메뉴 건너뛰기




Volumn 5, Issue , 2012, Pages 279-287

NGF - The TrkA to successful pain treatment

Author keywords

Anti NGF antibodies; Chronic pain; Nerve growth factor; Neurotrophic factor; Nociceptor neurons

Indexed keywords

BIOLOGICAL MARKER; NAPROXEN; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; PLACEBO; PROTEIN TYROSINE KINASE A; TANEZUMAB;

EID: 84874955155     PISSN: 11787090     EISSN: None     Source Type: Journal    
DOI: 10.2147/JPR.S33408     Document Type: Review
Times cited : (61)

References (57)
  • 1
    • 31844438588 scopus 로고    scopus 로고
    • Novel class of pain drugs based on antagonism of NGF
    • Hefti FF, Rosenthal A, Walicke PA, et al. Novel class of pain drugs based on antagonism of NGF. Trends Pharmacol Sci. 2006;27(2):85-91.
    • (2006) Trends Pharmacol Sci , vol.27 , Issue.2 , pp. 85-91
    • Hefti, F.F.1    Rosenthal, A.2    Walicke, P.A.3
  • 2
    • 0035855860 scopus 로고    scopus 로고
    • Molecular mechanisms of nociception
    • Sep
    • Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature. Sep 2001;413(6852):203-210.
    • (2001) Nature , vol.413 , Issue.6852 , pp. 203-210
    • Julius, D.1    Basbaum, A.I.2
  • 3
    • 56149111648 scopus 로고    scopus 로고
    • Targeting nerve growth factor in pain: What is the therapeutic potential?
    • Watson JJ, Allen SJ, Dawbarn D. Targeting nerve growth factor in pain: what is the therapeutic potential? Bio Drugs. 2008;22(6):349-359.
    • (2008) Bio Drugs , vol.22 , Issue.6 , pp. 349-359
    • Watson, J.J.1    Allen, S.J.2    Dawbarn, D.3
  • 4
    • 72049129149 scopus 로고    scopus 로고
    • A difficult balance-pain management, drug safety, and the FDA
    • Woodcock J. A difficult balance-pain management, drug safety, and the FDA. N Engl J Med. 2009;361(22):2105-2107.
    • (2009) N Engl J Med , vol.361 , Issue.22 , pp. 2105-2107
    • Woodcock, J.1
  • 5
    • 17744374814 scopus 로고    scopus 로고
    • Origins of growth factors: NGF and EGF
    • Cohen S. Origins of growth factors: NGF and EGF. Ann N Y Acad Sci. 2004;1038:98-102.
    • (2004) Ann N Y Acad Sci , vol.1038 , pp. 98-102
    • Cohen, S.1
  • 6
    • 34547735385 scopus 로고    scopus 로고
    • Nerve growth factor gene delivery: Animal models to clinical trials
    • Tuszynski MH. Nerve growth factor gene delivery: animal models to clinical trials. Dev Neurobiol. 2007;67(9):1204-1215.
    • (2007) Dev Neurobiol , vol.67 , Issue.9 , pp. 1204-1215
    • Tuszynski, M.H.1
  • 7
    • 0028152763 scopus 로고
    • Nerve growth factor in CNS repair
    • Varon S, Conner JM. Nerve growth factor in CNS repair. J Neurotrauma. 1994;11(5):473-486.
    • (1994) J Neurotrauma , vol.11 , Issue.5 , pp. 473-486
    • Varon, S.1    Conner, J.M.2
  • 8
    • 79953767729 scopus 로고    scopus 로고
    • Proof of concept trial of tanezumab for the treatment of symptoms associated with interstitial cystitis
    • Evans RJ, Moldwin RM, Cossons N, Darekar A, Mills IW, Scholfield D. Proof of concept trial of tanezumab for the treatment of symptoms associated with interstitial cystitis. J Urol. 2011;185(5):1716-1721.
    • (2011) J Urol , vol.185 , Issue.5 , pp. 1716-1721
    • Evans, R.J.1    Moldwin, R.M.2    Cossons, N.3    Darekar, A.4    Mills, I.W.5    Scholfield, D.6
  • 9
    • 69749097360 scopus 로고    scopus 로고
    • Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine-immune systems
    • Fiore M, Chaldakov GN, Aloe L. Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine-immune systems. Rev Neurosci. 2009;20(2):133-145.
