Carriage rates and characteristics of enterobacteriaceae producing extended-spectrum beta-lactamases in healthy individuals: Comparison of applicants for long-term care and individuals screened for employment purposes

Chemotherapy

Volumn 60, Issue 4, 2014, Pages 239-249

  Ebrahimi, Fatemeh ^a   Mózes, Julianna ^a   Mészáros, Júlia ^b   Juhász, Ágnes ^b   Kardos, Gábor ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b SYNLAB ACADEMY   (Germany)

Author keywords

Asymptomatic individuals; blaCTX M; Colonization; Escherichia coli; Klebsiella pneumoniae

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BACTERIAL DNA; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORIN; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; DOXYCYCLINE; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; IMIPENEM; TIGECYCLINE; TOBRAMYCIN; BETA LACTAMASE;

ADOLESCENT; ADULT; AGAR MEDIUM; AGED; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM CULTURE; BACTERIUM ISOLATE; EMPLOYMENT; ESCHERICHIA COLI; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; FECES ANALYSIS; FEMALE; GENE CASSETTE; GENETIC VARIABILITY; HUMAN; INTEGRON; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; LONG TERM CARE; MOUSE; NONHUMAN; NORMAL HUMAN; PHENOTYPE; PHYLOGENY; POLYMERASE CHAIN REACTION; PREEMPLOYMENT MEDICAL EXAMINATION; PRIORITY JOURNAL; PROTEUS MIRABILIS; SCREENING; COMPARATIVE STUDY; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; ENZYMOLOGY; FECES; GENETICS; JOB FINDING; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; OCCUPATIONAL HEALTH; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BETA-LACTAMASES; EMPLOYMENT; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; FECES; FEMALE; HUMANS; JOB APPLICATION; LONG-TERM CARE; MALE; MIDDLE AGED; OCCUPATIONAL HEALTH; YOUNG ADULT;

EID: 84929954995     PISSN: 00093157     EISSN: 14219794     Source Type: Journal    
DOI: 10.1159/000375407     Document Type: Article

References (62)

