Signal amplification strategies for DNA and protein detection based on polymeric nanocomposites and polymerization: A review

Analytica Chimica Acta

Volumn 877, Issue , 2015, Pages 19-32

  Zhou, Shaohong ^a   Yuan, Liang ^a   Hua, Xin ^a   Xu, Lingling ^a   Liu, Songqin ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

Atom transfer radical polymerization; Biosensor; Conjugated polymers; Polymeric DNA dendrimers; Polymerization; Signal amplification

Indexed keywords

ATOM TRANSFER RADICAL POLYMERIZATION; BIOMOLECULES; BIOSENSORS; CONJUGATED POLYMERS; DIAGNOSIS; FLUORESCENCE; FREE RADICAL REACTIONS; NANOCOMPOSITES; OPTICAL PROPERTIES; POLYMERIZATION;

DISEASE DIAGNOSIS; ENVIRONMENTAL MONITORING; FLUORESCENCE SIGNAL AMPLIFICATION; PHOTO-INITIATED POLYMERIZATIONS; POLYMER BACKBONES; POLYMERIC NANOCOMPOSITES; PROTEIN DETECTION; SIGNAL AMPLIFICATIONS;

AMPLIFICATION;

DENDRIMER; MICROSPHERE; NANOCOMPOSITE; POLYELECTROLYTE; POLYMER; DNA; PROTEIN;

ADSORPTION; ANODIC STRIPPING POTENTIOMETRY; ATOM TRANSFER RADICAL POLYMERIZATION; BIOSENSOR; BRANCHED DNA SIGNAL AMPLIFICATION ASSAY; DNA HYBRIDIZATION; ELECTRON TRANSPORT; ENERGY TRANSFER; ENVIRONMENTAL MONITORING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUID FLOW; FLUORESCENCE RESONANCE ENERGY TRANSFER; FOOD ANALYSIS; GENE AMPLIFICATION; HUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; GENETIC PROCEDURES; PROCEDURES; SYNTHESIS;

ANIMALS; BIOSENSING TECHNIQUES; DNA; EQUIPMENT DESIGN; HUMANS; MODELS, MOLECULAR; NANOCOMPOSITES; POLYMERIZATION; POLYMERS; PROTEINS;

EID: 84929948133     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2015.01.034     Document Type: Review

References (91)

