Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat

Osteoarthritis and Cartilage

Volumn 23, Issue 6, 2015, Pages 906-913

  Sagar, D R ^a   Nwosu, L ^a   Walsh, D A ^a   Chapman, V ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Monosodium iodoacetate; Osteoarthritis; Pain; Spinal

Indexed keywords

NERVE GROWTH FACTOR; IODOACETIC ACID;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED RESPONSE; HIND PAW; IN VIVO STUDY; KNEE; KNEE OSTEOARTHRITIS; KNEE PAIN; MALE; MECHANICAL STIMULATION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SPINAL CORD NERVE CELL; SYNOVIAL FLUID LEVEL; WEIGHT BEARING; ANIMAL; ANIMAL BEHAVIOR; COMPLICATION; DRUG EFFECTS; EXPERIMENTAL ARTHRITIS; INTRAARTICULAR DRUG ADMINISTRATION; METABOLISM; OSTEOARTHRITIS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PATHOLOGY; PATHOPHYSIOLOGY; PHYSICAL STIMULATION; PHYSIOLOGY; PROCEDURES; SPINAL NERVE; SPRAGUE DAWLEY RAT;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BEHAVIOR, ANIMAL; INJECTIONS, INTRA-ARTICULAR; IODOACETIC ACID; MALE; NERVE GROWTH FACTOR; NOCICEPTION; OSTEOARTHRITIS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION; RATS, SPRAGUE-DAWLEY; SPINAL NERVES;

EID: 84929706995     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.01.010     Document Type: Article

References (37)

