80155188567
-
Cross-resistance profile of the novel integrase inhibitor dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir
-
Canducci F, Ceresola ER, Boeri E et al. Cross-resistance profile of the novel integrase inhibitor dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir. J Infect Dis 2011; 204: 1811-5.
-
(2011)
J Infect Dis
, vol.204
, pp. 1811-1815
-
-
Canducci, F.1
Ceresola, E.R.2
Boeri, E.3
-
47
-
-
34147138794
-
Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen
-
Cozzi-Lepri A, Phillips AN, Ruiz L et al. Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen. AIDS 2007; 21: 721-32.
-
(2007)
AIDS
, vol.21
, pp. 721-732
-
-
Cozzi-Lepri, A.1
Phillips, A.N.2
Ruiz, L.3
|