1. Damjanova I, Toth A, Paszti J, Hajbel-Vekony G, Jakab M, Berta J, Milch H, Fuzi M: Expansion and countrywide dissemination of ST11, ST15 and ST147 ciprofloxacin-resistant CTX-M-15-type beta-lactamase-producing Klebsiella pneumoniae epidemic clones in Hungary in 2005 - the new 'MRSAs'? J Antimicrob Chemother 2008; 62: 978-985.
2. Woodford N, Ward ME, Kaufmann ME, Turton J, Fagan EJ, James D, Johnson AP, Pike R, Warner M, Cheasty T, Pearson A, Harry S, Leach JB, Loughrey A, Lowes JA, Warren RE, Livermore DM: Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK. J Antimicrob Chemother 2004; 54: 735-743.
3. Canton R, Coque TM: The CTX-M beta-lactamase pandemic. Curr Opin Microbiol 2006; 9: 466-475.
4. Livermore DM, Canton R, Gniadkowski M, Nordmann P, Rossolini GM, Arlet G, Ayala J, Coque TM, Kern-Zdanowicz I, Luzzaro F, Poirel L, Woodford N: CTX-M: changing the face of ESBLs in Europe. J Antimicrob Chemother 2007; 59: 165-174.
5. Ewers C, Grobbel M, Stamm I, Kopp PA, Diehl I, Semmler T, Fruth A, Beutlich J, Guerra B, Wieler LH, Guenther S: Emergence of human pandemic O25:H4-ST131 CTX-M-15 extended-spectrum-beta-lactamase-producing Escherichia coli among companion animals. J Antimicrob Chemother 2010; 65: 651-660.
6. Woerther PL, Burdet C, Chachaty E, Andremont A: Trends in human fecal carriage of extended-spectrum beta-lactamases in the community: toward the globalization of CTXM. Clin Microbiol Rev 2013; 26: 744-758.
7. Salyers AA, Gupta A, Wang Y: Human intestinal bacteria as reservoirs for antibiotic resistance genes. Trends Microbial 2004; 12: 412-416.
8. Tham J, Odenholt I, Walder M, Brolund A, Ahl J, Melander E: Extended-spectrum betalactamase-producing Escherichia coli in patients with travellers' diarrhoea. Scand J Infect Dis 2010; 42: 275-280.
9. Van der Bij AK, Pitout JD: The role of international travel in the worldwide spread of multiresistant Enterobacteriaceae. J Antimicrob Chemother 2012; 67: 2090-2100.
10. Heininger A, Binder M, Schmidt S, Unertl K, Botzenhart K, Doring G: PCR and blood culture for detection of Escherichia coli bacteremia in rats. J Clin Microbiol 1999; 37: 2479-2482.
11. Liu Y, Liu C, Zheng W, Zhang X, Yu J, Gao Q, Hou Y, Huang X: PCR detection of Klebsiella pneumoniae in infant formula based on 16S-23S internal transcribed spacer. Int J Food Microbiol 2008; 125: 230-235.
12. Versalovic J, Koeuth T, Lupski JR: Distribution of repetitive DNA sequences in eubacteria and application to fingerprinting of bacterial genomes. Nucleic Acid Res 1991; 19: 6823-6831.
13. Mozes J, Szcs I, Molnar D, Jakab P, Fatemeh E, Szilasi M, Majoros L, Orosi P, Kardos G: A potential role of aminoglycoside resistance in endemic occurrence of Pseudomonas aeruginosa strains in lower airways of mechanically ventilated patients. Diagn Microbiol Infect Dis 2014; 78: 79-84.
14. Hunter PR, Gaston MA: Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. J Clin Microbiol 1998; 26: 2465-2466.
15. Bedeni B, Randegger CC, Stobberingh E, Hachler H: Molecular epidemiology of extended-spectrum beta-lactamases from Klebsiella pneumoniae strains isolated in Zagreb, Croatia. Eur J Clin Microbiol Infect Dis 2001; 20: 505-508.
16. Edelstein M, Pimkin M, Palagin I, Edelstein I, Stratchounski L: Prevalence and molecular epidemiology of CTX-M extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Russian hospitals. Antimicrob Agents Chemother 2003; 47: 3724-3732.
17. Jouini A, Vinue L, Slama KB, Saenz Y, Klibi N, Hammami S, Boudabous A, Torres C: Characterization of CTX-M and SHV extended-spectrum beta-lactamases and associated resistance genes in Escherichia coli strains of food samples in Tunisia. Antimicrob Agents Chemother 2007; 60: 1137-1141.
