The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death

Biochemical and Biophysical Research Communications

Volumn 462, Issue 1, 2015, Pages 38-45

  Lyu, Qing ^a   Tou, Fangfang ^b   Su, Hong ^c   Wu, Xiaoyong ^c   Chen, Xinyi ^d   Zheng, Zhi ^b  

^a TSINGHUA UNIVERSITY   (China)

^b Jiangxi Cancer Hospital   (China)

^c GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE   (China)

^d BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Autophagic cell death; Autophagy; Natural product; Peiminine

Indexed keywords

ADENYLATE KINASE; BAFILOMYCIN A1; COMPLEMENTARY DNA; MAMMALIAN TARGET OF RAPAMYCIN; NATURAL PRODUCT; PEIMININE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RNA; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; CEVANE DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION ASSAY; COLORECTAL CANCER CELL LINE; COLORECTAL CARCINOMA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEPHOSPHORYLATION; FEMALE; FLOW CYTOMETRY; HCT116 CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; COLORECTAL NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HELA CELL LINE; IMMUNOBLOTTING; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR VOLUME;

EUKARYOTA;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; BIOLOGICAL PRODUCTS; CEVANES; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HCT116 CELLS; HELA CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84929959420     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.04.102     Document Type: Article

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