Propofol inhibits burn injury-induced hyperpermeability through an apoptotic signal pathway in microvascular endothelial cells

Brazilian Journal of Medical and Biological Research

Volumn 48, Issue 5, 2015, Pages 401-407

  Tian, K Y ^a   Liu, X J ^b   Xu, J D ^a   Deng, L J ^a   Wang, G ^a  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Burn injury; Endothelial cells; Hyperpermeability; Propofol

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CYTOCHROME C; DICHLORODIHYDROFLUORESCEIN DIACETATE; PROPOFOL; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; CYCLIN D1; DIABLO PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BURN INJURY INDUCED HYPERPERMEABILITY; CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; DOWN REGULATION; ELECTRIC RESISTANCE; ENZYME ACTIVATION; EXPERIMENTAL BURN; GENE OVEREXPRESSION; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BLOOD; BURN; CAPILLARY PERMEABILITY; CELL LINE; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMPEDANCE; METABOLISM; MICROVASCULATURE; PHYSIOLOGY; PROTO ONCOGENE; SECRETION (PROCESS); SERUM; SPRAGUE DAWLEY RAT;

RATTUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BURNS; CAPILLARY PERMEABILITY; CASPASE 3; CELL LINE; CYCLIN D1; CYTOCHROMES C; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENES, BCL-2; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROVESSELS; MITOCHONDRIAL PROTEINS; PROPOFOL; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SERUM; SIGNAL TRANSDUCTION;

EID: 84929996001     PISSN: None     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20144107     Document Type: Article

References (30)

