Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD

European Neuropsychopharmacology

Volumn 19, Issue 4, 2009, Pages 283-295

  Matar, Michael A ^a   Zohar, Joseph ^b   Kaplan, Zeev ^a   Cohen, Hagit ^a  

^a MENTAL HEALTH CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Animal model; Benzodiazepines; Corticosterone; Early drug intervention; Extreme behavioral response; Minimal behavioral response; Post traumatic stress disorder; Secondary prevention

Indexed keywords

ALPRAZOLAM; CORTICOSTERONE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; HABITUATION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION; MALE; MAZE TEST; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PREVALENCE; PRIORITY JOURNAL; RAT; STARTLE REFLEX; STRESS; THERAPY DELAY; TRANQUILIZING ACTIVITY; TREATMENT OUTCOME;

ACOUSTIC STIMULATION; ALPRAZOLAM; ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; CORTICOSTERONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FREEZING REACTION, CATALEPTIC; MALE; MAZE LEARNING; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SEVERITY OF ILLNESS INDEX; STARTLE REACTION; STRESS DISORDERS, POST-TRAUMATIC; TIME FACTORS;

EID: 60949091425     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2008.12.004     Document Type: Article

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