Bone marrow mesenchymal stem cell transplantation retards the natural senescence of rat hearts

Stem Cells Translational Medicine

Volumn 4, Issue 5, 2015, Pages 494-502

  Zhang, Mingyu ^a   Liu, Di ^a   Li, Shuang ^a   Chang, Lingling ^a   Zhang, Yu ^a   Liu, Ruixue ^a   Sun, Fei ^a   Duan, Wenqi ^a   Du, Weijie ^a   Wu, Yanping ^a   Zhao, Tianyang ^a   Xu, Chaoqian ^a   Lu, Yanjie ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Bone marrow mesenchymal stem cells; Heart; P53; Reactive oxygen species; Senescence

Indexed keywords

ACRIDINE ORANGE; BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; ETHIDIUM BROMIDE; GLUTATHIONE PEROXIDASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MALONALDEHYDE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; COCULTURE; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HISTOLOGY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PROTEIN EXPRESSION; RAT; SENESCENCE; TRANSTHORACIC ECHOCARDIOGRAPHY; UPREGULATION; VENTRICULAR CELL; WESTERN BLOTTING; ANIMAL; BONE MARROW CELL; CELL AGING; CELL DIFFERENTIATION; CYTOLOGY; HEART FAILURE; HEART VENTRICLE; MESENCHYMAL STROMA CELL; METABOLISM; MYOCARDIAL INFARCTION; PATHOLOGY; TRANSPLANTATION;

RATTUS;

ANIMALS; BONE MARROW CELLS; CELL AGING; CELL DIFFERENTIATION; HEART FAILURE; HEART VENTRICLES; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RATS;

EID: 84930464438     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2014-0206     Document Type: Article

References (37)

