Vitamin D Status and Severity of Clostridium difficile Infections: A Prospective Cohort Study in Hospitalized Adults

Journal of Parenteral and Enteral Nutrition

Volumn 39, Issue 4, 2015, Pages 465-470

  Van Der Wilden, Gwendolyn M ^a,b   Fagenholz, Peter J ^a   Velmahos, George C ^a   Quraishi, Sadeq A ^a   Schipper, Inger B ^b   Camargo, Carlos A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

25(OH)D; Clostridium difficile; vitamin D

Indexed keywords

25 HYDROXYERGOCALCIFEROL; 25 HYDROXYVITAMIN D; ALBUMIN; CALCIFEDIOL; CLOSTRIDIUM TOXIN; CREATININE; VITAMIN D; 25-HYDROXYVITAMIN D;

ABDOMINAL PAIN; ABDOMINAL TENDERNESS; ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; CHARLSON COMORBIDITY INDEX; CLINICAL FEATURE; CLOSTRIDIUM DIFFICILE INFECTION; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; ENZYME IMMUNOASSAY; FEMALE; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; LENGTH OF STAY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; PEPTOCLOSTRIDIUM DIFFICILE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT INFECTION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; BLOOD; CLOSTRIDIUM INFECTION; COLITIS; COMPLICATION; CROSS INFECTION; MICROBIOLOGY; ODDS RATIO; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; VERY ELDERLY; VITAMIN D DEFICIENCY;

CLOSTRIDIUM DIFFICILE;

ADULT; AGED; AGED, 80 AND OVER; CALCIFEDIOL; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COLITIS; CROSS INFECTION; FEMALE; HOSPITALIZATION; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84930509801     PISSN: 01486071     EISSN: 19412444     Source Type: Journal    
DOI: 10.1177/0148607113519129     Document Type: Article

References (39)