1. Vangala K., Yanney M., Hsiao C.T., Wu W.W., Shen R.F., Zou S.G., Sygula A., Zhang D.M. Sensitive carbohydrate detection using surface enhanced Raman tagging. Anal. Chem. 2010, 82:10164-10171.
2. Yang K., Zhang C.Y. Improved sensitivity for the electrochemical biosensor with an adjunct probe. Anal. Chem. 2010, 82:9500-9505.
3. Knox K., Carrigan D., Simmons G., Teque F., Zhou Y.C., Hackett J., Qiu X.X., Luk K.C., Schochetman G., Knox A., Kogelnik A.M., Levy J.A. No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected. Science 2011, 333:94-97.
4. Chen Y.H., Snyder M.R., Zhu Y., Tostrud L.J., Benson L.M., Katzmann J.A., Bergen H.R. Simultaneous phenotyping and quantification of α-1-antitrypsin by liquid chromatography-tandemmass spectrometry. Clin. Chem. 2011, 57:1161-1168.
5. Huang J., Chen Y., Yang L., Zhu Z., Zhu G.Z., Yang X.H., Wang K.M., Tan W.H. Amplified detection of cocaine based on strand-displacement polymerization and fluorescence resonance energy transfer. Biosens. Bioelectron. 2011, 28:450-453.
6. Zhu X.X., Kriegel A.M., Boustany C.A., Blake D.A. Single-chain variable fragment (scFv) antibodies optimized for environmental analysis of uranium. Anal. Chem. 2011, 83:3717-3724.
7. Whitcombe M.J., Chianella I., Larcombe L., Piletsky S.A., Noble J., Porter R., Horgan A. The rational development of molecularly imprinted polymer-based sensors for protein detection. Chem. Soc. Rev. 2011, 40:1547-1571.
8. Zeleny R., Schimmel H. Towards comparability of ELISA results for peanut proteins in food: a feasibility study. Food Chem. 2010, 123:1343-1351.
9. Takeuchi T., Matile S. DNA aptamers as analyte-responsive cation transporters in fluorogenic vesicles: signal amplification by supramolecular polymerization. J. Am. Chem. Soc. 2009, 131:18048-18049.
10. Seong J.K., Allen J.B. DNA analysis by application of Pt nanoparticle electrochemical amplification with single label response. J. Am. Chem. Soc. 2012, 134:10777-10779.
11. Zhang B., Liu B.Q., Tang D.P., Niessner R., Chen G.N., Knopp D. DNA-based hybridization chain reaction for amplified bioelectronic signal and ultrasensitive detection of proteins. Anal. Chem. 2012, 84:5392-5399.
12. Zhao W.W., Ma Z.Y., Yu P.P., Dong X.Y., Xu J.J., Chen H.Y. Highly sensitive photoelectrochemical immunoassay with enhanced amplification using horseradish peroxidase induced biocatalytic precipitation on a CdS quantum dots multilayer electrode. Anal. Chem. 2012, 84:917-923.
13. Yuan L., Wu Y.F., Shi H.Y., Liu S.Q. Surface-initiated atom-transfer radical polymerization of 4-acetoxystyrene for immunosensing. Chem. Eur. J. 2011, 17:976-983.
14. Grieshaber D., Lange V.D., Hirt T., Lu Z.H., Voros J. Vesicles for signal amplification in a biosensor for the detection of low antigen concentrations. Sensors 2008, 8:7894-7903.
15. Su H.Y., Meng X.C., Guo Q.P., Tan Y.J., Cai Q.Y., Qin H.T., Meng X.X. Label-free DNA sensor with PCR-like sensitivity based on background reduction and target-triggered polymerization. Biosens. Bioelectron. 2014, 52:417-421.
16. Luo X.L., Killard A.J., Morrin A., Smyth M.R. Enhancement of a conducting polymer-based biosensor using carbon nanotube-doped polyaniline. Anal. Chim. Acta 2006, 575:39-44.
17. Wu Y.F., Wei W., Liu S.Q. Target-triggered polymerization for biosensing. Acc. Chem. Rev. 2012, 45:1441-1450.
18. Wang J., Polsky R., Merkoci A., Turner K.L. Electroactive beads for ultrasensitive DNA detection. Langmuir 2003, 19:989-991.
19. Advincula R.C. Surface initiated polymerization from nanoparticle surfaces. J. Dispers. Sci. Technol. 2003, 24:343-361.
20. Wu Y.F., Liu S.Q., He L. Activators generated electron transfer for atom transfer radical polymerization for immunosensing. Biosens. Bioelectron. 2010, 26:970-975.
21. Fristrup C.J., Jankova K., Hvilsted S. Surface-initiated atom transfer radical polymerization a technique to develop biofunctional coatings. Soft Matter 2009, 5:4623-4634.
22. Pinijsuwan S., Rijiravanich P., Somasundrum M., Werasak S. Sub-femtomolar electrochemical detection of DNA hybridization based on latex/gold nanoparticle assisted signal amplification. Anal. Chem. 2008, 80:6779-6784.
