The impact of measurement frequency on the domains of glycemic control in the critically ill-a monte carlo simulation

Journal of Diabetes Science and Technology

Volumn 9, Issue 2, 2015, Pages 237-245

  Krinsley, James S ^a,b   Bruns, David E ^c   Boyd, James C ^c  

^a STAMFORD HOSPITAL   (United States)

^b Columbia University College of Phys and Surg ^*  (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Blood glucose; Critically ill; Glucose variability; Hyperglycemia; Hypoglycemia; Monitoring frequency; Monte Carlo simulation; Time in range

Indexed keywords

GLUCOSE; INSULIN; GLUCOSE BLOOD LEVEL;

ARTICLE; BLOOD GLUCOSE MONITORING; COHORT ANALYSIS; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN SENSITIVITY; MEASUREMENT; MONTE CARLO METHOD; OUTCOME ASSESSMENT; ANALYSIS; BLOOD; DIABETES MELLITUS;

BLOOD GLUCOSE; CRITICAL ILLNESS; DIABETES MELLITUS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; MONTE CARLO METHOD;

EID: 84930204332     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/1932296814566507     Document Type: Article

References (49)

1. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345:1359-1367.
2. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449-461.
3. Brunkhorst FM, Engel C, Bloos F, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358:125-139.
4. Preiser JC, Devos P, Ruiz-Santana S, et al. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med. 2009;35:1738-1748.
5. Arabi YM, Dabbagh OC, Tamim HM, et al. Intensive versus conventional insulin therapy: a randomized controlled trial in medical and surgical critically ill patients. Crit Care Med. 2008;36:3190-3197.
6. The NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283-1297.
7. Finkielman JD, Oyen LJ, Afessa B. Agreement between bedside blood and plasma glucose measurement in the ICU setting. Chest. 2005;127:1749-1751.
8. Desachy A, Vuagnat AC, Ghazali AD, et al. Accuracy of bedside glucometry in critically ill patients: influence of clinical characteristics and perfusion index. Mayo Clin Proc. 2008;83:400-405.
9. Kanji S, Buffie J, Hutton B, et al. Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med. 2005;33:2778-2785.
10. Watkinson PJ, Barber VS, Amira E, James T, Taylor R, Young JD. The effects of precision, haematocrit, pH and oxygen tension on point-of-care glucose measurement in critically ill patients: a prospective study. Ann Clin Biochem. 2012:49: 144-151.
11. Zueger T, Schuler V, Stettler C, Diem P, Christ ER. Assessment of three frequently used blood glucose monitoring devices in clinical routine. Swiss Med Wkly. 2012;142.
12. Pfutzner A, Mitri M, Musholt P, et al. Clinical assessment of the accuracy of blood glucose measurement. Diabetes. 2012;28:525-531.
13. Thomas F, Signal M, Harris DL, et al. Continuous glucose monitoring in newborn infants: how do errors in calibration measurements affect detected hypoglycemia J Diabetes Sci Technol. 2014;8:543-550.
14. Stork AD, Kemperman H, Erkelens DW, Venemann TF. Comparison of the accuracy of the HemoCue glucose analyzer with the Yellow Springs Instrument glucose oxidase analyzer, particularly in hypoglycemia. Eur J Endocrinol. 2005;153: 275-281.
15. Meyfroidt G, Keenan DM, Wang X, Wouters PJ, Veldhuis JD, Van den Berghe G. Dynamic characteristics of blood glucose time series during the course of critical illness: effects of intensive insulin therapy and relative association with mortality. Crit Care Med. 2010;38:1021-1029.
16. The NICE-SUGAR Study Investigators. Hypoglycemia and risk of death in critically ill patients. N Engl J Med. 2012;367:1108-1118.
17. Krinsley JS, Grover A. Severe hypoglycemia in critically ill patients: risk factors and outcomes. Crit Care Med. 2007;35:2262-2267.
18. Bagshaw SM, Egi M, George C, Bellomo R. Early blood glucose control and mortality in critically ill patients in Australia. Crit Care Med. 2009;37:463-470.
19. Egi M, Bellomo R, Stachowski E, et al. Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc. 2010;85: 217-224.
20. Krinsley JS, Schultz MJ, Spronk PE, et al. Mild hypoglycemia is independently associated with increased mortality in the critically ill. Crit Care. 2011;15:R173.
21. Holzinger U, Warszawska J, Kitzberger R, et al. Real-time continuous glucose monitoring in critically ill patients: a prospective randomized trial. Diabetes Care. 2010;33:467-472.
22. Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology. 2006;105: 244-252.
23. Krinsley JS. Glycemic variability: a strong independent predictor of mortality in critically ill patients. Crit Care Med. 2008;36:3008-3013.
24. Bagshaw SM, Bellomo R, Jacka MJ, Egi M, Hart GK, George C. The impact of early hypoglycemia and blood glucose variability on outcome in critical illness. Crit Care. 2009;13:R91.
25. Hermanides J, Vriesendorp TM, Bosman RJ, Zandstra DF, Hoekstra JB, Devries JH. Glucose variability is associated with intensive care unit mortality. Crit Care Med. 2010;38:838-842.
26. Krinsley JS, Egi M, Kiss A, et al. Diabetic status and the relationship of the 3 domains of glycemic control to mortality in critically ill patients: an international multi-center cohort study. Crit Care. 2013;17:R37.
27. Aragon D. Evaluation of nursing work effort and perceptions about blood glucose testing in tight glycemic control. Am J Crit Care. 2006;15:370-377.
28. Inzucchi SE, Kosiborod M. Continuous glucose monitoring during critical care. Anesthesiology. 2011;114:18-19.
29. Finfer S, Wernerman J, Preiser JC, et al. Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults. Crit Care. 2013;17:229.
30. Wernerman J, Desaive T, Finfer S, et al. Continuous glucose control in the ICU: report of a 2013 round table meeting. Crit Care. 2014;18:226.
31. Boyd JC, Bruns DE. Effects of measurement frequency on analytical quality required for glucose measurements in ICUs: assessments by simulation models. Clin Chem. 2014;60: 644-650.
32. Steil GM, Dess D, Shih J, Buckingham B, Weinzimer S, Agus MS. Intensive care insulin delivery algorithms: Why so many? How to choose? J Diabetes Sci Tech. 2009;3:125-140.
33. Goldberg PA, Siegel MD, Sherwin RS, et al. Implementation of a safe and effective insulin infusion protocol in a medical intensive care unit. Diabetes Care. 2004;27:461-467.
34. Trence DL, Kelly JL, Hirsch IB. The rationale and management of hyperglycemia for in-patients with cardiovascular disease: time for change. J Clin Endo Metabl. 2003;88: 2430-2437.
35. Boyd JC, Bruns DE. Performance requirements for glucose assays in intensive care units. Clin Chem. 2014;60:1463-1465.
36. Van Herpe T, De Moor B, Van den Berghe G, Mesotten D. Modeling of effect of glucose sensor errors on insulin dosage and glucose bolus computed by LOGIC-Insulin. Clin Chem. 2014;60:1510-8.
37. Wilinska M, Hovorka R. Glucose control in the intensive care unit by use of continuous glucose monitoring: What level of the measurement error is acceptable? Clin Chem. 2014;60: 1500-1509.
38. Robert CP, Casella G. Monte Carlo Statistical Methods. 2nd ed. New York, NY: Springer; 2004.
39. Boyd JC, Bruns DE. Monte Carlo simulation in establishing analytical quality requirements for clinical laboratory tests: meeting clinical needs. Methods Enzymol. 2009;467:411-33.
40. Cunningham VJ, Heath DF. An interpretation of the intravenous glucose tolerance test in the light of recent findings on the kinetics of glucose and insulin in man. Clin Sci Mol Med. 1978;2:161-173.
41. Park BS, Yoon JS. Predicting mortality of critically ill patients by blood glucose levels. Diabetes Metab J. 2013;37:385-390.
42. Christopher G, Pretty CG, Le Compte AJ, et al. Variability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control. Ann Int Care. 2012;2:17.
43. Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet. 2009;373:1798-1807.
44. Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc. 2003;78:1471-1478.
45. Jacobi J, Bircher N, Krinsley JS, et al. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med. 2012;40:3251-3276.
46. Schierenbeck F, Owall A, Franco-Cereceda A, Liska J. Evaluation of a continuous blood glucose monitoring system using a central venous catheter with an integrated microdialysis function. Diabetes Tech Ther. 2012;15:26-31.
47. van Hooijdonk Roosmarijn TM, van Hooijdonk R, Winters T, et al. Accuracy and limitations of continuous glucose monitoring using spectroscopy in critically ill patients. Ann Intens Care. 2014;4:8.
48. Inoue S, Egi M, Joji Kotani J, Morita K. Accuracy of blood glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review. Crit Care. 2013;17:R48.
49. Juneja R, Roudebush CP, Nasraway SA, et al. Computerized intensive insulin dosing can mitigate hypoglycemia and achieve tight glycemic control when glucose measurement is performed frequently and on time. Crit Care. 2009;13:R163.