The Dopamine D2 Receptor Polymorphism (DRD2 TaqIA) Interacts with Maternal Parenting in Predicting Early Adolescent Depressive Symptoms: Evidence of Differential Susceptibility and Age Differences

Journal of Youth and Adolescence

Volumn 44, Issue 7, 2015, Pages 1428-1440

  Zhang, Wenxin ^a   Cao, Yanmiao ^a   Wang, Meiping ^a   Ji, Linqin ^a   Chen, Liang ^a   Deater Deckard, Kirby ^a,b  

^a SHANDONG NORMAL UNIVERSITY   (China)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Age related changes; Depressive symptoms; DRD2 TaqIA polymorphism; Early adolescent; Gene environment interaction; Maternal parenting

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DRD4 PROTEIN, HUMAN;

ADOLESCENT; CHILD PARENT RELATION; CHINA; DEPRESSION; FEMALE; GENETIC ASSOCIATION STUDY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; LONGITUDINAL STUDY; MALE; PROSPECTIVE STUDY;

ADOLESCENT; CHINA; DEPRESSION; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LONGITUDINAL STUDIES; MALE; PARENT-CHILD RELATIONS; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4;

EID: 84930472199     PISSN: 00472891     EISSN: 15736601     Source Type: Journal    
DOI: 10.1007/s10964-015-0297-x     Document Type: Article

References (74)

