Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing

Breast Cancer Research and Treatment

Volumn 151, Issue 3, 2015, Pages 529-539

  Wu, Yong ^a,b   Sarkissyan, Marianna ^a   Mcghee, Eva ^a,c   Lee, Sangkyu ^d   Vadgama, Jaydutt V ^a,b  

^a CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2 Deoxyglucose; AMPK; Glycolysis; Metabolic adaptation; Mitochondrial biogenesis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEOXYGLUCOSE; ESTROGEN RELATED RECEPTOR ALPHA; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LUCIFERASE; LUCIFERIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; SMALL INTERFERING RNA; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; ERRALPHA ESTROGEN-RELATED RECEPTOR; ESTROGEN RECEPTOR; PPARGC1B PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

ARTICLE; BIOGENESIS; BREAST CANCER; CANCER CELL; CELL KILLING; CLONOGENIC ASSAY; CONTROLLED STUDY; CYTOTOXICITY; FAO GENE; FATTY ACID OXIDATION; GENE; GENE SILENCING; GLYCOLYSIS; HUMAN; HUMAN CELL; MCF 7 CELL LINE; MTT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; FEMALE; INTRACELLULAR SPACE; MCF-7 CELL LINE; METABOLISM; ORGANELLE BIOGENESIS; PHOSPHORYLATION; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEOXYGLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLYCOLYSIS; HUMANS; INTRACELLULAR SPACE; MCF-7 CELLS; ORGANELLE BIOGENESIS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTORS, ESTROGEN;

EID: 84930271812     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-015-3386-3     Document Type: Article

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