1. Senior K. A positive approach to burn care. Lancet 1999; 353: 1248, doi: 10.1016/S0140-6736(05)66929-2
2. Kraft R, Herndon DN, Al-mousawi AM, Williams FN, Finnerty CC, Jeschke MG. Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study. Lancet 2012; 379: 1013-1021, doi: 10.1016/S0140-6736(11)61345-7
3. Lund T, Onarheim H, Reed RK. Pathogenesis of edema formation in burn injuries. World J Surg 1992; 16: 2-9, doi: 10.1007/BF02067107
4. Latenser BA. Critical care of the burn patient: the first 48 hours. Crit Care Med 2009; 37: 2819-2826, doi: 10.1097/CCM.0b013e3181b3a08f.
5. Whaley JG, Tharakan B, Smith B, Hunter FA, Childs EW. (-)-Deprenyl inhibits thermal injury-induced apoptotic signaling and hyperpermeability in microvascular endothelial cells. J Burn Care Res 2009; 30: 1018-1027
6. Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X. Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol 2007; 292: H3179-H3189, doi: 10.1152/ajpheart.01337.2006
7. Sinha K, Das J, Pal PB, Sil PC. Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol 2013; 87: 1157-1180, doi: 10.1007/s00204-013-1034-4
8. Childs EW, Tharakan B, Byrge N, Tinsley JH, Hunter FA, Smythe WR. Angiopoietin-1 inhibits intrinsic apoptotic signaling and vascular hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol 2008; 294: H2285-H2295, doi: 10.1152/ajpheart.01361.2007
9. Tharakan B, Hellman J, Sawant DA, Tinsley JH, Parrish AR, Hunter FA, et al. beta-Catenin dynamics in the regulation of microvascular endothelial cell hyperpermeability. Shock 2012; 37: 306-311, doi: 10.1097/SHK.0b013e318240b564
10. Shi SS, Yang WZ, Chen Y, Chen JP, Tu XK. Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats. Neurochem Res 2014; 39: 793-799, doi: 10.1007/s11064-014-1272-8
11. Cui WY, Liu Y, Zhu YQ, Song T, Wang QS. Propofol induces endoplasmic reticulum (ER) stress and apoptosis in lung cancer cell H460. Tumour Biol 2014; 35: 5213-5217, doi: 10.1007/s13277-014-1677-7
12. Nakajima A, Tsuji M, Inagaki M, Tamura Y, Kato M, Niiya A, et al. Neuroprotective effects of propofol on ER stressmediated apoptosis in neuroblastoma SH-SY5Y cells. Eur J Pharmacol 2014; 725: 47-54, doi: 10.1016/j.ejphar.201401.003
13. Zhang Y, Dong Y, Xu Z, Xie Z. Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore. Med Gas Res 2012; 2: 20, doi: 10.1186/2045-9912-2-20
14. Zhang B, Tian M, Zhen Y, Yue Y, Sherman J, Zheng H, et al. The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg 2012; 114: 410-415, doi: 10.1213/ANE.0b013e31823b2602
15. Huang Q, Xu W, Ustinova E, Wu M, Childs E, Hunter F, et al. Myosin light chain kinase-dependent microvascular hyperpermeability in thermal injury. Shock 2003; 20: 363-368, doi: 10.1097/01.shk.0000079425.0000.db.
16. Wang L, Luo H, Chen X, Jiang Y, Huang Q. Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. PLoS One 2014; 9: e90472, doi: 10.1371/journal.pone.0090472
17. Tharakan B, Corprew R, Hunter FA, Whaley JG, Smythe WR, Childs EW. 17beta-estradiol mediates protection against microvascular endothelial cell hyperpermeability. Am J Surg 2009; 197: 147-154, doi: 10.1016/j.amjsurg.2008.10.003
18. Wang X, Song R, Bian HN, Brunk UT, Zhao M, Zhao KS. Polydatin, a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization followinghemorrhagic shock. AmJ Physiol Regul Integr Comp Physiol 2012; 302: R805-R814, doi: 10.1152/ajpregu.00350.2011
19. Mishra S, Chatterjee S. Lactosylceramide promotes hypertrophy through ROS generation and activation of ERK1/2 in cardiomyocytes. Glycobiology 2014; 24: 518-531, doi: 10.1093/glycob/cwu020
20. Walter DH, Haendeler J, Galle J, Zeiher AM, Dimmeler S. Cyclosporin A inhibits apoptosis of human endothelial cells by preventing release of cytochrome C from mitochondria. Circulation 1998; 98: 1153-1157, doi: 10.1161/01.CIR.98.12.1153
21. Duckett CS. IAP proteins: sticking it to Smac. Biochem J 2005; 385: e1-e2, doi: 10.1042/BJ20041800
22. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998; 94: 481-490, doi: 10.1016/S0092-8674(00)81589-5
23. Steinhusen U, Badock V, Bauer A, Behrens J, Wittman- Liebold B, Dorken B, et al. Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential. J Biol Chem 2000; 275: 16345-16353, doi: 10.1074/jbc.M001458200
24. Marin N, Zamorano P, Carrasco R, Mujica P, Gonzalez FG, Quezada C, et al. S-Nitrosation of beta-catenin and p120 catenin: a novel regulatory mechanism in endothelial hyperpermeability. Circ Res 2012; 111: 553-563, doi: 10.1161/CIRCRESAHA.112.274548
25. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997; 275: 1129-1132, doi: 10.1126/science.275.5303.1129
26. Song R, Bian H, Wang X, Huang X, Zhao KS. Mitochondrial injury underlies hyporeactivity of arterial smooth muscle in severe shock. Am J Hypertens 2011; 24: 45-51, doi: 10.1038/ajh.2010.184
27. Wang X, Song R, Chen Y, Zhao M, Zhao KS. Polydatin - a new mitochondria protector for acute severe hemorrhagic shock treatment. Expert Opin Investig Drugs 2013; 22: 169-179, doi: 10.1517/13543784.2013.748033
28. Faizi M, Salimi A, Rasoulzadeh M, Naserzadeh P, Pourahmad J. Schizophrenia induces oxidative stress and cytochrome C release in isolated rat brain mitochondria: a possible pathway for induction of apoptosis and neurodegeneration. Iran J Pharm Res 2014; 13: 93-100
29. Figarola JL, Singhal J, Rahbar S, Awasthi S, Singhal SS. LR- 90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells. Apoptosis 2014; 19: 776-788, doi: 10.1007/s10495-014-0974-3
30. Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000; 5: 415-418, doi: 10.1023/A:1009616228304.