Regadenoson for myocardial perfusion imaging: Is it safe?

Journal of Nuclear Cardiology

Volumn 21, Issue 5, 2014, Pages 871-876

  Hage, Fadi G ^a,b,c  

^a University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

^c AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2 RECEPTOR AGONIST; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; REGADENOSON; VASODILATOR AGENT;

ADVERSE EFFECTS; CHEMICALLY INDUCED; CORONARY ARTERY DISEASE; EXERCISE TEST; FEMALE; HEART ARREST; HUMAN; MALE; MYOCARDIAL PERFUSION IMAGING; SCINTISCANNING;

ADENOSINE A2 RECEPTOR AGONISTS; CORONARY ARTERY DISEASE; EXERCISE TEST; FEMALE; HEART ARREST; HUMANS; MALE; MYOCARDIAL PERFUSION IMAGING; PURINES; PYRAZOLES; VASODILATOR AGENTS;

EID: 84929938693     PISSN: 10713581     EISSN: 15326551     Source Type: Journal    
DOI: 10.1007/s12350-014-9922-4     Document Type: Editorial

References (40)

1. http://www.fda.gov/drugs/drugsafety/ucm375654.htm. Accessed April 30, 2014.
2. Rosenblatt J, Mooney D, Dunn T, Cohen M. Asystole following regadenoson infusion in stable outpatients. J Nucl Cardiol 2014;In same issue of this editorial.
3. Hsi DH, Marreddy R, Moshiyakhov M, Luft U. Regadenoson induced acute ST-segment elevation myocardial infarction and multivessel coronary thrombosis. J Nucl Cardiol 2013;20:481-4.
4. Shah S, Parra D, Rosenstein RS. Acute myocardial infarction during regadenoson myocardial perfusion imaging. Pharmacotherapy 2013;33:e90-5.
5. Bagley SJ, Lilly SM, Litwack AJ. Coronary vasospasm during a regadenoson stress test. Cardiol J 2012;19:92-4.
6. Iskandrian AE, Bateman TM, Belardinelli L, Blackburn B, Cerqueira MD, Hendel RC, et al. Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: Results of the ADVANCE phase 3 multicenter international trial. J Nucl Cardiol 2007;14:645-58.
7. Cerqueira MD, Nguyen P, Staehr P, Underwood SR, Iskandrian AE. Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective A2A agonist regadenoson versus adenosine in myocardial perfusion imaging: Integrated ADVANCE-MPI trial results. J Am Coll Cardiol Cardiol Image 2008;1:307-16.
8. Lieu HD, Shryock JC, von Mering GO, Gordi T, Blackburn B, Olmsted AW, et al. Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans. J Nucl Cardiol 2007;14:514-20.
9. Ananthasubramaniam K, Weiss R, McNutt B, Klauke B, Feaheny K, Bukofzer S. A randomized, double-blind, placebo-controlled study of the safety and tolerance of regadenoson in subjects with stage 3 or 4 chronic kidney disease. J Nucl Cardiol 2012;19:319-29.
10. Doukky R, Morales Demori R, Jain S, Kiriakos R, Mwansa V, Calvin JE. Attenuation of the side effect profile of regadenoson: a randomized double-blinded placebo-controlled study with aminophylline in patients undergoing myocardial perfusion imaging. “The ASSUAGE trial”. J Nucl Cardiol 2012;19:448-57.
11. Partington SL, Lanka V, Hainer J, Blankstein R, Skali H, Forman DE, et al. Safety and feasibility of regadenoson use for suboptimal heart rate response during symptom-limited standard Bruce exercise stress test. J Nucl Cardiol 2012;19:970-8.
12. Prenner BM, Bukofzer S, Behm S, Feaheny K, McNutt BE. A randomized, double-blind, placebo-controlled study assessing the safety and tolerability of regadenoson in subjects with asthma or chronic obstructive pulmonary disease. J Nucl Cardiol 2012;19:681-92.
13. Parker MW, Morales DC, Slim HB, Ahlberg AW, Katten DM, Cyr G, et al. A strategy of symptom-limited exercise with regadenoson-as-needed for stress myocardial perfusion imaging: a randomized controlled trial. J Nucl Cardiol 2013;20:185-96.
14. Ross MI, Wu E, Wilkins JT, Gupta D, Shen S, Aulwes D, et al. Safety and feasibility of adjunctive regadenoson injection at peak exercise during exercise myocardial perfusion imaging: The Both Exercise and Regadenoson Stress Test (BERST) trial. J Nucl Cardiol 2013;20:197-204.
15. Doukky R, Rangel MO, Wassouf M, Dick R, Alqaid A, Morales Demori R. The safety and tolerability of regadenoson in patients with end-stage renal disease: the first prospective evaluation. J Nucl Cardiol 2013;20:205-13.
16. AlJaroudi WA, Alraies MC, Cerquiera MD, Jaber WA. Safety and tolerability of regadenoson in 514 SPECT MPI patients with and without coronary artery disease and submaximal exercise heart rate response. Eur J Nucl Med Mol Imaging 2013;40:341-8.
