RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cells

Molecular Vision

Volumn 21, Issue , 2015, Pages 568-576

  Savage, Sara R ^a   McCollum, Gary W ^a   Yang, Rong ^a   Penn, John S ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(4 ANILINO 2 METHOXYPHENYL)SULFAMOYL] 2 THENOIC ACID METHYL ESTER; FRACTALKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 2; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; RANTES; SEMAPHORIN 3A; THYMIC STROMAL LYMPHOPOIETIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR GATA 6; TUMOR NECROSIS FACTOR ALPHA; CCL8 PROTEIN, HUMAN; CYTOKINE; SULFONE; THIOPHENE DERIVATIVE; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ANGPTL4 GENE; ARL14 GENE; ARTICLE; ATP2C2 GENE; CCL17 GENE; CCL5 GENE; CCL8 GENE; CELL PROTECTION; CONTROLLED STUDY; CX3CL1 GENE; CXCL10 GENE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; FAM151A GENE; GATA6 GENE; GCKR GENE; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LEUKOSTASIS; LIF GENE; MUC20 GENE; NOV GENE; PDPK1 GENE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RETINA CELL; RETINA VASCULITIS; RNA ANALYSIS; RNA SEQUENCE; SEMA3A GENE; SERPINB2 GENE; SHC3 GENE; STOX2 GENE; TNFRSF18 GENE; TRANSCRIPTION REGULATION; TSLP GENE; UPREGULATION; AGONISTS; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; RETINA BLOOD VESSEL; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

