The role of early pharmacotherapy in the development of posttraumatic stress disorder symptoms after traumatic injury: An observational cohort study in consecutive patients

General Hospital Psychiatry

Volumn 37, Issue 3, 2015, Pages 230-235

  Mouthaan, Joanne ^a,b   Sijbrandij, Marit ^a,c   Reitsma, Johannes B ^d,e   Luitse, Jan S K ^d   Goslings, J Carel ^d   Gersons, Berthold P R ^a,f   Olff, Miranda ^a,f  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f Arq Psychotrauma Expert Group   (Netherlands)

Author keywords

Injury; Opiates; Pharmacotherapy; Posttraumatic stress disorder; Prevention

Indexed keywords

BENZODIAZEPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; OPIATE; NARCOTIC ANALGESIC AGENT;

ACCIDENTAL INJURY; ADULT; ARTICLE; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; DISEASE CONTROL; DRUG RESPONSE; EARLY INTERVENTION; FEMALE; FOLLOW UP; HUMAN; INJURY SEVERITY; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PAIN ASSESSMENT; POSTTRAUMATIC STRESS DISORDER; PROSPECTIVE STUDY; RISK ASSESSMENT; STRUCTURED INTERVIEW; TREATMENT DURATION; GLASGOW COMA SCALE; INJURY SCALE; MIDDLE AGED; STRESS DISORDERS, POST-TRAUMATIC; TIME; WOUNDS AND INJURIES;

ADULT; ANALGESICS, OPIOID; FEMALE; FOLLOW-UP STUDIES; GLASGOW COMA SCALE; HUMANS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; STRESS DISORDERS, POST-TRAUMATIC; TIME FACTORS; WOUNDS AND INJURIES;

EID: 84930180275     PISSN: 01638343     EISSN: 18737714     Source Type: Journal    
DOI: 10.1016/j.genhosppsych.2015.02.010     Document Type: Article

References (68)