1. Qin F, Siwik DA, Lancel S et al. Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxationinsenescent mouseheart.JAmHeart Assoc 2013;2:e000184.
2. Johnson TL, Tulis DA, Keeler BE et al. The dopamine D3 receptor knockout mouse mimics aging-related changes in autonomic function and cardiac fibrosis. PLoS ONE 2013;8:e74116.
3. Shioi T, Inuzuka Y. Aging as a substrate of heart failure. J Cardiol 2012;60:423–428.
4. Jugdutt BI. Aging and heart failure: Changing demographics and implications for therapy in the elderly. Heart Fail Rev 2010;15:401–405.
5. Campisi J.The biologyofreplicative senescence. Eur J Cancer 1997;33:703–709.
6. Corbi G, Conti V, Scapagnini G et al. Role of sirtuins, calorie restriction and physical activity in aging. Front Biosci (Elite Ed) 2012;4:768–778.
7. Vasto S, Scapagnini G, Bulati M et al. Bio-markes of aging. Front Biosci (Schol Ed) 2010;2: 392–402.
8. Chen QM, Bartholomew JC, Campisi J et al. Molecular analysisof H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J 1998;332:43–50.
9. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: Signaling for suicide and survival. J Cell Physiol 2002;192:1–15.
10. Itahana K, Campisi J, Dimri GP. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004;5:1–10.
11. Campisi J. Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 2005;120:513–522.
12. Krishnamurthy J, Torrice C, Ramsey MR et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004;114:1299–1307.
13. Olivares EL, Ribeiro VP, Werneck de Castro JP et al. Bone marrow stromal cells improve cardiac performance in healed infarcted rat hearts. Am J Physiol Heart Circ Physiol 2004; 287:H464–H470.
14. Sauer H, Sharifpanah F, Hatry M et al. NOS inhibition synchronizes calcium oscillations in human adipose tissue-derived mesen-chymal stem cells by increasing gap-junctional coupling. J Cell Physiol 2011;226:1642–1650.
15. Liu Y, Zhang Y, Lin L et al. Effects of bone marrow-derived mesenchymal stem cells on the axonal outgrowth through activation of PI3K/AKT signaling in primary cortical neurons followed oxygen-glucose deprivation injury. PLoS One 2013;8:e78514.
16. Song M, Mohamad O, Gu X et al. Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesen-chymal stem cells into the ischemic brain of mice. Cell Transplant 2013;22:2001–2015.
17. Patel DM, Shah J, Srivastava AS. Therapeutic potential of mesenchymal stem cells in regenerative medicine. Stem Cells Int 2013; 2013:496218.
18. Yamaza T, Miura Y, Akiyama K et al. Mes-enchymal stem cell-mediated ectopic hemato-poiesis alleviates aging-related phenotype in immunocompromised mice. Blood 2009;113: 2595–2604.
19. Huang J, Yin SJ, Chen YJ et al. Transplanted bone marrow stromal cells improve cognitive dysfunction due to aging hypoperfu-sion in rats. Chin Med J (Engl) 2010;123: 3620–3625.
20. Ikehara S, Li M. Stem cell transplantation improves aging-related diseases. Front Cell Dev Biol 2014;2:16.
21. Zhao Y, Li T, Wei X et al. Mesenchymal stemcelltransplantation improvesregionalcar-diac remodeling following ovine infarction. Stem Cells Translational Medicine 2012;1: 685–695.
22. Li XH, Fu YH, Lin QX et al. Induced bone marrow mesenchymal stem cells improve cardiac performance of infarcted rat hearts. Mol Biol Rep 2012;39:1333–1342.
23. Chung YC, Ma MC, Huang BY et al. Protection of bone marrow-derived CD45+/CD342/ lin2 stromal cells with immunosuppressant activity against ischemia/reperfusion injury in rats. Chin J Physiol 2011;54:169–182.
24. Lee BC, Hsu HC, Tseng WY et al. Cell therapy generates a favourable chemokine gradient for stem cell recruitment into the infarcted heart in rabbits. Eur J Heart Fail 2009;11:238–245.
25. Benzhi C, Limei Z, Ning W et al. Bone marrow mesenchymal stem cells upregulate transient outward potassium currents in postnatal rat ventricular myocytes. J Mol Cell Cardiol 2009;47:41–48.
26. Cai B, Zhu S, Li J et al. Bone marrow-derived mesenchymal stem cells protected rat cardiomyocytes from premature senescence. Int J Cardiol 2012;154:180–182.
27. Yuan Q, Peng J, Liu SY et al. Inhibitory effect of resveratrol derivative BTM-0512 on high glucose-induced cell senescence involves dimethylaminohydrolase/asymmetric dime-thylarginine pathway. Clin Exp Pharmacol Phys-iol 2010;37:630–635.
28. Zhang B, Cui S, Bai X et al. SIRT3 overex-pression antagonizes high glucose accelerated cellular senescenceinhumandiploid fibroblasts via the SIRT3-FOXO1 signaling pathway. Age (Dordr) 2013;35:2237–2253.
29. Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 2012;24: 981–990.
30. Yoon YS, Wecker A, Heyd L et al. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 2005; 115:326–338.
31. Nagaya N, Kangawa K, Itoh T et al. Trans-plantationof mesenchymal stem cells improves cardiac functioninarat modelofdilated cardio-myopathy. Circulation 2005;112:1128–1135.
32. Khan M, Mohsin S, Khan SN et al. Repair of senescent myocardium by mesenchymal stem cells is dependent on the age of donor mice. J Cell Mol Med 2011;15:1515–1527.
33. DeSantiago J, Bare DJ, Banach K. Ischemia/reperfusion injury protection by mes-enchymal stem cell derived antioxidant capacity. Stem Cells Dev 2013;22:2497–2507.
34. DeSantiago J, Bare DJ, Semenov I et al. Excitation-contraction coupling in ventricular myocytes is enhanced by paracrine signaling from mesenchymal stem cells.JMol Cell Cardiol 2012;52:1249–1256.
35. Catalano A, Rodilossi S, Caprari P et al. 5-Lipoxygenase regulates senescence-like growth arrestbypromotingROS-dependentp53 activation. EMBO J 2005;24:170–179.
36. Macip S, Igarashi M, Berggren P et al. Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol 2003;23:8576–8585.
37. Polyak K, Xia Y, Zweier JL et al. A model for p53-induced apoptosis. Nature 1997;389:300–305.