HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2

Molecular and Cellular Biochemistry

Volumn 405, Issue 1-2, 2015, Pages 63-71

  Liang, Yue ^a   Hou, Changchun ^a   Kong, Jinliang ^a   Wen, Hanchun ^a   Zheng, Xiaowen ^a   Wu, Lihong ^a   Huang, Hong ^a   Chen, Yiqiang ^a  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

High mobility group box protein 1 (HMGB1); Human bronchial epithelial cells (HBECs); Receptor; Signal transduction

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; GELATINASE B; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 3 INBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; THYMIC STROMAL LYMPHOPOIETIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; CYTOKINE; HMGB1 PROTEIN, HUMAN; PROTEIN BINDING; TUMOR NECROSIS FACTOR; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CASE REPORT; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; MALE; PRIMARY CULTURE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; BRONCHUS; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; BRONCHI; CYTOKINES; EPITHELIAL CELLS; HMGB1 PROTEIN; HUMANS; INFLAMMATION; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 9; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84929957997     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-015-2396-0     Document Type: Article

References (29)

1. Hreggvidsdottir HS, Östberg T, Wähämaa H et al (2009) The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation[J]. J Leukoc Biol 86(3):655–662
2. Huang W, Tang Y, Li L (2010) HMGB1, a potent proinflammatory cytokine in sepsis[J]. Cytokine 51(2):119–126
3. McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis[J]. Nat Rev Immunol 7(6):429–442
4. Lamkanfi M, Sarkar A, Walle LV et al (2010) Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia[J]. J Immunol 185(7):4385–4392
5. Hou C, Zhao H, Liu L et al (2011) High mobility group protein B1 (HMGB1) in asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls[J]. Mol Med 17(7–8):807
6. Lee CC, Lai YT, Chang HT et al (2013) Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma[J]. Biochem Pharmacol 86(7):940–949
7. Jeffery PK, Haahtela T (2006) Allergic rhinitis and asthma: inflammation in a one-airway condition[J]. BMC Pulm Med 6(Suppl 1):S5
8. Holgate ST (2008) The airway epithelium is central to the pathogenesis of asthma[J]. Allergol Int 57(1):1–10
9. Page K, Hughes VS, Bennett GW et al (2006) German cockroach proteases regulate matrix metalloproteinase-9 in human bronchial epithelial cells[J]. Allergy 61(8):988–995
10. Kranenburg AR, De Boer WI, Alagappan VKT et al (2005) Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease[J]. Thorax 60(2):106–113
11. Davies DE (2009) The role of the epithelium in airway remodeling in asthma[J]. Proc Am Thorac Soc 6(8):678–682
12. Lambrecht BN, Hammad H (2012) The airway epithelium in asthma[J]. Nat Med 18(5):684–692
13. Piccinini AM, Midwood KS (2010) DAMPening inflammation by modulating TLR signalling[J]. Mediat Inflamm 42(4):506–508
14. Park JS, Svetkauskaite D, He Q et al (2004) Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein[J]. J Biol Chem 279(9):7370–7377
15. Park JS, Arcaroli J, Yum HK et al (2003) Activation of gene expression in human neutrophils by high mobility group box 1 protein[J]. Am J Physiol Cell Physiol 284(4):C870–C879
16. Oettgen HC (2011) Mast cells and tumour necrosis factor alpha (TNF-α): partners in crime in asthma pathogenesis[J]. Clin Immunol 140(1):1–2
17. Andersson U, Wang H, Palmblad K et al (2000) High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes[J]. J Exp Med 192(4):565–570
18. Fiuza C, Bustin M, Talwar S et al (2003) Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells[J]. Blood 101(7):2652–2660
19. Yamada S, Maruyama I (2007) HMGB1, a novel inflammatory cytokine[J]. Clin Chim Acta 375(1):36–42
20. Popa C, Netea MG, Van Riel PLCM et al (2007) The role of TNF-α in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk[J]. J Lipid Res 48(4):751–762
21. Ying S, O’Connor B, Ratoff J et al (2008) Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease[J]. J Immunol 181(4):2790–2798
22. Han Z, Zhong N (2003) Expression of matrix metalloproteinases MMP-9 within the airways in asthma[J]. Respir Med 97(5):563–567
23. Asai K, Kanazawa H, Kamoi H et al (2003) Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients[J]. Clin Exp Allergy 33(5):595–599
24. Sha Y, Zmijewski J, Xu Z et al (2008) HMGB1 develops enhanced proinflammatory activity by binding to cytokines[J]. J Immunol 180(4):2531–2537
25. Qin YH, Dai SM, Tang GS et al (2009) HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end products[J]. J Immunol 183(10):6244–6250
26. Yu M, Wang H, Ding A et al (2006) HMGB1 signals through toll-like receptor (TLR) 4 and TLR2[J]. Shock 26(2):174–179
27. van Beijnum JR, Buurman WA, Griffioen AW (2008) Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)[J]. Angiogenesis 11(1):91–99
28. Kaltschmidt B, Kaltschmidt C (2003) NF-кB in the nervous system[M]//nuclear factor кB. Springer, Netherlands, pp 373–392
29. Andersson U, Tracey KJ (2011) HMGB1 is a therapeutic target for sterile inflammation and infection[J]. Annu Rev Immunol 29:139–162