1. Aronen, E. T., & Soininen, M. (2000). Childhood depressive symptoms predict psychiatric problems in young adults. Canadian Journal of Psychiatry,45, 465–470.
2. Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2007). Research review: Genetic vulnerability or differential susceptibility in child development: The case of attachment. Journal of Child Psychology and Psychiatry,48, 1160–1173. doi:10.1111/j.1469-7610.2007.01801.x.
3. Belsky, J., Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2007). For better and for worse differential susceptibility to environmental influences. Current Directions in Psychological Science,16, 300–304. doi:10.1111/j.1467-8721.2007.00525.x.
4. Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009). Vulnerability genes or plasticity genes? Molecular Psychiatry,14, 746–754. doi:10.1038/mp.2009.44.
5. Belsky, J., Newman, D. A., Widaman, K. F., Rodkin, P., Pluess, M., Fraley, R. C., & Roisman, G. I. (2014). Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes. Development and Psychopathology. doi:10.1017/S0954579414000844.
6. Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin,135, 885–908. doi:10.1037/a0017376.
7. Benjamini, Y., & Hochberg, Y. (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological),57, 289–300. doi:10.2307/2346101.
8. Berman, S. M., & Noble, E. P. (1997). The D2 dopamine receptor (DRD2) gene and family stress; interactive effects on cognitive functions in children. Behavior Genetics,27, 33–43. doi:10.1023/A:1025611208475.
9. Berry, D., Deater-Deckard, K., McCartney, K., Wang, Z., & Petrill, S. A. (2013). Gene-environment interaction between DRD4 7-repeat VNTR and early maternal sensitivity predicts inattention trajectories across middle childhood. Development and Psychopathology,25, 291–306. doi:10.1017/S095457941200106X.
10. Bilsky, S. A., Cole, D. A., Dukewich, T. L., Martin, N. C., Sinclair, K. R., Tran, C. V., & Maxwell, M. A. (2013). Does supportive parenting mitigate the longitudinal effects of peer victimization on depressive thoughts and symptoms in children? Journal of Abnormal Psychology,122, 406–419. doi:10.1037/a0032501.
11. Block, J. H. (1981). The child-rearing practices report (CRPR): A set of Q items for the description of parental socialization attitudes and values. Berkeley, CA: University of California, Institute of Human Development.
12. Burmeister, M., McInnis, M. G., & Zöllner, S. (2008). Psychiatric genetics: Progress amid controversy. Nature Reviews Genetics,9, 527–540. doi:10.1038/nrg2381.
13. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science,301(5631), 386–389. doi:10.1126/science.1083968.
14. Chen, C., Chen, C., Moyzis, R., Stern, H., He, Q., Li, H., et al. (2011). Contributions of dopamine-related genes and environmental factors to highly sensitive personality: A multi-step neuronal system-level approach. PLoS One,6, e21636. doi:10.1371/journal.pone.0021636.
15. Chen, X., & Li, B. S. (2000). Depressed mood in Chinese children: Development significance for social and school adjustment. International Journal of Behavioral Development,24, 472–479. doi:10.1080/016502500750038026.
16. Chen, X., Liu, M., & Li, D. (2000). Parental warmth, control, and indulgence and their relations to adjustment in Chinese children: A longitudinal study. Journal of Family Psychology,14, 401–419. doi:10.1037//0893-3200.14.3.401.
17. Cheung, A. K., Harden, K. P., & Tucker-Drob, E. M. (2014). Gene × Environment interactions in early externalizing behaviors: Parental emotional support and socioeconomic context as moderators of genetic influences? Behavior Genetics,44, 468–486. doi:10.1007/s10519-014-9664-8.
18. Cinciripini, P. M., Wetter, D. W., Tomlinson, G. E., Tsoh, J. Y., De Moor, C. A., Cinciripini, L. G., & Minna, J. D. (2004). The effects of the DRD2 polymorphism on smoking cessation and negative affect: Evidence for a pharmacogenetic effect on mood. Nicotine and Tobacco Research,6, 229–239. doi:10.1080/14622200410001676396.
19. Cole, D. A., & Martin, N. C. (2005). The longitudinal structure of the children’s depression inventory: Testing a latent trait-state model. Psychological Assessment,17, 144–155. doi:10.1037/1040-3590.17.2.144.