18. Pitout JD, Hossain A, Hanson ND: Phenotypic and molecular detection of CTX-M-betalactamases produced by Escherichia coli and Klebsiella spp. J Clin Microbiol 2004; 42: 5715-5721.
19. Hannecart-Pokorni E, Depuydt F, De Wit L, van Bossuyt E, Content J, Vanhoof R: Characterization of the ± 9-N-aminoglycoside acetyltransferase gene aac(6)-Im associated with a sulI-type integron. Antimicrob Agents Chemother 1997; 41: 314-318.
20. Noppe-Leclercq I, Wallet F, Haentjens S, Courcol R, Simonet M: PCR detection of aminoglycoside resistance genes: a rapid molecular typing method for Acinetobacter baumannii. Res Microbiol 1999; 150: 317-322.
21. Frana TS, Carlson SA, Griffith RW: Relative distribution and conservation of genes encoding aminoglycoside-modifying enzymes in Salmonella enterica serotype Typhimurium phage type DT104. Appl Environ Microbiol 2001; 67: 445-448.
22. Bogaerts P, Galimand M, Bauraing C, Deplano A, Vanhoof R, De Mendonca R, Rodriguez-Villalobos H, Struelens M, Glupczynski Y: Emergence of ArmA and RmtB aminoglycoside resistance 16S rRNA methylases in Belgium. J Antimicrob Chemother 2007; 59: 459-464.
23. Mazel D, Dychinco B, Webb VA, Davies J: Antibiotic resistance in the ECOR collection: integrons and identification of a novel aad gene. Antimicrob Agents Chemother 2000; 44: 1568-1574.
24. White DG, Zhao S, Sudler R, Ayers S, Friedman S, Chen S, McDermott PF, McDermott S, Wagner DD, Meng J: The isolation of antibiotic-resistant Salmonella from retail ground meats. N Engl J Med 2001; 345: 1147-1154.
25. Clermont O, Bonacorsi S, Bingen E: Rapid and simple determination of the Escherichia coli phylogenetic group. Appl Environ Microbiol 2000; 66: 4555-4558.
26. Clermont O, Dhanji H, Upton M, Gibreel T, Fox A, Boyd D, Mulvey MR, Nordmann P, Ruppe E, Sarthou JL, Frank T, Vimont S, Arlet G, Branger C, Woodford N, Denamur E: Rapid and simple detection of the O25b-ST131 clone of Escherichia coli encompassing the CTXM-15 producing strains. J Antimicrob Chemother 2009; 64: 274-277.
27. Persson S, Olsen KE, Scheutz F, Krogfelt KA, Gerner-Smidt P: A method for fast and simple detection of major diarrhoeagenic Escherichia coli in the routine diagnostic laboratory. Clin Microbiol Infect 2007; 13: 516-524.
28. Braun G, Vidotto MC: Evaluation of adherence, hemagglutination, and presence of genes codifying for virulence factors of Acinetobacter baumannii causing urinary tract infection. Mem Inst Oswaldo Cruz 2004; 99: 839-844.
29. Hammer Q, Harper DAT, Ryan PD: PAST: paleontological statistics software package for education and data analysis, v1.34 (March 17, 2005).
30. De Champs C, Sauvant MP, Chanal C, Sirot D, Gazuy N, Malhuret R, Baguet JC, Sirot J: Prospective survey of colonization and infection caused by expanded-spectrum-beta-lactamase-producing members of the family Enterobacteriaceae in an intensive care unit. J Clin Microbiol 1989; 27: 2887-2890.
31. Franiczek R, Sobieszczanska B, Grabowski M, Mowszet K, Pytrus T: Occurrence of extended-spectrum beta-lactamases among Escherichia coli isolates from hospitalized and healthy children. Folia Microbiol (Praha) 2003; 48: 243-247.
32. Rodrigues C, Shukla U, Jog S, Mehta A: Extended-spectrum beta-lactamase-producing flora in healthy persons. Emerg Infect Dis 2005; 6: 981-982.
33. Abdul Rahman EM, El-Sherif RH: High rates of intestinal colonization with extended-spectrum lactamase-producing Enterobacteriaceae among healthy individuals. J Investig Med 2011; 59: 1284-1286.
34. Luvsansharav UO, Hirai I, Nakata A, Imura K, Yamauchi K, Niki M, Komalamisra C, Kusolsuk T, Yamamoto Y: Prevalence of and risk factors associated with faecal carriage of CTXM beta-lactamase producing Enterobacteriaceae in rural Thai communities. J Antimicrob Chemother 2012; 67: 1769-1774.
