Is Alzheimer's disease autoimmune inflammation of the brain that can be treated with nasal nonsteroidal anti-inflammatory drugs?

American Journal of Alzheimer's Disease and other Dementias

Volumn 30, Issue 3, 2015, Pages 225-227

  Lehrer, Steven ^a   Rheinstein, Peter H ^b  

^a Fermata Pharma Inc   (United States)

^b Severn Health Solutions   (United States)

Author keywords

autoimmunity; brain; nasal; NSAIDs

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT;

ALZHEIMER DISEASE; ARTICLE; AUTOIMMUNE DISEASE; CARDIOVASCULAR DISEASE; FEMALE; HUMAN; INFLAMMATORY DISEASE; LONGEVITY; MALE; NONHUMAN; AGED; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; BRAIN; DRUG EFFECTS; INTRANASAL DRUG ADMINISTRATION;

ADMINISTRATION, INTRANASAL; AGED; ALZHEIMER DISEASE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; BRAIN; FEMALE; HUMANS; MALE;

EID: 84930463989     PISSN: 15333175     EISSN: 19382731     Source Type: Journal    
DOI: 10.1177/1533317514545478     Document Type: Article

References (33)

1. 2014 Alzheimer's Disease Facts and Figures. Alzheimer's & Dementia. 10 ( 2 ):
2. Chene G, Beiser A, Au R, et al. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life [Published online January 10, 2014]. Alzheimers Dement. 2014 ;:
3. D'Andrea MR, Cole GM, Ard MD. The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging. 2004 ; 25 (5). 675-683
4. Wyss-Coray T, Rogers J. Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med. 2012 ; 2 (1). a006346
5. Lee Hg, Zhu X, Castellani RJ, Nunomura A, Perry G, Smith MA. Amyloid-β in Alzheimer disease: the null versus the alternate hypotheses. J Pharmacol Exp Ther. 2007 ; 321 (3). 823-829
6. McFarland HF, Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol. 2007 ; 8 (9). 913-919
7. McLeod JG, Hammond SR, Hallpike JF. Epidemiology of multiple sclerosis in Australia. With NSW and SA survey results. Med J Aust. 1994 ; 160 (3). 117-122
8. Symmons D, Turner G, Webb R, et al. The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology (Oxford). 2002 ; 41 (7). 793-800
9. Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002 ; 347 (12). 911-920
10. D'Andrea MR. Add Alzheimer's disease to the list of autoimmune diseases. Med Hypotheses. 2005 ; 64 (3). 458-463
11. D'Andrea MR. Evidence linking neuronal cell death to autoimmunity in Alzheimer's disease. Brain Res. 2003 ; 982 (1). 19-30
12. Genovesi G, Paolini P, Marcellini L, et al. Relationship between autoimmune thyroid disease and Alzheimer's disease. Panminerva Med. 1996 ; 38 (1). 61-63
13. Phan GQ, Yang JC, Sherry RM, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA. 2003 ; 100 (14). 8372-8377
14. Romero JP, Benito-Leon J, Louis ED, Bermejo-Pareja F. Alzheimer's disease is associated with decreased risk of cancer-specific mortality: a prospective study (NEDICES). J Alzheimers Dis. 2014 ; 40 (2). 465-473
15. Mruthinti S, Schade RF, Harrell DU, et al. Autoimmunity in Alzheimer's disease as evidenced by plasma immunoreactivity against RAGE and Abeta42: complication of diabetes. Curr Alzheimer Res. 2006 ; 3 (3). 229-235
16. Lockshin MD. Sex differences in autoimmune disease. Lupus. 2006 ; 15 (11). 753-756
17. Invernizzi P, Pasini S, Selmi C, Gershwin ME, Podda M. Female predominance and X chromosome defects in autoimmune diseases. J Autoimmun. 2009 ; 33 (1). 12-16
18. Beeri MS, Rapp M, Schmeidler J, et al. Number of children is associated with neuropathology of Alzheimer's disease in women. Neurobiol Aging. 2009 ; 30 (8). 1184-1191
19. Sobow T, Kloszewska I. Parity, number of pregnancies, and the age of onset of Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 2004 ; 16 (1). 120-121
20. Elias MF, Beiser A, Wolf PA, Au R, White RF, D'Agostino RB. The preclinical phase of alzheimer disease: a 22-year prospective study of the Framingham Cohort. Arch Neurol. 2000 ; 57 (6). 808-813
21. Friedrich MJ. Researchers test strategies to prevent Alzheimer disease. JAMA. 2014 ; 311 (16). 1596-1598
22. Tabas I, Glass CK. Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science. 2013 ; 339 (6116). 166-172
23. Stewart WF, Kawas C, Corrada M, Metter EJ. Risk of Alzheimer's disease and duration of NSAID use. Neurology. 1997 ; 48 (3). 626-632
24. Lindsay J, Laurin D, Verreault R, et al. Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol. 2002 ; 156 (5). 445-453
25. Jaturapatporn D, Isaac MG, McCleery J, Tabet N. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst Rev. 2012 ; 2: CD006378
26. Lehrer S. Nasal NSAIDs for Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2014 ; 29 (5). 401-403
27. Parepally JM, Mandula H, Smith QR. Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin. Pharm Res. 2006 ; 23 (5). 873-881
28. Adams SS, Bough RG, Cliffe EE, Lessel B, Mills RF. Absorption, distribution and toxicity of ibuprofen. Toxicol Appl Pharmacol. 1969 ; 15 (2). 310-330
29. Skoog I, Wallin A, Fredman P, et al. A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia. Neurology. 1998 ; 50 (4). 966-971
30. Bahadur S, Pathak K. Physicochemical and physiological considerations for efficient nose-to-brain targeting. Expert Opin Drug Deliv. 2012 ; 9 (1). 19-31
31. Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol. 2012 ; 69 (1). 29-38
32. Liu L, Drouet V, Wu JW, et al. Trans-synaptic spread of tau pathology in vivo. PLoS One. 2012 ; 7 (2). e31302
33. Marchetti B, Abbracchio MP. To be or not to be (inflamed) - is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?. Trends Pharmacol Sci. 2005 ; 26 (10). 517-525