B cells produce less IL-10, IL-6 and TNF-α in myasthenia gravis

Autoimmunity

Volumn 48, Issue 4, 2015, Pages 201-207

  Yilmaz, Vuslat ^a   Oflazer, Piraye ^a   Aysal, Fikret ^b   Parman, Yeşim G ^a   Direskeneli, Haner ^c   Deymeer, Feza ^a   Saruhan Direskeneli, Güher ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b BAKIRKOY DR SADI KONUK TRAINING AND RESEARCH HOSPITAL   (Turkey)

^c MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Autoantibody; B cell; Cytokine; Myasthenia gravis

Indexed keywords

CD40 ANTIGEN; CHOLINERGIC RECEPTOR ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12P35; INTERLEUKIN 6; MUSCLE SPECIFIC KINASE; PHOSPHOTRANSFERASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTOANTIBODY; CHOLINERGIC RECEPTOR; CYTOKINE; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; B LYMPHOCYTE; CHILD; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; IMMUNOASSAY; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; MYASTHENIA GRAVIS; PHENOTYPE; SCHOOL CHILD; BIOSYNTHESIS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; B-LYMPHOCYTES; CHILD; CYTOKINES; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-10; INTERLEUKIN-6; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; PHENOTYPE; RECEPTORS, CHOLINERGIC; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84929752876     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2014.992517     Document Type: Article

References (43)