    • (2009) Rev Neurosci , vol.20 , Issue.2 , pp. 133-145
    • Fiore, M.1    Chaldakov, G.N.2    Aloe, L.3
  • 10
    • 14844303990 scopus 로고    scopus 로고
    • A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF
    • Zhu W, Galoyan SM, Petruska JC, Oxford GS, Mendell LM. A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF. J Neurophysiol. 2004;92(5):3148-3152.
    • (2004) J Neurophysiol , vol.92 , Issue.5 , pp. 3148-3152
    • Zhu, W.1    Galoyan, S.M.2    Petruska, J.C.3    Oxford, G.S.4    Mendell, L.M.5
  • 11
    • 0041488911 scopus 로고    scopus 로고
    • Trk receptors: Roles in neuronal signal transduction
    • Huang EJ, Reichardt LF. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem. 2003;72:609-642.
    • (2003) Annu Rev Biochem , vol.72 , pp. 609-642
    • Huang, E.J.1    Reichardt, L.F.2
  • 12
    • 0028911398 scopus 로고
    • TrkA expression in the CNS: Evidence for the existence of several novel NGF-responsive CNS neurons
    • Holtzman DM, Kilbridge J, Li Y, et al. TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. J Neurosci. 1995;15(2):1567-1576.
    • (1995) J Neurosci , vol.15 , Issue.2 , pp. 1567-1576
    • Holtzman, D.M.1    Kilbridge, J.2    Li, Y.3
  • 13
    • 0033951624 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor and neuronal apoptosis
    • Barrett GL. The p75 neurotrophin receptor and neuronal apoptosis. Prog Neurobiol. 2000;61(2):205-229.
    • (2000) Prog Neurobiol , vol.61 , Issue.2 , pp. 205-229
    • Barrett, G.L.1
  • 14
    • 0042164216 scopus 로고    scopus 로고
    • Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site
    • Lad SP, Peterson DA, Bradshaw RA, Neet KE. Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site. J Biol Chem. 2003;278(27):24808-24817.
    • (2003) J Biol Chem , vol.278 , Issue.27 , pp. 24808-24817
    • Lad, S.P.1    Peterson, D.A.2    Bradshaw, R.A.3    Neet, K.E.4
  • 15
    • 29244484493 scopus 로고    scopus 로고
    • NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    • Zhang X, Huang J, McNaughton PA. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J. 2005;24(24): 4211-4223.
    • (2005) EMBO J , vol.24 , Issue.24 , pp. 4211-4223
    • Zhang, X.1    Huang, J.2    McNaughton, P.A.3
  • 16
    • 33947672465 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Mol Cell Neurosci
    • Zhu W, Oxford GS. Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Mol Cell Neurosci. Apr 2007;34(4):689-700.
    • (2007) Apr , vol.34 , Issue.4 , pp. 689-700
    • Zhu, W.1    Oxford, G.S.2
  • 18
    • 0141634247 scopus 로고    scopus 로고
    • Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor
    • Bonnington JK, McNaughton PA. Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. J Physiol. 2003;551(Pt 2):433-446.
    • (2003) J Physiol , vol.551 , Issue.PART 2 , pp. 433-446
    • Bonnington, J.K.1    McNaughton, P.A.2
  • 19
    • 0029034576 scopus 로고
    • Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons
    • Averill S, McMahon SB, Clary DO, Reichardt LF, Priestley JV. Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur J Neurosci. 1995;7(7):1484-1494.
    • (1995) Eur J Neurosci , vol.7 , Issue.7 , pp. 1484-1494
    • Averill, S.1    McMahon, S.B.2    Clary, D.O.3    Reichardt, L.F.4    Priestley, J.V.5
  • 20
    • 36248975322 scopus 로고    scopus 로고
    • Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture
    • Jimenez-Andrade JM, Martin CD, Koewler NJ, et al. Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture. Pain. 2007;133(1-3):183-196.