20. Cole, D. A., Tram, J. M., Martin, J. M., Hoffman, K. B., Ruiz, M. D., Jacquez, F. M., & Maschman, T. L. (2002). Individual differences in the emergence of depressive symptoms in children and adolescents: A longitudinal investigation of parent and child reports. Journal of Abnormal Psychology,111, 156–165. doi:10.1037//0021-843X.111.1.156.
21. Dannlowski, U., Domschke, K., Birosova, E., Lawford, B., Young, R., Voisey, J., & Zwanzger, P. (2013). Dopamine D3 receptor gene variation: impact on electroconvulsive therapy response and ventral striatum responsiveness in depression. International Journal of Neuropsychopharmacology,16, 1443–1459. doi:10.1017/S1461145711001659.
22. De Goede, I. H., Branje, S. J., & Meeus, W. H. (2009). Developmental changes in adolescents’ perceptions of relationships with their parents. Journal of Youth and Adolescence,38, 75–88. doi:10.1007/s10964-008-9286-7.
23. Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., & Craig, I. W. (2004). Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry,9, 908–915. doi:10.1038/sj.mp.4001546.
24. Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary-neurodevelopmental theory. Development and Psychopathology,23, 7–28. doi:10.1017/S0954579410000611.
25. Elovainio, M., Jokela, M., Kivimäki, M., Pulkki-Råback, L., Lehtimäki, T., Airla, N., & Keltikangas-Järvinen, L. (2007). Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults: Cardiovascular risk in young Finns study. Psychosomatic Medicine,69, 391–395. doi:10.1097/psy.0b013e31806bf365.
26. England, M. J., & Sim, L. J. (Eds.). (2009). Depression in parents, parenting, and children: Opportunities to improve identification, treatment, and prevention. Washington, DC: The National Academies Press.
27. Garber, J., Robinson, N. S., & Valentiner, D. (1997). The relation between parenting and adolescent depression self-worth as a mediator. Journal of Adolescent Research, 12, 12–33. doi:10.1177/0743554897121003.
28. Gaté, M. A., Watkins, E. R., Simmons, J. G., Byrne, M. L., Schwartz, O. S., Whittle, S., & Allen, N. B. (2013). Maternal parenting behaviors and adolescent depression: The mediating role of rumination. Journal of Clinical Child and Adolescent Psychology,42, 348–357. doi:10.1080/15374416.2012.755927.
29. Gundlah, C., Lu, N. Z., & Bethea, C. L. (2002). Ovarian steroid regulation of monoamine oxidase-A and B mRNAs in the macaque dorsal raphe and hypothalamic nuclei. Psychopharmacology,160, 271–282. doi:10.1007/s00213-001-0959-0.
30. Hasler, G., Pine, D. S., Kleinbaum, D. G., Gamma, A., Luckenbaugh, D., Ajdacic, V., & Angst, J. (2005). Depressive symptoms during childhood and adult obesity: The Zurich Cohort Study. Molecular Psychiatry,10, 842–850. doi:10.1038/sj.mp.4001671.
31. Hipwell, A., Keenan, K., Kasza, K., Loeber, R., Stouthamer-Loeber, M., & Bean, T. (2008). Reciprocal influences between girls’ conduct problems and depression, and parental punishment and warmth: A six year prospective analysis. Journal of Abnormal Child Psychology,36, 663–677. doi:10.1007/s10802-007-9206-4.
32. Holshausen, K., Bowie, C. R., & Harkness, K. L. (2014). The relation of childhood maltreatment to psychotic symptoms in adolescents and young adults with depression. Journal of Clinical Child & Adolescent Psychology. doi:10.1080/15374416.2014.952010.
33. Johnson, L. J., & Tricker, P. J. (2010). Epigenomic plasticity within populations: Its evolutionary significance and potential. Heredity,105, 113–121. doi:10.1038/hdy.2010.25.
34. Kapur, S., & Mann, J. (1992). Role of the dopaminergic system in depression. Biological Psychiatry,32, 1–17. doi:10.1016/0006-3223(92)90137-O.
35. Katz, L. F., & Hunter, E. C. (2007). Maternal meta-emotion philosophy and adolescent depressive symptomatology. Social Development,16, 343–360. doi:10.1111/j.1467-9507.2007.00388.x.
36. Kendler, K. S., Thornton, L. M., & Prescott, C. A. (2001). Gender differences in the rates of exposure to stressful life events and sensitivity to their depressogenic effects. American Journal of Psychiatry,158, 587–593. doi:10.1176/appi.ajp.158.4.587.
37. Kessler, R. C., Avenevoli, S., & Merikangas, K. R. (2001). Mood disorders in children and adolescents: An epidemiologic perspective. Biological Psychiatry,49, 1002–1014. doi:10.1016/S0006-3223(01)01129-5.
38. Kochanska, G. (1997). Multiple pathways to conscience for children with different temperaments: From toddlerhood to age 5. Developmental Psychology,33, 228–240. doi:10.1037/0012-1649.33.2.228.
