Extended-spectrum β-lactamase (ESBL) in Danish clinical isolates of Escherichia coli and Klebsiella pneumoniae: Prevalence, β-lactamase distribution, phylogroups, and co-resistance

Scandinavian Journal of Infectious Diseases

Volumn 44, Issue 3, 2012, Pages 174-181

  Hansen, Dennis Schrøder ^a,b   Schumacher, Helga ^c   Hansen, Frank ^b   Stegger, Marc ^b   Hertz, Frederik Botius ^b   Schønning, Kristian ^d   Justesen, Ulrik Stenz ^e   Frimodt Møller, Niels ^b  

^a HILLERØD HOSPITAL   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

^c HERNING HOSPITAL   (Denmark)

^d HVIDOVRE HOSPITAL   (Denmark)

^e ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Co resistance; Community acquired infection; CTX M 15; National epidemiology; Nosocomial infection; Phylogroup B2

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; BETA LACTAMASE CTX M; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CIPROFLOXACIN; CLAVULANIC ACID; FOSFOMYCIN; GENTAMICIN; MECILLINAM; MEROPENEM; NITROFURANTOIN; PIPERACILLIN PLUS TAZOBACTAM; TEMOCILLIN; TICARCILLIN; TIGECYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; BLOOD CULTURE; BLOOD SAMPLING; DENMARK; ESCHERICHIA COLI; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; GENE SEQUENCE; HUMAN; KLEBSIELLA PNEUMONIAE; PHENOTYPE; PREVALENCE; PROTEUS MIRABILIS; URINALYSIS; URINE CULTURE;

BETA-LACTAMASES; BLOOD; CLUSTER ANALYSIS; DENMARK; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROBACTERIACEAE INFECTIONS; ESCHERICHIA COLI; HUMANS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR TYPING; PHYLOGENY; PREVALENCE; PROTEUS MIRABILIS; URINE;

EID: 84857557018     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2011.632642     Document Type: Article

References (33)

