TAAR1-dependent effects of apomorphine in mice

International Journal of Neuropsychopharmacology

Volumn 17, Issue 10, 2014, Pages 1683-1693

  Sukhanov, Ilya ^a,b   Espinoza, Stefano ^a   Yakovlev, Dmitriy S ^c   Hoener, Marius C ^d   Sotnikova, Tatiana D ^a   Gainetdinov, Raul R ^a,e,f  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b PAVLOV FIRST SAINT PETERSBURG STATE MEDICAL UNIVERSITY   (Russian Federation)

^c VOLGOGRAD STATE MEDICAL UNIVERSITY   (Russian Federation)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

^e SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY   (Russian Federation)

^f ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

Author keywords

Apomorphine; Climbing; Dopamine (DA); Dopamine receptor 2 (D2R); Stereotypies; Trace amine associate receptor 1 (TAAR1)

Indexed keywords

APOMORPHINE; BENZAZEPINE DERIVATIVE; CYCLIC AMP; DOPAMINE RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR; OXAZOLE DERIVATIVE; PHENETHYLAMINE DERIVATIVE; PROTEIN BINDING; QUINPIROLE; RO5166017; SK&F 81297; TRACE AMINE-ASSOCIATED RECEPTOR 1;

AGONISTS; ANIMAL; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; DRUG INTERACTION; GENETICS; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOTOR ACTIVITY; MOUSE; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; RADIOASSAY; TIME;

ANIMALS; APOMORPHINE; BENZAZEPINES; CYCLIC AMP; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; OXAZOLES; PHENETHYLAMINES; PROTEIN BINDING; PSYCHOMOTOR PERFORMANCE; QUINPIROLE; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; TIME FACTORS;

EID: 84930246219     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145714000509     Document Type: Article

References (43)