1. de Vries G.J., Olff M. The lifetime prevalence of traumatic events and posttraumatic stress disorder in the Netherlands. J Trauma Stress 2009, 22(4):259-267.
2. Kessler R.C., Chiu W.T., Demler O., Merikangas K.R., Walters E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005, 62(6):617-627.
3. American Psychiatric Association Diagnostic and statistical manual of mental disorders 2013, American Psychiatric Publishing, Arlington, VA. 5th ed.
4. Rose S., Bisson J., Wessely S. A systematic review of single-session psychological interventions ('debriefing') following trauma. Psychother Psychosom 2003, 72(4):176-184.
5. Sijbrandij M., Olff M., Reitsma J.B., Carlier I.V., Gersons B.P. Emotional or educational debriefing after psychological trauma. Randomised controlled trial. Br J Psychiatry 2006, 189:150-155.
6. Pitman R.K. Post-traumatic stress disorder, hormones, and memory. Biol Psychiatry 1989, 26(3):221-223.
7. Bryant R.A., Marosszeky J.E., Crooks J., Gurka J.A. Elevated resting heart rate as a predictor of posttraumatic stress disorder after severe traumatic brain injury. Psychosom Med 2004, 66(5):760-761.
8. O'Donnell M.L., Creamer M., Elliott P., Bryant R. Tonic and phasic heart rate as predictors of posttraumatic stress disorder. Psychosom Med 2007, 69(3):256-261.
9. Shaikh al arab A., Guedon-Moreau L., Ducrocq F., Molenda S., Duhem S., Salleron J., et al. Temporal analysis of heart rate variability as a predictor of post traumatic stress disorder in road traffic accidents survivors. J Psychiatr Res 2012, 46(6):790-796.
10. Zatzick D.F., Russo J., Pitman R.K., Rivara F., Jurkovich G., Roy-Byrne P. Reevaluating the association between emergency department heart rate and the development of posttraumatic stress disorder: a public health approach. Biol Psychiatry 2005, 57(1):91-95.
11. Delahanty D.L., Nugent N.R., Christopher N.C., Walsh M. Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims. Psychoneuroendocrinology 2005, 30(2):121-128.
12. Delahanty D.L., Raimonde A.J., Spoonster E., Cullado M. Injury severity, prior trauma history, urinary cortisol levels, and acute PTSD in motor vehicle accident victims. J Anxiety Disord 2003, 17(2):149-164.
13. Delahanty D.L., Raimonde A.J., Spoonster E. Initial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims. Biol Psychiatry 2000, 48(9):940-947.
14. Aardal-Eriksson E., Eriksson T.E., Thorell L.H. Salivary cortisol, posttraumatic stress symptoms, and general health in the acute phase and during 9-month follow-up. Biol Psychiatry 2001, 50(12):986-993.
15. McFarlane A.C., Barton C.A., Yehuda R., Wittert G. Cortisol response to acute trauma and risk of posttraumatic stress disorder. Psychoneuroendocrinology 2011, 36(5):720-727.
16. Mouthaan J., Sijbrandij M., Luitse J.S., Goslings J.C., Gersons B.P., Olff M. The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms. Psychoneuroendocrinology 2014, 45:179-186.
17. Ehring T., Ehlers A., Cleare A.J., Glucksman E. Do acute psychological and psychobiological responses to trauma predict subsequent symptom severities of PTSD and depression?. Psychiatry Res 2008, 161(1):67-75.
18. van Stegeren A.H. The role of the noradrenergic system in emotional memory. Acta Psychol (Amst) 2008, 127(3):532-541.
19. Pitman R.K., Sanders K.M., Zusman R.M., Healy A.R., Cheema F., Lasko N.B., et al. Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiatry 2002, 51(2):189-192.
20. Vaiva G., Ducrocq F., Jezequel K., Averland B., Lestavel P., Brunet A., et al. Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biol Psychiatry 2003, 54(9):947-949.
21. Nugent N.R., Christopher N.C., Crow J.P., Browne L., Ostrowski S., Delahanty D.L. The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: a pilot study. J Trauma Stress 2010, 23(2):282-287.
22. Stein M.B., Kerridge C., Dimsdale J.E., Hoyt D.B. Pharmacotherapy to prevent PTSD: results from a randomized controlled proof-of-concept trial in physically injured patients. J Trauma Stress 2007, 20(6):923-932.
23. McGhee L.L., Maani C.V., Garza T.H., Desocio P.A., Gaylord K.M., Black I.H. The effect of propranolol on posttraumatic stress disorder in burned service members. J Burn Care Res 2009, 30(1):92-97.