35. Peirano G, Laupland KB, Gregson DB, Pitout JD: Colonization of returning travelers with CTX-M-producing Escherichia coli. J Travel Med 2011; 18: 299-303.
36. Tangden T, Cars O, Melhus A, Lowdin E: Foreign travel is a major risk factor for colonization with Escherichia coli producing CTXMtype extended-spectrum beta-lactamases: a prospective study with Swedish volunteers. Antimicrob Agents Chemother 2010; 54: 3564-3568.
37. Coque TM, Baquero F, Canton R: Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe. Euro Surveill 2008; 13: 19044.
38. Nicolas-Chanoine MH, Gruson C, Bialek-Davenet S, Bertrand X, Thomas-Jean F, Bert F, Moyat M, Meiller E, Marcon E, Danchin N, Noussair L, Moreau R, Leflon-Guibout V: 10-fold increase (2006-2011) in the rate of healthy subjects with extended-spectrum beta-lactamase producing Escherichia coli faecal carriage in a Parisian check-up centre. J Antimicrob Chemother 2013; 68: 562-568.
39. Stromdahl H, Tham J, Melander E, Walder M, Edquist PJ, Odenholt I: Prevalence of faecal ESBL carriage in the community and in a hospital setting in a county of Southern Sweden. Eur J Clin Microbiol Infect Dis 2011; 30: 1159-1162.
40. Geser N, Stephan R, Korczak BM, Beutin L, Hachler H: Molecular identification of extended-spectrum-beta-lactamase genes from Enterobacteriaceae isolated from healthy human carriers in Switzerland. Antimicrob Agents Chemother 2012; 56: 1609-1612.
41. Rodriguez-Bano J, Lopez-Cerero L, Navarro MD, Diaz de Alba P, Pascual A: Faecal carriage of extended-spectrum beta-lactamase producing Escherichia coli : prevalence, risk factors and molecular epidemiology. J Antimicrob Chemother 2008; 62: 1142-1149.
42. Schoevaerdts D, Verroken A, Huang TD, Frennet M, Berhin C, Jamart J, Bogaerts P, Swine C, Glupczynski Y: Multidrug-resistant bacteria colonization amongst patients newly admitted to a geriatric unit: a prospective cohort study. J Infect 2012; 65: 109-118.
43. Tofteland S, Haldorsen B, Dahl KH, Simonsen GS, Steinbakk M, Walsh TR, Sundsfjord A; Norwegian ESBL Study Group: Effects of phenotype and genotype on methods for detection of extended-spectrum-beta-lactamase-producing clinical isolates of Escherichia coli and Klebsiella pneumoniae in Norway. J Clin Microbiol 2007; 45: 199-205.
44. Pitout JD, Hanson ND, Church DL, Laupland KB: Population-based laboratory surveillance for Escherichia coli-producing extendedspectrum beta-lactamases: importance of community isolates with bla CTX-M genes. Clin Infect Dis 2004; 38: 1736-1741.
45. Hansen DS, Schumacher H, Hansen F, Stegger M, Hertz FB, Schonning K, Justesen US, Frimodt-Moller N; DANRES Study Group: Extended-spectrum beta-lactamase (ESBL) in Danish clinical isolates of Escherichia coli and Klebsiella pneumoniae : prevalence, betalactamase distribution, phylogroups, and coresistance. Scand J Infect Dis 2012; 44: 174-181.
46. Tsukamoto N, Ohkoshi Y, Okubo T, Sato T, Kuwahara O, Fujii N, Tamura Y, Yokota S: High prevalence of cross-resistance to aminoglycosides in fluoroquinolone-resistant Escherichia coli clinical isolates. Chemotherapy 2013; 59: 379-384.
47. Skurnik D, Le Menac'h A, Zurakowski D, Mazel D, Courvalin P, Denamur E, Andremont A, Ruimy R: Integron-associated antibiotic resistance and phylogenetic grouping of Escherichia coli isolates from healthy subjects free of recent antibiotic exposure. Antimicrob Agents Chemother 2005; 49: 3062-3065.
