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Volumn 42, Issue 1, 2013, Pages 42-47

A cohort study of treatment-experienced HIV-1-infected patients treated with raltegravir: Factors associated with virological response and mutations selected at failure

(24)  Marcelin, Anne Geneviève a,p   Delaugerre, Constance b   Beaudoux, Céline a   Descamps, Diane a   Morand Joubert, Laurence a   Amiel, Corinne a   Schneider, Veronique a   Ferre, Virginie c   Izopet, Jacques d   Si Mohamed, Ali e   Maillard, Anne f   Henquell, Cécile g   Desbois, Delphine h   Lazrek, Mouna i   Signori Schmuck, Anne j   Rogez, Sylvie k   Yerly, Sabine l   Trabaud, Mary Anne m   Plantier, Jean Christophe n   Fourati, Slim a   more..


Author keywords

Efficacy; HIV 1; Inhibitor; Integrase; Mutations; Raltegravir; Response

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; DARUNAVIR; DARUNAVIR PLUS RITONAVIR; EMTRICITABINE; ENFUVIRTIDE; ETRAVIRINE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INTEGRASE; LAMIVUDINE; MARAVIROC; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RALTEGRAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR DISOPROXIL; VIRUS RNA;

EID: 84879218945     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.02.016     Document Type: Article
Times cited : (19)