39. Kochanska, G., Kim, S., Barry, R. A., & Philibert, R. A. (2011). Children’s genotypes interact with maternal responsive care in predicting children’s competence: Diathesis-stress or differential susceptibility? Development and Psychopathology,23, 605–616. doi:10.1017/S0954579411000071.
40. Kovacs, M. (1992). Children’s depression inventory (CDI) manual. Toronto, Canada: Multi-Health Systems Inc.
41. Lansford, J. E., Criss, M. M., Laird, R. D., Shaw, D. S., Pettit, G. S., Bates, J. E., & Dodge, K. A. (2011). Reciprocal relations between parents’ physical discipline and children’s externalizing behavior during middle childhood and adolescence. Development and Psychopathology,23, 225–238. doi:10.1017/S0954579410000751.
42. Lee, S. H., Ham, B. J., Cho, Y. H., Lee, S. M., & Shim, S. H. (2007). Association study of dopamine receptor D2 TaqIA polymorphism and reward-related personality traits in healthy Korean young females. Neuropsychobiology,56(2–3), 146–151. doi:10.1159/000115781.
43. Lenroot, R. K., & Giedd, J. N. (2011). Annual research review: Developmental considerations of gene by environment interactions. Journal of Child Psychology and Psychiatry,52, 429–441. doi:10.1111/j.1469-7610.2011.02381.x.
44. Lerner, R. M. (1985). Adolescent maturational changes and psychosocial development: A dynamic interactional perspective. Journal of Youth and Adolescence,14, 355–372. doi:10.1007/BF02089239.
45. McLeod, B. D., Wood, J. J., & Weisz, J. R. (2007). Examining the association between parenting and childhood anxiety: A meta-analysis. Clinical Psychology Review,27, 155–172. doi:10.1016/j.cpr.2006.09.002.
46. Meyer, B. M., Huemer, J., Rabl, U., Boubela, R. N., Kalcher, K., Berger, A., & Pezawas, L. (2014). Oppositional COMT Val158Met al connectivity in adolescents and adults. Brain Structure and Function. doi:10.1007/s00429-014-0895-5.
47. Mills-Koonce, W. R., Gariépy, J. L., Propper, C., Sutton, K., Calkins, S., Moore, G., & Cox, M. (2007). Infant and parent factors associated with early maternal sensitivity: A caregiver-attachment systems approach. Infant Behavior and Development,30, 114–126. doi:10.1016/j.infbeh.2006.11.010.
48. Monroe, S. M., & Harkness, K. L. (2005). Life stress, the “kindling” hypothesis, and the recurrence of depression: Considerations from a life stress perspective. Psychological Review,112, 417–445. doi:10.1037/0033-295X.112.2.417.
49. Monroe, S. M., & Reid, M. W. (2008). Gene-environment interactions in depression research genetic polymorphisms and life-stress polyprocedures. Psychological Science,19, 947–956. doi:10.1111/j.1467-9280.2008.02181.x.
50. Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders. Psychological Bulletin,110, 406–425. doi:10.1037/0033-2909.110.3.406.
51. Moretti, M. M., & Craig, S. G. (2013). Maternal versus paternal physical and emotional abuse, affect regulation and risk for depression from adolescence to early adulthood. Child Abuse and Neglect,37, 4–13. doi:10.1016/j.chiabu.2012.09.015.
52. Natsuaki, M. N., Biehl, M. C., & Ge, X. (2009). Trajectories of depressed mood from early adolescence to young adulthood: The effects of pubertal timing and adolescent dating. Journal of Research on Adolescence,19, 47–74. doi:10.1111/j.1532-7795.2009.00581.x.
53. Nederhof, E., Belsky, J., Ormel, J., & Oldehinkel, A. J. (2012). Effects of divorce on Dutch boys’ and girls’ externalizing behavior in Gene × Environment perspective: Diathesis stress or differential susceptibility in the Dutch tracking adolescents’ individual lives survey study? Development and Psychopathology,24, 929–939. doi:10.1017/S0954579412000454.
54. Nelemans, S. A., Hale, W. W, I. I. I., Branje, S. J., Hawk, S. T., & Meeus, W. H. (2014). Maternal criticism and adolescent depressive and generalized anxiety disorder symptoms: A 6-year longitudinal community study. Journal of Abnormal Child Psychology,42, 755–766. doi:10.1007/s10802-013-9817-x.
55. Noble, E. P., Blum, K., Ritchie, T., Montgomery, A., & Sheridan, P. J. (1991). Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Archives of General Psychiatry,48, 648–654. doi:10.1001/archpsyc.1991.01810310066012.
56. Noble, E. P., Gottschalk, L. A., Fallon, J. H., Ritchie, T. L., & Wu, J. C. (1997). D2 dopamine receptor polymorphism and brain regional glucose metabolism. American Journal of Medical Genetics,74, 162–166. doi:10.1002/(SICI)1096-8628(19970418)74:2<162:AID-AJMG9>3.0.CO;2-W.
