Copper Binding to the N-Terminally Acetylated, Naturally Occurring Form of Alpha-Synuclein Induces Local Helical Folding

Journal of the American Chemical Society

Volumn 137, Issue 20, 2015, Pages 6444-6447

  Miotto, Marco C ^a,b   Valiente Gabioud, Ariel A ^a,b   Rossetti, Giulia ^c   Zweckstetter, Markus ^d,e,f   Carloni, Paolo ^c   Selenko, Philipp ^g   Griesinger, Christian ^d   Binolfi, Andres ^a,b,g   Fernández, Claudio O ^a,b  

^a Universidad Nacional de Rosario   (Argentina)

^b UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^f UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^g LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; COPPER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY;

COPPER BINDING; COPPER COMPLEXES; COPPER HOMEOSTASIS; HELICAL FOLDING; MEMBRANE BINDING; NATURALLY OCCURRING; PARKINSON DISEASE; SECONDARY STRUCTURES;

COPPER COMPOUNDS;

ALPHA SYNUCLEIN; COPPER; CUPROUS ION; METAL COMPLEX; ORGANOMETALLIC COMPOUND;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; MEMBRANE BINDING; METAL BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARKINSON DISEASE; PROTEIN ACETYLATION; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; ACETYLATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY;

ACETYLATION; ALPHA-SYNUCLEIN; BINDING SITES; COPPER; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PROTEIN FOLDING;

EID: 84930227389     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b01911     Document Type: Article

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