    • (2007) Pain , vol.133 , Issue.1-3 , pp. 183-196
    • Jimenez-Andrade, J.M.1    Martin, C.D.2    Koewler, N.J.3
  • 21
    • 20144388553 scopus 로고    scopus 로고
    • Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization
    • Sevcik MA, Ghilardi JR, Peters CM, et al. Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization. Pain. 2005;115(1-2):128-141.
    • (2005) Pain , vol.115 , Issue.1-2 , pp. 128-141
    • Sevcik, M.A.1    Ghilardi, J.R.2    Peters, C.M.3
  • 22
    • 0029621824 scopus 로고
    • Role of nerve growth factor in the expression of trkA mRNA in cultured embryonic rat basal forebrain cholinergic neurons
    • Kojima M, Ikeuchi T, Hatanaka H. Role of nerve growth factor in the expression of trkA mRNA in cultured embryonic rat basal forebrain cholinergic neurons. J Neurosci Res. 1995;42(6):775-783.
    • (1995) J Neurosci Res , vol.42 , Issue.6 , pp. 775-783
    • Kojima, M.1    Ikeuchi, T.2    Hatanaka, H.3
  • 23
    • 0034941330 scopus 로고    scopus 로고
    • Nerve growth factor signaling, neuroprotection, and neural repair
    • Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217-1281.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 1217-1281
    • Sofroniew, M.V.1    Howe, C.L.2    Mobley, W.C.3
  • 24
    • 0032906125 scopus 로고    scopus 로고
    • Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin
    • Koltzenburg M, Bennett DL, Shelton DL, McMahon SB. Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin. Eur J Neurosci. 1999;11(5):1698-1704.
    • (1999) Eur J Neurosci , vol.11 , Issue.5 , pp. 1698-1704
    • Koltzenburg, M.1    Bennett, D.L.2    Shelton, D.L.3    McMahon, S.B.4
  • 25
    • 0029085192 scopus 로고
    • The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
    • McMahon SB, Bennett DL, Priestley JV, Shelton DL. The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule. Nat Med. 1995;1(8):774-780.
    • (1995) Nat Med , vol.1 , Issue.8 , pp. 774-780
    • McMahon, S.B.1    Bennett, D.L.2    Priestley, J.V.3    Shelton, D.L.4
  • 26
    • 77951768402 scopus 로고    scopus 로고
    • Treatment of murine osteoarthritis with TrkAd5reveals a pivotal role for nerve growth factor in non-inflammatory joint pain
    • McNamee KE, Burleigh A, Gompels LL, et al. Treatment of murine osteoarthritis with TrkAd5reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain. 2010;149(2):386-392.
    • (2010) Pain , vol.149 , Issue.2 , pp. 386-392
    • McNamee, K.E.1    Burleigh, A.2    Gompels, L.L.3
  • 27
    • 79952233342 scopus 로고    scopus 로고
    • Taking pain out of NGF: A "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity
    • Capsoni S, Covaceuszach S, Marinelli S, et al. Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity. PLoS One. 2011;6(2):e17321.
    • (2011) PLoS One , vol.6 , Issue.2
    • Capsoni, S.1    Covaceuszach, S.2    Marinelli, S.3
  • 28
    • 15844369925 scopus 로고    scopus 로고
    • Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis
    • Indo Y, Tsuruta M, Hayashida Y, et al. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat Genet. 1996;13(4):485-488.
    • (1996) Nat Genet , vol.13 , Issue.4 , pp. 485-488
    • Indo, Y.1    Tsuruta, M.2    Hayashida, Y.3
  • 29
    • 70349273250 scopus 로고    scopus 로고
    • Urinary nerve growth factor level is increased in patients with interstitial cystitis/bladder pain syndrome and decreased in responders to treatment
    • Liu HT, Tyagi P, Chancellor MB, Kuo HC. Urinary nerve growth factor level is increased in patients with interstitial cystitis/bladder pain syndrome and decreased in responders to treatment. BJU Int. 2009;104(10):1476-1481.