1. Vincent, A., J. Palace, and D. Hilton-Jones. 2001. Myasthenia gravis. Lancet. 357: 2122-2128
2. Drachman, D. B. 1994. Myasthenia gravis. N. Engl. J. Med. 330: 1797-1810
3. Vincent, A., J. McConville, M. E. Farrugia, et al. 2003. Antibodies in myasthenia gravis and related disorDers. Ann. N. Y. Acad. Sci. 998: 324-335
4. Rodgaard, A., F. C. Nielsen, R. Djurup, et al. 1987. Acetylcholine receptor antibody in myasthenia gravis: predominance of IgG subclasses 1 and 3. Clin. Exp. Immunol. 67: 82-88
5. McConville, J., M. E. Farrugia, D. Beeson, et al. 2004. Detection and characterization of MuSK antibodies in seronegative myasthenia gravis. Ann. Neurol. 55: 580-584
6. Leite, M. I., S. Jacob, S. Viegas, et al. 2008. IgG1 antibodies to acetylcholine receptors in seronegative myasthenia gravis. Brain 131: 1940-1952
7. Pevzner, A., B. Schoser, K. Peters, et al. 2012. Anti-LRP4 autoantibodies in AChR-And MuSK-Antibody-negative myasthenia gravis. J. Neurol. 259: 427-435
8. Zhang, B., J. S. Tzartos, M. Belimezi, et al. 2012. Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis. Arch. Neurol. 69: 445-451
9. Zhang, B., C. Shen, B. Bealmear, et al. 2014. Autoantibodies to agrin in myasthenia gravis patients. PLoS One 9: e91816
10. Milani, M., N. Ostlie, H. Wu, et al. 2006. CD4+ T and B cells cooperate in the immunoregulation of experimental autoimmune myasthenia gravis. J. Neuroimmunol. 179: 152-162
11. Yi, Q., R. Ahlberg, R. Pirskanen, and A. K. Lefvert. 1994. Acetylcholine receptor-reactive T cells in myasthenia gravis: eviDence for the involvement of different subpopulations of T helper cells. J. Neuroimmunol. 50: 177-186
12. Zhang, G. X., V. Navikas, and H. Link. 1997. Cytokines and the pathogenesis of myasthenia gravis. Muscle Nerve 20: 543-551
13. Tangye, S. G., A. Ferguson, D. T. Avery, et al. 2002. Isotype switching by human B cells is division-Associated and regulated by cytokines. J. Immunol. 169: 4298-4306
14. Huang, W.-X., P. Huang, S. Fredrikson, et al. 2000. Decreased mRNA expression of TNFa and IL-10 in non-stimulated peripheral blood mononuclear cells in myasthenia gravis. Eur. J. Neurol. 7: 195-202
15. Link, J., V. Navikas, M. Yu, et al. 1994. Augmented interferongamma, interleukin-4 and transforming growth factor beta mRNA expression in blood mononuclear cells in myasthenia gravis. J. Neuroimmunol. 51: 185-192
16. Yoshikawa, H., K. Satoh, Y. Yasukawa, and M. Yamada. 2002. Cytokine secretion by peripheral blood mononuclear cells in myasthenia gravis. J. Clin. Neurosci. 9: 133-136
17. Huang, Y. M., P. Kivisakk, V. Ozenci, et al. 1999. Increased levels of circulating acetylcholine receptor (AChR)-reactive IL-10-secreting cells are characteristic for myasthenia gravis (MG). Clin. Exp. Immunol. 118: 304-308
18. Duddy, M. E., A. Alter, and A. Bar-Or. 2004. Distinct profiles of human B cell effector cytokines: a role in immune regulation? J. Immunol. 172: 3422-3427
19. Pistoia, V. 1997. Production of cytokines by human B cells in health and disease. Immunol. Today 18: 343-350
20. Luu, V. P., M. I. Vazquez, and A. Zlotnik. 2014. B cells participate in tolerance and autoimmunity through cytokine production. Autoimmunity 47: 1-12
21. Burdin, N., C. Van Kooten, L. Galibert, et al. 1995. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-Activated human B lymphocytes. J. Immunol. 154: 2533-2544
22. Agematsu, K., H. Nagumo, F. C. Yang, et al. 1997. B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur. J. Immunol 27: 2073-2079
23. Duddy, M., M. Niino, F. Adatia, et al. 2007. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J. Immunol. 178: 6092-6099
24. Jagannathan, M., M. McDonnell, Y. Liang, et al. 2010. Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia 53: 1461-1471
25. Fillatreau, S., C. H. Sweenie, M. J. McGeachy, et al. 2002. B cells regulate autoimmunity by provision of IL-10. Nat. Immunol. 3: 944-950
26. Nakano, S., S. Morimoto, J. Suzuki, et al. 2008. Role of pathogenic auto-Antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus. Rheumatology (Oxford) 47: 145-149
27. Pisetsky, D. S. 2008. The role of innate immunity in the induction of autoimmunity. Autoimmun. Rev. 8: 69-72
28. Baccam, M., and G. A. Bishop. 1999. Membrane-bound CD154, but not CD40-specific antibody, mediates NF-kappaB-inDepenDent IL-6 production in B cells. Eur. J. Immunol. 29: 3855-3866
29. Kawanami, S., S. Mori, H. Kamei, et al. 1990. Cellular immunity in myasthenia gravis after thymectomy and corticosteroid therapy. Jpn. J. Med. 29: 138-145
30. Kohler, S., T. O. Keil, M. Swierzy, et al. 2013. Disturbed B cell subpopulations and increased plasma cells in myasthenia gravis patients. J. Neuroimmunol. 264: 114-119
31. Baumgarth, N. 2000. A two-phase moDel of B-cell activation. Immunol. Rev. 176: 171-180
32. Wheeler, K., J. D. Pound, J. Gordon, and R. Jefferis. 1993. Engagement of CD40 lowers the threshold for activation of resting B cells via antigen receptor. Eur. J. Immunol. 23: 1165-1168
33. Harp, C. T., S. Ireland, L. S. Davis, et al. 2010. Memory B cells from a subset of treatment-naive relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFNgamma production in response to myelin basic protein and myelin oligoDendrocyte glycoprotein. Eur. J. Immunol. 40: 2942-2956
34. Sun, F., S. S. Ladha, L. Yang, et al. 2014. Interleukin-10 producing-B cells and their association with responsiveness to rituximab in myasthenia gravis. Muscle Nerve 49: 487-494
35. Barr, T. A., P. Shen, S. Brown, et al. 2012. B cell Depletion therapy ameliorates autoimmune disease through ablation of IL-6 producing B cells. J. Exp. Med. 209: 1001-1010
36. Nielsen, C. H., L. Hegedus, K. Rieneck, et al. 2007. Production of interleukin (IL)-5 and IL-10 accompanies T helper cell type 1 (Th1) cytokine responses to a major thyroid self-Antigen, thyroglobulin, in health and autoimmune thyroid disease. Clin. Exp. Immunol. 147: 287-295
37. Link, H., O. Olsson, J. Sun, et al. 1991. Acetylcholine receptorreactive T and B cells in myasthenia gravis and controls. J. Clin. Invest. 87: 2191-2196
38. Lampropoulou, V., K. Hoehlig, T. Roch, et al. 2008. TLR-Activated B cells suppress T cell-mediated autoimmunity. J. Immunol. 180: 4763-4773
39. Ruprecht, C. R., and A. Lanzavecchia. 2006. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur. J. Immunol. 36: 810-816
40. Cufi, P., N. Dragin, J. M. Weiss, et al. 2013. Implication of doublestranDed RNA signaling in the etiology of autoimmune myasthenia gravis. Ann. Neurol. 73: 281-293
41. Fillatreau, S., D. Gray, and S. M. AnDerton. 2008. Not always the bad guys: B cells as regulators of autoimmune pathology. Nat. Rev. Immunol. 8: 391-397
42. Stubgen, J. P. 2008. B cell-targeted therapy with rituximab and autoimmune neuromuscular disorDers. J. Neuroimmunol. 204: 1-12
43. Berrih-Aknin, S., S. Ragheb, R. Le Panse, and R. P. Lisak. 2013. Ectopic germinal centers, BAFF and anti-B-cell therapy in myasthenia gravis. Autoimmun. Rev. 12: 885-893