24. Cohen H., Kaplan Z., Koresh O., Matar M.A., Geva A.B., Zohar J. Early post-stressor intervention with propranolol is ineffective in preventing posttraumatic stress responses in an animal model for PTSD. Eur Neuropsychopharmacol 2011, 21(3):230-240.
25. McFarlane A.C., Atchison M., Yehuda R. The acute stress response following motor vehicle accidents and its relation to PTSD. Ann N Y Acad Sci 1997, 821:437-441.
26. Resnick H.S., Yehuda R., Acierno R. Acute post-rape plasma cortisol, alcohol use, and PTSD symptom profile among recent rape victims. Ann N Y Acad Sci 1997, 821:433-436.
27. Yehuda R., Resnick H.S., Schmeidler J., Yang R.K., Pitman R.K. Predictors of cortisol and 3-methoxy-4-hydroxyphenylglycol responses in the acute aftermath of rape. Biol Psychiatry 1998, 43(11):855-859.
28. Yehuda R. Clinical relevance of biologic findings in PTSD. Psychiatr Q 2002, 73(2):123-133.
29. Cohen H., Matar M.A., Buskila D., Kaplan Z., Zohar J. Early post-stressor intervention with high-dose corticosterone attenuates posttraumatic stress response in an animal model of posttraumatic stress disorder. Biol Psychiatry 2008, 64(8):708-717.
30. Cohen H., Zohar J., Gidron Y., Matar M.A., Belkind D., Loewenthal U., et al. Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats. Biol Psychiatry 2006, 59(12):1208-1218.
31. Schelling G., Stoll C., Kapfhammer H.P., Rothenhausler H.B., Krauseneck T., Durst K., et al. The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors. Crit Care Med 1999, 27(12):2678-2683.
32. Delahanty D.L., Gabert-Quillen C., Ostrowski S.A., Nugent N.R., Fischer B., Morris A., et al. The efficacy of initial hydrocortisone administration at preventing posttraumatic distress in adult trauma patients: a randomized trial. CNS Spectr 2013, 18(2):103-111.
33. Schelling G., Roozendaal B., Krauseneck T., Schmoelz M. de QD, Briegel J. Efficacy of hydrocortisone in preventing posttraumatic stress disorder following critical illness and major surgery. Ann N Y Acad Sci 2006, 1071:46-53.
34. Schelling G., Kilger E., Roozendaal B., de Quervain D.J., Briegel J., Dagge A., et al. Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study. Biol Psychiatry 2004, 55(6):627-633.
35. Schelling G., Briegel J., Roozendaal B., Stoll C., Rothenhausler H.B., Kapfhammer H.P. The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors. Biol Psychiatry 2001, 50(12):978-985.
36. Zohar J., Yahalom H., Kozlovsky N., Cwikel-Hamzany S., Matar M.A., Kaplan Z., et al. High dose hydrocortisone immediately after trauma may alter the trajectory of PTSD: interplay between clinical and animal studies. Eur Neuropsychopharmacol 2011, 21(11):796-809.
37. Good A.J., Westbrook R.F. Effects of a microinjection of morphine into the amygdala on the acquisition and expression of conditioned fear and hypoalgesia in rats. Behav Neurosci 1995, 109(4):631-641.
38. McNally G.P., Westbrook R.F. Temporally graded, context-specific retrograde amnesia and its alleviation by context preexposure: effects of postconditioning exposures to morphine in the rat. J Exp Psychol Anim Behav Process 2003, 29(2):130-142.
39. Saxe G., Stoddard F., Courtney D., Cunningham K., Chawla N., Sheridan R., et al. Relationship between acute morphine and the course of PTSD in children with burns. J Am Acad Child Adolesc Psychiatry 2001, 40(8):915-921.
40. Stoddard F.J., Sorrentino E.A., Ceranoglu T.A., Saxe G., Murphy J.M., Drake J.E., et al. Preliminary evidence for the effects of morphine on posttraumatic stress disorder symptoms in one- to four-year-olds with burns. J Burn Care Res 2009, 30(5):836-843.
41. Nixon R.D., Nehmy T.J., Ellis A.A., Ball S.A., Menne A., McKinnon A.C. Predictors of posttraumatic stress in children following injury: the influence of appraisals, heart rate, and morphine use. Behav Res Ther 2010, 48(8):810-815.
42. Bryant R.A., Creamer M., O'Donnell M., Silove D., McFarlane A.C. A study of the protective function of acute morphine administration on subsequent posttraumatic stress disorder. Biol Psychiatry 2009, 65(5):438-440.
43. Holbrook T.L., Galarneau M.R., Dye J.L., Quinn K., Dougherty A.L. Morphine use after combat injury in Iraq and post-traumatic stress disorder. N Engl J Med 2010, 362(2):110-117.