1. Lucado J, Elishauser A Clostridium difficile Infections (CDI) in Hospital Stays, 2009. Rockville, MD: Agency for Healthcare Research and Quality ;
2. HCUP Projections: Clostridium difficile Infection 2011 to 2012. Rockville, MD: Agency for Healthcare Research and Quality ; 2012 :
3. Kyne L, Hamel MB, Polavaram R, et al. Health care costs and mortality associated with nosocomial diarrhea due to. Clostridium difficile. Clin Infect Dis. 2002 ; 34 (3). 346-353
4. Dubberke ER, Reske KA, Olsen MA, et al. Short- and long-term attributable costs of Clostridium difficile-associated disease in nonsurgical inpatients. Clin Infect Dis. 2008 ; 46 (4). 497-504
5. O'Brien JA, Lahue BJ, Caro JJ, et al. The emerging infectious challenge of Clostridium difficile-associated disease in Massachusetts hospitals: clinical and economic consequences. Infect Control Hosp Epidemiol. 2007 ; 28 (11). 1219-1227
6. Wang L, Stewart DB. Increasing hospital costs for Clostridium difficile colitis: type of hospital matters. Surgery. 2011 ; 150 (4). 727-735
7. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010 ; 31 (5). 431-455
8. Kelly CP, Pothoulakis C, LaMont JT. Clostridium difficile colitis. N Engl J Med. 1994 ; 330 (4). 257-262
9. Rubin MS, Bodenstein LE, Kent KC. Severe Clostridium difficile colitis. Dis Colon Rectum. 1995 ; 38 (4). 350-354
10. Ricciardi R, Rothenberger DA, Madoff RD, et al. Increasing prevalence and severity of Clostridium difficile colitis in hospitalized patients in the United States. Arch Surg. 2007 ; 142 (7). 624-631
11. Bhangu A, Nepogodiev D, Gupta A, et al. Systematic review and meta-analysis of outcomes following emergency surgery for Clostridium difficile colitis. Br J Surg. 2012 ; 99 (11). 1501-1513
12. Morris AM, Jobe BA, Stoney M, et al. Clostridium difficile colitis: an increasingly aggressive iatrogenic disease?. Arch Surg. 2002 ; 137 (10). 1096-1100
13. Sailhamer EA, Carson K, Chang Y, et al. Fulminant Clostridium difficile colitis: patterns of care and predictors of mortality. Arch Surg. 2009 ; 144 (5). 433-440
14. Bradbury AW, Barrett S. Surgical aspects of Clostridium difficile colitis. Br J Surg. 1997 ; 84 (2). 150-159
15. Bartley J. Vitamin D: emerging roles in infection and immunity. Expert Rev Anti Infect Ther. 2010 ; 8 (12). 1359-1369
16. Bikle DD. Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens. 2008 ; 17 (4). 348-352
17. Holick MF. Vitamin D deficiency. N Engl J Med. 2007 ; 357 (3). 266-281
18. Youssef DA, Ranasinghe T, Grant WB, et al. Vitamin D's potential to reduce the risk of hospital-acquired infections. Dermatoendocrinology. 2012 ; 4 (2). 167-175
19. QuraishiSALitonjuaAAMoromizatoT. Association between pre-hospital vitamin D deficiency and hospital-acquired Clostridium difficile infections. JPEN J Parenter Enteral Nutr. 2015;39(1):47-55.
20. Singh RJ, Taylor RL, Reddy GS, et al. C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. J Clin Endocrinol Metab. 2006 ; 91 (8). 3055-3061
21. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 ; 96 (7). 1911-1930
22. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987 ; 40 (5). 373-383
23. Youssef D, Bailey B, El Abbassi A, et al. Healthcare costs of Staphylococcus aureus and Clostridium difficile infections in veterans: role of vitamin D deficiency. Epidemiol Infect. 2010 ; 138 (9). 1322-1327
24. Youssef D, Grant WB, Peiris AN. Vitamin D deficiency: a potential risk factor for Clostridium difficile infection. Risk Manag Healthc Policy. 2012 ; 5: 115-116
25. Loo VG, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med. 2005 ; 353 (23). 2442-2449
26. McDonald LC, Killgore GE, Thompson A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med. 2005 ; 353 (23). 2433-2441
27. Pepin J, Alary ME, Valiquette L, et al. Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin Infect Dis. 2005 ; 40 (11). 1591-1597
28. Pepin J, Valiquette L, Cossette BCINCF, et al. Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ. 2005 ; 173 (9). 1037-1042
29. Warny M, Pepin J, Fang A, et al. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet. 2005 ; 366 (9491). 1079-1084
30. Kelly CP, LaMont JT. Clostridium difficile - more difficult than ever. N Engl J Med. 2008 ; 359 (18). 1932-1940
31. Kuijper EJ, Coignard B, Tull P, et al. Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect. 2006 ; 12: 2-18
32. Kelly CP. A 76-year-old man with recurrent Clostridium difficile-associated diarrhea: review of C. difficile infection. JAMA. 2009 ; 301 (9). 954-962
33. Sunenshine RH, McDonald LC. Clostridium difficile-associated disease: new challenges from an established pathogen. Cleve Clin J Med. 2006 ; 73 (2). 187-197
34. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008 ; 4 (2). 80-90
35. Youssef DA, Miller CW, El-Abbassi AM, et al. Antimicrobial implications of vitamin D. Dermatoendocrinology. 2011 ; 3 (4). 220-229
36. Tulk S, Hitota S, MacDonald J, Beck P. Vitamin D downregulates NLRP3 and protects against Clostridium difficile toxin-induced cell death. Abstract presented at Canadian Digestive Diseases Week 2012 ; Montreal, Quebec ;..
37. Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012 ; 95 (6). 1357-1364
38. Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 ; 84 (4). 694-697
39. Quraishi SA, Camargo CA. Vitamin D in acute stress and critical illness. Curr Opin Clin Nutr Metab Care. 2012 ; 15 (6). 625-634