23. Dong H.F., Yan F., Ji H.X., Wong D.K.Y., Ju H.X. Quantum-dot-functionalized poly(styrene-co-acrylic acid) microbeads: step-wise self-assembly characterization, and applications for sub-femtomolar electrochemical detection of DNA hybridization. Adv. Funct. Mater. 2010, 20:1173-1179.
24. 4 nanoparticles-loaded PEG-PLA polymeric vesicles as labels for ultrasensitive immunosensors. Biomaterials 2010, 31:7332-7339.
25. Yuan L., Hua X., Wu Y.F., Pan X.H., Liu S.Q. Polymer-functionalized silica nanosphere labels for ultrasensitive detection of tumor necrosis factor-alpha. Anal. Chem. 2011, 83:6800-6809.
26. Lei J.P., Ju H.X. Signal amplification using functional nanomaterials for biosensing. Chem. Soc. Rev. 2012, 41:2122-2134.
27. Decher G. Fuzzy nanoassemlies: toward layered polymeric multicomposites. Science 1997, 277:1232-1237.
28. 3 microparticles templating. Biomacromolecules 2004, 5:1962-1972.
29. Bao B.Q., Tao N.J., Ma M.F., Zhang L., Yuwen L.H., Fan Q.L., Wang L.H., Huang W. Fluorescence turn-on sensing of ascorbic acid based on a hyperbranched conjugated polyelectrolyte. Soft Mater. 2014, 12:73-78.
30. Le V.S., Kim B., Lee W., Jeong J.E., Yang R.Q., Woo H.Y. Ratiometric fluorescent ion detection in water with high sensitivity via aggregation-mediated fluorescence resonance energy transfer using a conjugated polyelectrolyte as an opticalplatform. Macromol. Rapid Commun. 2013, 34:772-778.
31. Trau D., Yang W., Seydack M., Caruso F., Yu N.T., Renneberg R. Nanoencapsulated microcrystalline particles for super amplified biochemical assays. Anal. Chem. 2002, 74:5480-5486.
32. Chan C.P., Bruemmel Y., Seydack M., Sin K.K., Wong L.W., Liversidge E.M., Trau D., Renneberg R. Nanocrystal biolabels with releasable fluorophores for immunoassays. Anal. Chem. 2004, 76:3638-3645.
33. Mak W.C., Cheung K.Y., Trau D., Warsinke A., Scheller F., Renneberg R. Electrochemical bioassay utilizing encapsulated electrochemical active microcrystal biolabels. Anal. Chem. 2005, 77:2835-2841.
34. 4 magnetic composites combined with silver enhancement. Analyst 2010, 135:1672-1679.
35. Sergiy P., Vladimir V.T. Assembling hyperbranched polymerics. J. Polym. Sci. B Polym. Phys. 2012, 50:83-100.
36. Jin H.B., Huang W., Zhu X.Y., Zhou Y.F., Yan D.Y. Biocompatible or biodegradable hyperbranched polymers: from self-assembly to cytomimetic applications. Chem. Soc. Rev. 2012, 41:5986-5997.
37. Liu J.F., Zhang J., Zhang S.S., Suzuki N., Fujiki M., Wang L.B., Li L., Zhang W., Zhou N.C., Zhu X.L. Chiroptical generation and amplification of hyperbranched π-conjugated polymers in aggregation states driven by limonene chirality. Polym. Chem. 2014, 5:784-791.
38. Chen S.F., Yu Q.M., Li L.Y., Boozer C.L., Homola J., Yee S.S., Jiang S.Y. Detecting the adsorption of dye molecules in homogenous poly(propyleneimine) dendrimer monolayers by surface plasma resonance sensor. J. Am. Chem. Soc. 2002, 124:3395-3401.
39. Lin S.M., Liu S.P., Ye F.Q., Xu L., Zeng W.N., Wang L.Y., Li L., Beuerman R., Cao D.R. Sensitive detection of DNA by hyperbranched diketopyrrolopyrrole-based conjugated polyelectrolytes. Sens. Actuators B Chem. 2013, 182:176-183.
40. Zhou Y.F., Huang W., Liu J.Y., Zhu X.Y., Yan D.Y. Self-assembly of hyperbranched polymers and its biomedical applications. Adv. Mater. 2010, 22:4567-4590.
41. Lowe M., Spiro A., Zhang Y.Z., Getts R. Multiplexed, particle-based detection of DNA using flow cytometry with 3DNA dendrimers for signal amplification. Cytometry A 2004, 60:135-144.
42. Wangler C., Moldenhauer G., Saffrich R., Knapp E.M., Beijer B., Schnolzer M., Wangler B., Eisenhut M., Haberkorn U., Mier W. PAMAM structure-based multifunctional fluorescent conjugates for improved fluorescent labeling of biomacromolecules. Chem. Eur. J. 2008, 14:8116-8130.
43. Zhu N.N., Gao H., Gu Y.F., Xu Q., He P.G., Fang Y.Z. PAMAM dendrimer-enhanced DNA biosensors based on electrochemical impedance spectroscopy. Analyst 2009, 134:860-866.
44. Liu P., Hun X., Qing H.Q. Dendrimer-based biosensor for chemiluminescent detection of DNA hybridization. Microchim. Acta 2011, 175:201-207.
45. Lu C., Wang X.F., Xu J.J., Chen H.Y. Electrochemical modulation of electrogenerated chemiluminescence of CdS nano-composite. Electrochem. Commun. 2008, 10:1530-1532.