44. Zatzick D., Roy-Byrne P.P. From bedside to bench: how the epidemiology of clinical practice can inform the secondary prevention of PTSD. Psychiatr Serv 2006, 57(12):1726-1730.
45. Page C., Curtis M., Walker M. Integrated pharmacology 2005, Elsevier Health Sciences.
46. Zohar J., Juven-Wetzler A., Sonnino R., Cwikel-Hamzany S., Balaban E., Cohen H. New insights into secondary prevention in post-traumatic stress disorder. Dialogues Clin Neurosci 2011, 13(3):301-309.
47. Gelpin E., Bonne O., Peri T., Brandes D., Shalev A.Y. Treatment of recent trauma survivors with benzodiazepines: a prospective study. J Clin Psychiatry 1996, 57(9):390-394.
48. Mellman T.A., Byers P.M., Augenstein J.S. Pilot evaluation of hypnotic medication during acute traumatic stress response. J Trauma Stress 1998, 11(3):563-569.
49. Matar M.A., Zohar J., Kaplan Z., Cohen H. Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD. Eur Neuropsychopharmacol 2009, 19(4):283-295.
50. McGhee L.L., Maani C.V., Garza T.H., DeSocio P.A., Gaylord K.M., Black I.H. The relationship of intravenous midazolam and posttraumatic stress disorder development in burned soldiers. J Trauma 2009, 66(4 Suppl.):S186-S190.
51. American Psychiatric Association Diagnostic and statistical manual of mental disorders (revised 4th Ed.) 2000, American Psychiatric Association, Washington, D.C.
52. Teasdale G., Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974, 2(7872):81-84.
53. Mouthaan J., Sijbrandij M., Reitsma J.B., Gersons B.P., Olff M. Internet-based prevention of posttraumatic stress symptoms in injured trauma patients: design of a randomized controlled trial. Eur J Psychotraumatol 2011, 2.
54. Copes W.S., Champion H.R., Sacco W.J., Lawnick M.M., Gann D.S., Gennarelli T., et al. Progress in characterizing anatomic injury. J Trauma 1990, 30(10):1200-1207.
55. Blake D.D., Weathers F.W., Nagy L.M., Kaloupek D.G., Gusman F.D., Charney D.S., et al. The development of a Clinician-Administered PTSD Scale. J Trauma Stress 1995, 8(1):75-90.
56. Weathers F.W., Keane T.M., Davidson J.R. Clinician-administered PTSD scale: a review of the first ten years of research. Depress Anxiety 2001, 13(3):132-156.
57. Weathers F.W., Ruscio A.M., Keane T.M. Psychometric properties of nine scoring rules for the Clinician-Administered Posttraumatic Stress Disorder Scale. Psychol Assess 1999, 11(2):124-133.
58. van Buuren S. Multiple imputation of multilevel data. The Handbook of Advanced Multilevel Analysis 2011, 173-196. Routledge, Milton Park, U.K. J.J. Hox, J.K. Roberts (Eds.).
59. Christie M.J. Mechanisms of opioid actions on neurons of the locus coeruleus. Prog Brain Res 1991, 88:197-205.
60. Westbrook R.F., Greeley J.D., Nabke C.P., Swinbourne A.L. Aversive conditioning in the rat: effects of a benzodiazepine and of an opioid agonist and antagonist on conditioned hypoalgesia and fear. J Exp Psychol Anim Behav Process 1991, 17(3):219-230.
61. Kohno Y., Tanaka M., Hoaki Y., Ida Y., Nagasaki N. Differential modification by opioid agents of acutely enhanced noradrenaline release in discrete brain regions. Eur J Pharmacol 1983, 92(3-4):265-268.
62. Tanaka M., Tsuda A., Yokoo H., Yoshida M., Mizoguchi K., Shimizu T. Psychological stress-induced increases in noradrenaline release in rat brain regions are attenuated by diazepam, but not by morphine. Pharmacol Biochem Behav 1991, 39(1):191-195.
63. Tanaka M., Kohno Y., Tsuda A., Nakagawa R., Ida Y., Iimori K., et al. Differential effects of morphine on noradrenaline release in brain regions of stressed and non-stressed rats. Brain Res 1983, 275(1):105-115.
64. Ehlers A., Clark D.M. A cognitive model of posttraumatic stress disorder. Behav Res Ther 2000, 38(4):319-345.
65. Olff M., Langeland W., Gersons B.P. The psychobiology of PTSD: coping with trauma. Psychoneuroendocrinology 2005, 30(10):974-982.
66. Norman S.B., Stein M.B., Dimsdale J.E., Hoyt D.B. Pain in the aftermath of trauma is a risk factor for post-traumatic stress disorder. Psychol Med 2008, 38(4):533-542.
67. Zatzick D.F., Galea S. An epidemiologic approach to the development of early trauma focused intervention. J Trauma Stress 2007, 20(4):401-412.
68. [accessed February 19, 2015]. http://www.nlm.nih.gov/medlineplus/medlineplus.html.