Transforming growth factor β signaling in colorectal cancer cells with microsatellite instability despite biallelic mutations in TGFBR2

Gastroenterology

Volumn 148, Issue 7, 2015, Pages 1427-1437.e8

  De Miranda, Noel F C C ^a   Van Dinther, Maarten ^a   Van Den Akker, Brendy E W M ^a   Van Wezel, Tom ^a   Ten Dijke, Peter ^a,b   Morreau, Hans ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Colon Cancer; RNA Editing; Signal Transduction; Tumor Suppressor

Indexed keywords

PROTEIN; PROTEIN TMEPAI; SHORT HAIRPIN RNA; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE; SMAD2 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ACVR2A GENE; ARTICLE; CANCER TISSUE; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TGFBR2 GENE; AGONISTS; COLORECTAL TUMOR; DRUG EFFECTS; FRAMESHIFT MUTATION; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HCT116 CELL LINE; HEK293 CELL LINE; METABOLISM; PATHOLOGY; PHENOTYPE; PHOSPHORYLATION; RNA INTERFERENCE;

COLORECTAL NEOPLASMS; FRAMESHIFT MUTATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HCT116 CELLS; HEK293 CELLS; HUMANS; MICROSATELLITE INSTABILITY; PHENOTYPE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84930031024     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.02.052     Document Type: Article

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