메뉴 건너뛰기




Volumn , Issue , 2013, Pages 9-32

Discovery process for antibody-based therapeutics

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84930144728     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-5955-3_2     Document Type: Chapter
Times cited : (11)

References (40)
  • 2
    • 33947383745 scopus 로고    scopus 로고
    • Identification and removal of immunogenicity in therapeutic proteins
    • Baker MP, Jones TD (2007) Identification and removal of immunogenicity in therapeutic proteins. Curr Opin Drug Discov Dev 10:219-227
    • (2007) Curr Opin Drug Discov Dev , vol.10 , pp. 219-227
    • Baker, M.P.1    Jones, T.D.2
  • 4
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K et al (2000) Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6:916-919
    • (2000) Nat Med , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6    Guido, T.7    Hu, K.8    Huang, J.9    Johnson-Wood, K.10
  • 6
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders
    • Brody DL, Holtzman DM (2008) Active and passive immunotherapy for neurodegenerative disorders. Annu Rev Neurosci 31:175-193
    • (2008) Annu Rev Neurosci , vol.31 , pp. 175-193
    • Brody, D.L.1    Holtzman, D.M.2
  • 8
    • 0029835023 scopus 로고    scopus 로고
    • INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group
    • Cohen J, Carlet J (1996) INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 24:1431-1440
    • (1996) Crit Care Med , vol.24 , pp. 1431-1440
    • Cohen, J.1    Carlet, J.2
  • 11
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98:8850-8855
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8850-8855
    • Demattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 12
    • 77953677314 scopus 로고    scopus 로고
    • Immunotoxicity of monoclonal antibodies
    • Descotes J (2009) Immunotoxicity of monoclonal antibodies. MAbs 1:104-111
    • (2009) MAbs , vol.1 , pp. 104-111
    • Descotes, J.1
  • 13
    • 0035093479 scopus 로고    scopus 로고
    • Omalizumab
    • discussion 261
    • Easthope S, Jarvis B (2001) Omalizumab. Drugs 61:253-260 discussion 261
    • (2001) Drugs , vol.61 , pp. 253-260
    • Easthope, S.1    Jarvis, B.2
  • 15
    • 0033921481 scopus 로고    scopus 로고
    • Factor VIII Inhibitors. Natural autoantibodies and anti-idiotypes
    • Gilles JG, Vanzieleghem B, Saint-Remy JM (2000) Factor VIII Inhibitors. Natural autoantibodies and anti-idiotypes. Semin Thromb Hemost 26:151-155
    • (2000) Semin Thromb Hemost , vol.26 , pp. 151-155
    • Gilles, J.G.1    Vanzieleghem, B.2    Saint-Remy, J.M.3
  • 16
    • 33747855481 scopus 로고    scopus 로고
    • Comparing antibody and small-molecule therapies for cancer
    • Imai K, Takaoka A (2006) Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6:714-727
    • (2006) Nat Rev Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 17
    • 67349088299 scopus 로고    scopus 로고
    • How to systematically evaluate immunogenicity of therapeutic proteins-regulatory considerations
    • Jahn EM, Schneider CK (2009) How to systematically evaluate immunogenicity of therapeutic proteins-regulatory considerations. N Biotechnol 25:280-286
    • (2009) N Biotechnol , vol.25 , pp. 280-286
    • Jahn, E.M.1    Schneider, C.K.2
  • 18
    • 79959700509 scopus 로고    scopus 로고
    • Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
    • Junttila TT, Li G, Parsons K, Phillips GL, Sliwkowski MX (2010) Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer. Breast Cancer Res Treat 128:347-356
    • (2010) Breast Cancer Res Treat , vol.128 , pp. 347-356
    • Junttila, T.T.1    Li, G.2    Parsons, K.3    Phillips, G.L.4    Sliwkowski, M.X.5
  • 20
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-497
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 21
    • 38449088277 scopus 로고    scopus 로고
    • Antibody-based approaches in Alzheimer's research: Safety, pharmacokinetics, metabolism, and analytical tools
    • Lichtlen P, Mohajeri MH (2008) Antibody-based approaches in Alzheimer's research: safety, pharmacokinetics, metabolism, and analytical tools. J Neurochem 104:859-874
    • (2008) J Neurochem , vol.104 , pp. 859-874
    • Lichtlen, P.1    Mohajeri, M.H.2
  • 22
    • 78650578346 scopus 로고    scopus 로고
    • Acute infusion reactions induced by monoclonal antibody therapy
    • Maggi E, Vultaggio A, Matucci A (2011) Acute infusion reactions induced by monoclonal antibody therapy. Expert Rev Clin Immunol 7:55-63
    • (2011) Expert Rev Clin Immunol , vol.7 , pp. 55-63
    • Maggi, E.1    Vultaggio, A.2    Matucci, A.3
  • 23
    • 78650210590 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • Morgan D (2011) Immunotherapy for Alzheimer's disease. J Int Med 269:54-63