    • (2009) BJU Int , vol.104 , Issue.10 , pp. 1476-1481
    • Liu, H.T.1    Tyagi, P.2    Chancellor, M.B.3    Kuo, H.C.4
  • 30
    • 80052076515 scopus 로고    scopus 로고
    • Nerve growth factor in bladder dysfunction: Contributing factor, biomarker, and therapeutic target
    • Ochodnický P, Cruz CD, Yoshimura N, Michel MC. Nerve growth factor in bladder dysfunction: contributing factor, biomarker, and therapeutic target. Neurourol Urodyn. 2011;30(7):1227-1241.
    • (2011) Neurourol Urodyn , vol.30 , Issue.7 , pp. 1227-1241
    • Ochodnický, P.1    Cruz, C.D.2    Yoshimura, N.3    Michel, M.C.4
  • 31
    • 69949187131 scopus 로고    scopus 로고
    • NGF and its receptor system: A new dimension in the pathogenesis of psoriasis and psoriatic arthritis
    • Raychaudhuri SK, Raychaudhuri SP. NGF and its receptor system: a new dimension in the pathogenesis of psoriasis and psoriatic arthritis. Ann N Y Acad Sci. 2009;1173:470-477.
    • (2009) Ann N Y Acad Sci , vol.1173 , pp. 470-477
    • Raychaudhuri, S.K.1    Raychaudhuri, S.P.2
  • 32
    • 79959952666 scopus 로고    scopus 로고
    • Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment
    • Watanabe T, Inoue M, Sasaki K, et al. Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment. BJU Int. 2011;108(2):248-251.
    • (2011) BJU Int , vol.108 , Issue.2 , pp. 248-251
    • Watanabe, T.1    Inoue, M.2    Sasaki, K.3
  • 33
    • 77953579275 scopus 로고    scopus 로고
    • Urinary nerve growth factor is a better biomarker than detrusor wall thickness for the assessment of overactive bladder with incontinence
    • Kuo HC, Liu HT, Chancellor MB. Urinary nerve growth factor is a better biomarker than detrusor wall thickness for the assessment of overactive bladder with incontinence. Neurourol Urodyn. 2010;29(3):482-487.
    • (2010) Neurourol Urodyn , vol.29 , Issue.3 , pp. 482-487
    • Kuo, H.C.1    Liu, H.T.2    Chancellor, M.B.3
  • 34
    • 79958097544 scopus 로고    scopus 로고
    • Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers
    • Bloom AP, Jimenez-Andrade JM, Taylor RN, et al. Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers. J Pain. 2011;12(6):698-711.
    • (2011) J Pain , vol.12 , Issue.6 , pp. 698-711
    • Bloom, A.P.1    Jimenez-Andrade, J.M.2    Taylor, R.N.3
  • 35
    • 78049509543 scopus 로고    scopus 로고
    • Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain
    • Jimenez-Andrade JM, Bloom AP, Stake JI, et al. Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain. J Neurosci. 2010;30(44):14649-14656.
    • (2010) J Neurosci , vol.30 , Issue.44 , pp. 14649-14656
    • Jimenez-Andrade, J.M.1    Bloom, A.P.2    Stake, J.I.3
  • 36
    • 84855196022 scopus 로고    scopus 로고
    • Increased cutaneous NGF and CGRP-labelled trkA-positive intra-epidermal nerve fibres in rat diabetic skin
    • Evans L, Andrew D, Robinson P, Boissonade F, Loescher A. Increased cutaneous NGF and CGRP-labelled trkA-positive intra-epidermal nerve fibres in rat diabetic skin. Neurosci Lett. 2012;506(1):59-63.
    • (2012) Neurosci Lett , vol.506 , Issue.1 , pp. 59-63
    • Evans, L.1    Andrew, D.2    Robinson, P.3    Boissonade, F.4    Loescher, A.5
  • 37
    • 80054988003 scopus 로고    scopus 로고
    • Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain
    • Jimenez-Andrade JM, Ghilardi JR, Castañeda-Corral G, Kuskowski MA, Mantyh PW. Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain. Pain. 2011;152(11):2564-2574.