46. Jie G.F., Wang L., Yuan J.X., Zhang S.S. Versatile electrochemiluminescence assays for cancer cells based on dendrimer/CdSe-ZnS-quantum dot nanoclusters. Anal. Chem. 2011, 83:3873-3880.
47. Divsar F., Ju H.X. Electrochemiluminescence detection of near single DNA molecules byusing quantum dots-dendrimer nanocomposites for signal amplification. Chem. Commun. 2011, 47:9879-9881.
48. An Y.R., Jiang X.L., Bi W.J., Chen H., Jin L.T., Zhang S.P., Wang C.G., Zhang W. Sensitive electrochemical immunosensor for α-synuclein based on dual signal amplification using PAMAM dendrimer-encapsulated Au and enhanced gold nanoparticle labels. Biosens. Bioelectron. 2012, 32:224-230.
49. Li Y.G., Tseng Y.D., Kwon S.Y., D'Espaux L., Bunch J.S., McEuen P.L., Luo D. Controlled assembly of dendrimer-like DNA. Nat. Mater. 2004, 3:38-42.
50. Mese F., Congur G., Erdem A. Voltammetric and impedimetric detection of DNA hybridization by using dendrimer modified graphite electrodes. J. Electroanal. Chem. 2014, 719:92-97.
51. Wang G.F., Chen L., He X.P., Zhu Y.H., Zhang X.J. Detection of polynucleotide kinase activity by using a gold electrode modified with magnetic microspheres coated with titanium dioxide nanoparticles and a DNA dendrimer. Analyst 2014, 139:3895-3900.
52. Zhang J., Yuan Y.L., Xie S.B., Chai Y.Q., Yuan R. Amplified amperometric aptasensor for selective detection of protein using catalase-functional DNA-PtNPs dendrimer as a synergetic signal amplification label. Biosens. Bioelectron. 2014, 60:224-230.
53. Mora J.R., Zielinski T.L., Nelson B.P., Getts R.C. Protein detection enhanced by 3DNA dendrimer signal amplification. Biotechniques 2008, 44:815-818.
54. Wei F., Liao W., Xu Z., Yang Y., Wong D.T., Ho C.M. Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis. Small 2009, 5:1784-1790.
55. Thomas S.W., Joly G.D., Swager T.M. Chemical sensors based on amplifying fluorescent conjugated polymers. Chem. Rev. 2007, 107:1339-1386.
56. Li K., Liu B. Water-soluble conjugated polymers as the platform for protein sensors. Polym. Chem. 2010, 1:252-259.
57. Chen L.H., McBranch D.W., Wang H.L., Helgeson R., Wudl F., Whitten D.G. Highly sensitive biological and chemical sensors based on reversible fluorescence quenching in a conjugated polymer. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:12287-12292.
58. Jiang H., Taranekar P., Reynolds J.R., Schanze K.S. Conjugated polyelectrolytes: synthesis, photophysics, and applications. Angew. Chem. Int. Ed. 2009, 48:4300-4316.
59. Tan C.Y., Alas E., Muller J.G., Pinto M.R., Kleiman V.D., Schanze K.S. Amplified quenching of a conjugated polyelectrolyte by cyanine dyes. J. Am. Chem. Soc. 2004, 126:13685-13694.
60. Gaylord B.S., Heeger A.J., Bazan G.C. DNA hybridization detection with water-soluble conjugated polymers and chromophore-labeled single-stranded DNA. J. Am. Chem. Soc. 2003, 125:896-900.
61. Dore K., Dubus S., Ho H.A., Levesque I., Brunette M., Corbeil G., Boissinot M., Boivin G., Bergeron M.G., Boudreau D., Leclerc M. Fluorescent polymeric transducer for the rapid simple, and specific detection of nucleic acids at the zeptomole level. J. Am. Chem. Soc. 2004, 126:4240-4244.
62. Ho H.A., Najari A., Leclerc M. Optical detection of DNA and proteins with cationic polythiophenes. Acc. Chem. Rev. 2008, 41:168-178.
63. Lee K., Maisel K., Rouillard J.M., Gulari E., Kim J. Sensitive and selective label-free DNA detection by conjugated polymer-based microarrays and intercalating dye. Chem. Mater. 2008, 20:2848-2850.
64. Lee K., Rouillard J.M., Pham T., Gulari E., Kim J. Signal-amplifying conjugated polymer-DNA hybrid chips. Angew. Chem. Int. Ed. 2007, 46:4667-4670.
65. Liu B., Bazan G.C. Homogeneous fluorescence-based DNA detection with water-soluble conjugated polymers. Chem. Mater. 2004, 16:4467-4476.
66. Lee K., Povlich L.K., Kim J. Recent advances in fluorescent and colorimetric conjugated polymer-based biosensors. Analyst 2010, 135:2179-2189.
67. Kim J., Swager M. Control of conformational and interpolymer effects in conjugated polymers. Nature 2001, 413:1030-1034.
68. Lebouch N., Garreau S., Louarn G., Belletete M., Durocher G., Leclerc M. Structural study of the thermochromic transition in poly(2,5-dialkyl-p-phenyleneethynylene)s. Macromolecules 2005, 38:9631-9637.
