Attenuation of the side effect profile of regadenoson: A randomized double-blinded placebo-controlled study with aminophylline in patients undergoing myocardial perfusion imaging. "the ASSUAGE trial"

Journal of Nuclear Cardiology

Volumn 19, Issue 3, 2012, Pages 448-457

  Doukky, Rami ^a   Demori, Raysa Morales ^a   Jain, Sidharth ^a   Kiriakos, Roy ^b   Mwansa, Victor ^b   Calvin, James E ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Jr Hospital of Cook County   (United States)

Author keywords

Aminophylline; ASSUAGE trial; Gastrointestinal adverse effects; Myocardial perfusion imaging: SPECT; Regadenoson

Indexed keywords

AMINOPHYLLINE; PLACEBO; REGADENOSON; TETROFOSMIN TC 99M;

ABDOMINAL CRAMP; ABDOMINAL DISCOMFORT; ADULT; AGE DISTRIBUTION; ANGINA PECTORIS; ARTICLE; BRONCHOSPASM; COMPETITIVE INHIBITION; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; DYSPNEA; EXERCISE TEST; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HEART ATRIUM FIBRILLATION; HEART NONSUSTAINED VENTRICLE TACHYCARDIA; HEART VENTRICLE TACHYCARDIA; HOT FLUSH; HUMAN; HYPOTENSION; IMAGE ANALYSIS; INCIDENCE; ISOTOPE LABELING; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MYOCARDIAL PERFUSION IMAGING; NAUSEA; PRIORITY JOURNAL; QUANTITATIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SUPRAVENTRICULAR TACHYCARDIA; SUSTAINED VETRICULAR TACHYCARDIA; TACHYCARDIA; THORAX PAIN;

ABDOMINAL PAIN; ADENOSINE A2 RECEPTOR ANTAGONISTS; AMINOPHYLLINE; CARDIOTONIC AGENTS; DIARRHEA; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; EXERCISE TEST; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; MYOCARDIAL PERFUSION IMAGING; PLACEBO EFFECT; PREMEDICATION; PURINES; PYRAZOLES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TREATMENT OUTCOME;

EID: 84864056167     PISSN: 10713581     EISSN: 15326551     Source Type: Journal    
DOI: 10.1007/s12350-012-9533-x     Document Type: Article

References (20)

1. Zhao G, Linke A, Xu X, Ochoa M, Belloni F, Belardinelli L, et al. Comparative profile of vasodilation by CVT-3146, a novel A2A receptor agonist, and adenosine in conscious dogs. J Pharmacol Exp Ther 2003;307:182-9. (Pubitemid 37151905)
2. Gao Z, Li Z, Baker SP, Lasley RD, Meyer S, Elzein E, et al. Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: Inverse relationship between affinity and duration of action of A2A agonists. J Pharmacol Exp Ther 2001;298:209-18. (Pubitemid 32574529)
3. Iskandrian AE, Bateman TM, Belardinelli L, Blackburn B, Cerqueira MD, Hendel RC, et al. Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: results of the ADVANCE phase 3 multicenter international trial. J Nucl Cardiol 2007;14:645-58. (Pubitemid 47355078)
4. Cerqueira MD, Nguyen P, Staehr P, Underwood SR, Iskandrian AE. Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective A2A agonist regadenoson versus adenosine in myocardial perfusion imaging integrated ADVANCE-MPI trial results. JACC Cardiovasc Imaging 2008;1:307-16. (Pubitemid 351676842)
5. Atellas-Pharma-US. Regadenoson Highlights of Prescribing Information. April 2011 updated April 2011. http://www.astellas. us/docs/lexiscan.pdf, Accessed September 19, 2011.
6. Daly JW, Jacobson KA, Ukena D. Adenosine receptors: Development of selective agonists and antagonists. Prog Clin Biol Res 1987;230:41-63.
7. Afonso S. Inhibition of coronary vasodilating action of dipyrid-amole and adenosine by aminophylline in the dog. Circ Res 1970; 26:743-52.
8. Beller GA. Pharmacologic stress imaging. JAMA 1991;265:633-8.
9. Doukky R. Pharmacologic Stress testing in myocardial perfusion imaging: Technical applications. In: Mann A, Heller GV, Hendel RC, editors. Nuclear cardiology: Technical applications. New York: McGraw-Hill; 2007. p. 107-24.
10. Henzlova MJ, Cerqueira MD, Mahmarian JJ, Yao SS. Stress protocols and tracers. J Nucl Cardiol 2006;13:e80-90. (Pubitemid 44913649)
11. Hospira. Aminophylline injection, USP. Lake Forest, IL; 2009 updated 2009 November 2009; Prescribing information. http://products.hospira.com/assets/ pdfs/EN-2301.pdf, Accessed December 24, 2011.
12. Hansen CL, Goldstein RA, Berman DS, Churchwell KB, Cooke CD, Corbett JR, et al. Myocardial perfusion and function single photon emission computed tomography. J Nucl Cardiol 2006;13: e97-120.
13. Nichols KJ, Bacharach SL, Bergmann SR, Cullom SJ, Ficaro EP, Galt JR, et al. Instrumentation quality assurance and performance. J Nucl Cardiol 2006;13:e25-41. (Pubitemid 44913643)
14. Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997;32:920-4. (Pubitemid 27382038)
15. Gordi T, Blackburn B, Lieu H. Regadenoson pharmacokinetics and tolerability in subjects with impaired renal function. J Clin Pharmacol 2007;47:825-33.
16. Aljaroudi W, Hermann D, Hage F, Heo J, Iskandrian AE. Safety of regadenoson in patients with end-stage renal disease. Am J Cardiol 2010;105:133-5.
17. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: A statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the American heart association. Circulation 2002;105:539-42. (Pubitemid 34262671)
18. Picano E, Lattanzi F, Masini M, Distante A, L'Abbate A. Ami-nophylline termination of dipyridamole stress as a trigger of coronary vasospasmin variant angina. Am J Cardiol 1988;62:694-7.
19. Varriale P, Ramaprasad S. Aminophylline induced atrial fibrillation. Pacing Clin Electrophysiol 1993;16:1953-5. (Pubitemid 23306492)
20. Sinusas AJ, Shi Q, Saltzberg MT, Vitols P, Jain D, Wackers FJ, et al. Technetium-99m-tetrofosmin to assess myocardial blood flow: Experimental validation in an intact canine model of ischemia. J Nucl Med 1994;35:664-71. (Pubitemid 24114567)