48. Lau SH, Kaufmann ME, Livermore DM, Woodford N, Willshaw GA, Cheasty T, Stamper K, Reddy S, Cheesbrough J, Bolton FJ, Fox AJ, Upton M: UK epidemic Escherichia coli strains A-E, with CTX-M-15 beta-lactamase, all belong to the international O25:H4-ST131 clone. J Antimicrob Chemother 2008; 62: 1241-1244.
49. Coque TM, Oliver A, Perez-Diaz JC, Baquero F, Canton R: Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989-2000). Antimicrob Agents Chemother 2002; 46: 500-510.
50. Tellevik MG, Sollid JE, Blomberg B, Jureen R, Urassa WK, Langeland N: Extended-spectrum beta-lactamase-type SHV-12-producing Enterobacteriaceae causing septicemia in Tanzanian children: vectors for horizontal transfer of antimicrobial resistance. Diagn Microbiol Infect Dis 2007; 59: 351-354.
51. Doi Y, Adams-Haduch JM, Peleg AY, D'Agata EM: The role of horizontal gene transfer in the dissemination of extended-spectrum beta-lactamase-producing E scherichia coli and K lebsiella pneumoniae isolates in an endemic setting. Diagn Microbiol Infect Dis 2012; 74: 34-38.
52. Geser N, Stephan R, Hachler H: Occurrence and characteristics of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk. BMC Vet Res 2012; 8: 21.
53. Toth A, Juhasz-Kaszanyitzky E, Mag T, Hajbel-Vekony G, Paszti J, Damjanova I: Characterization of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli strains isolated from animal and human clinical samples in Hungary in 2006-2007. Acta Microbiol Immunol Hung 2013; 60: 175-185.
54. Carattoli A, Lovari S, Franco A, Cordaro G, Di Matteo P, Battisti A: Extended-spectrum beta-lactamases in Escherichia coli isolated from dogs and cats in Rome, Italy, from 2001 to 2003. Antimicrob Agents Chemother 2005; 49: 833-835.
55. Wieler LH, Ewers C, Guenther S, Walther B, Lubke-Becker A: Methicillin-resistant staphylococci (MRS) and extended-spectrum betalactamases (ESBL)-producing Enterobacteriaceae in companion animals: nosocomial infections as one reason for the rising prevalence of these potential zoonotic pathogens in clinical samples. Int J Med Microbiol 2011; 301: 635-641.
56. Bonnedahl J, Drobni M, Gauthier-Clerc M, Hernandez J, Granholm S, Kayser Y, Melhus A, Kahlmeter G, Waldenstrom J, Johansson A, Olsen B: Dissemination of Escherichia coli with CTX-M type ESBL between humans and yellow-legged gulls in the south of France. PLoS One 2009; 4:e5958.
57. Literak I, Dolejska M, Janoszowska D, Hrusakova J, Meissner W, Rzyska H, Bzoma S, Cizek A: Antibiotic-resistant Escherichia coli bacteria, including strains with genes encoding the extended-spectrum beta-lactamase and QnrS, in waterbirds on the Baltic Sea coast of Poland. Appl Environ Microbiol 2010; 76: 8126-8134.
58. Tacao M, Moura A, Correia A, Henriques I: Co-resistance to different classes of antibiotics among ESBL-producers from aquatic systems. Water Res 2014; 48: 100-107.
59. De Boeck H, Miwanda B, Lunguya-Metila O, Muyembe-Tamfum JJ, Stobberingh E, Glupczynski Y, Jacobs J: ESBL-positive Enterobacteria isolates in drinking water. Emerg Infect Dis 2012; 18: 1019-1020.
60. Bortolaia V, Larsen J, Damborg P, Guardabassi L: Potential pathogenicity and host range of extended-spectrum beta-lactamaseproducing Escherichia coli isolates from healthy poultry. Appl Environ Microbiol 2011; 77: 5830-5833.
61. Overdevest I, Willemsen I, Rijnsburger M, Eustace A, Xu L, Hawkey P, Heck M, Savelkoul P, Vandenbroucke-Grauls C, van der Zwaluw K, Huijsdens X, Kluytmans J: Extended-spectrum beta-lactamase genes of Escherichia coli in chicken meat and humans, The Netherlands. Emerg Infect Dis 2011; 17: 1216-1222.
62. Valverde A, Coque TM, Sanchez-Moreno MP, Rollan A, Baquero F, Canton R: Dramatic increase in prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae during non-outbreak situations in Spain. J Clin Microbiol 2004; 42: 4769-4775.