69. Haskins-Glusac K., Pinto M.R., Tan C.Y., Schanze K.S. Luminescence quenching of a phosphorescent conjugated polyelectrolyte. J. Am. Chem. Soc. 2004, 126:14964-14971.
70. Gaylord B.S., Heeger A.J., Bazan G.C. DNA detection using water-soluble conjugated polymers and peptide nucleic acid probes. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:10954-10957.
71. Ho H.A., Leclerc M. Optical sensors based on hybrid aptamer/conjugated polymer complexes. Optical sensors based on hybrid aptamer/conjugated polymer complexes. J. Am. Chem. Soc. 2004, 126:1384-1387.
72. Wang Y.Y., Liu B. Conjugated polymer as a signal amplifier for novel nanoparticle-based fluoroimmunoassay. Biosens. Bioelectron. 2009, 24:3293-3298.
73. Wang Y.Y., Liu B. Conjugated polyelectrolyte-sensitized fluorescent detection of thrombin in blood serum using aptamer-immobilized silica nanoparticles as the platform. Langmuir 2009, 25:12787-12793.
74. Zhan R.Y., Tan A.J.H., Liu B. Conjugated polyelectrolyte as signal amplifier for fluorogenic probe based enzyme activity study. Polym. Chem. 2011, 2:417-421.
75. Kaja K., Hadley D.S. Polymerization-based signal amplification under ambient conditions with thirty-five second reaction times. Lab Chip 2012, 12:4055-4058.
76. Wu Y.F., Xue P., Hui K.M., Kang Y.J. A paper-based microfluidic electrochemical immunodevice integrated with amplification-by-polymerization for the ultrasensitive multiplexed detection of cancer biomarkers. Biosens. Bioelectron. 2014, 52:180-187.
77. Lee J.K., Sikes H.D. Balancing the initiation and molecular recognition capabilities of eosin macroinitiators of polymerization-based signal amplification reactions. Macromol. Rapid Commun. 2014, 35:981-986.
78. Xu L.L., Yuan L., Liu S.Q. Macroinitiator triggered polymerization for versatile immunoassay. RSC Adv. 2014, 4:140-146.
79. Hu W.H., Chen H.M., Shi Z.Z., Yu L. Dual signal amplification of surface plasmon resonance imaging for sensitive immunoassay of tumor marker. Anal. Biochem. 2014, 453:16-21.
80. Yuan L., Xu L.L., Liu S.Q. Integrated tyramide and polymerization-assisted signal amplification for highly-sensitive immunoassay. Anal. Chem. 2012, 84:10737-10744.
81. Yuan L., Wei W., Liu S.Q. Label-free electrochemical immunosensors based on surface-initiated atom radical polymerization. Biosens. Bioelectron. 2012, 38:79-85.
82. Sikes H.D., Hansen R.R., Johnson L.M., Jenison R., Birks J.W., Rowlen K.L., Bowman C.N. Using polymeric materials to generate an amplified response to molecular recognition events. Nat. Mater. 2008, 7:52-56.
83. Hansen R.R., Sikes H.D., Bowman C.N. Visual detection of labeled oligonucleotides using visible-light-polymerization-based amplification. Biomacromolecules 2008, 9:355-362.
84. Padon K.S., Scranton A.B. A mechanistic investigation of the three-component radical photoinitiator system eosin Y spirit soluble, N-methyldiethanolamine, and diphenyliodonium chloride. J. Polym. Sci. A Polym. Chem. 2001, 39:715-723.
85. Hansen R.R., Johnson L.M., Bowman C.N. Visual, base-specific detection of nucleic acid hybridizationusing polymerization-based amplification. Anal. Biochem. 2009, 386:285-287.
86. Johnson L.M., Avens H.J., Hansen R.R., Sewell H.L., Bowman C.N. Characterization of the assaying methods in polymerization-based amplification of surface biomarkers. Aust. J. Chem. 2009, 62:877-884.
87. Kaastrup K., Chan L., Sikes H.D. Impact of dissociation constant on the detection sensitivity of polymerization-based Signal amplification reactions. Anal. Chem. 2013, 85:8055-8060.
88. Iwata H., Hata Y., Matsuda T., Ikada Y. Initiation of radical polymerization byglucose-oxidase utilizing dissolved-oxygen. J. Polym. Sci. A Polym. Chem. 1991, 29:1217-1218.
89. Johnson L.M., Fairbanks B.D., Anseth K.S., Bowman C.N. Enzyme-mediated redoxinitiation for hydrogel generation and cellular encapsulation. Biomacromolecules 2009, 10:3114-3121.
90. Berron B.J., Johnson L.M., Ba X., McCall J.D., Alvey N.J., Anseth K.S., Bowman C.N. Glucose oxidase-mediated polymerization as a platform for dual-mode signal amplification and biodetection. Biotechnol. Bioeng. 2011, 108:1521-1528.
91. Berron B.J., May A.M., Zheng Z., Balasubramaniam V., Bowman C.N. Antigen-responsive, microfluidic valves for single use diagnostics. Lab Chip 2012, 12:708-710.