    • (2011) Pain , vol.152 , Issue.11 , pp. 2564-2574
    • Jimenez-Andrade, J.M.1    Ghilardi, J.R.2    Castañeda-Corral, G.3    Kuskowski, M.A.4    Mantyh, P.W.5
  • 38
    • 20444498114 scopus 로고    scopus 로고
    • Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis
    • Shelton DL, Zeller J, Ho WH, Pons J, Rosenthal A. Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis. Pain. 2005;116(1-2):8-16.
    • (2005) Pain , vol.116 , Issue.1-2 , pp. 8-16
    • Shelton, D.L.1    Zeller, J.2    Ho, W.H.3    Pons, J.4    Rosenthal, A.5
  • 39
    • 48249146140 scopus 로고    scopus 로고
    • Probing the binding mechanism and affinity of tanezumab, a recombinant humanized anti-NGF monoclonal antibody, using a repertoire of biosensors
    • Abdiche Y, Malashock DS, Pons J. Probing the binding mechanism and affinity of tanezumab, a recombinant humanized anti-NGF monoclonal antibody, using a repertoire of biosensors. Protein Science. 2008;17(8):1326-1335.
    • (2008) Protein Science , vol.17 , Issue.8 , pp. 1326-1335
    • Abdiche, Y.1    Malashock, D.S.2    Pons, J.3
  • 41
    • 76749118433 scopus 로고    scopus 로고
    • Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic pain
    • Cattaneo A. Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic pain. Curr Opin Mol Ther. 2010;12(1):94-106.
    • (2010) Curr Opin Mol Ther , vol.12 , Issue.1 , pp. 94-106
    • Cattaneo, A.1
  • 42
    • 84874975743 scopus 로고    scopus 로고
    • Efficacy and safety of intravenous tanezumab in osteoarthritis hip and knee pain: Comparison to placebo and naproxen in two phase III studies (NCT00830063 and NCT00863304)
    • Ekman E, Gimbel J, Bello A, et al. Efficacy and safety of intravenous tanezumab in osteoarthritis hip and knee pain: comparison to placebo and naproxen in two phase III studies (NCT00830063 and NCT00863304). The Journal of Pain: Official Journal of the American Pain Society. 2011;12(4):P55.
    • (2011) The Journal of Pain: Official Journal of the American Pain Society , vol.12 , Issue.4
    • Ekman, E.1    Gimbel, J.2    Bello, A.3
  • 43
    • 77955461004 scopus 로고    scopus 로고
    • Tanezumab. Anti-NGF monoclonal antibody, Treatment of pain, Treatment of osteoarthritis
    • Haddley K. Tanezumab. Anti-NGF monoclonal antibody, Treatment of pain, Treatment of osteoarthritis. Drugs of the Future. 2010;35(5):373-378.
    • (2010) Drugs of the Future , vol.35 , Issue.5 , pp. 373-378
    • Haddley, K.1
  • 45
    • 77957934893 scopus 로고    scopus 로고
    • Tanezumab for the treatment of pain from osteoarthritis of the knee
    • Lane NE, Schnitzer TJ, Birbara CA, et al. Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med. 2010;363(16):1521-1531.
    • (2010) N Engl J Med , vol.363 , Issue.16 , pp. 1521-1531
    • Lane, N.E.1    Schnitzer, T.J.2    Birbara, C.A.3
  • 46
    • 82955195766 scopus 로고    scopus 로고
    • Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: A randomized, double-blind, dose-escalation, placebo-controlled study
    • Nagashima H, Suzuki M, Araki S, Yamabe T, Muto C. Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized, double-blind, dose-escalation, placebo-controlled study. Osteoarthritis and Cartilage/OARS, Osteoarthritis Research Society. 2011;19(12):1405-1412.
    • (2011) Osteoarthritis and Cartilage/OARS, Osteoarthritis Research Society , vol.19 , Issue.12 , pp. 1405-1412
    • Nagashima, H.1    Suzuki, M.2    Araki, S.3    Yamabe, T.4    Muto, C.5
  • 48
    • 80053194062 scopus 로고    scopus 로고
    • Efficacy and safety of tanezumab in the treatment of chronic low back pain
    • Katz N, Borenstein DG, Birbara C, et al. Efficacy and safety of tanezumab in the treatment of chronic low back pain. Pain. 2011;152(10): 2248-2258.
