An analysis of different therapeutic options in patients with Cushing's syndrome due to bilateral macronodular adrenal hyperplasia: A single-centre experience

Clinical Endocrinology

Volumn 82, Issue 6, 2015, Pages 808-815

  Albiger, Nora M ^a   Ceccato, F ^a   Zilio, M ^a   Barbot, M ^a   Occhi, G ^a   Rizzati, S ^a   Fassina, A ^a   Mantero, F ^a   Boscaro, M ^a   Iacobone, M ^a   Scaroni, C ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; KETOCONAZOLE; OCTREOTIDE; PROPRANOLOL;

ADRENAL HYPERPLASIA; ADRENALECTOMY; ADULT; ARTICLE; BILATERAL MACRONODULAR ADRENAL HYPERPLASIA; CLINICAL ARTICLE; CUSHING DISEASE; CUSHING SYNDROME; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; MALE; PRIORITY JOURNAL; PROVOCATION TEST; RECURRENCE RISK; REMISSION; TREATMENT OUTCOME; ADRENAL GLAND; ADVERSE EFFECTS; AGED; BLOOD; ENDOCRINE SYSTEM EXAMINATION; HYPERPLASIA; ITALY; METABOLISM; MIDDLE AGED; OUTCOME ASSESSMENT; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; RECURRENT DISEASE; RETROSPECTIVE STUDY; URINE;

ADRENAL GLANDS; ADRENALECTOMY; ADULT; AGED; CUSHING SYNDROME; DIAGNOSTIC TECHNIQUES, ENDOCRINE; FEMALE; HUMANS; HYDROCORTISONE; HYPERPLASIA; ITALY; MALE; MIDDLE AGED; PATIENT OUTCOME ASSESSMENT; RECURRENCE; RETROSPECTIVE STUDIES;

EID: 84929688896     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12763     Document Type: Article

References (39)

