Early blood glucose control and mortality in critically ill patients in Australia

Critical Care Medicine

Volumn 37, Issue 2, 2009, Pages 463-470

  Bagshaw, Sean M ^a,b   Egi, Moritoki ^c   George, Carol ^d   Bellomo, Rinaldo ^b,e  

^a UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

^b AUSTIN HOSPITAL   (Australia)

^c OKAYAMA UNIVERSITY HOSPITAL   (Japan)

^d Clinical Trials Group Executive   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cardiac surgery; Critically ill; Glucose; Hyperglycemia; Hypoglycemia; Intensive insulin therapy; Mortality; Multicentered; Sepsis

Indexed keywords

GLUCOSE; INSULIN;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; AUSTRALIA; COHORT ANALYSIS; CRITICALLY ILL PATIENT; DEMOGRAPHY; DOSE RESPONSE; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART SURGERY; HOSPITALIZATION; HUMAN; HYPOGLYCEMIA; INSULIN TREATMENT; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEPSIS; SEPTIC SHOCK; SURGICAL PATIENT;

AGED; AUSTRALIA; BLOOD GLUCOSE; COHORT STUDIES; CRITICAL ILLNESS; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MULTICENTER STUDIES AS TOPIC; ODDS RATIO; PROSPECTIVE STUDIES; SEPSIS; THORACIC SURGERY;

EID: 64949093742     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318194b097     Document Type: Article

References (38)

1. Egi M, Bellomo R, Stachowski E, et al: Blood glucose on day of intensive care unit admission as a surrogate of subsequent glucose control in intensive care. J Crit Care 2006; 21:197-202
2. McCowen KC, Malhotra A, Bistrian BR: Stress-induced hyperglycemia. Crit Care Clin 2001; 17:107-124
3. Van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367
4. Thomas G, Rojas MC, Epstein SK, et al: Insulin therapy and acute kidney injury in critically ill patients a systematic review. Nephrol Dial Transplant 2007; 22:2849-2855
5. Hermans G, Wilmer A, Meersseman W, et al: Impact of intensive insulin therapy on neuro-muscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med 2007; 175:480-489
6. Langouche L, Vanhorebeek I, Vlasselaers D, et al: Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 2005; 115:2277-2286
7. Grey NJ, Perdrizet GA: Reduction of nosocomial infections in the surgical intensive-care unit by strict glycemic control. Endocr Pract 2004; 10(Suppl 2):46-52
8. Krinsley JS: Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004; 79:992-1000
9. Krinsley JS: Association between hyperglyce-mia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003; 78:1471-1478
10. Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354:449-461
11. Dellinger RP, Carlet JM, Masur H, et al: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873
12. Heyland DK, Dhaliwal R, Drover JW, et al: Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr 2003; 27:355-373
13. Klaff LS, Wisse BE: Current controversy related to glucocorticoid and insulin therapy in the intensive care unit. Endocr Pract 2007; 13:542-549
14. Schultz MJ, Royakkers AA, Levi M, et al: Intensive insulin therapy in intensive care: An example of the struggle to implement evidence-based medicine. PLoS Med 2006; 3:e456
15. Vanhorebeek I, Langouche L, Van den Berghe G: Tight blood glucose control with insulin in the ICU: Facts and controversies. Chest 2007; 132:268-278
16. Devos P, Preiser JC: Current controversies around tight glucose control in critically ill patients. Curr Opin Clin Nutr Metab Care 2007; 10:206-209
17. Preiser JC, Devos P: Clinical experience with tight glucose control by intensive insulin therapy. Crit Care Med 2007; 35:S503-S507
18. Mackenzie I, Ingle S, Zaidi S, et al: Hypogly-caemia? So what! Intensive Care Med 2006; 32:620-621
19. Angus DC, Abraham E: Intensive insulin therapy in critical illness. Am J Respir Crit Care Med 2005; 172:1358-1359
20. Stow PJ, Hart GK, Higlett T, et al: Development and implementation of a high-quality clinical database: The Australian and New Zealand Intensive Care Society Adult Patient Database. J Crit Care 2006; 21:133-141
21. Kosiborod M, Inzucchi SE, Krumholz HM, et al: Glucometrics in patients hospitalized with acute myocardial infarction: Defining the optimal outcomes-based measure of risk. Circulation 2008; 117:1018-1027
22. Egi M, Bellomo R, Stachowski E, et al: Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 2006; 105:244-252
23. Egi M, Bellomo R, Stachowski E, et al: Intensive insulin therapy in postoperative intensive care unit patients: A decision analysis. Am J Respir Crit Care Med 2006; 173: 407-413
24. Mitchell I, Finfer S, Bellomo R, et al: Management of blood glucose in the critically ill in Australia and New Zealand: A practice survey and inception cohort study. Intensive Care Med 2006; 32:867-874
25. Gandhi GY, Nuttall GA, Abel MD, et al: Intensive intraoperative insulin therapy versus conventional glucose management during cardiac surgery: A randomized trial. Ann Intern Med 2007; 146:233-243
26. Finney SJ, Zekveld C, Elia A, et al: Glucose control and mortality in critically ill patients. JAMA 2003; 290:2041-2047
27. Malmberg K: Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. BMJ 1997; 314:1512-1515
28. Malmberg K, Ryden L, Efendic S, et al: Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): Effects on mortality at 1 year. J Am Coll Cardiol 1995; 26:57-65
29. Egi M, Bellomo R, Stachowski E, et al: Cir-cadian rhythm of blood glucose values in critically ill patients. Crit Care Med 2007; 35:416-421
30. Brunkhorst FM, Engel C, Bloos F, et al: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358:125-139
31. Mitchell I, Knight E, Gissane J, et al: A phase II randomised controlled trial of intensive insulin therapy in general intensive care patients. Crit Care Resusc 2006; 8:289-293
32. Shulman R, Finney SJ, O'Sullivan C, et al: Tight glycaemic control: A prospective observational study of a computerised decision-supported intensive insulin therapy protocol. Crit Care 2007; 11:R75
33. Krinsley JS, Grover A: Severe hypoglycemia in critically ill patients: Risk factors and outcomes. Crit Care Med 2007; 35:2262-2267
34. Devos P: A multi-center study comparing the effects of two glucose control regimens by insulin in intensive care unit patients (GLUCONTROL). Available at: (http://clinicaltrials.gov/ct2/show/ record?spons = %22Belgian+Government% 22&spons-ex=Y&rank= 1). Accessed April 29, 2008
35. Devos P, Preiser JC, Melot C: Effect of intensive insulin therapy in critically ill patients on long-term outcome variables: Data from the GLUCONTROL study [Abstract 0005]. Clin Nutr 2007; 2(Suppl):5
36. Devos P, Preiser JC, Melot C: Incidence and risk factors for hypoglycemia during intensive insulin therapy in critically ill patients: Data from the GLUCONTROL Study [Abstract 175]. Clin Nutr 2007; 2(Suppl):93
37. Ingels C, Debaveye Y, Milants I, et al: Strict blood glucose control with insulin during intensive care after cardiac surgery: Impact on 4-years survival, dependency on medical care, and quality-of-life. Eur Heart J 2006; 27:2716-2724
38. Van den Berghe G, Wouters PJ, Kesteloot K, et al: Analysis of healthcare resource utilization with intensive insulin therapy in critically ill patients. Crit Care Med 2006; 34: 612-616