Investigation of association of the IL12B and IL23R genes with psoriatic arthritis

Arthritis and Rheumatism

Volumn 58, Issue 12, 2008, Pages 3705-3709

  Filer, Charlotte ^a   Ho, Pauline ^a   Smith, Rhodri L ^a   Griffiths, Christopher ^a   Young, Helen S ^a   Worthington, Jane ^a   Bruce, Ian N ^a   Barton, Anne ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12P40;

ALLELE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA DETERMINATION; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; INTERLEUKIN 23 RECEPTOR GENE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PSORIATIC ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ARTHRITIS, PSORIATIC; CASE-CONTROL STUDIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HOMOZYGOTE; HUMANS; INTERLEUKIN-12 SUBUNIT P40; POLYMORPHISM, SINGLE NUCLEOTIDE; PSORIASIS; RECEPTORS, INTERLEUKIN;

EID: 57349093812     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24128     Document Type: Article

References (14)

1. Moll JM, Wright V. Familial occurrence of psoriatic arthritis. Ann Rheum Dis 1973;32:181-201.
2. Myers A, Kay LJ, Lynch SA, Walker DJ. Recurrence risk for psoriasis and psoriatic arthritis within sibships. Rheumatology (Oxford) 2005;44:773-6.
3. Ho PY, Barton A, Worthington J, Plant D, Griffiths CE, Young HS, et al. Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis. Ann Rheum Dis 2008;67:677-82.
4. Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 2007;80:273-90.
5. Smith RL, Warren RB, Eyre S, Ho P, Ke X, Young HS, et al. Polymorphisms in the IL-12β and IL-23R genes are associated with psoriasis of early onset in a UK cohort. J Invest Dermatol 2008;158:962-8.
6. Nair RP, Ruether A, Stuart PE, Jenisch S, Tejasvi T, Hiremagalore R, et al. Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 2008;128:1653-61.
7. Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H, and the CASPAR Study Group. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum 2006;54:2665-73.
8. Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008;4:e1000041.
9. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5.
10. Capon F, Di Meglio P, Szaub J, Prescott NJ, Dunster C, Baumber L, et al. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 2007;122:201-6.
11. Gonzalez S, Brautbar C, Martinez-Borra J, Lopez-Vazquez A, Segal R, Blanco-Gelaz MA, et al. Polymorphism in MICA rather than HLA-B/C genes is associated with psoriatic arthritis in the Jewish population. Hum Immunol 2001;62:632-8.
12. Marchini J, Howie B, Myers S, McVean G, Donnelly P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 2007;39:906-13.
13. Gottlieb AB, Menter A, Mendelsohn A, Shen YK, Li S, Fretzin S, et al. Phase II, randomized, placebo-controlled study of CNTO 1275, a human interleukin-12/23 monoclonal antibody, in psoriatic arthritis [abstract]. Arthritis Rheum 2007;56 Suppl 9:S4310.
14. Wellcome Trust Case Control Consortium. Genome wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.