Parkinson's disease-associated PINK1 G309D mutation increases abnormal phosphorylation of Tau

IUBMB Life

Volumn 67, Issue 4, 2015, Pages 286-290

  Ye, Ming ^a   Zhou, Dai ^a   Zhou, Youxin ^a   Sun, Chunming ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

GSK3 ; mutations; Parkinson's disease; PINK1; tau

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN SERINE THREONINE KINASE; PTEN INDUCED PUTATIVE KINASE 1; TAU PROTEIN; UNCLASSIFIED DRUG; CDK5 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; IMMUNOCYTOCHEMISTRY; NONHUMAN; PARKINSON DISEASE; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; GENETICS; HUMAN; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY;

CYCLIN-DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MUTATION; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN KINASES; TAU PROTEINS;

EID: 84930194480     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1367     Document Type: Article

References (28)

1. Lang, A. E., and, Lozano, A. M., (1998) Parkinson's disease. First of two parts. N. Engl. J. Med. 339, 1044-1053.
2. Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M., Harvey, K., et al., (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304, 1158-1160.
3. Valente, E. M., Salvi, S., Ialongo, T., Marongiu, R., Elia, A. E., et al., (2004) PINK1 mutations are associated with sporadic early-onset parkinsonism. Ann. Neurol. 56, 336-441.
4. Crosiers, D., Theuns, J., Cras, P., and, Van Broeckhoven, C., (2011) Parkinson disease: insights in clinical, genetic and pathological features of monogenic disease subtypes. J. Chem. Neuroanat. 42, 131-141.
5. Gandhi, S., Muqit, M. M., Stanyer, L., Healy, D. G., Abou-Sleiman, P. M., et al., (2006) PINK1 protein in normal human brain and Parkinson's disease. Brain 129, 1720-1731.
6. Petit, A., Kawarai, T., Paitel, E., Sanjo, N., Maj, M., et al., (2005) Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J. Biol. Chem. 280, 34025-34032.
7. Criscuolo, C., Volpe, G., De Rosa, A., Varrone, A., Marongiu, R., et al., (2006) PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of parkinsonism. Mov. Disord. 21, 1265-1267.
8. Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., and, Crowther, R. A., (1989) Cloning and sequencing of the cDNA encoding an isoform of microtubule associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J. 8, 393-399.
9. Tian, Q., and, Wang, J., (2002) Role of serine/threonine protein phosphatase in Alzheimer's disease. Neurosignals 11, 262-269.
10. Obulesu, M., Venu, R., and, Somashekhar, R., (2011) Tau mediated neurodegeneration: an insight into Alzheimer's disease pathology. Neurochem. Res. 36, 1329-1335.
11. Rosenmann, H., (2012) CSF biomarkers for amyloid and tau pathology in Alzheimer's disease. J. Mol. Neurosci. 47, 1-14.
12. Biernat, J., Gustke, N., Drewes, G., Mandelkow, E. M., and, Mandelkow, E., (1993) Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron 11, 153-163.
13. Muntané, G., Dalfõ, E., Martinez, A., and, Ferrer, I., (2008) Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies. Neuroscience 152, 913-923.
14. Gaig, C., Ezquerra, M., Martí, M. J., Valldeoriola, F., Muñoz, E., et al., (2008) Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of Parkinsonian syndromes and frontotemporal lobar degeneration. J. Neurol. Sci. 270, 94e8.
15. Sánchez-Mora, R. M., Arboleda, H., and, Arboleda, G., (2012) PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway. J. Mol. Neurosci. 47, 582-594.
16. Bournival, J., Plouffe, M., Renaud, J., Provencher, C., and, Martinoli, M. G., (2012) Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system. Oxid. Med. Cell Longev. 2012, 921941.
17. Zhou, J., Wang, H., Feng, Y., and, Chen, J., (2010) Increased expression of cdk5/p25 in N2a cells leads to hyperphosphorylation and impaired axonal transport of neurofilament proteins. Life Sci. 86, 532-537.
18. Kong, Y., Grimaldi, M., Curtin, E., Dougherty, M., Kaufman, C., et al., (2014) Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation. Chem. Biol. 21, 488-501.
19. Kong, Y., Jing, G., Yan, Z., Li, C., Gong, N., et al., (2009) Cloning and characterization of Prisilkin-39, a novel matrix protein serving a dual role in the prismatic layer formation from the oyster Pinctada fucata. J. Biol. Chem. 284, 10841-10854.
20. Belin, A. C., and, Westerlund, M., (2008) Parkinson's disease: a genetic perspective. FEBS J. 275, 1377-1383.
21. Wood-Kaczmar, A., Gandhi, S., Yao, Z., Abramov, A. Y., Miljan, E. A., et al., (2008) PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One 3, e2455.
22. Yuan, X. L., Guo, J. F., Shi, Z. H., Xiao, Z. Q., Yan, X. X., et al., (2010) R492X mutation in PTEN-induced putative kinase 1 induced cellular mitochondrial dysfunction and oxidative stress. Brain Res. 1351, 229-237.
23. Su, B., Wang, X., Lee, H. G., Tabaton, M., Perry, G., et al., (2010) Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells. Neurosci. Lett. 468, 267-271.
24. Qi, Z., Yang, W., Liu, Y., Cui, T., Gao, H., et al., (2011) Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. Neurochem. Int. 59, 572-581.
25. Smith, P. D., Crocker, S. J., Jackson-Lewis, V., Jordan-Sciutto, K. L., Hayley, S., et al., (2003) Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 100, 13650-13655.
26. Qu, D., Rashidian, J., Mount, M. P., Aleyasin, H., Parsanejad, M., et al., (2007) Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron 55, 37-52.
27. Nagao, M., and, Hayashi, H., (2009) Glycogen synthase kinase-3beta is associated with Parkinson's disease. Neurosci. Lett. 449, 103-107.
28. Kawakami, F., Shimada, N., Ohta, E., Kagiya, G., Kawashima, R., et al., (2014) Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β. FEBS J. 281, 3-13.