Large scale meta-analysis of fragment-based screening campaigns: Privileged fragments and complementary technologies

Journal of Biomolecular Screening

Volumn 20, Issue 5, 2015, Pages 588-596

  Kutchukian, Peter S ^a,c   Wassermann, Anne Mai ^a   Lindvall, Mika K ^a   Wright, S Kirk ^a   Ottl, Johannes ^b   Jacob, Jaison ^a   Scheufler, Clemens ^b   Marzinzik, Andreas ^b   Brooijmans, Natasja ^a,d   Glick, Meir ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c MERCK RESEARCH LABORATORIES   (United States)

^d Blueprint Medicines   (United States)

Author keywords

fragment; fragment based screen; naive Bayesian model; privileged substructure

Indexed keywords

ARTICLE; BAYES THEOREM; BIOCHEMICAL ANALYSIS; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING FLUORIMETRY; DRUG SCREENING; FLUOROMETRY; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; TECHNOLOGY; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CONFORMATION; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; META ANALYSIS; MOLECULAR LIBRARY; PROCEDURES; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

MOLECULAR LIBRARY;

BAYES THEOREM; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SMALL MOLECULE LIBRARIES;

EID: 84930348403     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114565080     Document Type: Article

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