CELLS, CULTURED; CHEMOKINE CCL8; CYTOKINES; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; PPAR DELTA; PPAR-BETA; RETINAL VESSELS; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; SULFONES; THIOPHENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84930210110     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Saaddine JB, Honeycutt AA, Narayan KM, Zhang X, Klein R, Boyle JP. Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005–2050. Arch Ophthalmol 2008; 126:1740-7. [PMID: 19064858].
2. Yuuki T, Kanda T, Kimura Y, Kotajima N, Tamura J, Kobayashi I, Kishi S. Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy. J Diabetes Complications 2001; 15:257-9. [PMID: 11522500].
3. Tang J, Kern TS. Inflammation in diabetic retinopathy. Prog Retin Eye Res 2011; 30:343-58. [PMID: 21635964].
4. Zorena K, Myśliwska J, Myśliwiec M, Balcerska A, Hak Ł, Lipowski P, Raczyńska K. Serum TNF-alpha level predicts nonproliferative diabetic retinopathy in children. Mediators Inflamm 2007; 2007:92196. . Murugeswari P, Shukla D, Rajendran A, Kim R, Namperumalsamy P, Muthukkaruppan V. Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales’ disease. Retina 2008; 28:817-24. [PMID: 18536597].
5. Huang H, Gandhi JK, Zhong X, Wei Y, Gong J, Duh EJ, Vinores SA. TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. Invest Ophthalmol Vis Sci 2011; 52:1336-44. [PMID: 21212173].
6. Joussen AM, Doehmen S, Le ML, Koizumi K, Radetzky S, Krohne TU, Poulaki V, Semkova I, Kociok N. TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations. Mol Vis 2009; 15:1418-28. [PMID: 19641635].
7. Schröder S, Palinski W, Schmid-Schonbein GW. Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. Am J Pathol 1991; 139:81-100. [PMID: 1713023].
8. Mackay F, Loetscher H, Stueber D, Gehr G, Lesslauer W. Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55. J Exp Med 1993; 177:1277-86. [PMID: 8386742].
9. Li Y, Chi L, Stechschulte DJ, Dileepan KN. Histamine-induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha. Microvasc Res 2001; 61:253-62. [PMID: 11336536].
10. Daynes RA, Jones DC. Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2002; 2:748-59. [PMID: 12360213].
11. Fan Y, Wang Y, Tang Z, Zhang H, Qin X, Zhu Y, Guan Y, Wang X, Staels B, Chien S, Wang N. Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arterioscler Thromb Vasc Biol 2008; 28:315-21. [PMID: 18048767].
12. Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y, Bishop-Bailey D. Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukoc Biol 2009; 86:115-22. [PMID: 19389799].
13. Shearer BG. Steger DJ, Way JM, Stanley TB, Lobe DC, Grillot DA, Iannone MA, Lazar MA, Willson TM, Billin AN. Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. Mol Endocrinol 2008; 22:523-9. [PMID: 17975020].
14. Capozzi ME, McCollum GW, Savage SR, Penn JS. Peroxisome proliferator-activated receptor-beta/delta regulates angiogenic cell behaviors and oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 2013; 54:4197-207. [PMID: 23716627].
15. Zhao S, Fung-Leung WP, Bittner A, Ngo K, Liu X. Comparison of RNA-Seq and microarray in transcriptome profiling of activated T cells. PLoS ONE 2014; 9:e78644-[PMID: 24454679].
16. Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol 2013; 14:R36-[PMID: 23618408].
17. Guo Y, Zhao S, Ye F, Sheng Q, Shyr Y. MultiRankSeq: multiperspective approach for RNAseq differential expression analysis and quality control. BioMed Research International. 2014; 2014:248090-[PMID: 24977143].
18. Chen H, Boutros PC. VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R. BMC Bioinformatics 2011; 12:35 [PMID: 21269502].
19. Huang W. Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4:44-57. [PMID: 19131956].
20. Huang W. Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37:1-13. [PMID: 19033363].
21. Miscia S, Marchisio M, Grilli A, Di Valerio V, Centurione L, Sabatino G, Garaci F, Zauli G, Bonvini E, Di Baldassarre A. Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells. Cell Growth Differ 2002; 13:13-8. [PMID: 11801527].
22. Syed MM, Phulwani NK, Kielian T. Tumor necrosis factor-alpha (TNF-alpha) regulates Toll-like receptor 2 (TLR2) expression in microglia. J Neurochem 2007; 103:1461-71. [PMID: 17961202].
23. Sheerin NS, Zhou W, Adler S, Sacks SH. TNF-alpha regulation of C3 gene expression and protein biosynthesis in rat glomerular endothelial cells. Kidney Int 1997; 51:703-10. [PMID: 9067902].
24. Serrano-Marco L, Chacón MR, Maymó-Masip E, Barroso E, Salvadó L, Wabitsch M, Garrido-Sánchez L, Tinahones FJ, Palomer X, Vendrell J, Vázquez-Carrera M. TNF-alpha inhibits PPARbeta/delta activity and SIRT1 expression through NF-kappaB in human adipocytes. Biochim Biophys Acta 2012; 1821:1177-85. [PMID: 22683888].
25. Yang X, Kume S, Tanaka Y, Isshiki K, Araki S, Chin-Kanasaki M, Sugimoto T, Koya D, Haneda M, Sugaya T, Li D, Han P, Nishio Y, Kashiwagi A, Maegawa H, Uzu T. GW501516, a PPARdelta agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFkappaB pathway in mice. PLoS ONE 2011; 6:e25271 [PMID: 21966476].
26. Bao XC, Fang YQ, You P, Zhang S, Ma J. Protective role of peroxisome proliferator-activated receptor beta/delta in acute lung injury induced by prolonged hyperbaric hyperoxia in rats. Respir Physiol Neurobiol 2014; 199:9-18. [PMID: 24780550].
27. Paterniti I, Esposito E, Mazzon E, Galuppo M, Di Paola R, Bramanti P, Kapoor A, Thiemermann C, Cuzzocrea S. Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury. J Pharmacol Exp Ther 2010; 333:465-77. [PMID: 20176685].
28. Lin JW, Cherng YG, Chen LJ, Niu HS, Chang CK, Niu CS. Ginseng is useful to enhance cardiac contractility in animals. BioMed Research International. 2014; 2014:723084 [PMID: 24689053].
29. Tsai CC, Lee KS, Chen SH, Chen LJ, Liu KF, Cheng JT. Decrease of PPARdelta in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury. PPAR Res 2014; 2014:456386 [PMID: 24817882].
30. Suarez S, McCollum GW, Bretz CA, Yang R, Capozzi ME, Penn JS. Modulation of VEGF-Induced Retinal Vascular Permeability by Peroxisome Proliferator-Activated Receptor-beta/delta. Invest Ophthalmol Vis Sci 2014; 55:8232-40. [PMID: 25406289].
31. Hack K, Reilly L, Palmer C, Read KD, Norval S, Kime R, Booth K, Foerster J. Skin-targeted inhibition of PPAR beta/delta by selective antagonists to treat PPAR beta/delta-mediated psoriasis-like skin disease in vivo. PLoS ONE 2012; 7:e37097 [PMID: 22606335].