1. Kumar V., Mahal B.A. NGF - the TrkA to successful pain treatment. JPain Res 2012, 5:279-287.
2. Pezet S., McMahon S.B. Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci 2006, 29:507-538.
3. Seidel M.F., Herguijuela M., Forkert R., Otten U. Nerve growth factor in rheumatic diseases. Semin Arthritis Rheum 2010, 40:109-126.
4. Walsh D.A., McWilliams D.F., Turley M.J., Dixon M.R., Franses R.E., Mapp P.I., et al. Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis. Rheumatology (Oxford) 2010, 49:1852-1861.
5. Stoppiello L.A., Mapp P.I., Wilson D., Hill R., Scammell B.E., Walsh D.A. Structural associations of symptomatic knee osteoarthritis. Arthritis Rheum 2014 Nov, 66(11):3018-3027. 10.1002/art.38778.
6. Iannone F., De Bari C., Dell'Accio F., Covelli M., Patella V., Lo Bianco G., et al. Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes. Rheumatology (Oxford) 2002, 41:1413-1418.
7. Brown M.T., Murphy F.T., Radin D.M., Davignon I., Smith M.D., West C.R. Tanezumab reduces osteoarthritic knee pain: results of a randomized, double-blind, placebo-controlled phase III trial. JPain 2012, 13:790-798.
8. Gimbel J.S., Kivitz A.J., Bramson C., Nemeth M.A., Keller D.S., Brown M.T., et al. Long-term safety and effectiveness of tanezumab as treatment for chronic low back pain. Pain 2014 Sep, 155(9):1793-1801. 10.1016/j.pain.2014.06.004 13.
9. Bannwarth B., Kostine M. Targeting nerve growth factor (NGF) for pain management: what does the future hold for NGF antagonists?. Drugs 2014, 74:619-626.
10. Sagar D.R., Staniaszek L.E., Okine B.N., Woodhams S., Norris L.M., Pearson R.G., et al. Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. Arthritis Rheum 2010, 62:3666-3676.
11. McNamee K.E., Burleigh A., Gompels L.L., Feldmann M., Allen S.J., Williams R.O., et al. Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain 2010, 149:386-392.
12. Hendiani J.A., Westlund K.N., Lawand N., Goel N., Lisse J., McNearney T. Mechanical sensation and pain thresholds in patients with chronic arthropathies. JPain 2003, 4:203-211.
13. Lluch E., Torres R., Nijs J., Van Oosterwijck J. Evidence for central sensitization in patients with osteoarthritis pain: a systematic literature review. Eur J Pain 2014 Nov, 18(10):1367-1375. 10.1002/j.1532-2149.2014.499.x.
14. Gwilym S.E., Keltner J.R., Warnaby C.E., Carr A.J., Chizh B., Chessell I., et al. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum 2009, 61:1226-1234.
15. Ashraf S., Mapp P.I., Burston J., Bennett A.J., Chapman V., Walsh D.A. Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis. Ann Rheum Dis 2014, 73:1710-1718.
16. Tiseo P.J., Kivitz A.J., Ervin J.E., Ren H., Mellis S.J. Fasinumab (REGN475), an antibody against nerve growth factor for the treatment of pain: results from a double-blind, placebo-controlled exploratory study in osteoarthritis of the knee. Pain 2014, 155:1245-1252.
17. Bove S.E., Calcaterra S.L., Brooker R.M., Huber C.M., Guzman R.E., Juneau P.L., et al. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthritis Cartilage 2003, 11:821-830.
18. Sagar D.R., Ashraf S., Xu L., Burston J.J., Menhinick M.R., Poulter C.L., et al. Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis. Ann Rheum Dis 2013.
19. Neugebauer V., Vanegas H., Nebe J., Rumenapp P., Schaible H.G. Effects of N- and L-type calcium channel antagonists on the responses of nociceptive spinal cord neurons to mechanical stimulation of the normal and the inflamed knee joint. JNeurophysiol 1996, 76:3740-3749.
20. Salo P.T., Theriault E. Number, distribution and neuropeptide content of rat knee joint afferents. JAnat 1997, 190:515-522.
21. Dostrovsky J.O., Craig A.D. Ascending projection systems. Wall and Melzack's Textbook of Pain 2013, Elsevier.
22. Elmes S.J., Jhaveri M.D., Smart D., Kendall D.A., Chapman V. Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naive rats and in rat models of inflammatory and neuropathic pain. Eur J Neurosci 2004, 20:2311-2320.
23. Guingamp C., Gegout-Pottie P., Philippe L., Terlain B., Netter P., Gillet P. Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry. Arthritis Rheum 1997, 40:1670-1679.
24. Vincent T.L., Williams R.O., Maciewicz R., Silman A., Garside P. Mapping pathogenesis of arthritis through small animal models. Rheumatology (Oxford) 2012, 51:1931-1941. Arthritis Research UKamwg.
25. Graven-Nielsen T., Wodehouse T., Langford R.M., Arendt-Nielsen L., Kidd B.L. Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum 2012, 64:2907-2916.
26. Sagar D.R., Burston J.J., Hathway G.J., Woodhams S.G., Pearson R.G., Bennett A.J., et al. The contribution of spinal glial cells to chronic pain behaviour in the monosodium iodoacetate model of osteoarthritic pain. Mol Pain 2011, 7:88.
27. Ferreira-Gomes J., Adaes S., Sarkander J., Castro-Lopes J.M. Phenotypic alterations of neurons that innervate osteoarthritic joints in rats. Arthritis Rheum 2010, 62:3677-3685.
28. Kelly S., Dobson K.L., Harris J. Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat. Osteoarthritis Cartilage 2013, 21:1327-1335.
29. Bajaj P., Graven-Nielsen T., Arendt-Nielsen L. Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study. Pain 2001, 93:107-114.
30. Hoheisel U., Reuter R., de Freitas M.F., Treede R.D., Mense S. Injection of nerve growth factor into a low back muscle induces long-lasting latent hypersensitivity in rat dorsal horn neurons. Pain 2013, 154:1953-1960.
31. Park K.A., Fehrenbacher J.C., Thompson E.L., Duarte D.B., Hingtgen C.M., Vasko M.R. Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons. Neuroscience 2010, 171:910-923.
32. Mills C.D., Nguyen T., Tanga F.Y., Zhong C., Gauvin D.M., Mikusa J., et al. Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats. Eur J Pain 2013, 17:469-479.
33. Saxler G., Loer F., Skumavc M., Pfortner J., Hanesch U. Localization of SP- and CGRP-immunopositive nerve fibers in the hip joint of patients with painful osteoarthritis and of patients with painless failed total hip arthroplasties. Eur J Pain 2007, 11:67-74.
34. Bullock C.M., Wookey P., Bennett A., Mobasheri A., Dickerson I., Kelly S. Increased peripheral calcitonin gene-related peptide receptor signalling drives mechanical sensitization of the joint in rat models of osteoarthritis pain. Arthritis Rheumatol 2014.
35. Kelly S., Chapman R.J., Woodhams S., Sagar D.R., Turner J., Burston J.J., et al. Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. Ann Rheum Dis 2013.
36. Ota H., Katanosaka K., Murase S., Kashio M., Tominaga M., Mizumura K. TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness. PLoS One 2013, 8:e65751.
37. Allen K.D., Mata B.A., Gabr M.A., Huebner J.L., Adams S.B., Kraus V.B., et al. Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis. Arthritis Res Ther 2012, 14:R78.