57. Nolan, S. A., Flynn, C., & Garber, J. (2003). Prospective relations between rejection and depression in young adolescents. Journal of Personality and Social Psychology,85, 745–755. doi:10.1037/0022-3514.85.4.745.
58. Odgers, C. L., Moffitt, T. E., Broadbent, J. M., Dickson, N., Hancox, R. J., Harrington, H., & Caspi, A. (2008). Female and male antisocial trajectories: From childhood origins to adult outcomes. Development and Psychopathology,20, 673–716. doi:10.1017/S0954579408000333.
59. Petersen, I. T., Bates, J. E., Goodnight, J. A., Dodge, K. A., Lansford, J. E., Pettit, G. S., & Dick, D. M. (2012). Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents’ trajectories of anxious/depressed symptoms. Developmental Psychology,48, 1463–1475. doi:10.1037/a0027471.
60. Plomin, R., Kennedy, J. K., & Craig, I. W. (2006). The quest for quantitative trait loci associated with intelligence. Intelligence,34, 513–526. doi:10.1016/j.intell.2006.01.001.
61. Pohjalainen, T., Rinne, J. O., Någren, K., Lehikoinen, P., Anttila, K., Syvälahti, E. K., & Hietala, J. (1998). The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Molecular Psychiatry,3, 256–260. doi:10.1038/sj.mp.4000350.
62. Propper, C., Willoughby, M., Halpern, C. T., Carbone, M. A., & Cox, M. (2007). Parenting quality, DRD4, and the prediction of externalizing and internalizing behaviors in early childhood. Developmental Psychobiology,49, 619–632. doi:10.1002/dev.20249.
63. Roisman, G. I., Newman, D. A., Fraley, R. C., Haltigan, J. D., Groh, A. M., & Haydon, K. C. (2012). Distinguishing differential susceptibility from diathesis-stress: Recommendations for evaluating interaction effects. Development and Psychopathology,24, 389–409. doi:10.1017/S0954579412000065.
64. Rutter, M. (2007). Gene-environment interdependence. Developmental Science,10, 12–18. doi:10.1111/j.1467-7687.2007.00557.x.
65. Steinberg, L. (2014). Adolescence (10th ed.). New York: McGraw-Hill.
66. van der Voort, A., Linting, M., Juffer, F., Bakermans-Kranenburg, M. J., Schoenmaker, C., & van IJzendoorn, M. H. (2014). The development of adolescents’ internalizing behavior: Longitudinal effects of maternal sensitivity and child inhibition. Journal of Youth and Adolescence,43, 528–540. doi:10.1007/s10964-013-9976-7.
67. van Roekel, E., Goossens, L., Scholte, R. H., Engels, R. C., & Verhagen, M. (2011). The dopamine D2 receptor gene, perceived parental support, and adolescent loneliness: Longitudinal evidence for gene-environment interactions. Journal of Child Psychology and Psychiatry,52, 1044–1051. doi:10.1111/j.1469-7610.2011.02424.x.
68. Vaske, J., Beaver, K. M., Wright, J. P., Boisvert, D., & Makarios, M. (2009a). Moderating effects of DRD2 on depression. Stress and Health,25, 453–462. doi:10.1002/smi.1277.
69. Vaske, J., Makarios, M., Boisvert, D., Beaver, K. M., & Wright, J. P. (2009b). The interaction of DRD2 and violent victimization on depression: An analysis by gender and race. Journal of Affective Disorders,112, 120–125. doi:10.1016/j.jad.2008.03.027.
70. Vaughan, C. A., Foshee, V. A., & Ennett, S. T. (2010). Protective effects of maternal and peer support on depressive symptoms during adolescence. Journal of Abnormal Child Psychology,38, 261–272. doi:10.1007/s10802-009-9362-9.
71. Weaver, I. C., Cervoni, N., Champagne, F. A., D’Alessio, A. C., Sharma, S., Seckl, J. R., & Meaney, M. J. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience,7, 847–854. doi:10.1038/nn1276.
72. Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., & Vos, T. (2013). Global burden of disease attributable to mental and substance use disorders: Findings from the Global Burden of Disease Study 2010. The Lancet,382(9904), 1575–1586. doi:10.1016/S0140-6736(13)61611-6.
73. Yang, Y. J., & Yeh, K. H. (2006). Differentiating the effects of enacted parental support on adolescent adjustment in Taiwan: Moderating role of relationship intimacy. Asian Journal of Social Psychology,9, 161–166. doi:10.1111/j.1467-839X.2006.00193.x.
74. Young, J. F., Berenson, K., Cohen, P., & Garcia, J. (2005). The role of parent and peer support in predicting adolescent depression: A longitudinal community study. Journal of Research on Adolescence,15, 407–423. doi:10.1111/j.1532-7795.2005.00105.x.