Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity

Toxicology Letters

Volumn 235, Issue 3, 2015, Pages 216-217

  Jaeschke, Hartmut ^a   McGill, Mitchell R ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Hepatotoxicity; HepG2 cells; Mitochondria; Oxidant stress; Protein adducts

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; GLUTATHIONE DISULFIDE; PARACETAMOL; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; MULTIENZYME COMPLEX;

CELL DEATH; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; HEPG2 CELL LINE; HUMAN; LETTER; LIPID PEROXIDATION; LIVER CELL; LIVER INJURY; LIVER MICROSOME; LIVER MITOCHONDRION; LIVER TOXICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR PATHOLOGY; MOUSE MODEL; NONHUMAN; OXIDATIVE STRESS; PRIMARY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT MODEL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; METABOLISM;

ACETAMINOPHEN; DRUG-INDUCED LIVER INJURY; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; HEPATOCYTES; HUMANS; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84929955867     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2015.04.002     Document Type: Letter

References (19)

1. Adams J.D., Lauterburg B.H., Mitchell J.R. Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. J. Pharmacol. Exp. Ther. 1983, 227:749-754.
2. Agarwal R., MacMillan-Crow L.A., Rafferty T.M., Saba H., Roberts D.W., Fifer E.K., James L.P., Hinson J.A. Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase. J. Pharmacol. Exp. Ther. 2011, 337:110-116.
3. Aninat C., Piton A., Glaise D., Le Charpentier T., Langouët S., Morel F., Guguen-Guillouzo C., Guillouzo A. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab. Dispos. 2005, 34:75-83.
4. Bajt M.L., Knight T.R., Lemasters J.J., Jaeschke H. Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol. Sci. 2004, 80:343-349.
5. Cover C., Mansouri A., Knight T.R., Bajt M.L., Lemasters J.J., Pessayre D., Jaeschke H. Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J. Pharmacol. Exp. Ther. 2005, 315:879-887.
6. Guillouzo A., Corlu A., Aninat C., Glaise D., Morel F., Guguen-Guillouzo C. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem. Biol. Interact. 2007, 168:66-73.
7. Jaeschke H. Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol. J. Pharmacol. Exp. Ther. 1990, 255:935-941.
8. Jaeschke H., McGill M.R., Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab. Rev. 2012, 44:88-106.
9. Jiang J., Briedé J.J., Jennen D.G., Van Summeren A., Saritas-Brauers K., Schaart G., Kleinjans J.C., de Kok T.M. Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol. Lett. 2015, 234:139-150.
10. Kanebratt K.P., Andersson T.B. Evalutation of HepaRG cells as an in vitro model for human drug metabolism studies. Drug Metab. Dispos. 2008, 36:1444-1452.
11. Kon K., Kim J.S., Uchiyama A., Jaeschke H., Lemasters J.J. Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol. Sci. 2010, 117:101-108.
12. Kuthan H., Ullrich V. Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system. Eur. J. Biochem. 1982, 126:583-588.
13. McGill M.R., Yan H.M., Ramachandran A., Murray G.J., Rollins D.E., Jaeschke H. HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology 2011, 53:974-982.
14. McGill M.R., Sharpe M.R., Williams C.D., Taha M., Curry S.C., Jaeschke H. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J. Clin. Invest. 2012, 122:1574-1583.
15. McGill M.R., Williams C.D., Xie Y., Ramachandran A., Jaeschke H. Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol. Appl. Pharmacol. 2012, 264:387-394.
16. Ramachandran A., Lebofsky M., Weinman S.A., Jaeschke H. The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity. Toxicol. Appl. Pharmacol. 2011, 251:226-233.
17. Smith C.V., Jaeschke H. Effect of acetaminophen on hepatic content and biliary efflux of glutathione disulfide in mice. Chem. Biol. Interact. 1989, 70:241-248.
18. Wendel A., Feuerstein S. Drug-induced lipid peroxidation in mice. I. Modulation by monooxygenase activity, glutathione and selenium status. Biochem. Pharmacol. 1981, 30:2513-2520.
19. Xie Y., McGill M.R., Dorko K., Kumer S.C., Schmitt T.M., Forster J., Jaeschke H. Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol. Appl. Pharmacol. 2014, 279:266-274.