Heightened inflammation in severe malaria is associated with decreased IL-10 expression levels and neutrophils

Innate Immunity

Volumn 21, Issue 5, 2015, Pages 546-552

  Mahanta, Anusree ^a   Kar, Santosh K ^b   Kakati, Sanjeeb ^c   Baruah, Shashi ^a  

^a TEZPUR UNIVERSITY   (India)

^b KIIT UNIVERSITY   (India)

^c ASSAM MEDICAL COLLEGE   (India)

Author keywords

Cytokine; gene expression; malaria; neutrophils; northeast India

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P35; INTERLEUKIN 1BETA; INTERLEUKIN 8; RANTES; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; MESSENGER RNA;

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOKINE RESPONSE; DISEASE ASSOCIATION; HUMAN; INFLAMMATION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALARIA; MALARIA FALCIPARUM; NEUTROPHIL; NEUTROPHIL COUNT; PARASITEMIA; PROTEIN EXPRESSION; UPREGULATION; ADOLESCENT; ANEMIA; ANIMAL; BIOSYNTHESIS; BLOOD; CHILD; FEMALE; GENETICS; LEUKOCYTE COUNT; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; YOUNG ADULT;

PLASMODIUM FALCIPARUM;

ADOLESCENT; ADULT; ANEMIA; ANIMALS; CHILD; CYTOKINES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFLAMMATION; INTERLEUKIN-10; LEUKOCYTE COUNT; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; NEUTROPHILS; RNA, MESSENGER; YOUNG ADULT;

EID: 84930385437     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425914561277     Document Type: Article

References (29)

1. Miller LH, Baruch DI, Marsh K, et al. The pathogenic basis of malaria. Nature. 2002; 415: 673-679
2. Schofield L, Grau GE. Immunological processes in malaria pathogenesis. Nat. Rev. Immunol. 2005; 5: 722-735
3. Rovira-Vallbona E, Moncunill G, Bassat Q, et al. Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study. Malar J. 2012; 11: 181-181
4. Anyona SB, Kempaiah P, Raballah E, et al. Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality. Infect Immun. 2011; 79: 4923-4932
5. Ayimba E, Hegewald J, Segbena AY, et al. Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria. Clin Exp Immunol. 2011; 166: 218-226
6. Boeuf PS, Loizon S, Awandare GA, et al. Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia. Malar J. 2012; 11: 253-253
7. Michon P, Cole-Tobian JL, Dabod E, et al. The risk of malarial infections and disease in Papua New Guinean children. Am J Trop Med Hyg. 2007; 76: 997-1008
8. Baird JK, Snow RW. Acquired immunity in a holoendemic setting of Plasmodium falciparum and P. vivax malaria. Am J Trop Med Hyg. 2007; 76: 995-996
9. D'Ombrain MC, Robinson LJ, Stanisic DI, et al. Association of early interferon-γ production with immunity to clinical malaria: a longitudinal study among Papua New Guinean children. Clin Infect Dis. 2008; 47: 1380-1387
10. Mahanta A, Kakati S, Baruah S. The association of IL-8-251T/A polymorphism with complicated malaria in Karbi Anglong district of Assam. Cytokine. 2014; 65: 210-216
11. Malhotra I, Dent A, Mungai P, et al. Real-time quantitative PCR for determining the burden of Plasmodium falciparum parasites during pregnancy and infancy. J Clin Microbiol. 2005; 43: 3630-3635
12. Troye-Blomberg M, Romero P, Patarroyo ME, et al. Regulation of the immune response in Plasmodium falciparum malaria. III. Proliferative response to antigen in vitro and subset composition of T cells from patients with acute infection or from immune donors. Clin Exp Immunol. 1984; 58: 380-387
13. Perkins DJ, Were T, Davenport GC, et al. Severe malarial anemia: innate immunity and pathogenesis. Int J Biol Sci. 2011; 7: 1427-1442
14. Schofield L, Grau GE. Immunological processes in malaria pathogenesis. Nat Rev Immunol. 2005; 5: 722-735
15. Lourembam SD, Sawian CE, Baruah S. Dysregulation of cytokines expression in complicated falciparum malaria with increased TGF-β and IFN-γ and decreased IL-2 and IL-12. Cytokine. 2013; 64: 503-508
16. Torre D, Speranza F, Giola M, et al. Role of Th1 and Th2 cytokines in immune response to uncomplicated Plasmodium falciparum malaria. Clin Diagn Lab Immunol. 2002; 9: 348-351
17. Mendonça VRR, Queiroz ATL, Lopes FM, et al. Networking the host immune response in Plasmodium vivax malaria. Malar J. 2013; 12: 69-69
18. Margadant C, Sonnenberg A. Integrin-TGF-β crosstalk in fibrosis, cancer and wound healing. EMBO Rep. 2010; 11: 97-105
19. Kubo M, Mototmura Y. Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cell. Front Immunol. 2012; 3: 275-275
20. Andrieux G, Borgne ML, Théret N. An integrative modeling framework reveals plasticity of TGF-β signalling. BMC Syst Biol. 2014; 8: 30-30
21. Scholzen A, Mittag D, Rogerson SJ, et al. Plasmodium falciparum-mediated induction of human CD25hiFoxp3hi CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFβ. PLoS Pathog. 2009; 5: e1000543 - e1000543
22. Kremsner PG, Greve B, Lell B, et al. Malarial anaemia in African children associated with high oxygen-radical production. Lancet. 2000; 355: 40-41
23. Francischetti IMB, Gordon E, Bizzarro B, et al. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. PLoS One. 2014; 28: e87140 - e87140
24. Mócsai A. Diverse novel functions of neutrophils in immunity, inflammation, and beyond. J Exp Med. 2013; 210: 1283-1299
25. Mantovani A, Cassatella MA, Costantini C, et al. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 2011; 11: 519-531
26. Scapini P, Lapinet-Vera JA, Gasperini S, et al. The neutrophil as a cellular source of chemokines. Immunol Rev. 2000; 177: 195-203
27. Kasama T, Miwa Y, Isozaki T, et al. Neutrophil-derived cytokines: potential therapeutic targets in inflammation. Curr Drug Targets Inflamm Allergy. 2005; 4: 273-279
28. Ellis TN, Beaman BL. Interferon-γ activation of polymorphonuclear neutrophil function. Immunology. 2004; 112: 2-12
29. Cassatella MA. Neutrophil-derived proteins: selling cytokines by the pound. Adv Immunol. 1999; 73: 369-509