References (19)
  • 1
    • 52449097240 scopus 로고    scopus 로고
    • Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
    • V. Summa, A. Petrocchi, F. Bonelli, B. Crescenzi, M. Donghi, and M. Ferrara Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection J Med Chem 51 2008 5843 5855
    • (2008) J Med Chem , vol.51 , pp. 5843-5855
    • Summa, V.1    Petrocchi, A.2    Bonelli, F.3    Crescenzi, B.4    Donghi, M.5    Ferrara, M.6
  • 2
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: A multicentre, double-blind randomised controlled trial
    • J.L. Lennox, E. DeJesus, A. Lazzarin, R.B. Pollard, J.V. Madruga, and D.S. Berger Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial Lancet 374 2009 796 806
    • (2009) Lancet , vol.374 , pp. 796-806
    • Lennox, J.L.1    Dejesus, E.2    Lazzarin, A.3    Pollard, R.B.4    Madruga, J.V.5    Berger, D.S.6
  • 4
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
    • M. Markowitz, B.Y. Nguyen, E. Gotuzzo, F. Mendo, W. Ratanasuwan, and C. Kovacs Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study J Acquir Immune Defic Syndr 46 2007 125 133
    • (2007) J Acquir Immune Defic Syndr , vol.46 , pp. 125-133
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3    Mendo, F.4    Ratanasuwan, W.5    Kovacs, C.6
  • 5
    • 75749107023 scopus 로고    scopus 로고
    • Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: Week 96 results of the BENCHMRK 1 and 2 phase III trials
    • R.T. Steigbigel, D.A. Cooper, H. Teppler, J.J. Eron, J.M. Gatell, and P.N. Kumar Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: Week 96 results of the BENCHMRK 1 and 2 phase III trials Clin Infect Dis 50 2010 605 612
    • (2010) Clin Infect Dis , vol.50 , pp. 605-612
    • Steigbigel, R.T.1    Cooper, D.A.2    Teppler, H.3    Eron, J.J.4    Gatell, J.M.5    Kumar, P.N.6
  • 6
    • 77953263347 scopus 로고    scopus 로고
    • Raltegravir as functional monotherapy leads to virological failure and drug resistance in highly treatment-experienced HIV-infected patients
    • F. Caby, N. Valin, A.G. Marcelin, L. Schneider, R. Andrade, and M. Guiguet Raltegravir as functional monotherapy leads to virological failure and drug resistance in highly treatment-experienced HIV-infected patients Scand J Infect Dis 42 2010 527 532
    • (2010) Scand J Infect Dis , vol.42 , pp. 527-532
    • Caby, F.1    Valin, N.2    Marcelin, A.G.3    Schneider, L.4    Andrade, R.5    Guiguet, M.6
  • 7
    • 84863850985 scopus 로고    scopus 로고
    • 96 Week follow-up of HIV-infected patients in rescue with raltegravir plus optimized backbone regimens: A multicentre Italian experience
    • A. Capetti, S. Landonio, P. Meraviglia, A. Di Biagio, S. Lo Caputo, and G. Sterrantino 96 Week follow-up of HIV-infected patients in rescue with raltegravir plus optimized backbone regimens: a multicentre Italian experience PLoS ONE 7 2012 e39222
    • (2012) PLoS ONE , vol.7 , pp. 39222
    • Capetti, A.1    Landonio, S.2    Meraviglia, P.3    Di Biagio, A.4    Lo Caputo, S.5    Sterrantino, G.6
  • 8
    • 31144450251 scopus 로고    scopus 로고
    • Repeated HIV-1 resistance genotyping external quality assessments improve virology laboratory performance
    • D. Descamps, C. Delaugerre, B. Masquelier, A. Ruffault, A.G. Marcelin, and J. Izopet Repeated HIV-1 resistance genotyping external quality assessments improve virology laboratory performance J Med Virol 78 2006 153 160
    • (2006) J Med Virol , vol.78 , pp. 153-160
    • Descamps, D.1    Delaugerre, C.2    Masquelier, B.3    Ruffault, A.4    Marcelin, A.G.5    Izopet, J.6
  • 10
    • 77949563400 scopus 로고    scopus 로고
    • High frequency of integrase Q148R minority variants in HIV-infected patients naive of integrase inhibitors
    • C. Charpentier, D. Laureillard, C. Piketty, P. Tisserand, D. Batisse, and M. Karmochkine High frequency of integrase Q148R minority variants in HIV-infected patients naive of integrase inhibitors AIDS 24 2010 867 873
    • (2010) AIDS , vol.24 , pp. 867-873
    • Charpentier, C.1    Laureillard, D.2    Piketty, C.3    Tisserand, P.4    Batisse, D.5    Karmochkine, M.6
  • 12
    • 33746146917 scopus 로고    scopus 로고
    • Concomitant use of an active boosted protease inhibitor with enfuvirtide in treatment-experienced, HIV-infected individuals: Recent data and consensus recommendations
    • M. Youle, S. Staszweski, B. Clotet, J.R. Arribas, A. Blaxhult, and G. Carosi Concomitant use of an active boosted protease inhibitor with enfuvirtide in treatment-experienced, HIV-infected individuals: recent data and consensus recommendations HIV Clin Trials 7 2006 86 96
    • (2006) HIV Clin Trials , vol.7 , pp. 86-96
    • Youle, M.1    Staszweski, S.2    Clotet, B.3    Arribas, J.R.4    Blaxhult, A.5    Carosi, G.6
  • 13
    • 0242331663 scopus 로고    scopus 로고
    • Predictors of the virological response to a change in the antiretroviral treatment regimen in HIV-1-infected patients enrolled in a randomized trial comparing genotyping, phenotyping and standard of care (Narval trial, ANRS 088)
    • M. Vray, J.L. Meynard, C. Dalban, L. Morand-Joubert, F. Clavel, and F. Brun-Vézinet Predictors of the virological response to a change in the antiretroviral treatment regimen in HIV-1-infected patients enrolled in a randomized trial comparing genotyping, phenotyping and standard of care (Narval trial, ANRS 088) Antivir Ther 8 2003 427 434
    • (2003) Antivir Ther , vol.8 , pp. 427-434
    • Vray, M.1    Meynard, J.L.2    Dalban, C.3    Morand-Joubert, L.4    Clavel, F.5    Brun-Vézinet, F.6
  • 14
    • 34347327010 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
    • J.V. Madruga, P. Cahn, B. Grinsztejn, R. Haubrich, J. Lalezari, and A. Mills Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial Lancet 370 2007 29 38
    • (2007) Lancet , vol.370 , pp. 29-38
    • Madruga, J.V.1    Cahn, P.2    Grinsztejn, B.3    Haubrich, R.4    Lalezari, J.5    Mills, A.6
  • 15
    • 34047207229 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir at Week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
    • B. Clotet, N. Bellos, J.M. Molina, D. Cooper, J.C. Goffard, and A. Lazzarin Efficacy and safety of darunavir-ritonavir at Week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials Lancet 369 2007 1169 1178
    • (2007) Lancet , vol.369 , pp. 1169-1178
    • Clotet, B.1    Bellos, N.2    Molina, J.M.3    Cooper, D.4    Goffard, J.C.5    Lazzarin, A.6
  • 16
    • 42049119625 scopus 로고    scopus 로고
    • Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
    • I. Malet, O. Delelis, M.A. Valantin, B. Montes, C. Soulie, and M. Wirden Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro Antimicrob Agents Chemother 52 2008 1351 1358
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1351-1358
    • Malet, I.1    Delelis, O.2    Valantin, M.A.3    Montes, B.4    Soulie, C.5    Wirden, M.6
  • 18
    • 79952443361 scopus 로고    scopus 로고
    • Emerging integrase inhibitor resistance mutations in raltegravir-treated HIV-1-infected patients with low-level viremia
    • S. Gallien, C. Delaugerre, I. Charreau, J. Braun, T. Boulet, and A. Barrail-Tran Emerging integrase inhibitor resistance mutations in raltegravir-treated HIV-1-infected patients with low-level viremia AIDS 25 2011 665 669
    • (2011) AIDS , vol.25 , pp. 665-669
    • Gallien, S.1    Delaugerre, C.2    Charreau, I.3    Braun, J.4    Boulet, T.5    Barrail-Tran, A.6
  • 19
    • 85027921809 scopus 로고    scopus 로고
    • The activity of the integrase inhibitor dolutegravir against HIV-1 variants isolated from raltegravir-treated adults
    • M.R. Underwood, B.A. Johns, A. Sato, J.N. Martin, S.G. Deeks, and T. Fujiwara The activity of the integrase inhibitor dolutegravir against HIV-1 variants isolated from raltegravir-treated adults J Acquir Immune Defic Syndr 61 2012 297 301
    • (2012) J Acquir Immune Defic Syndr , vol.61 , pp. 297-301
    • Underwood, M.R.1    Johns, B.A.2    Sato, A.3    Martin, J.N.4    Deeks, S.G.5    Fujiwara, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.