    • (2011) Pain , vol.152 , Issue.10 , pp. 2248-2258
    • Katz, N.1    Borenstein, D.G.2    Birbara, C.3
  • 49
    • 84874976450 scopus 로고    scopus 로고
    • Accessed April 15, In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2009 [updated March 14, 2011]. Available from
    • Pfizer. An efficacy and safety study of tanezumab for the treatment of pain associated with chronic abacterial prostatitis. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2009 [updated March 14, 2011]. Available from: http://clinicaltrials.gov/ct2/show/study/NCT00826514?term=NCT00826514&rank=1. NLM identifier: NCT00826514. Accessed April 15, 2012.
    • (2012) An efficacy and safety study of tanezumab for the treatment of pain associated with chronic abacterial prostatitis
    • Pfizer1
  • 50
    • 84874998624 scopus 로고    scopus 로고
    • Tanezumab therapy for chronic prostatitis/chronic pelvic pain syndrome (cp/cpps): Preliminary assessment of efficacy and safety in a randomized controlled trial
    • Nickel JC, Atkinson G, Krieger J, et al. Tanezumab therapy for chronic prostatitis/chronic pelvic pain syndrome (cp/cpps): preliminary assessment of efficacy and safety in a randomized controlled trial. The Journal of Urology. 2011;185(4):e573-e574.
    • (2011) The Journal of Urology , vol.185 , Issue.4
    • Nickel, J.C.1    Atkinson, G.2    Krieger, J.3
  • 51
    • 77949423573 scopus 로고    scopus 로고
    • New treatments for chronic prostatitis/chronic pelvic pain syndrome
    • Strauss AC, Dimitrakov JD. New treatments for chronic prostatitis/chronic pelvic pain syndrome. Nat Rev Urol. 2010;7(3):127-135.
    • (2010) Nat Rev Urol , vol.7 , Issue.3 , pp. 127-135
    • Strauss, A.C.1    Dimitrakov, J.D.2
  • 52
    • 77957963249 scopus 로고    scopus 로고
    • Nerve growth factor and pain
    • Oct
    • Wood JN. Nerve growth factor and pain. N Engl J Med. Oct 2010; 363(16):1572-1573.
    • (2010) N Engl J Med. , vol.363 , Issue.16 , pp. 1572-1573
    • Wood, J.N.1
  • 53
    • 84875001966 scopus 로고    scopus 로고
    • Accessed April 15, Bethesda, MD: US National Library of Medicine; 2010 [updated April 13, 2011], Pfizer, In: ClinicalTrials. gov [website on the Internet], Available from
    • Pfizer. Safety and efficacy of tanezumab in patients with chronic pancreatitis. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010 [updated April 13, 2011]. Available from: http://clinicaltrials.gov/ct2/show/NCT01146561?term=NCT01146561&rank=1. NLM identifier: NCT01146561. Accessed April 15, 2012.
    • (2012) Safety and efficacy of tanezumab in patients with chronic pancreatitis
  • 55
    • 79960567234 scopus 로고    scopus 로고
    • The role of phenotyping in chronic prostatitis/chronic pelvic pain syndrome
    • Mahal BA, Cohen JM, Allsop SA, et al. The role of phenotyping in chronic prostatitis/chronic pelvic pain syndrome. Curr Urol Rep. 2011; 12(4):297-303.
    • (2011) Curr Urol Rep , vol.12 , Issue.4 , pp. 297-303
    • Mahal, B.A.1    Cohen, J.M.2    Allsop, S.A.3
  • 56
    • 0014262643 scopus 로고
    • Bacteriologic localization patterns in bacterial prostatitis and urethritis
    • Meares EM, Stamey TA. Bacteriologic localization patterns in bacterial prostatitis and urethritis. Invest Urol. 1968;5(5):492-518.
    • (1968) Invest Urol , vol.5 , Issue.5 , pp. 492-518
    • Meares, E.M.1    Stamey, T.A.2
  • 57
    • 0019368245 scopus 로고
    • Prostatitis
    • Stamey TA. Prostatitis. J R Soc Med. 1981;74(1):22-40.
    • (1981) J R Soc Med , vol.74 , Issue.1 , pp. 22-40
    • Stamey, T.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.