1. Lefebvre, H., Duparc, C., Chartrel, N., et al,. (2003) Intraadrenal adrenocorticotropin production in a case of bilateral macronodular adrenal hyperplasia causing Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 88, 3035-3042.
2. Louiset, E., Duparc, C., Young, J., et al,. (2013) Intraadrenal corticotrophin in bilateral macronodular adrenal hyperplasia. New England Journal of Medicine, 369, 2112-2125.
3. Hsiao, H.P., Kirschner, L.S., Bourdeau, I., et al,. (2009) Clinical and genetic heterogeneity, overlap with other tumor syndromes and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors. Journal of Clinical Endocrinology and Metabolism, 94, 2930-2937.
4. Rosenberg, D., Groussin, L., Bertagna, X., et al,. (2002) cAMP pathway alterations from the cell surface to the nucleus in adrenocortical tumors. Endocrine Research, 28, 765-775.
5. Libé, R., Coste, J., Guignat, L., et al,. (2010) Aberrant cortisol regulations in bilateral macronodular adrenal hyperplasia: a frequent finding in a prospective study of 32 patients with overt or subclinical Cushing's syndrome. European Journal of Endocrinology, 163, 129-138.
6. Libe, R., Fratticci, A., Coste, J., et al,. (2008) Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors. Clinical Cancer Research, 14, 4016-4024.
7. Horvath, A., Boikos, S., Giatzakis, C., et al,. (2006) A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia. Nature Genetics, 38, 794-800.
8. Horvath, A., Mericq, V., &, Stratakis, C.A., (2008) Mutation in PDE8B, a cyclic AMP-specific phosphodiesterase in adrenal hyperplasia. New England Journal of Medicine, 358, 750-752.
9. Vezzosi, D., Libé, R., Baudry, C., et al,. (2012) Phosphodiesterase 11(PDE11A) gene defects in patients with ACTH-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors. Journal of Clinical Endocrinology and Metabolism, 97, E2036-E2069.
10. Tsai, L.C., Shimizu-Albergine, M., &, Beavo, J.A., (2011) The high affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Molecular Pharmacology, 79, 639-648.
11. Assié, G., Libé, R., Espiard, S., et al,. (2013) ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome. New England Journal of Medicine., 369, 2105-2114.
12. Gagliardi, L., Schreiber, A.W., Hahn, C.N., et al,. (2014) ARMC5 mutations are common in familial bilateral macronodular adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism, 99, E1784-E1792.
13. Alencar, G.A., Lerario, A.M., Nishi, M.Y., et al,. (2014) ARMC5 mutations are a frequent cause of primary macronodular adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism, 99, E1501-E1509.
14. Faucz, F.R., Zilbermint, M., Lodish, M.B., et al,. (2014) Macronodular adrenal hyperplasia due to mutations in armadillo repeat containing 5 (ARMC5) gene: a clinical and genetic investigation. Journal of Clinical Endocrinology and Metabolism, 99, E1113-E1119.
15. Iacobone, M., Albiger, N., Scaroni, C., et al,. (2008) The role of unilateral adrenalectomy in ACTH-independent macronodular adrenal hyperplasia (AIMAH). World Journal of Surgery, 32, 882-889.
16. Lacroix, A., Bourdeau, I., Lampron, A., et al,. (2010) Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction. Clinical Endocrinology (Oxf), 73, 1-15.
17. Grumbach, M.M., Biller, B.M., Braunstein, G.D., et al,. (2003) Management of the clinically inapparent adrenal mass ("incidentaloma"). Annals of Internal Medicine, 138, 424-429.
18. Lacroix, A., Mircescu, H., &, Hamet, P., (1999) Clinical evaluation of the presence of abnormal hormone receptors in adrenal Cushing's syndrome. Endocrinologist, 9, 9-15.
19. Christopoulos, S., Bourdeau, I., &, Lacroix, A., (2005) Clinical and subclinical ACTH-independent macronodular adrenal hyperplasia and aberrant hormone receptors. Hormone Research, 64, 119-131.
20. Albiger, N.M., Occhi, G., Mariniello, B., et al,. (2007) Food-dependent Cushing's syndrome: from molecular characterization to therapeutical results. European Journal of Endocrinology, 157, 771-778.
21. Bourdeau, I., D'Amour, P., Hamet, P., et al,. (2001) Aberrant membrane hormone receptors in incidentally discovered bilateral macronodular adrenal hyperplasia with subclinical Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 86, 5534-5540.
22. Hofland, J., Hofland, L.J., van Koetsveld, P.M., et al,. (2013) ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitro responses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11beta-hydroxylase. Orphanet Journal of Rare Diseases, 8, 142.
23. Assie, G., Louiset, E., Sturm, N., et al,. (2010) Systematic analysis of G protein-coupled receptor gene expression in adrenocorticotropin-independent macronodular adrenocortical hyperplasia identifies novel targets for pharmacological control of adrenal Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 95, E253-E262.
24. Lacroix, A., Hamet, P., &, Boutin, J.M., (1999) Leuprolide acetate therapy in luteinizing hormone-dependent Cushing's syndrome. New England Journal of Medicine, 341, 1577-1581.
25. Karapanou, O., Vlassopoulou, B., Tzanela, M., et al,. (2013) ACTH-independent macronodular adrenal hyperplasia due to aberrant receptor expression: is medical treatment always an option? Endocrine Practice, 20, 1-20.
26. Lacroix, A., Tremblay, J., Rousseau, G., et al,. (1997) Propranolol therapy for ectopic beta-adrenergic receptors in adrenal Cushing's syndrome. New England Journal of Medicine, 337, 1429-1434.
27. Mazzuco, T.L., Chaffanjon, P., Martinie, M., et al,. (2009) Adrenal Cushing's syndrome due to bilateral macronodular adrenal hyperplasia: prediction of the efficacy of β-blockade therapy and interest of unilateral adrenalectomy. Endocrine Journal, 56, 867-877.
28. Reznik, Y., Allali-Zerah, V., Chayvialle, J.A., et al,. (1992) Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide. New England Journal of Medicine, 327, 981-986.
29. De Herder, W.W., Hofland, L.J., Usdin, T.B., et al,. (1996) Food-dependent Cushing's syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells. Journal of Clinical Endocrinology and Metabolism, 81, 3168-3172.
30. Preumont, V., Mermejo, L.M., Damoiseaux, P., et al,. (2011) Transient efficacy of octreotide and pasireotide (SOM230) treatment in GIP-dependent Cushing's syndrome. Hormone Metabolic Research, 43, 287-291.
31. Mazzuco, T.L., Chabre, O., Feige, J.J., et al,. (2007) Aberrant GPCR expression is a sufficient genetic event to trigger adrenocortical tumorigenesis. Molecular Cellular Endocrinology, 265-266, 23-28.
32. Mazzuco, T.L., Chabre, O., Sturm, N., et al,. (2006) Ectopic expression of the gastric inhibitory polypeptide receptor gene is a sufficient genetic event to induce benign adrenocortical tumor in a xenotransplantation model. Endocrinology, 147, 782-790.
33. Grossman, A., Johannsson, G., Quinkler, M., et al,. (2013) Therapy of endocrine disease: perspectives on the management of adrenal insufficiency: clinical insights from across Europe. European Journal of Endocrinology, 169, R165-R175.
34. Lamas, C., Alfaro, J.J., Lucas, T., et al,. (2002) Is unilateral adrenalectomy an alternative treatment for ACTH-independent macronodular adrenal hyperplasia? Long-term follow-up of four cases. European Journal of Endocrinology, 146, 237-240.
35. Ogura, M., Kusaka, I., Nagasaka, S., et al,. (2003) Unilateral adrenalectomy improves insulin resistance and diabetes mellitus in a patient with ACTH-independent macronodular adrenal hyperplasia. Endocrine Journal, 50, 715-721.
36. Xu, Y., Rui, W., Qi, Y., et al,. (2013) The role of unilateral adrenalectomy in corticotropin-independent bilateral adrenocortical hyperplasias. World Journal of Surgery, 37, 1626-1632.
37. Tung, S.C., Wang, P.W., Huang, T.L., et al,. (2004) Bilateral adrenocortical adenomas causing ACTH-independent Cushing's syndrome at different periods: a case report and discussion of corticosteroid replacement therapy following bilateral adrenalectomy. Journal of Endocrinological Investigation, 27, 375-379.
38. N'Diaye, N., Hamet, P., Tremblay, J., et al,. (1999) Asynchronous development of bilateral nodular adrenal hyperplasia in gastric inhibitory polypeptide-dependent Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 84, 2616-2622.
39. Elbelt, U., Trovato, A., &, Kloth, M., (2015) Molecular and clinical evidence for an ARMC5 tumor syndrome: concurrent inactivating germline and somatic mutations are associated with both primary macronodular adrenal hyperplasia and meningioma. Journal of Clinical Endocrinology and Metabolism, 100, E119-E128.