17. Brinkert M, Reyes E, Walker S, Latus K, Maenhout A, Mizumoto R, et al. Regadenoson in Europe: First-year experience of regadenoson stress combined with submaximal exercise in patients undergoing myocardial perfusion scintigraphy. Eur J Nucl Med Mol Imaging 2014;41:511-21.
18. Zoghbi GJ, Iskandrian AE. Selective adenosine agonists and myocardial perfusion imaging. J Nucl Cardiol 2012;19:126-41.
19. Gao Z, Li Z, Baker SP, Lasley RD, Meyer S, Elzein E, et al. Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: Inverse relationship between affinity and duration of action of A2A agonists. J Pharmacol Exp Ther 2001;298:209-18.
20. Shryock JC, Snowdy S, Baraldi PG, Cacciari B, Spalluto G, Monopoli A, et al. A2A-adenosine receptor reserve for coronary vasodilation. Circulation 1998;98:711-8.
21. Pandit A, Unzek Freiman S. Complete heart block associated with regadenoson: A real side effect. J Nucl Cardiol 2012;19:1236-9.
22. Grady EC, Barron JT, Wagner RH. Development of asystole requiring cardiac resuscitation after the administration of regadenoson in a patient with pulmonary fibrosis receiving n-acetylcysteine. J Nucl Cardiol 2011;18:521-5.
23. Dhalla AK, Wong MY, Wang WQ, Biaggioni I, Belardinelli L. Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats. J Pharmacol Exp Ther 2006;316:695-702.
24. Minic Z, O’Leary DS, Scislo TJ. Nucleus tractus solitarii A(2a) adenosine receptors inhibit cardiopulmonary chemoreflex control of sympathetic outputs. Auton Neurosci 2014;180:32-42.
25. Hage FG, Heo J, Franks B, Belardinelli L, Blackburn B, Wang W, et al. Differences in heart rate response to adenosine and regadenoson in patients with and without diabetes mellitus. Am Heart J 2009;157:771-6.
26. Hage FG, Dean P, Iqbal F, Heo J, Iskandrian AE. A blunted heart rate response to regadenoson is an independent prognostic indicator in patients undergoing myocardial perfusion imaging. J Nucl Cardiol 2011;18:1086-94.
27. Gordi T, Frohna P, Sun HL, Wolff A, Belardinelli L, Lieu H. A population pharmacokinetic/pharmacodynamic analysis of regadenoson, an adenosine A2A-receptor agonist, in healthy male volunteers. Clin Pharmacokinet 2006;45:1201-12.
28. Zhao G, Serpllion S, Shryock J, Messina E, Xu X, Ochoa M, et al. Regadenoson, a novel pharmacologic stress agent for use in myocardial perfusion imaging, does not have a direct effect on the QT interval in conscious dogs. J Cardiovasc Pharmacol 2008;52:467-73.
29. Yesil M, Arikan E, Postaci N, Bayata S, Yilmaz R. Locations of coronary artery lesions in patients with severe conduction disturbance. Int Heart J 2008;49:525-31.
30. Abuin G, Nieponice A, Barcelo A, Rojas-Granados A, Leu PH, Arteaga-Martinez M. Anatomical reasons for the discrepancies in atrioventricular block after inferior myocardial infarction with and without right ventricular involvement. Tex Heart Inst J 2009;36:8-11.
31. Saadjian AY, Gerolami V, Giorgi R, Mercier L, Berge-Lefranc JL, Paganelli F, et al. Head-up tilt induced syncope and adenosine A2A receptor gene polymorphism. Eur Heart J 2009;30:1510-5.
32. Hurle A, Sanchez-Quintana D, Ho SY, Bernabeu E, Murillo M, Climent V. Capillary supply to the sinus node in subjects with long-term atrial fibrillation. Ann Thorac Surg 2010;89:38-43.
33. Andreassi MG, Laghi Pasini F, Picano E, Capecchi PL, Pompella G, Foffa I, et al. Adenosine A2(A) receptor gene polymorphism (1976C>T) affects coronary flow reserve response during vasodilator stress testing in patients with non ischemic-dilated cardiomyopathy. Pharmacogenet Genomics 2011;21:469-75.
34. 2013 Nuclear Cardiology Trend Survey. J Nucl Cardiol 2014;21:Supplement 1.
35. https://www.fbo.gov/index?s=opportunity&mode=form&id=a54939566ff0f502b8da95ab23e34d2b&tab=core&tabmode=list&=. Accessed 05/02/2014.
36. Stuart RJ Jr, Ellestad MH. National survey of exercise stress testing facilities. Chest 1980;77:94-7.
37. Cerqueira MD, Verani MS, Schwaiger M, Heo J, Iskandrian AS. Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry. J Am Coll Cardiol 1994;23:384-9.
38. Lette J, Tatum JL, Fraser S, Miller DD, Waters DD, Heller G, et al. Safety of dipyridamole testing in 73,806 patients: The Multicenter Dipyridamole Safety Study. J Nucl Cardiol 1995;2:3-17.
39. Geleijnse ML, Fioretti PM, Roelandt JR. Methodology, feasibility, safety and diagnostic accuracy of dobutamine stress echocardiography. J Am Coll Cardiol 1997;30:595-606.
40. Sokol DK. “First do no harm” revisited. BMJ 2013;347:f6426.