1. Bradford PA. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev 2001;14:933-51. (Pubitemid 32979636)
2. Paterson DL, Bonomo RA. Extended-spectrum betalactamases: a clinical update. Clin Microbiol Rev 2005;18: 657-86.
3. Bush K, Jacoby GA. Updated functional classification of β -lactamases. Antimicrob Agents Chemother 2010;54:969-76.
4. Canton R, Novais A, Valverde A, Machado E, Peixe L, Baquero F, et al. Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe. Clin Microbiol Infect 2008;14(Suppl 1):144-53. (Pubitemid 350269194)
5. Coque TM, Baquero F, Canton R. Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe. Euro Surveill 2008;13. pii: 19044.
6. Fang H, Lundberg C, Olsson-Liljequist B, Hedin G, Lindback E, Rosenberg A, et al. Molecular epidemiological analysis of Escherichia coli isolates producing extendedspectrum beta-lactamases for identification of nosocomial outbreaks in Stockholm, Sweden. J Clin Microbiol 2004; 42:5917-20. (Pubitemid 39664394)
7. Naseer U, Natas OB, Haldorsen BC, Bue B, Grundt H, Walsh TR, et al. Nosocomial outbreak of CTX-M-15-producing E. coli in Norway. APMIS 2007;115:120-6. (Pubitemid 46208087)
8. Schumacher H, Bengtsson B, Bjerregaard-Andersen H, Jensen TG. Detection of extended-spectrum beta-lactamases. The reliability of methods for susceptibility testing as used in Denmark. APMIS 1998;106:979-86. (Pubitemid 28512151)
9. Tofteland S, Haldorsen B, Dahl KH, Simonsen GS, Steinbakk M, Walsh TR, et al. Effects of phenotype and genotype on methods for detection of extended-spectrum-beta-lactamase-producing clinical isolates of Escherichia coli and Klebsiella pneumoniae in Norway. J Clin Microbiol 2007; 45:199-205. (Pubitemid 46106427)
10. Lytsy B, Sandegren L, Tano E, Torell E, Andersson DI, Melhus A. The first major extended-spectrum beta-lactamase outbreak in Scandinavia was caused by clonal spread of a multiresistant Klebsiella pneumoniae producing CTX-M-15. APMIS 2008;116:302-8. (Pubitemid 351499162)
11. Naseer U, Haldorsen B, Tofteland S, Hegstad K, Scheutz F, Simonsen GS, Sundsfjord A; Norwegian ESBL Study Group. Molecular characterization of CTX-M-15-producing clinical isolates of Escherichia coli reveals the spread of multidrugresistant ST131 (O25:H4) and ST964 (O102:H6) strains in Norway. APMIS 2009;117:526-36.
12. Alsterlund R, Carlsson B, Gezelius L, Haeggman S, Olsson-Liljequist B. Multiresistant CTX-M-15 ESBL-producing Escherichia coli in southern Sweden: description of an outbreak. Scand J Infect Dis 2009;41:410-5.
13. Kjerulf A, Hansen DS, Sandvang D, Hansen F, Frimodt-Møller N. The prevalence of ESBL-producing E. coli and Klebsiella strains in the Copenhagen area of Denmark. APMIS 2008;116:118-24. (Pubitemid 351347590)
14. NORM/NORM-VET 2009. Usage of antimicrobial agents and occurrence of antimicrobial resistance in Norway. Tromsø, Oslo; 2010.
15. Rosco users guide. 19t h ed. Taastrup, Denmark: Rosco Diagnostica A/S; 2007/2008, pp 53-5.
16. Andrews JM, Jevons G, Walker R, Ashby J, Fraise AP. Temocillin susceptibility by BSAC methodology. J Antimicrob Chemother 2007;60:185-7.
17. Coudron PE. Inhibitor-based methods for detection of plasmid-mediated AmpC β -lactamases in Klebsiella spp., Escherichia coli, and Proteus mirabilis. J Clin Microbiol 2005;43:4163-7. (Pubitemid 41129715)
18. Woodford N, Fagan EJ, Ellington MJ. Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum β -lactamases. J Antimicrob Chemother 2005;57:154-5.
19. Sahly H, Aucken H, Benedí VJ, Forestier C, Fussing V, Hansen DS, et al. Increased serum resistance in Klebsiella pneumoniae strains producing extended-spectrum β -lactamases. Antimicrob Agents Chemother 2004;48:3477-82. (Pubitemid 39129348)
20. Clermont O, Bonacorsi S, Bingen E. Rapid and simple determination of the Escherichia coli phylogenetic group. Appl Environ Microbiol 2000;66:4555-8.
21. Johnson JR, Stell AL. Extended virulence genotypes of Escherichia coli strains from patients with urosepsis in relation to phylogeny and host compromise. J Infect Dis 2000;181:261-72. (Pubitemid 30049057)
22. Gordon DM, Clermont O, Tolley H, Denamur E. Assigning Escherichia coli strains to phylogenetic groups: multi-locus sequence typing versus the PCR triplex method. Environ Microbiol 2008;10:2484-96.
23. Naas T, Nordmann P. OXA-type beta-lactamases. Curr Pharm Des 1999;5:865-79.
24. Hansen DS, Sirot D, Kolmos HJ. Betalaktamaser med udvidet spektrum hos danske Klebsiella-isolater. Ugeskr Laeger 1998;15:2261-2. (Pubitemid 28231698)
25. Lester CH, Olsen SS, Jakobsen L, Arpi M, Fuursted K, Hansen DS, et al. Emergence of extended-spectrum β -lactamase (ESBL)-producing Klebsiella pneumoniae in Danish hospitals; this is in part explained by spread of two CTX-M-15 clones with multilocus sequence types 15 and 16 in Zealand. Int J Antimicrob Agents 2011;38:180-2.
26. Cantón R, Novais A, Valverde A, Machado E, Peixe L, Baquero F, Coque TM. Prevalence and spread of extendedspectrum beta-lactamase-producing Enterobacteriaceae in Europe. Clin Microbiol Infect 2008;14(Suppl 1):144-53. (Pubitemid 350269194)
27. Jorgensen CJ, Cavaco LM, Hasman H, Emborg HD, Guardabassi L. Occurrence of CTX-M-1-producing Escherichia coli in pigs treated with ceftiofur. J Antimicrob Chemother 2007;59: 1040-2. (Pubitemid 47073385)
28. Bergenholtz RD, Jørgensen MS, Hansen LH, Jensen LB, Hasman H. Characterization of genetic determinants of extended-spectrum cephalosporinases (ESCs) in Escherichia coli isolates from Danish and imported poultry meat. J Antimicrob Chemother 2009;64:207-9.
29. Tängdén T, Cars O, Melhus Å, Löwdin E. Foreign travel is a major risk factor for colonization with Escherichia coli producing CTX-M-type extended-spectrum β -lactamases: a prospective study with Swedish volunteers. Antimicrob Agents Chemother 2010;54:3564-8.
30. Harris AD, Perencevich EN, Johnson JK, Paterson DL, Morris JG, Strauss SM, et al. Patient-to-patient transmission is important in extended-spectrum beta-lactamase-producing Klebsiella pneumoniae acquisition. Clin Infect Dis 2007;45:1347-50. (Pubitemid 351411912)
31. Melzer M, Petersen I. Mortality following bacteraemic infection caused by extended spectrum beta-lactamase (ESBL) producing E. coli compared to non-ESBL producing E. coli. J Infect 2007;55:254-9. (Pubitemid 47244918)
32. Ortega M, Marco F, Soriano A, Almela M, Martinez JA, Munoz A, et al. Analysis of 4758 Escherichia coli bacteraemia episodes: predictive factors for isolation of an antibioticresistant strain and their impact on the outcome. J Antimicrob Chemother 2009;63:568-74.
33. Tumbarello M, Sanguinetti M, Montuori E, Trecarichi EM, Posteraro B, Fiori B, et al. Predictors of mortality in patients with bloodstream infections caused by extended-spectrumbeta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother 2007;51:1987-94. (Pubitemid 46903084)