1. Barak LS, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RR (2008) Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. Mol Pharmacol 74:585-594.
2. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA 98:8966-8971.
3. Boulton AA (1980) Trace amines and mental disorders. Can J Neurol Sci 7:261-263.
4. Budygin EA (2007) Dopamine uptake inhibition is positively correlated with cocaine-induced stereotyped behavior. Neurosci Lett 429:55-58.
5. Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, Kennedy JL, Olson SB, Magenis RE, Amara SG, Grandy DK (2001) Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 60:1181-1188.
6. Burban A, Sadakhom C, Dumoulin D, Rose C, Le PG, Frances H, Arrang JM (2010) Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists. Psychopharmacology (Berl) 210:591-604.
7. Costall B, Naylor RJ, Nohria V (1978a) Climbing behaviour induced by apomorphine in mice: a potential model for the detection of neuroleptic activity. Eur J Pharmacol 50:39-50.
8. Costall B, Naylor RJ, Nohria V (1978b) Differential actions of typical and atypical neuroleptic agents on two behavioural effects of apomorphine in the mouse [proceedings]. Br J Pharmacol 63:381P-382P.
9. Del ZM, Bocchetta A, Piccardi MP, Corsini GU (1986) Dopamine agonists in the treatment of schizophrenia. Prog Brain Res 65:41-48.
10. Espinoza S, Salahpour A, Masri B, Sotnikova TD, Messa M, Barak LS, Caron MG, Gainetdinov RR (2011) Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Mol Pharmacol 80:416-425.
11. Espinoza S, Masri B, Salahpour A, Gainetdinov RR (2013) BRET approaches to characterize dopamine and TAAR1 receptor pharmacology and signaling. Methods Mol Biol 964:107-122.
12. Gainetdinov RR, Sotnikova TD, Grekhova TV, Rayevsky KS (1996) In vivo evidence for preferential role of dopamine D3 receptor in the presynaptic regulation of dopamine release but not synthesis. Eur. J. Pharmacol 308:261-269.
13. Geter-Douglass B, Katz JL, Alling K, Acri JB, Witkin JM (1997) Characterization of unconditioned behavioral effects of dopamine D3/D2 receptor agonists. J Pharmacol Exp Ther 283:7-15.
14. Grandy DK (2007) Trace amine-associated receptor 1-Family archetype or iconoclast? Pharmacol Ther 116:355-390.
15. Gunzler SA, Shakil S, Carlson NE, Nutt JG, Meshul CK (2007) Low doses of apomorphine transiently reduce locomotor activity in MPTP-treated mice. Neurosci Lett 428:64-67.
16. Hedley LR, Wallach MB (1983) Potentiation of apomorphine-induced gnawing in mice. Prog Neuropsychopharmacol Biol Psychiatry 7:47-56.
17. Hu LA, Zhou T, Ahn J, Wang S, Zhou J, Hu Y, Liu Q (2009) Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. Biochem J 424:39-45.
18. Leo D, Mus L, Espinoza S, Hoener MC, Sotnikova TD, Gainetdinov RR (2014) Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors. Neuropharmacology 21:71-79.
19. Lindemann L, Hoener MC (2005) A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci 26:274-281.
20. Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (2005) Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Genomics 85:372-385.
21. Lindemann L, Meyer CA, Jeanneau K, Bradaia A, Ozmen L, Bluethmann H, Bettler B, Wettstein JG, Borroni E, Moreau JL, Hoener MC (2008) Trace amine-associated receptor 1 modulates dopaminergic activity. J Pharmacol Exp Ther 324:948-956.
22. Millan MJ, Maiofis L, Cussac D, Audinot V, Boutin JA, Newman-Tancredi A (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther 303:791-804.
23. Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK (2005) Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther 313:983-994.
24. Moore NA, Axton MS (1988) Production of climbing behaviour in mice requires both D1 and D2 receptor activation. Psychopharmacology (Berl) 94:263-266.
25. Nally RE, McNamara FN, Clifford JJ, Kinsella A, Tighe O, Croke DT, Fienberg AA, Greengard P, Waddington JL (2003) Topographical assessment of ethological and dopamine receptor agonist-induced behavioral phenotype in mutants with congenic DARPP-32 'Knockout'. Neuropsychopharmacology 28:2055-2063.
26. Philips SR, Rozdilsky B, Boulton AA (1978) Evidence for the presence of m-tyramine, p-tyramine, tryptamine, and phenylethylamine in the rat brain and several areas of the human brain. Biol Psychiatry. 13:51-57.
27. Philp RB, Fields GN, Johnston JP (1986) Effects of nitrogen and helium at pressure on drug-induced stereotypy and locomotion in mice. Aviat Space Environ Med 57:769-776.
28. Protais P, Costentin J, Schwartz JC (1976) Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacology (Berl) 50:1-6.
29. Puech AJ, Simon P, Boissier JR (1976) Antagonism by sulpiride of three apomorphine-induced effects in rodents. Eur J Pharmacol 36:439-441.
30. Reese EA, Norimatsu Y, Grandy MS, Suchland KL, Bunzow JR, Grandy DK (2014) Exploring the determinants of trace amine-associated receptor 1's functional selectivity for the stereoisomers of amphetamine and methamphetamine. J Med Chem 57:378-390.
31. Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, Meyer CA, Metzler V, Chaboz S, Ozmen L, Trube G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC (2011) TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A 108:8485-8490.
32. Revel FG, Moreau JL, Gainetdinov RR, Ferragud A, Velázquez-Sánchez C, Sotnikova TD, Morairty SR, Harmeier A, Groebke Zbinden K, Norcross RD, Bradaia A, Kilduff TS, Biemans B, Pouzet B, Caron MG, Canales JJ, Wallace TL, Wettstein JG, Hoener MC (2012) Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biol Psychiatry 72:934-942.
33. Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC (2013) A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry 18:543-556.
34. Salahpour A, Espinoza S, Masri B, Lam V, Barak LS, Gainetdinov RR (2012) BRET biosensors to study GPCR biology, pharmacology, and signal transduction. Front Endocrinol (Lausanne) 3:105.
35. Sluyter F, Bohus B, Beldhuis HJ, van Oortmerssen GA (1995) Autosomal and Y chromosomal effects on the stereotyped response to apomorphine in wild house mice. Pharmacol Biochem Behav 52:17-22.
36. Sotnikova TD, Budygin EA, Jones SR, Dykstra LA, Caron MG, Gainetdinov RR (2004) Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine. J Neurochem 91:362-373.
37. Sotnikova TD, Caron MG, Gainetdinov RR (2009) Trace amine-associated receptors as emerging therapeutic targets. Mol Pharmacol 76:229-235.
38. Sotnikova TD, Beaulieu JM, Espinoza S, Masri B, Zhang X, Salahpour A, Barak LS, Caron MG, Gainetdinov RR (2010) The dopamine metabolite 3-methoxytyramine is a neuromodulator. PLoS ONE 5:e13452.
39. Strombom U (1976) Catecholamine receptor agonists: effects on motor activity and rate of tyrosine hydroxylation in mouse brain. Naunyn Schmiedebergs Arch Pharmacol 292:167-176.
40. Tirelli E, Witkin JM (1995) Differential effects of direct and indirect dopamine agonists on the induction of gnawing in C57Bl/6J mice. J Pharmacol Exp Ther 273:7-15.
41. Wilcox RE, Smith RV, Anderson JA, Riffee WH (1980) Apomorphine-induced stereotypic cage climbing in mice as a model for studying changes in dopamine receptor sensitivity. Pharmacol Biochem Behav 12:29-33.
42. Wolinsky TD, Swanson CJ, Smith KE, Zhong H, Borowsky B, Seeman P, Branchek T, Gerald CP (2007) The trace amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia. Genes Brain Behav 6:628-639.
43. Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, Vallender EJ, Yao WD, Madras BK, Miller GM (2007) Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther 321:116-127.