    • (2011) J Int Med , vol.269 , pp. 54-63
    • Morgan, D.1
  • 24
    • 77957361348 scopus 로고    scopus 로고
    • Development trends for human monoclonal antibody therapeutics
    • Nelson AL, Dhimolea E, Reichert JM (2010) Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov 9:767-774
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 767-774
    • Nelson, A.L.1    Dhimolea, E.2    Reichert, J.M.3
  • 26
    • 0036734997 scopus 로고    scopus 로고
    • Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide
    • Pan W, Solomon B, Maness LM, Kastin AJ (2002) Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide. Exp Biol Med (Maywood) 227:609-615
    • (2002) Exp Biol Med (Maywood) , vol.227 , pp. 609-615
    • Pan, W.1    Solomon, B.2    Maness, L.M.3    Kastin, A.J.4
  • 27
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • Reichert JM (2011) Antibody-based therapeutics to watch in 2011. MAbs 3:76-99
    • (2011) MAbs , vol.3 , pp. 76-99
    • Reichert, J.M.1
  • 28
    • 15844367464 scopus 로고    scopus 로고
    • Immunologic mechanisms of EPO-associated pure red cell aplasia
    • Schellekens H (2005) Immunologic mechanisms of EPO-associated pure red cell aplasia. Best Pract Res Clin Haematol 18:473-480
    • (2005) Best Pract Res Clin Haematol , vol.18 , pp. 473-480
    • Schellekens, H.1
  • 30
    • 0035081475 scopus 로고    scopus 로고
    • Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein
    • Selkoe DJ (2001) Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J Alzheimers Dis 3:75-80
    • (2001) J Alzheimers Dis , vol.3 , pp. 75-80
    • Selkoe, D.J.1
  • 31
    • 77951086901 scopus 로고    scopus 로고
    • Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease
    • Siemers ER, Friedrich S, Dean RA, Gonzales CR, Farlow MR, Paul SM, Demattos RB (2010) Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease. Clin Neuropharmacol 33:67-73
    • (2010) Clin Neuropharmacol , vol.33 , pp. 67-73
    • Siemers, E.R.1    Friedrich, S.2    Dean, R.A.3    Gonzales, C.R.4    Farlow, M.R.5    Paul, S.M.6    Demattos, R.B.7
  • 32
    • 70449717019 scopus 로고    scopus 로고
    • Safety of biologics, lessons learnt from TGN1412
    • Stebbings R, Poole S, Thorpe R (2009) Safety of biologics, lessons learnt from TGN1412. Curr Opin Biotechnol 20:673-677
    • (2009) Curr Opin Biotechnol , vol.20 , pp. 673-677
    • Stebbings, R.1    Poole, S.2    Thorpe, R.3
  • 33
    • 0034680852 scopus 로고    scopus 로고
    • Generation and characterization of a recombinant human CCR5-specific antibody. A phage display approach for rabbit antibody humanization
    • Steinberger P, Sutton JK, Rader C, Elia M, Barbas CF 3rd (2000) Generation and characterization of a recombinant human CCR5-specific antibody. A phage display approach for rabbit antibody humanization. J Biol Chem 275:36073-36078
    • (2000) J Biol Chem , vol.275 , pp. 36073-36078
    • Steinberger, P.1    Sutton, J.K.2    Rader, C.3    Elia, M.4    Barbas Iii., C.F.5
  • 34
    • 70449727004 scopus 로고    scopus 로고
    • Optimization of Fc-mediated effector functions of monoclonal antibodies
    • Strohl WR (2009) Optimization of Fc-mediated effector functions of monoclonal antibodies. Curr Opin Biotechnol 20:685-691
    • (2009) Curr Opin Biotechnol , vol.20 , pp. 685-691
    • Strohl, W.R.1
  • 37
    • 59149104037 scopus 로고    scopus 로고
    • General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold
    • Vincke C, Loris R, Saerens D, Martinez-Rodriguez S, Muyldermans S, Conrath K (2009) General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold. J Biol Chem 284:3273-3284
    • (2009) J Biol Chem , vol.284 , pp. 3273-3284
    • Vincke, C.1    Loris, R.2    Saerens, D.3    Martinez-Rodriguez, S.4    Muyldermans, S.5    Conrath, K.6
  • 39
    • 79952450499 scopus 로고    scopus 로고
    • The safety of using anti-VEGF: Is there strength in numbers?
    • Wong D, Joussen AM (2010) The safety of using anti-VEGF: is there strength in numbers? Graefes Arch Clin Exp Ophthalmol 249:161-162
    • (2010) Graefes Arch Clin Exp Ophthalmol , vol.249 , pp. 161-162
    • Wong, D.1    Joussen, A.M.2
  • 40
    • 34047143155 scopus 로고    scopus 로고
    • Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract
    • Wu H, Pfarr DS, Johnson S, Brewah YA, Woods RM, Patel NK, White WI, Young JF, Kiener PA (2007) Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract. J Mol Biol 368:652-665
    • (2007) J Mol Biol , vol.368 , pp. 652-665
    • Wu, H.1    Pfarr, D.S.2    Johnson, S.3    Brewah, Y.A.4    Woods, R.M.5    Patel, N.K.6    White, W.I.7    Young, J.F.8    Kiener, P.A.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.