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Volumn 14, Issue 6, 2015, Pages 442-444

Drug discovery for the developing world: Progress at the Novartis Institute for Tropical Diseases

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ANTIVIRUS AGENT; ARTEMISININ; ARTESUNATE; CHLOROQUINE; CIPARGAMIN; ENDOPEPTIDASE CLP; FIDAXOMICIN; GLYCEROL; HELICASE; IMIDAZOLECARBOXAMIDE; IMIDAZOPYRIDINE DERIVATIVE; ISONIAZID; KAF 156; KAI 407; MEFLOQUINE; METHYLTRANSFERASE; NITD 008; NITD 304; NITD 349; NITD 916; PRIMAQUINE; PROTEINASE; PYRAZOLOPYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; S ADENOSYLMETHIONINE; SODIUM CHANNEL; TUBERCULOSTATIC AGENT; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84930333856     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4001-c1     Document Type: Letter
Times cited : (6)

References (21)
  • 1
    • 84877267006 scopus 로고    scopus 로고
    • Advances in the development of new tuberculosis drugs and treatment regimens
    • Zumla A., Nahid P. & Cole S. T. Advances in the development of new tuberculosis drugs and treatment regimens. Nature Rev. Drug Discov. 12, 388-404 (2013
    • (2013) Nature Rev. Drug Discov , vol.12 , pp. 388-404
    • Zumla, A.1    Nahid, P.2    Cole, S.T.3
  • 2
    • 79953322662 scopus 로고    scopus 로고
    • Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery
    • Dembele L., et al. Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery. PLoS ONE 6, e18162 (2011
    • (2011) Plos One , vol.6 , pp. e18162
    • Dembele, L.1
  • 3
    • 84896837621 scopus 로고    scopus 로고
    • Kai407, a potent non 8 aminoquinoline compound that kills plasmodium cynomolgi early dormant liver stage parasites in vitro antimicrob
    • Zeeman A. M., et al. KAI407, a potent non 8 aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrob. Agents Chemother. 58, 1586-1595 (2014
    • (2014) Agents Chemother , vol.58 , pp. 1586-1595
    • Zeeman, A.M.1
  • 4
    • 33847042742 scopus 로고    scopus 로고
    • A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs
    • Schul W., Liu W., Xu H. Y., Flamand M. & Vasudevan S. G. A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. J. Infect. Dis. 195, 665-674 (2007
    • (2007) J. Infect. Dis , vol.195 , pp. 665-674
    • Schul, W.1    Liu, W.2    Xu, H.Y.3    Flamand, M.4    Vasudevan, S.G.5
  • 5
    • 73949141554 scopus 로고    scopus 로고
    • An adenosine nucleoside inhibitor of dengue virus
    • Yin Z., et al. An adenosine nucleoside inhibitor of dengue virus. Proc. Natl Acad. Sci. USA 106, 20435-20439 (2009
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 20435-20439
    • Yin, Z.1
  • 6
    • 33745025763 scopus 로고    scopus 로고
    • Structural basis for the activation of flaviviral ns3 proteases from dengue and west nile virus
    • Erbel P., et al. Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nature Struct. Mol. Biol. 13, 372-373 (2006
    • (2006) Nature Struct. Mol. Biol , vol.13 , pp. 372-373
    • Erbel, P.1
  • 7
    • 84855921187 scopus 로고    scopus 로고
    • Ligand-bound structures of the dengue virus protease reveal the active conformation
    • Noble C. G., Seh C. C., Chao A. T. & Shi P. Y. Ligand-bound structures of the dengue virus protease reveal the active conformation. J. Virol. 86, 438-446 (2012
    • (2012) J. Virol , vol.86 , pp. 438-446
    • Noble, C.G.1    Seh, C.C.2    Chao, A.T.3    Shi, P.Y.4
  • 8
    • 79953188722 scopus 로고    scopus 로고
    • Small molecule inhibitors that selectively block dengue virus methyltransferase
    • Lim S. P., et al. Small molecule inhibitors that selectively block dengue virus methyltransferase. J. Biol. Chem. 286, 6233-6240 (2011
    • (2011) J. Biol. Chem , vol.286 , pp. 6233-6240
    • Lim, S.P.1
  • 9
    • 34247610261 scopus 로고    scopus 로고
    • Crystal structure of the dengue virus rna-dependent rna polymerase catalytic domain at 1.85å resolution
