Cardiac-specific SOCS3 deletion prevents in vivo myocardial ischemia reperfusion injury through sustained activation of cardioprotective signaling molecules

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Nagata, Takanobu ^a   Yasukawa, Hideo ^a,b   Kyogoku, Sachiko ^a   Oba, Toyoharu ^a   Takahashi, Jinya ^a   Nohara, Shoichiro ^a   Minami, Tomoko ^a   Mawatari, Kazutoshi ^a   Sugi, Yusuke ^a   Shimozono, Koutatsu ^a   Pradervand, Sylvain ^c   Hoshijima, Masahiko ^d   Aoki, Hiroki ^b   Fukumoto, Yoshihiro ^a,b   Imaizumi, Tsutomu ^e  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KURUME UNIVERSITY   (Japan)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 11; INTERLEUKIN 17C; INTERLEUKIN 27; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; JANUS KINASE; LEPTIN; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL 2; PROTEIN MCL 1; RNA; STAT PROTEIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; MCL1 PROTEIN, MOUSE; MUSCLE PROTEIN; PROTEIN KINASE B; SOCS3 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY LIGATION; ARTICLE; CONTROLLED STUDY; CYTOSOL; GENE DELETION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VIVO STUDY; KNOCKOUT MOUSE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; RNA EXTRACTION; TRANSTHORACIC ECHOCARDIOGRAPHY; TUNEL ASSAY; WESTERN BLOTTING; WILD TYPE; ANIMAL; CARDIAC MUSCLE; GENETICS; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; GENE DELETION; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE PROTEINS; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 84930226410     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127942     Document Type: Article

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