    • Yap T. L., et al. Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85Å resolution. J. Virol. 81, 4753-4765 (2007
    • (2007) J. Virol , vol.81 , pp. 4753-4765
    • Yap, T.L.1
  • 10
    • 23244464646 scopus 로고    scopus 로고
    • Structure of the dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 å
    • Xu T., et al. Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 Å. J. Virol. 79, 10278-10288 (2005
    • (2005) J. Virol , vol.79 , pp. 10278-10288
    • Xu, T.1
  • 11
    • 77956280420 scopus 로고    scopus 로고
    • Spiroindolones, a potent compound class for the treatment of malaria
    • Rottmann M., et al. Spiroindolones, a potent compound class for the treatment of malaria. Science 329, 1175-1180 (2010
    • (2010) Science , vol.329 , pp. 1175-1180
    • Rottmann, M.1
  • 12
    • 84873901917 scopus 로고    scopus 로고
    • Na+ regulation in the malaria parasite plasmodium falciparum involves the cation atpase pfatp4 and is a target of the spiroindolone antimalarials
    • Spillman N. J., et al. Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host Microbe 13, 227-237 (2011
    • (2011) Cell Host Microbe , vol.13 , pp. 227-237
    • Spillman, N.J.1
  • 13
    • 84904909454 scopus 로고    scopus 로고
    • Spiroindolone KAE609 for falciparum and vivax malaria
    • White N. J., et al. Spiroindolone KAE609 for falciparum and vivax malaria. N. Engl. J. Med. 371, 403-410 (2014
    • (2014) N. Engl. J. Med , vol.371 , pp. 403-410
    • White, N.J.1
  • 14
    • 83255176722 scopus 로고    scopus 로고
    • Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
    • Meister S., et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science 334, 1372-1377 (2011
    • (2011) Science , vol.334 , pp. 1372-1377
    • Meister, S.1
  • 15
    • 84906079854 scopus 로고    scopus 로고
    • Kaf156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission
    • Kuhen K. L., et al. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrob. Agents Chemother. 58, 5060-5067 (2014
    • (2014) Antimicrob. Agents Chemother , vol.58 , pp. 5060-5067
    • Kuhen, K.L.1
  • 16
    • 84890428942 scopus 로고    scopus 로고
    • Targeting plasmodium pi(4)k to eliminate malaria
    • McNamara C. W., et al. Targeting Plasmodium PI(4)K to eliminate malaria. Nature 504, 248-253 (2013
    • (2013) Nature , vol.504 , pp. 248-253
    • McNamara, C.W.1
  • 17
    • 79251537963 scopus 로고    scopus 로고
    • A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
    • Pethe K., et al. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy. Nature Commun. 1, 57 (2010
    • (2010) Nature Commun , vol.1 , pp. 57
    • Pethe, K.1
  • 18
    • 84883824094 scopus 로고    scopus 로고
    • Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
    • Pethe K., et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nature Med. 19, 1157-1160 (2013
    • (2013) Nature Med , vol.19 , pp. 1157-1160
    • Pethe, K.1
  • 19
    • 84877697081 scopus 로고    scopus 로고
    • Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents
    • Yokokawa F., et al. Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents. ACS Med. Chem. Lett. 4, 451-455 (2013
    • (2013) ACS Med. Chem. Lett , vol.4 , pp. 451-455
    • Yokokawa, F.1
  • 20
    • 84891722137 scopus 로고    scopus 로고
    • Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis
    • 214ra168
    • Rao S. P., et al. Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis. Sci. Transl Med. 5, 214ra168 (2013
    • (2013) Sci. Transl Med , vol.5
    • Rao, S.P.1
  • 21
    • 84920711914 scopus 로고    scopus 로고
    • Direct inhibitors of InhA are active against Mycobacterium tuberculosis
    • 269ra263
    • Manjunatha U. H., et al. Direct inhibitors of InhA are active against Mycobacterium tuberculosis. Sci. Transl Med. 7, 269ra263 (2015
    • (2015) Sci. Transl Med , vol.7
    • Manjunatha, U.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.